彭鲁英 教授
硕士招生类型：学术型
硕士招生专业：基础医学
博士招生类型：学术型
博士招生专业：临床医学（基础医学方向）
所在院系：同济大学医学院
联系方式：luyingpeng@tongji.edu.cn
课题组链接：http://202.120.165.73/ktz/Group.aspx?id=40
研究方向
主要任职
科研业绩


干细胞分化的表观遗传机制研究；
心脏重构和心脏疾病大鼠模型的研究；
遗传疾病分子机制研究；






曾任上海交通大学海科院助理研究员，复旦大学上海医学院分子遗传学副教授；先后在美国亚历桑那大学和纽约西奈山医学院从事肌球蛋白磷酸化酶生物化学和钾离子通道分子遗传学研究，曾任西奈山医学院儿科系研究员，从事发育早期细胞分化方面的研究；回国后创建同济大学医学院医学遗传学教研室，并任创建主任。目前担任同济大学医学院教授委员会主任；同济大学医学院转化医学研究管理办公室主任；心律失常教育部重点实验室常务副主任；美国人类遗传学会(ASHG)会员；国际干细胞研究学会（ISSCR）会员；美洲华人遗传学会会员；中国药理学会药物基因组学专业委员会委员。






科研业绩：
一、承担的国家级科研项目
国家科技部国际合作项目：
干细胞治疗的基础与临床前研究及产品研发；
国家自然科学基金面上项目：
组蛋白乙酰化对分化中的心机细胞Kir2.1的表达调控；
国家自然科学基金面上项目：
去乙酰化酶抑制剂调节肠上皮细胞紧密连接的信号通路；
国家自然科学基金面上项目：
KCNQ1 和KCNE1 双基因修饰构建大鼠心律失常遗传模型及在体功能研究
国家自然科学基金创新群体项目：
重大心脏疾病分子机理和干预策略的基础研究；
国家科技部重大研究计划（973计划）：
组织干细胞识别、谱系重编程和示踪研究；
二、奖励
上海浦江计划
上海自然科学一等奖。
三、代表性论文
Impact of miR-26b on cardiomyocytedifferentiation in P19 cells through regulating canonical/non-canonical Wntsignalling. Wang D, Liu C, Wang Y, Wang W, Wang K, Wu X, Li Z, Zhao C, Li L,Peng L. Cell Prolif. 2017 Dec;50(6).doi: 10.1111/cpr.12371. Epub 2017 Aug 15.PubMed PMID: **.
Regulation of Histone Acetylation on ExpressionProfiles of Potassium Channels During Cardiomyocyte Differentiation From MouseEmbryonic Stem Cells. Wang D, Liu C, Li Z, Wang Y, Wang W, Wu X, Wang K, MiaoW, Li L, Peng L. J Cell Biochem. 2017 Dec;118(12):4460-4467. doi:10.1002/jcb.26102. Epub 2017 May 31.PubMed PMID: **.
Sodium Butyrate Promotes Reassembly ofTight Junctions in Caco-2 Monolayers Involving Inhibition of MLCK/MLC2 Pathwayand Phosphorylation of PKCβ2. Miao W, Wu X, Wang K, Wang W, Wang Y, Li Z, LiuJ, Li L, Peng L. Int J Mol Sci. 2016 Oct 10;17(10). pii: E1696. PubMedPMID: **; PubMed Central PMCID:PMC**.
Liu JJ, Zhao CM, Li ZG, Wang YM, Miao W,Wu XJ, Wang WJ, Liu C, Wang D, Wang K, Li L, Peng LY.miR-218 Involvement inCardiomyocyte Hypertrophy Is Likely through Targeting REST. Int J Mol Sci. 2016May 31;17(6). pii: E848. doi: .3390/ijms**. PMID: ** Free PMCArticle
Li J, Li C, Liang D, Lv F, Yuan T, The E,Ma X, Wu Y, Zhen L, Xie D, Wang S,Liu Y, Huang J, Shi J, Liu Y, Shi D, Xu L,Lin L, Peng L, Cui J, Zhu W, Chen YH. LRP6 acts as a scaffold protein incardiac gap junction assembly. Nat Commun.2016 Jun 2;7:11775. doi:10.1038/ncomms11775. PubMed PMID: **; PubMed Central PMCID: PMC**.
Li J, Li C, Zhang D, Shi D, Qi M, Feng J,Yuan T, Xu X, Liang D, Xu L, Zhang H, Liu Y, Chen J, Ye J, Jiang W, Cui Y,Zhang Y, Peng L, Zhou Z, Chen YH. SNX13 reduction mediates heart failurethrough degradative sorting of apoptosis repressor with caspase recruitmentdomain. Nat Commun. 2014 Oct 8;5:5177. doi: 10.1038/ncomms6177. PubMed PMID:**.
Shi D, Xie D, Zhang H, Zhao H, Huang J, LiC, Liu Y, Lv F, The E, Liu Y, Yuan T, Wang S, Chen J, Pan L, Yu Z, Liang D, ZhuW, Zhang Y, Li L, Peng L, Li J, Chen YH. Reduction in dynamin-2 is implicatedin ischaemic cardiac arrhythmias. J Cell Mol Med. 2014 Oct;18(10):1992-9. doi:10.1111/jcmm.12335. Epub 2014 Aug 5. PubMed PMID: **; PubMed CentralPMCID: PMC**.
Li J, Qi M, Li C, Shi D, Zhang D, Xie D,Yuan T, Feng J, Liu Y, Liang D, Xu X, Chen J, Xu L, Zhang H, Ye J, Lv F, HuangJ, Peng L, Chen YH. Tom70 serves as a molecular switch to determinepathological cardiac hypertrophy. Cell Res. 2014 Aug;24(8):977-93. doi:10.1038/cr.2014.94. Epub 2014 Jul 15. PubMed PMID: **; PubMed CentralPMCID: PMC**.1:
Li J, Xu L, Ye J, Li X, Zhang D, Liang D,Xu X, Qi M, Li C, Zhang H, Wang J, Liu Y, Zhang Y, Zhou Z, Liang X, Li J, PengL, Zhu W, Chen YH. Aberrant dynamin 2-dependent Na(+) /H(+) exchanger-1trafficking contributes to cardiomyocyte apoptosis. J Cell Mol Med. 2013 Jul 9.doi: 10.1111/jcmm.12086. [Epub ahead of print] PubMed PMID: **.
Yan B, Huo Z, Liu Y, Lin X, Li J, Peng L,Zhao H, Zhou ZN, Liang X, Liu Y, Zhu W, Liang D, Li L, Sun Y, Cui J, Chen YH.Prolyl hydroxylase 2: a novel regulator of β2 -adrenoceptor internalization. JCell Mol Med. 2011 Dec;15(12):2712-22.

Xiao J, Cao H, Liang D, Liu Y, Zhang H,Zhao H, Liu Y, Li J, Yan B, Peng L, Zhou Z, Chen YH. Taxol, a microtubulestabilizer, prevents ischemic ventricular arrhythmias in rats. J Cell Mol Med.2011 May;15(5):1166-76.

Yang Y, Yang Y, Liang B, Liu J, Li J,Grunnet M, Olesen SP, Rasmussen HB, Ellinor PT, Gao L, Lin X, Li L, Wang L,Xiao J, Liu Y, Liu Y, Zhang S, Liang D, Peng L, Jespersen T, Chen YH.Identification of a Kir3.4 mutation in congenital long QT syndrome. Am J HumGenet. 2010 Jun 11;86(6):872-80.

Li J, Yan B, Huo Z, Liu Y, Xu J, Sun Y,Liu Y, Liang D, Peng L, Zhang Y, Zhou ZN, Shi J, Cui J, Chen YH. beta2-but not beta1-adrenoceptor activation modulates intracellular oxygen availability.J Physiol. 2010 Aug 15;588(Pt 16):2987-98.

Li J, Xiao J, Liang D, Zhang H, Zhang G,Liu Y, Zhang Y, Liu Y, Yu Z, Yan B, Jiang B, Li F, Peng L, Zhou ZN, Chen YH.Inhibition of mitochondrial translocator protein prevents atrial fibrillation.Eur J Pharmacol. 2010 Apr 25;632(1-3):60-4.

Peng L, Li ZR, Green RS, Holzman IR, LinJ. Butyrate enhances the intestinal barrier by facilitating tight junctionassembly via activation of AMP-activated protein kinase in Caco-2 cellmonolayers. J Nutr. 2009 Sep;139(9):1619-25.

Li J, Xiao J, Liu Y, Zhang G, Zhang H,Liang D, Liu Y, Zhang Y, Hu Y, Yu Z, Yan B, Jiang B, Peng L, Zhou ZN, Chen YH.Mitochondrial benzodiazepine receptors mediate cardioprotection of estrogenagainst ischemic ventricular fibrillation. Pharmacol Res. 2009 Jul;60(1):61-7.

Liang L, Pan Q, Liu Y, Chen H, Li J,Brugada R, Brugada P, Hong K, Perez GJ, Zhao C, Qi J, Zhang Y, Peng L, Li L,Chen YH. High sensitivity of the sheep pulmonary vein antrum to acetylcholinestimulation. J Appl Physiol (1985). 2008 Jul;105(1):293-8.

Yang Y, Liu Y, Dong X, Kuang Y, Lin J, SuX, Peng L, Jin Q, He Y, Liu B, Pan Z, Li L, Zhu Q, Lin X, Zhou Q, Pan Q,Eurlings PM, Fei J, Wang Z, Chen YH. Human KCNQ1 S140G mutation is associatedwith atrioventricular blocks. Heart Rhythm. 2007 May;4(5):611-8.

Peng L, He Z, Chen W, Holzman IR, Lin J.Effects of butyrate on intestinal barrier function in a Caco-2 cell monolayermodel of intestinal barrier. Pediatr Res. 2007 Jan;61(1):37-41.
Nafday SM, Chen W, Peng L, Babyatsky MW,Holzman IR, Lin J. Short-chain fatty acids induce colonic mucosal injury inrats with various postnatal ages. Pediatr Res. 2005 Feb;57(2):201-4.

Peng L, Mirshahi T, Zhang H, Hirsch JP,Logothetis DE. Critical determinants of the G protein gamma subunits in theGbetagamma stimulation of G protein-activated inwardly rectifying potassium(GIRK) channel activity. J Biol Chem. 2003 Dec 12;278(50):50203-11.

Jin T, Peng L, Mirshahi T, Rohacs T, Chan KW,Sanchez R, Logothetis DE. The (beta)gamma subunits of G proteins gate a K(+)channel by pivoted bending of a transmembrane segment. Mol Cell. 2002Sep;10(3):469-81.