占贞贞 研究员-高研院
硕士招生类型：学术型
硕士招生专业：基础医学
博士招生类型：学术型
博士招生专业：基础医学
所在院系：附属东方医院
联系方式：zhanzz@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

临床重大慢病发生发展中的免疫炎症调控The regulation of immune inflammation in clinical chronic disease
上海市曙光****、上海市卫健委优秀学科带头人、上海市青年科技启明星
中华医学会医学工程学分会干细胞工程专业学组委员、中整协干细胞研究与应用分会青委会副秘书长、中国心胸血管麻醉分会疼痛学分会委员、上海市免疫学会免疫遗传专业委员会委员
作为项目负责人主持国家自然科学基金6项，国家重点研发计划课题1项，省部级课题5项。
代表性研究论文如下：
(1) Zhou Qingqing#, Zhang Yunkai#, Wang Bo#, Zhou Weihui, Bi Yong, Huai Wanwan, Chen Xi, Chen Yihan, Liu Zhongmin, Liu Xingguang*, Zhan Zhenzhen*. KDM2B epigenetically promotes IL-6 production and inflammatory responses through Brg1-mediated chromatin remodeling. Cellular & Molecular Immunology. 2020 Aug;17(8):834-842.（通讯作者，IF 8.484）
(2) Wang Bo#, Zhou Qingqing#, Bi Yong#, Zhou Weihui, Zeng Qiyan, Liu Zhongmin, Liu Xingguang*, Zhan Zhenzhen*. Phosphatase PPM1L Prevents Excessive Inflammatory Responses and Cardiac Dysfunction after Myocardial Infarction by Inhibiting IKKβ Activation. J Immunol. 2019 Sep 1;203(5):1338-1347.（通讯作者，IF 4.886）
(3) Yang, Linshan; Wang, Bo; Zhou, Qingqing; Wang, Yiru; Liu, Xingguang; Liu, Zhongmin*; Zhan Zhenzhen*. MicroRNA-21 prevents excessive inflammation and cardiac dysfunction after myocardial infarction through targeting KBTBD7. Cell Death and Disease. 2018;9(7):769. （通讯作者，IF 5.959）
(4) Liu, Xingguang#; Cao, Hao#; Li, Jian#; Wang, Bo; Zhang, Peng; Zhang, Xu Dong; Liu, Zhongmin; Yuan, Hongbin*; Zhan, Zhenzhen*. Autophagy induced by DAMPs facilitates the inflammation response in lungs undergoing ischemia-reperfusion injury through promoting TRAF6 ubiquitination. Cell Death and Differentiation, 2017, 24(4): 683~693. （通讯作者，IF 10.717）
(5) Zhan, Zhenzhen*; Cao, Hao; Xie, Xuefeng; Yang, Linshan; Zhang, Peng; Chen, Yihan; Fan, Huimin; Liu, Zhongmin; Liu, Xingguang*. Phosphatase PP4 negatively regulates type I interferon production and antiviral innate immunity by dephosphorylating and deactivating TBK1. The Journal of Immunology, 2015, 195(8): 3849~3857. （第一兼通讯作者，IF 4.985）
(6) Zhan, Zhenzhen#; Xie, Xuefeng#; Cao, Hao; Zhou, Xiaohui; Zhang, Xu Dong; Fan, Huimin*; Liu, Zhongmin*. Autophagy facilitates TLR4-and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination. Autophagy, 2014,10(2): 257~268. （第一作者，IF 11.753）
(7) Zhan, Zhenzhen; Li, Qun; Wu, Ping; Ye, Yan; Tseng, Hsin-Yi; Zhang, Linjie*; Zhang, Xudong*. Autophagy-mediated HMGB1 release antagonizes apoptosis of gastric cancer cells induced by vincristine via transcriptional regulation of Mcl-1. Autophagy, 2012, 8(1): 109~121.（第一作者，IF 12.042）
(8) Liu, Xingguang; Zhan, Zhenzhen; Li, Dong; Xu, Li; Ma, Feng; Zhang, Peng; Yao, Hangping; Cao, Xuetao*. Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nature Immunology, 2011,12(5): 416~424.（IF 26.008）
(9) Liu, Xingguang#; Zhan, Zhenzhen#; Xu, Li; Ma, Feng; Li, Dong; Guo, Zhenhong; Li, Nan; Cao, Xuetao*. MicroRNA-148/152 Impair Innate Response and Antigen Presentation of TLR-Triggered Dendritic Cells by Targeting CaMKIIalpha. The Journal of Immunology, 2010, 185(12): 7244~7251. （共同第一作者，IF 5.745）
(10) Jing Yang, Bo Wang, Na Li, Qingqing Zhou, Wenhui Zhou, Zhenzhen Zhan*. Salvia miltiorrhiza and Carthamus tinctorius extract prevents cardiac fibrosis and dysfunction after myocardial infarction by epigenetically inhibiting Smad3 expression. Evidence-Based Complementary and Alternative Medicine. 2019 May 30; 2019:**. doi: 10.1155/2019/**. eCollection 2019. （通讯作者，IF 1.984）