张杰 副教授
硕士招生类型：学术型
硕士招生专业：公共卫生与预防医学
博士招生类型：无
博士招生专业：无
所在院系：医学院
联系方式：jiezhang@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

基于多组学数据信息的癌症相关基因的挖掘及预后模型的构建；
癌症空间转录组的数据挖掘方法的研究；
脊髓损伤相关基因的数据挖掘及实验证实；
Meta分析
Data mining for cancer-related genes and the construction of prognostic models based on multiple sets of data;
Data mining on space transcriptome;Data mining on spinal cord injury related genes and the experiment validation；
Meta-analysis
同济大学医学院副教授，同济大学新生院特聘本科生导师，中科院上海生命科学研究院博士后。美国华盛顿大学公共卫生学院生物统计学系访问****，新加坡国立大学计算机学院计算生物学系访问****。现任中国抗癌协会骨与软组织肿瘤热疗及生物信息专家委员会副主委，上海医学会临床流行病学与循证医学分会委员，上海医学会临床流行病学与循证医学专科分会临床研究方法学组副组长。Frontiers in Bioengineering and Biotechnology(IF:5.122), Frontiers in Genetics(IF:3.517)和Frontiers in Plant Science(IF:4.106)杂志的审稿编辑，同济大学学报（医学版）审稿人，累计审稿30余篇。2019 年度同济大学新生院优秀本科生导师。
Associate professor in Tongji University; Undergraduate Tutor for Freshmen in Tongji University; Postdoctoral fellow in Chinese Academy of Sciences; Visiting Scholar in Department of Biostatistics, University of Washington USA; Visiting Scholar in Department of Computational Biology, School of Computer Science, National University of Singapore. She is now the deputy chair of the expert Committee of bone and soft tissue tumor hyperthermia and bioinformatics of The Chinese Anti-cancer Association; member of the Clinical Epidemiology and Evidence-based Medicine Branch of the Shanghai Medical Association; the deputy leader of the Clinical Research Methods Group of the Clinical Epidemiology and Evidence-based Medicine Branch of the Shanghai Medical Association. Editor reviewer of Frontiers in Bioengineering and Biotechnology (IF:3.644), Frontiers in Genetics(IF:3.258), and Plant Science(IF:4.402); Reviewer of The Journal of Tongji University (Medical Edition), and she has reviewed more than 30 articles. Awards as Outstanding Undergraduate Tutor of Freshmen College of Tongji University in 2019
主持的科研项目主要有：
1）国家自然基金项目；
2) 上海市卫生健康委员会卫生行业临床研究专项；
3）上海市卫生局青年项目；
4）上海市气象与健康重点实验室项目；
5）同济大学医学院起航计划项目；
6）同济大学优秀青年教师基金。
Projects:
1) National Natural funding;
2) Shanghai Health Commission Health Industry Clinical Research Special Project;
3) Shanghai Municipal Health Bureau project for Youth;
4) Shanghai Key Laboratory of Meteorology and Health Project;
5) Tongji University medical school Set-sail program;
6) Tongji University Excellent young teachers fund.
近年来以第一作者或通讯作者发表SCI及核心期刊论文20余篇，主要如下：
1.Runzhi Huang, Zhenyu Li, Xiaolong Zhu, Penghui Yan, Dianwen Song, Huabin Yin, Peng Hu, Ruoyi Lin, Shengyu Wu, Tong Meng, Jie Zhang, Zongqiang Huang, Collagen Type III Alpha 1 chain regulated by GATA-Binding Protein 6 affects Type II IFN response and propanoate metabolism in the recurrence of lower grade glioma, Journal of Cellular and Molecular Medicine, 2020. DOI: 10.1111/jcmm.15705. (并列通讯作者, IF:5.515)；
2.Runzhi Huang, Juanru Guo, Penghui Yan, Suna Zhai, Peng Hu, Xiaolong Zhu, Jiayao Zhang, Yannan Qiao, Yu Zhang, Hui Liu1, Ling Huang, Jie Zhang, Daoke Yang and Zongqiang Huang, The Construction of Bone Metastasis-Specific Prognostic Model and Co-expressed Network of Alternative Splicing in Breast Cancer, Front.Cell.Dev.Biol. 2020, doi.org/10.3389/fcell.2020.00790. (并列通讯作者, IF:5.206)；
3.Zhengyan Chang, Guo Ji, Runzhi Huang, Hong Chen, Yaohui Gao, Weifeng Wang, Xuechen Sun, Jie Zhang, Jiayi Zheng, and Qing Wei. PIWI-interacting RNAs piR-13643 and piR-21238 are promising diagnostic biomarkers of thyroid cancer，Aging in US, 2020, 12 (并列通讯作者, IF:5.515)；
4.Wei Li, Jie Zhang, Shifu Xiao, Lin Sun, Characteristics of health worker fatality in China during the outbreak of COVID-19 infection， JOURNAL OF INFECTION. 2020, (并列第一作者, IF:5.099)；
5.Jie Zhang, Jiaqi Wang, Han Yu, Guanghua Wang, Junfang Zhang, Rui Zhu, Xuebo Liu, and Jue Li, Comparison between atorvastatin and rosuvastatin on secondary percutaneous coronary intervention rate and the risk factors in patietnts with coronary heart disease. Current drug metabolisms, 2020, 21, (第一作者, IF:2.960，已接受)；
6.Runzhi Huang, Tong Meng, Rui Zhu, Lijuan Zhao, Dianwen Song, Huabin Yin, Zongqiang Huang, Liming Cheng and Jie Zhang, The Integrated Transcriptome Bioinformatics Analysis Identifies Key Genes and Cellular Components for Spinal Cord Injury-related Neuropathic Pain，Front Bioeng Biotechnol. 2020, 8(101). (通讯作者, IF:5.122)；
7.Runzhi, Huang, Zhenyu Li, Chen Li, Guanghua Wang, Penghui Yan, Li Peng, Jiaqi Wang, Xiaolong Zhu, Peng Hu, Junfang Zhang, Zhengyan Chang, Zongqiang Huang, liming Cheng, Jie Zhang, Germ Cell-Specific Gene 1-Like Protein Regulated by Splicing Factor CUGBP Elav-Like Family Member 5 and Primary Bile Acid Biosynthesis are Prognostic in Glioblastoma Multiforme, Frontier in Genetics,10, 1380, 2020. (通讯作者，IF:3.517)；
8.Runzhi Huang, Ziqi Liu, Tingli Tian, Dianwen Song, Penghui Yan, Huabin Yin, Peng Hu, Xiaolong Zhu, Yihan Liu, Zhenyu Li, Tong Meng, Jie Zhang, Zongqiang Huang, The construction and analysis of tumor-infiltrating immune cells and ceRNA networks in metastatic adrenal cortical carcinoma, Bioscience Reports, 2020, 40, BSR**. (通讯作者，IF: 2.535)；
9.Runzhi Huang, Jiawen Wu, Zixuan Zheng, Guanghua Wang, Dianwen Song, Penghui Yan, Huabin Yin, Peng Hu, Xiaolong Zhu, Haiyun Wang6, Qi Lv, Tong Meng, Zongqiang Huang, Jie Zhang，The construction and analysis of ceRNA network and Patterns of immune infiltration in Mesothelioma with bone metastasis, Front Bioeng Biotechnol. 2019 Oct 18; 7:257. doi: 10.3389/fbioe.2019.00257. eCollection 2019. (通讯作者, , IF:5.122)；
10.陈静静，王光花，彭丽，许炜晨，徐润平，张杰，中国南北方地区阴道试产孕妇不良母婴结局分析，同济大学学报（医学版），2019， 40（4），501-506. （通讯作者，核心期刊）；
11.Tong Meng, Runzhi Huang, Zhiwei Zeng, Zongqiang Huang, Huabin Yin, ChenChen Jiao, Penghui Yan, Peng Hu, Xiaolong Zhu, Zhenyu Li, Dianwen Song, Jie Zhang, Liming Cheng, Identification of prognostic and metastatic alternative splicing signatures in kidney renal clear cell carcinoma, Frontiers in Bioengineering and Biotechnology, 7, 270, 2019. (共同通讯作者, IF:5.122)；
12.Runzhi Huang, Zhiwei Zeng, Guangyu Li,Dianwen Song, Penghui Yan, Huabin Yin, Peng Hu,Xiaolong Zhu, Ruizhi Chang, Xu Zhang, Jie Zhang, Tong Meng, Zongqiang Huang, The construction and comprehensive analysis of ceRNA networks and tumorinfiltrating immune cells in bone metastatic melanoma, Frontier in Genetics, 10，828，2019. (共同通讯作者, IF:3.517)；
13.Lin Sun, Hua Xu, Jie Zhang*, Wei Li, Jing Nie, QiQiu, Yuanyuan Liu, Yuan Fang, Zhi Yang, Xia Li and Shifu Xiao, Alcohol Consumption and Subclinical Findings on Cognitive Function, Biochemical Indexes, and Cortical Anatomy in Cognitively Normal Aging Han Chinese Population, Frontiers in Aging Neuroscience, 10:182,2018. (并列第一作者, IF:3.63)；
14.Yongzhao Zhao, Huixian Wang, Yan Shi, Shangli Cai, Tongwei Wu, Guangyue Yan, Sijin Cheng, Kang Cui, Ying Xi, Xiaolong Qi, Jie Zhang*, and Wang Ma. Comparative effectiveness of combined therapy inhibiting EGFR and VEGF pathways in patients with advanced non-small-cell lung cancer: a meta-analysis of 16 phase II/III randomized trials. Oncotarget, 8(4): 7014-7024.2017. (通讯作者, IF:5.168)；
15.Jie Zhang*, Rui Song, Luying Peng, Jue Li. Integration of Cardiomyopathy Microarray profiles and the Potential Role of Ube3a in apoptosis, Molecular Medicine Reports9: 621-625, 2014. （第一&通讯作者, IF:1.484）；
16.Li Y, Shen D, Tang X, Li X, Wo D, Yan H, Song R, Feng J, Li P, Zhang J*, Li J. Chlorogenic acid prevents isoproterenol-induced hypertrophy in neonatal rat myocytes, Toxicol Lett. 226(3):257-263,2014. （通讯作者, IF:3.355）；
17.R. Song, J. Zhang*, L. Zhang, G. Wang, D. Wo, J. Feng, X. Li and J. Li, H2O2 Induces Myocardial Hypertrophy in H9c2 Cells: A Potential Role of Ube3a. Cardiovascular toxicology, 2014, DOI: 10.1007/s12012-014-9264-0. (共同第一&通讯作者, IF:2.989)；
18.Zhang J, Wang G, Feng J, Zhang L, Li J. Identifying ion channel genes related to cardiomyopathy using a novel decision forest strategy. Mol Biosyst. 10(9):2407-14, 2014. （第一&通讯作者, IF:2.759）；
19.Jie Zhang*, Li Li, Luying Peng, Yingxian Sun, Jue Li. An efficient weighted graph strategy to identify relevant genes for the control of the embryonic stem cell differentiation. Plos one, Volume 8, Issue 4, e62716, 2013.（第一&通讯作者, IF: 3.534）；
20.Yanfei Li, Jie Zhang*，Chlorogenic acid can improve isoproterenol-induced myocardial hypertrophy. Heart. 2013。（通讯作者）；
21.宋瑞，张杰，李觉，ADRB1基因多态性及其与心血管疾病关系的研究进展，同济大学学报（医学版），34期，28-31页，2013（通讯作者）；
22.Dong Z, Shi J, Dorhoi A, Zhang J, Soodeen-Lalloo AK, Tan W, Yin H, Sha W, Li W, Zheng R, Liu Z, Yang H, Qin L, Wang J, Huang X, Wu C, Kaufmann SHE, Feng Y. Hemostasis and Lipoprotein Indices Signify Exacerbated Lung Injury in TB With Diabetes Comorbidity. Chest. 153(5): 1187-1200, 2017 WOS:025; PubMed(**)；
23.Yongzhao Zhao, Yanjie Zhu, Guangyue Yan, Jie Zhang, Letter to the Editor concerning "Association between IGF1 gene single nucleotide polymorphism (rs**) and adolescent idiopathic scoliosis: a meta-analysis" by M. Guan et al. (Eur Spine J; 26(4): 1312-1313, 2016. WOS:045); PubMed(**)；
24.Zhang Jie, Li Li, Li Xia, Haiyun Wang. Unravelling the Hidden Relationship Between Subtype of Ion Channel and Channlopathy Based on CTWC Approach. Bioinformatics and Biomedical Engineering, 676-679, 2008；
25.Huang R, Meng T, Chen R, Yan P, Zhang J, Hu P, Zhu X, Yin H, Song D and Huang Z. The construction and analysis of tumor-infiltrating immune cell and ceRNA networks in recurrent soft tissue sarcoma. Aging. 2019; 11(22):10116-10143；
26.Huang R, Sun Z, Zheng H, Yan P, Hu P, Yin H, Zhang J, Meng T and Huang Z. Identifying the Prognosis Factors and Predicting the Survival Probability in Patients with Non-Metastatic Chondrosarcoma from the SEER Database. Orthopaedic surgery. 2019; 11(5):801-810；
27.Huang R, Zeng Z, Li G, Song D, Yan P, Yin H, Hu P, Zhu X, Chang R, Zhang X, Zhang J, Meng T and Huang Z. The Construction and Comprehensive Analysis of ceRNA Networks and Tumor-Infiltrating Immune Cells in Bone Metastatic Melanoma. Frontiers in genetics. 2019; 10:828；
28.Yan P, Huang R, Hu P, Liu F, Zhu X, Hu P, Yin H, Zhang J, Meng T and Huang Z. Nomograms for predicting the overall and cause-specific survival in patients with malignant peripheral nerve sheath tumor: a population-based study. Journal of neuro-oncology. 2019; 143(3):495-503；
29.Yang J, Zhang G, Huang R, Yan P, Hu P, Huang L, Meng T, Zhang J, Liu R, Zeng Y, Wei C, Shen H, Xuan M, et al. Nomograms Predicting Self-Regulated Learning Levels in Chinese Undergraduate Medical Students. Frontiers in psychology. 2019; 10:2858；
30.Wang G, Zheng L, Li X, Wu J, Zhang L, Zhang J, Zou L, Li X, Zhang Y, Zhou Q, Fan H, Li Y, Li J. Using brachial-ankle pulse wave velocity to screen for metabolic syndrome in community populations. Sci Rep. 2015 Mar 30; 5:9438. IF:4.122；
31.Ren L, Zheng Y, Wu L, Gu Y, He Y, Jiang B, Zhang J, Zhang L*, Li J*. Investigation of the prevalence of Cognitive Impairment and its risk factors within the elderly population in Shanghai, China. Sci Rep. 2018 Feb 23;8(1):3575. IF:4.122；
32.Lijuan Zhang, Zhiqiang Li, Xucheng Li, Jie Zhang, Liang Zheng, Chenghua Jiang, Jue Li*. Study on the trend and disease burden of injury deaths in Chinese population, 2004-2010. Plos One, 2014 9(1) e85319. IF:2.766；
33.Yuan Ma, Y.H., Jiawen Wu, Junru Wen, Sen Li, Lijuan Zhang, Jie Zhang, Yanfei Li, Jue Li, Epigalocatechin-3-gallate inhibits angiotensin II-induced cardiomyocyte hypertrophy via regulating Hippo signaling pathway in H9C2 rat cardiomyocytes. Acta Biochimicaet Biophysica Sinica, 2019 51(4): 422-430；
34.Shengyang Jiang, C.G., Wei Zhang, Wenliang Che, Jie Zhang, Shaowei Zhuang, Yiting Wang, Yangyang Zhang, Ban Liu, The integrative regulatory network of circRNA, microRNA and mRNA in atrial fibrillation, Frontiers in Genetics, 2019, 10 (526).
参编并出版书籍
1.Jie Zhang*, Genomic Approach Asthma, chapter 15: Biostatistics, data mining and computational modeling, Springer Publishing, 2018；
2.参编《流行病学双语教材》同济大学出版社。(Bilingual Textbook of Epidemiology)