罗坤甜 研究员
硕士招生类型：学术型
硕士招生专业：基础医学
博士招生类型：学术型
博士招生专业：临床医学（基础医学方向）
所在院系：附属东方医院
联系方式：amethystian@hotmail.com
课题组链接：
研究方向
主要任职
科研业绩

致力于DNA损伤与基因组稳定性的研究。工作重点集中在DNA损伤诱导肿瘤相关重要因子的翻译后修饰与肿瘤发生信号调控网络相关性研究。



1、美国癌症协会（AACR）会员 ；
2、Mayo Clinic Research Fellow’s Association（梅奥医院研究****联合会会员）；
3、Breast Cancer Research杂志审稿人



罗坤甜教授一直致力于DNA损伤与基因组稳定性研究。DNA损伤应答是保持基因组稳定性从而抑制肿瘤发生的关键。罗教授发现并解析了多个DNA损伤应答通路中关键蛋白的翻译后修饰，以及关键因子间相互作用的信号调控网络机制与保持基因组稳定性的关系，已取得的研究成果处于世界先进水平，这些工作对于研究肿瘤的发生与治疗意义重大。近年来，共发表SCI论文17篇，通讯作者及第一作者7篇，主要论著在Nature Cell Biology、EMBO J、Proc Natl Acad Sci USA、Cell、Nature、及J Biol Chem等高水平国际杂志上发表，现主持国家自然科学基金青年项目一项。
主要代表性论文：
1. Luo K （罗坤甜）, Zhang H, Wang L, Yuan J, Lou Z. Sumoylation of MDC1 is important for proper DNA damage response. EMBO J. 2012 May 25;31(13):3008-19. IF=9.025

2. Yuan J, Luo K（罗坤甜）, Liu T, Lou Z. Regulation of SIRT1 activity by genotoxic stress. Genes Dev. 2012 Apr 15;26(8):791-6. IF=11.659

3. Luo K（罗坤甜）, Yuan J, Lou Z. Oligomerization of MDC1 protein is important for proper DNA damage response. J Biol Chem. 2011 Aug 12;286(32):28192-9. (第一作者及通讯作者) IF=4.773

4. Pei H, Zhang L, Luo K（罗坤甜）, Qin Y, Chesi M, Fei F, Bergsagel PL, Wang L, You Z, Lou Z. MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites. Nature. 2011 Feb 3;470(7332):124-8. (并列第二作者) IF=36.280

5. Yuan J, Luo K（罗坤甜）, Zhang L, Cheville JC, Lou Z. USP10 regulates p53 localization and stability by deubiquitinating p53. Cell. 2010 Feb 5;140(3):384-96. IF=32.403

6. Luo K（罗坤甜）, Lou Z. Dual roles of topoisomerase II. Cell Cycle. 2009 Mar 1;8(5):679. IF=5.359

7. Luo K（罗坤甜）, Yuan J, Chen J, Lou Z. Topoisomerase IIalpha controls the decatenation checkpoint. Nat Cell Biol. 2009 Feb;11(2):204-10. IF=19.488

8. Wu L, Luo K（罗坤甜）, Lou Z, Chen J. MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11200-5. (并列第一作者) IF=9.681

9. Guo Z, Yuan J, Tang W, Chen X, Gu X, Luo K（罗坤甜）, Wang Y, Wan B, Yu L. Cloning and characterization of the human gene RAP2C, a novel member of Ras family, which activates transcriptional activities of SRE. Mol Biol Rep. 2007 Sep;34(3):137-44. IF=2.929

10. Guo Z, Tang W, Yuan J, Chen X, Wan B, Gu X, Luo K（罗坤甜）, Wang Y, Yu L. BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260. Biochem Biophys Res Commun. 2006 Sep 8;347(4):867-71. IF=2.484

11. Yuan J, Tang W, Luo K（罗坤甜）, Chen X, Gu X, Wan B, Yu L. Cloning and characterization of the human gene DERP6, which activates transcriptional activities of p53. Mol Biol Rep. 2006 Sep;33(3):151-8. IF=2.929

12. Luo K（罗坤甜）, Li J, Cui Y, Xu M, Yuan J, Tang W, Wan B, Yu L. Identification and characterization of the human SCAN domain zinc-finger gene ZNF449. Mol Biol Rep. 2006 Mar;33(1):51-7. IF=2.929

13. Luo K（罗坤甜）, Yuan J, Shan Y, Li J, Xu M, Cui Y, Tang W, Wan B, Zhang N, Wu Y, Yu L. Activation of transcriptional activities of AP1 and SRE by a novel zinc finger protein ZNF445. Gene. 2006 Feb 15;367:89-100. IF=2.341

14. Yuan J, Shan Y, Chen X, Tang W, Luo K（罗坤甜）, Ni J, Wan B, Yu L. Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B. Mol Biol Rep. 2005 Dec;32(4):205-14. IF=2.929

Wu Y, Yu L, Bi G, Luo K（罗坤甜）, Zhou G, Zhao S. Identification and characterization of two novel human SCAN domain-containing zinc finger genes ZNF396 and ZNF397.Gene. 2003 May 22;310:193-201. IF=2.341