李丽 教授
硕士招生类型：学术型
硕士招生专业：生物医学工程
博士招生类型：学术型
博士招生专业：临床医学（基础医学方向）
所在院系：医学院
联系方式：lilirz@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

表观遗传学与生物信息学/心肌细胞定向分化的表观遗传调节机制




教育背景：毕业于同济大学生物医学工程专业
工作经历：2004-至今 同济大学
2013-2014 美国南加州大学访问****
主要任职：美国人类遗传学学会会员；上海医学遗传学会委员



主要从事生物信息学与表观遗传学的研究。利用生物信息学策略和分子遗传学技术研究心肌细胞定向分化的表观遗传调节机制和心脏病相关基因的识别；基于生物大数据的复杂疾病的生物标志物识别、分子分型及网络构建。
科研项目：
1. 项目来源：国家自然科学基金面上项目；项目名称：ERG1介导Integrinβ1维持大鼠心脏发育信号稳态的研究；项目负责人。
2. 项目来源：上海市科委基础领域重点项目；项目名称：microRNA-26b核内调节机制；项目负责人。
3. 项目来源：中央高校基本科研业务费重点学科交叉；项目名称：新的先天性致病基因CX45的识别功能研究及诊断芯片研制；项目负责人。
4. 项目来源：国家自然科学基金面上项目；项目名称：microRNA-26b在心肌细胞分化中对GATA4和KCNJ2的同步调节机制；项目负责人。
5. 项目来源：国家重点基础研究发展计划；项目名称：miRNA和蛋白质修饰在干细胞对称和不对称分裂过程中的作用及机理；项目骨干。
6. 项目来源：国家自然科学基金面上项目；项目名称：离子通道药物靶点识别的生物信息融合方法研究；项目负责人。


发表论文：

1. Wen-JingWang Yu-Wei Wang, Yi Hu, Lin Qin, Rou Chen, Huan Liu, Wen-Ze Cao, Hui-Fang Zhu,Chang Tong, Li Li* and Lu-Ying Peng*.,HDncRNA: a manually constructeddatabase of relationship between heart disease and noncoding RNAs. Database.2018 Jan 1; doi: 10.1093/database/bay067.
2. WangW, Zhang P, Li L, Chen Z, Bai W, Liu G, Zhang L, Jia H, Li L*, Yu Y*,Liao M*. ATD: a comprehensive bioinformatics resource for deciphering theassociation of autophagy and diseases. 1. Database (Oxford).2018 Jan 1; doi: 10.1093/database/bay093.
3. YaoL, Xie D, Geng L, Shi D, Huang J, Wu Y, Lv F, Liang D, Li L, Liu Y, LiJ, Chen YH. REEP5 (Receptor Accessory Protein 5) Acts as a SarcoplasmicReticulum Membrane Sculptor to Modulate Cardiac Function. J Am Heart Assoc. 2018Feb 3;7(3).
4. LiRG, Xu YJ, Wang J, Liu XY, Yuan F, Huang RT, Xue S, Li L, Liu H, Li YJ,Qu XK, Shi HY, Zhang M, Qiu XB, Yang YQ. GATA4 Loss-of-Function Mutation andthe Congenitally Bicuspid Aortic Valve. Am J Cardiol. 2018 Feb15;121(4):469-474.
5. YuanT, Wang S, Hu C, Wu Y, Liang D, Li L, Liu Y, Li J, Chen YH. Low-densitylipoprotein receptor-related protein 6 regulates alternative pre-mRNA splicing.J Cell Mol Med. 2018 Oct;22(10):4653-4663.
6. WangD, Liu C, Wang Y, Wang W, Wang K, Wu X, Li Z, Zhao C, Li L*, Peng L*. Impactof miR-26b on cardiomyocyte differentiation in P19 cells through regulatingcanonical/non-canonical Wnt signalling. Cell Prolif. 2017 Dec;50(6).
7. WangD, Liu C, Li Z, Wang Y, Wang W, Wu X, Wang K, Miao W, Li L*, Peng L*. Regulationof Histone Acetylation on Expression Profiles of Potassium Channels DuringCardiomyocyte Differentiation From Mouse Embryonic Stem Cells. J Cell Biochem.2017 Dec;118(12):4460-4467. doi: 10.1002/jcb.26102. Epub 2017 May 31.
8. LiuJJ, Zhao CM, Li ZG, Wang YM, Miao W, Wu XJ, Wang WJ, Liu C, Wang D, Wang K, LiL*, Peng LY*. miR-218 Involvement in Cardiomyocyte Hypertrophy Is Likelythrough Targeting REST. Int J Mol Sci. 2016 May 31;17(6). (CorrespondingAuthor)
9. MiaoW, Wu X, Wang K, Wang W, Wang Y, Li Z, Liu J, Li L*, Peng L*. Sodium ButyratePromotes Reassembly of Tight Junctions in Caco-2 Monolayers Involving Inhibitionof MLCK/MLC2 Pathway and Phosphorylation of PKCβ2. Int J Mol Sci. 2016 Oct10;17(10). (Corresponding Author)
10. Li L, LiX, The E, Wang LJ, Yuan TY, Wang SY, Feng J, Wang J, Liu Y, Wu YH, Ma XE, Ge J,Cui YY, Jiang XY. Low expression of lncRNA-GAS5 is implicated in human primaryvaricose great saphenous veins. PLoS One. 2015 Mar 25;10(3):e**.
11. Li L, LiuV, Wang F, Miao W, Zhang J, Kang ZQ, Chen YH, Peng LY. Unraveling the hiddenheterogeneities of breast cancer based on functional miRNA cluster. Plos one.2014; 9: e87601.
12. Li L,Chen H, Liu C, Wang F, Zhang F, Bai L, Chen Y, Peng L. A robust hybrid approachbased on estimation of distribution algorithm and support vector machine forhunting candidate disease genes. ScientificWorldJournal. 2013;2013:393570. Epub2013 Feb 7.
13. LiRG#, Li L#, Qiu XB, Yuan F, Xu L, Li X, Xu YJ, Jiang WF, Jiang JQ, LiuX, Fang WY, Zhang M, Peng LY, Qu XK, Yang YQ.GATA4 loss-of-function mutationunderlies familial dilated cardiomyopathy. Biochem Biophys Res Commun. 2013 Oct4;439(4):591-6. doi: 10.1016/j.bbrc.2013.09.023. Epub 2013 Sep 13.
14. YangYQ#, Li L#, Wang J, Zhang XL, Li RG, Xu YJ, Tan HW, Wang XH, Jiang JQ,Fang WY, Liu X. GATA6 loss-of-function mutation in atrial fibrillation. Eur JMed Genet. 2012; 55(10): 520-526. (* Equal contributors)
15. YangYQ#, Li L#, Wang J, Liu XY, Chen XZ, Zhang W, Wang XZ, Jiang JQ, Liu X,Fang WYA Novel GATA4 Loss-of-Function Mutation Associated With CongenitalVentricular Septal Defect. Pediatr Cardiol. 2012; Apr;33(4):539-46. (* Equalcontributors)
16. Li L, XuJ, Yang D, Tan X, Wang H. Computational approaches for microRNA studies: areview. Mamm Genome. 2010; 21(1-2):1-12.
17. ZhangW#, Li L#, Li X, Jiang W, Huo J, Wang Y, Lin M, Rao S. Unravelling thehidden heterogeneities of diffuse large B-cell lymphoma based on coupledtwo-way clustering. BMC Genomics. 2007; 8:332. (* Equal contributors)
18. Li Li, WeiJiang, Xia Li, Guo Zheng, Shaoqi Rao. A robust hybrid between genetic algorithmand support vector machine for extracting an optimal feature gene subset.Genomics. 2005; 85(1):16-23.
19. ZhaoCM, Peng LY, Li L, Liu XY, Wang J, Zhang XL, Yuan F, Li RG, Qiu XB, YangYQ. PITX2 Loss-of-Function Mutation Contributes to Congenital EndocardialCushion Defect and Axenfeld-Rieger Syndrome. PLoS One. 2015 Apr20;10(4):e**.
20. Li Y,Liang C, Ma H, Zhao Q, Lu Y, Xiang Z, Li L, Qin J, Chen Y, Cho WC,Pestell RG, Liang L, Yu Z. miR-221/222 promotes S-phase entry and cellularmigration in control of basal-like breast cancer. Molecules. 2014 May30;19(6):7122-37.
21. LiangD, Zhen L, Yuan T, Huang J, Deng F, Wuyahan, Zhang H, Pan L, Liu Y, The E, YuZ, Zhu W, Zhang Y, Li L, Peng L, Li J, Chen YH. miR-10a regulatesproliferation of human cardiomyocyte progenitor cells by targeting GATA6. PLoSOne. 2014 Jul 28;9(7):e103097.
22. ShiD, Xie D, Zhang H, Zhao H, Huang J, Li C, Liu Y, Lv F, The E, Liu Y, Yuan T,Wang S, Chen J, Pan L, Yu Z, Liang D, Zhu W, Zhang Y, Li L, Peng L, LiJ, Chen YH. Reduction in dynamin-2 is implicated in ischaemic cardiacarrhythmias. J Cell Mol Med. 2014 Oct;18(10):1992-9.
23. ZhangJ, Li L, Peng L, Sun Y, Li J. An efficient weighted graph strategy toidentify differentiation associated genes in embryonic stem cells. PLoS One.2013 Apr 26;8(4):e62716.
24. YangYZ, Yang YQ, Liang B, Liu JQ, Li J, Grunnet M, Olesen SP, Rasmussen HB, EllinorPT, Gao LJ, Lin XP, Li L, Wang L, Xiao JJ, Liu Y, Liu Y, Zhang SL, LiangDD, Peng LY, Jespersen T, Chen YH. Identification of a Kir3.4 mutation incongenital long QT syndrome. Am J Hum Genet. 2010;86(6):872-880.
25. XiaoJ, Liang D, Zhang Y, Liu Y, Zhang H, Liu Y, Li L, Liang X, Sun Y, ChenYH. MicroRNA expression signature in atrial fibrillation with mitral stenosis.Physiol Genomics. 2011;15;43(11):655-664.
26. YanB, Huo Z, Liu Y, Lin X, Li J, Peng L, Zhao H, Zhou ZN, Liang X, Liu Y, Zhu W,Liang D, Li L, Sun Y, Cui J, Chen YH. Prolyl hydroxylase 2: A novelregulator of β2-adrenoceptor internalization. J Cell Mol Med.2011;15(12):2712-2722.
27. WangY, Chen X, Jiang W, Li L, Li W, Yang L, Liao M, Lian B, Lv Y, Wang S,Wang S, Li X. Predicting human microRNA precursors based on an optimizedfeature subset generated by GA-SVM. Genomics. 2011 Aug;98(2):73-8. Epub 2011May 1.
28. LinX, Huo Z, Liu X, Zhang Y, Li L, Zhao H, Yan B, Liu Y, Yang Y, Chen YH. Anovel GATA6 mutation in patients with tetralogy of Fallot or atrial septaldefect. J Hum Genet. 2010;55(10):662-667.
29. LiuY, Huo Z, Yan B, Lin X, Zhou ZN, Liang X, Zhu W, Liang D, Li L, Liu Y,Zhao H, Sun Y, Chen YH. Prolyl hydroxylase 3 interacts with Bcl-2 to regulatedoxorubicin- induced apoptosis in H9c2 cells. Biochem Biophys Res Commun.2010;401(2):231-237.
30. YangY, Li J, Lin X, Yang Y, Hong K, Wang L, Liu J, Li L, Yan D, Liang D,Xiao J, Jin H, Wu J, Zhang Y, Chen YH. Novel KCNA5 loss-of-function mutationsresponsible for atrial fibrillation. J Hum Genet. 2009;54(5):277-283.
31. LiangL, Pan Q, Liu Y, Chen H, Li J, Brugada R, Brugada P, Hong K, Perez GJ, Zhao C,Qi J, Zhang Y, Peng L, Li L, Chen YH. High sensitivity of the sheeppulmonary vein antrum to acetylcholine stimulation. J Appl Physiol.2008;105(1):293-298.
32. ZhaoC, Qi J, Liu X, Chen H, Li J, Li Y, Liang L, Zhang Y, Xiao J, Li L, PengL, Xu J, Ma J, Yang Y, Wu X, Chen YH. Refractoriness of the sheep superior venacava myocardial sleeve. Exp Biol Med. 2008;233(11):1441-1447.
33. YangY, Liu Y, Dong X, Kuang Y, Lin J, Su X, Peng L, Jin Q, He Y, Liu B, Pan Z, LiL, Zhu Q, Lin X, Zhou Q, Pan Q, Eurlings PMH, Fei J, Wang Z, Chen YH. HumanKCNQ1 S140G mutation is associated with atrioventricular blocks. Heart Rhythm.2007;4(5):611-618.
34. VoldersPG, Zhu Q, Timmermans C, Eurlings PM, Su X, Arens YH, Li L, JongbloedRJ, Xia M, Rodriguez LM, Chen YH. Mapping a novel locus for familial atrialfibrillation on chromosome 10p11-q21. Heart Rhythm. 2007;4(4):469-475.
35. Li X,Rao S, Jiang W, Li C, Xiao Y, Guo Z, Zhang Q, Wang L, Du L, Li J, Li L,Zhang T, Wang QK. Discovery of time-delayed gene regulatory networks based ontemporal gene expression profiling. BMC Bioinformatics.2006. 7(1):26.
36. XiaM, Jin Q, Bendahhou S, He Y, Larroque MM, Chen Y, Zhou Q, Yang Y, Liu Y, Liu B,Zhu Q, Zhou Y, Lin J, Liang B, Li L, Dong X, Pan Z, Wang R, Wan H, QiuW, Xu W, Eurlings P, Barhanin J, Chen Y. A Kir2.1 gain-of-function mutationunderlies familial atrial fibrillation. Biochem Biophys Res Commun.2005;332(4):1012-1019.
奖励：
心房颤动发生机制研究，上海市自然科学奖，一等奖，2011年（排名第五）