游洁芸 讲师，主治医师
硕士招生类型：学术型，专业型
硕士招生专业：内科学（心血管内科学）
博士招生类型：
博士招生专业：
所在院系：附属东方医院
联系方式：youjieyun1118@hotmail.com
课题组链接：
研究方向
主要任职
科研业绩

冠心病，心力衰竭，高血压
coronaryheart disease, heart failure, hypertension

现任同济大学附属东方医院心内科主治医师、讲师，上海市医学会心血管病专科分会第十一届委员会青年委员会委员，CIT工作组成员。目前主要从事心内科急危重症的诊治及冠心病介入治疗。
Attending doctor and lecturer, Departmentof Cardiology, Shanghai East Hospital, Tongji University School of Medicine
Youth committee, the 11^th Committeeof Cardiovascular Disease, Shanghai Medical Association
The member of CIT (China InterventionalTherapeutics) Working Group
Focusedon the emergency and intensive cardiovascular diseases, and specialized ininterventional cardiology.

2014年获复旦大学博士学位，就读博士期间获国家留学基金委资助至美国俄克拉荷马大学联合培养。主持国家自然科学基金项目1项，浦东新区卫健委科研项目1项，并作为主要研究者参与国家自然科学基金项目9项，先后发表SCI论文16篇，其中第一作者或并列第一作者7篇，第二作者4篇。曾受邀至美国TCT、日本循环器学会学术集会等国际学术会议进行学术交流。
Jieyun You obtained the Ph.D. Degreefrom Fudan University in 2014. During her Ph.D. study, she has been in theUniversity of Oklahoma Health Sciences Center as a visiting Ph.D. studentsponsored by China Scholarship Council. She is the director of 2 researchprojects, sponsored by National Natural Science Foundation (NSFC) and PudongNew Area Health Committee, respectively. As a major researcher, sheparticipated in 9 NSFC projects. She has published 16 SCI papers, including 7first-author and 4 second-author papers. She has been invited to internationalconferences such as TCT and Japanese Circulation Society.

主持或参加科研项目：
1、国家自然科学基金青年科学基金项目，**，Carabin介导的钙调神经磷酸酶活性在压力超负荷和容量超负荷导致的不同心肌重构中的作用和机制，2016/01-2018/12，18万元，已结题，主持。
2、浦东新区卫生和计划生育委员会卫生计生科研项目，GSDMD介导的细胞焦亡触发高血压心脏重构的机制和干预研究，2020/01-2022/12，11.5万元，在研，主持。
3、国家自然科学基金面上项目，**，外泌体介导环状RNA调控miR-378促进心肌细胞自噬的作用和机制，2019/01-2022/12，57万元，在研，参加。
4、国家自然科学基金面上项目，**，R-spondin1/LGR4/β-catenin信号通路参与心梗后心肌损伤和重构的作用和机制研究，2019/01-2022/12，57万元，在研，参加。
5、国家自然科学基金面上项目，**，HRF-circRNA靶向miR-199b-5p/HSF1信号粥调控心力衰竭发生的机制研究，2019/01-2022/12，57万元，在研，参加。
6、国家自然科学基金青年科学基金项目，**，心肌细胞分泌外泌体AT1-R促进机械应力引起心肌纤维化的作用和机制研究，2019/01-2022/12，21万元，在研，参加。
7、国家自然科学基金面上项目，**，CCR7在急性心肌梗死后对树突状细胞来源的外泌体迁移至淋巴组织的调控作用，2018/01-2021/12，52万元，在研，参加。
8、国家自然科学基金面上项目，**，外泌体介导的AT1-R/Carabin通路对心肌肥厚预适应的调控作用及其机制，2017/01-2020/12，52万元，在研，参加。
9、国家自然科学基金青年科学基金项目，**，CXCR6在压力超负荷诱导心室重构中的作用及机制研究，2014/01-2016/12，23万元，已结题，参加。
10、国家自然科学基金青年科学基金项目，**，压力超负荷和容量超负荷所致心脏肥大中β-arrestin-2的作用差异及其机制的研究，2013/01-2015/12，23万元，已结题，参加。
11、国家自然科学基金青年科学基金项目，**，心肌肥厚中miR-98表达变化的调控机制及其作用的研究，2013/01-2015/12，23万元，已结题，参加。

代表性论著：
1、第一作者论文：
① You J#, Wang X#, Wu J#, Gao L#, Wang X, Du P, Liu H, Li J, Wang Y, LiangY, Guo W, Zhang Q*. Predictors and prognosis of left ventricular thrombus inpost-myocardial infarction patients with left ventricular dysfunction afterpercutaneous coronary intervention. J Thorac Dis. 2018 Aug;10(8):4912-4922.
② Wang S#*, Wu J#, YouJ#, Shi H#, Xue X#, Huang J, Xu L, Jiang G, Yuan L, Gong X, Luo H, Ge J,Cui Z*, Zou Y*. HSF1 deficiency accelerates the transition from pressureoverload-induced cardiac hypertrophy to heart failure through endothelialmiR-195a-3p-mediated impairment of cardiac angiogenesis. J Mol Cell Cardiol.2018 May;118:193-207.
③ You J#, WuJ#, Zhang Q#, Ye Y#, Wang S, Huang J, Liu H, Wang X, Zhang W, Bu L, Li J, Lin L,Ge J, Zou Y*. Differential cardiac hypertrophy and signaling pathways inpressure versus volume overload. Am J Physiol Heart Circ Physiol. 2018 Mar1;314(3):H552-H562.
④ Huang J#, Wu J#, Wang S#, You J#, YeY, Ding Z, Yang F, Wang X, Guo J, Ma L, Yuan J, Shen Y, Yang X, Sun A, Jiang H,Bu L, Backx PH, Ge J, Zou Y*. Ultrasound biomicroscopy validation of a murinemodel of cardiac hypertrophic preconditioning: comparison with a hemodynamicassessment. Am J Physiol Heart Circ Physiol. 2017 Jul 1;313(1):H138- H148.
⑤ You J#, WuJ#, Jiang G, Guo J, Wang S, Li L, Ge J, Zou Y*. Olmesartan attenuates cardiacremodeling through DLL4/Notch1 pathway activation in pressure overload mice. J CardiovascPharmacol. 2013 Feb;61(2):142-151.
⑥ You J#, WuJ#, Ge J, Zou Y*. Comparison between adenosine and isoflurane for assessing thecoronary flow reserve in mouse models of left ventricular pressure and volumeoverload. Am J Physiol Heart Circ Physiol. 2012 Nov;303(10):H1199- H1207.
⑦ Wu J#, You J#, Jiang G, Li L, GuanA, Ye Y, Li DW, Gong H, Ge J, Zou Y*. Noninvasive estimation of infarct size ina mouse model of myocardial infarction by echocardiographic coronary perfusion.J Ultrasound Med. 2012 Jul;31(7):1111-1121.
2、既非第一作者又非通讯作者论文：
① Shen Y#, Gong S#, Li J#, Wang Y, Zhang X,Zheng H, Zhang Q, You J, Huang Z, Chen Y. Co-loading antioxidantN-acetylcysteine attenuates cytotoxicity of iron oxide nanoparticles inhypoxia/reoxygenation cardiomyocytes. Int J Nanomedicine. 2019 Aug 1;14:6103-6115.
② Wang X, Pei C, Bai Y, Dai Q, Deng X, Liu Y,Li Z, You J, Peng J, Lin L, Zou Y. Predictive Value of CHA2DS2-VAScScore for Ischemic Events in Patients Undergoing Percutaneous CoronaryIntervention. Angiology. 2019 Oct;70(9):878-886.
③ Wu J#, You J, Wang S, Ye Y, Wang X,Jia J, Zou Y*. Letter to the editor: When what you see might not be what youget: prudent considerations of anesthetics for murine echocardiography. Am JPhysiol Heart Circ Physiol. 2015 Jun 15;308(12):H1612- H1613.
④ Wu J#, You J, Wang S, Zhang L, GongH, Zou Y*. Insights into the activation and inhibition of angiotensin II type 1receptor in the mechanically loaded heart. Circ J. 2014 May 23;78(6):1283-1289.
⑤ Wang X#, Wu J#, Zhu D#, You J, ZouY, Qian J, Ge J*. Characterization of coronary flow reserve and leftventricular remodeling in a mouse model of chronic aortic regurgitation withcarvedilol intervention. J Ultrasound Med. 2015 Mar;34(3):483-493.
⑥ Weng L#, Zhang W#, Ye Y#, Yin P#, Yuan J#,Wang X, Kang L, You J, Wu J, Gong H, Ge J*, Zou Y*. Aliskirenameliorates pressure overload-induced heart hypertrophy and fibrosis in mice.Acta Pharmacol Sin. 2014 Aug;35(8):1005-1014.
⑦ Ouyang C#, You J, Xie Z*.Theinterplay between autophagy and apoptosis in the diabetic heart. J Mol CellCardiol. 2014 Jun;71:71-80.
⑧ Wang S#, Gong H#, Jiang G#, Ye Y#, Wu J, YouJ, Zhang G, Sun A, Komuro I, Ge J, Zou Y*. Src is required for mechanicalstretch-induced cardiomyocyte hypertrophy through angiotensin II type 1receptor-dependent β-arrestin2 pathways. PLoS One. 2014 Apr 3;9(4):e92926.
⑨ WuJ#, You J, Li L, Ma H, Jia J, Jiang G, Chen Z, Ye Y, Gong H, Bu L, Ge J,Zou Y*. Early estimation of left ventricular systolic pressure and predictionof successful aortic constriction in a mouse model of pressure overload byultrasound biomicroscopy. Ultrasound Med Biol. 2012 Jun;38(6):1030-1039.