李纪明 副主任医师，副教授
硕士招生类型：学术型；专业型
硕士招生专业：内科学（心血管内科学）
博士招生类型：学术型；专业型
博士招生专业：内科学（心血管内科学）
所在院系：附属东方医院
联系方式：ljm**@126.com
课题组链接：
研究方向
主要任职
科研业绩


心力衰竭的诊疗
Diagnosis and treatment of heart failure
冠脉介入诊疗
Percutaneouscoronary intervention



国家自然科学基金项目评审专家
EvaluationExpert of National Natural Science Foundation of China
上海市硕士学位论文评审专家
Shanghaimaster's degree thesis review expert
《中国医药导报》期刊杂志评审专家。
ChinaMedical Herald review expert

临床工作业绩：
Clinical performance
从事内科工作10余年，熟练掌握内科学急、危、重症的诊治，尤其擅长急性心力衰竭、急性心肌梗死、高血压危象、主动脉夹层、恶性心律失常等的诊治，熟练掌握心内科常见病的诊治，包括高血压病、冠心病、心律失常、心肌病、心包炎、心肌炎、瓣膜病等，熟悉冠心病PCI术、心律失常射频消融术、起搏器植入等技术及其并发症的防治，主攻方向为冠心病的介入诊疗。参与《内科学》、《诊断学》的本科生及留学生等的见习、实习和授课工作。
I have engaged in internal medicine for more than 10 years andfamiliar with diagnosis and treatment of acute, sinister and serious symptomsin internal medicine, especiallyin acute heart failure, acutemyocardial infarction, hypertensivecrisis, aortic dissection and malignant arrhythmia. I am also skilled in diagnosis and treatmentof cardiovascular’s common diseases, including hypertension, coronary heart disease, cardiac arrhythmia, cardiomyopathy, pericarditis, myocarditis, valvular heart disease, etc. I am still good at techniques ofpercutaneous coronary intervention (PCI), arrhythmia radiofrequency ablation,pacemaker implantation and preventing complications of them. I am major ininterventional therapy of coronary heart disease. Besides, I am enjoying inundergraduates and InternationalStudents’ probation, practice and teaching in internal medicine anddiagnostics.

科研工作业绩：
scientific researchperformance
心脏存在许多内源性的保护因子，互相联系形成网络，而单个因子的保护作用往往有限。不良刺激下心肌受到损伤时，这些因子互相调节发挥保护作用，但不良刺激因素长期存在时则打破了这种互相联系互相调节的网络关系，使得保护作用失效。早期激发心肌内源性保护机制是预防心力衰竭的关键问题之一，但干预单个因子保护心脏的作用有限，阐明多个因子的调节关系，从多个环节激发心肌的内源性保护机制是更有效的预防心脏疾病策略。本人长期致力于热休克转录因子1保护心脏疾病的研究。曾参与国家“863”项目﹑国家****科学基金﹑国家自然科学基金﹑复旦大学博士点基金等科研项目10余项，发表相关文章30余篇，其中15篇被SCI收录，作为负责人主持科研项目6项。
There are many endogenous protective factors in the heart and theycontact each other forming a network. However, every single factor has ownlimitation in protecting heart. These factors regulate each other to protectthe myocardium when it is damaged by harmful simulation, but the relationshipbetween every factor can be broken by the long-term harmful simulation, whichmake the failures of protection. Simulating myocardial endogenesis protectmechanism is one of the key issues to protect heart failure. Nevertheless, theintervention of single factor is limited. So, explaining the relationshipbetween every factor and the simulating myocardial endogenesis protectmechanism in multiple ways are more effective in protecting heart disease. Iwork on the research of heat shock transcription factor 1 for a long time. Iused to participate in more than ten scientific research programs and takecharge of five of them, such as 863 Program, the National Natural ScienceFoundation of China, the National Science Fund for Distinguished YoungScholars, etc. I have published more than thirty papers and fifteen of them hadbeen recorded by SCI.

近三年在研课题：
Researching Programsrecently 3 years
国家自然科学基金面上项目
《miR-199b-5p通过 HSF1信号途径调控心力衰竭发生的分子机制研究》
General Program of National Natural Science Foundation ofChina
“Study on molecular mechanism of miR-199b-5p on heartfailure mediated by HSF1 signal pathway”
浦东新区卫生和计划生育委员会学科带头人培养项目
《circRNA-006964调控HSF1信号轴改善心力衰竭发生的作用及机制》
Pudong New Area discipline leader training project
Experimentalstudy of circRNA-006964 regulating HSF1 signal axis in the development of heartfailure