姓 名：毛志勇
行政职务：同济大学附属第一妇婴保健院转化医学研究中心主任
学 位：博士
导师情况：博士生导师
研究领域：老年医学
研究方向：
1、衰老及相关疾病发生发展过程中DNA修复变化和调控机制
2、干细胞基因组稳定性维持和调控机制
3、延缓衰老及预防、治疗衰老相关疾病的新方法的开发和转化
E-mail：zhiyong_mao@tongji.edu.cn

联系电话：
通讯地址：上海市四平路1239号，同济大学生命科学与技术学院（200092）
个人简介:
毛志勇，教授，博士生导师。2002、2004年先后毕业于南京大学生命科学学院，获学士和硕士学位；2010年毕业于美国罗彻斯特大学，获博士学位，主要从事DNA双链断裂修复的分子生物学机制的研究。2010年-2012年于罗彻斯特大学生物系从事博士后研究，主要研究方向是衰老以及肿瘤与DNA修复之间的关系。2012年9月于同济大学建立课题组开展衰老相关基因组稳定性的机制研究。
毛志勇教授现已在Nature、PNAS、Nucleic Acids Res.、Cell Death Differ.、eLife、Cell Reports、Oncogene、Aging Cell等重要学术期刊发表通讯作者论文10余篇，在Science、PNAS等学术期刊发表第一作者论文7篇。
毛志勇教授于2013年担任科技部“973”计划青年项目首席科学家，2013年获上海市“浦江人才”项目资助，2016年获国家自然科学基金委优秀青年项目资助，2019年获上海市“优秀学术带头人”项目和“曙光计划”资助。
毛志勇课题组具有完整的科研梯队，现有博士后1名、博士生8名、硕士生4名、本科生3名。已毕业博士5名，硕士7名。截止至2020年12月，课题组先后有9人次获得研究生国家奖学金及其他校级奖学金，毕业同学均在重要高校、科研院所、企事业单位继续从事教学和科研相关工作。 代表性文章：

2020年
1.Wang C, Tang H, Geng A, Dai B, Zhang H, Sun X, Chen Y, Qiao Z, Zhu H, Yang J, Chen J, He Q, Qin N, Xie J, Tan R, Wan X, Gao S, Jiang Y^*, Sun FL^*, Mao Z^*. Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PKcs inhibitors.Proc Natl Acad Sci U S A. 2020 Oct 20;117(42):26356-26365. * Corresponding authors.
2. Chen Y, Geng A, Zhang W, Qian Z, Wan X, Jiang Y, Mao Z^*. Fight to the bitter end: DNA repair and aging. Ageing Research Reviews.2020 Sep 22;64:101154. * Corresponding author.
3.Geng A, Tang H, Huang J, Qian Z, Qin N, Yao Y, Xu Z, Chen H, Lan L, Xie H, Zhang J, Jiang Y, Mao Z^*. The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2. Nucleic Acids Res.2020 Sep 18;48(16):9181-9194. * Corresponding author
4.Chen Y, Chen J, Sun X, Yu J, Qian Z, Wu L, Xu X, Wan X, Jiang Y, Zhang J^*, Gao S^*, Mao Z^*. The SIRT6 activator MDL-800 improvesgenomic stability and pluripotency of old murine-derived iPS cells. Aging Cell. 2020. doi: 10.1111/acel.13185. * Corresponding authors.5. Zhang W, Chen Y, Yang J, Zhang J, Yu J, Wang M, Zhao X, Wei K, Wan X, Xu X, Jiang Y, Chen J^*, Gao S^*,Mao Z^*. A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing. eLife.2020. Jul 9;9:e56008. doi: 10.7554/eLife.56008. * Corresponding authors.
6.Zhang H, Cai B, Geng A, Tang H, Zhang W, Li S, Jiang Y, Tan R^*, Wan X^*, Mao Z^*. Base excision repair but not DNA double strand break repair is impaired in aged human adipose-derived stem cells (ADSCs). Aging Cell.2020 Feb;19(2):e13062. doi: 10.1111/acel.13062. * Corresponding authors.
2019年
1. Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, SuT, ShiJ, Jiang C, Tian X, SeluanovA, HuangJ, WanX, Jiang Y^*, Gorbunova V^*,Mao Z^*. A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites. Nucleic Acids Res.2019 Jul 10. pii: gkz592. doi: 10.1093/nar/gkz592.* Corresponding authors.
2. Tang H, Geng A, Zhang T, Wang C, Jiang Y,Mao Z^*.Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion. Protein & Cell.2019 May;10(5):370-375. doi: 10.1007/s13238-018-0591-y.* Corresponding author.
2018年
1.Liu H, Zhang H, Wu X, Ma D, Wu J, Wang L, Jiang Y, Fei Y, Zhu C, Tan R, Jungblut P, Pei G, Dorhoi A, Yan Q, Zhang F, Zheng R, Liu S, Liang H, Liu Z, Yang H, Chen J, Wang P, Tang T, Peng W, Hu Z, Xu Z, Huang X, Wang J, Li H, Zhou Y, Liu F, Yan D, Kaufmann SH, Chen C, Mao Z^*, Ge B^*. Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Nature.2018 Nov;563(7729):131-136. doi: 10.1038/s41586-018-0629-6. Epub 2018 Oct 24. * Corresponding authors.
2. Chen Y, Li Z, Xu Z, Tang H, Guo W, Sun X, Zhang W, Zhang J, Wan X, Jiang Y^*,Mao Z^*.Use of the XRCC2 promoter for in vivocancer diagnosis and therapy. Cell Death & Disease.2018 Mar 16;9(4):420. doi: 10.1038/s41419-018-0453-9. * Corresponding authors.
2017年
1. Yu Y, Tang R, Ren Q, Gao B, Sheng Z, Zhang J, Zheng X, Jiang Y^*, Li Lan^*,Mao Z^*. POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions. Aging (Albany NY). 2017 Dec 8;9(12):2529-2543. * Corresponding authors.
2. Zhang F, Tang H, Jiang Y^*,Mao Z^*. The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression. Oncogene.2017 Sep 7;36(36):5168-5176. doi: 10.1038/onc.2017.127. * Corresponding authors.

3.Chen W, Liu N, Zhang H-X, Zhang H-P, Qiao J, Jia W, Zhu S, Mao Z*, Kang J*. Sirt6 promotes DNA end joining in iPS cells derived from old mice. Cell Reports.2017 March 21: 18: 2880–2892. * Corresponding authors.
2016年
1. Li Z, Zhang W, Chen Y, Guo W, Zhang J, Tang H, Xu Z, Zhang H, Tao Y, Wang F, Jiang Y, Sun FL,Mao Z^*. Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans.Cell Death Differ.2016 Nov 1;23(11):1765-1777. doi: 10.1038/cdd.2016.65.Corresponding author.
2015年
1.Chen S, Wang C, Sun L, Wang DL, Chen L, Huang Z, Yang Q, Gao J, Yang XB, Chang JF, Chen P, Lan L, Mao Z^*, Sun FL^*. RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1. Mol Cell Biol.2015 Jan 15;35(2):406-16. * Corresponding authors.
2. Xu Z, Zhang L, Zhang W, Meng D, Zhang H, Jiang Y, Xu X, Van Meter M, Seluanov A, Gorbunova V, Mao Z^*.SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. Cell Cycle.2015;14(2):269-76. doi: 10.4161/**.2014.980641. * Corresponding author.
第一（含共同第一）作者论文
1.Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A.Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence.Proc Natl Acad Sci U S A.2012 Jul 17;109(29):11800-5.
2. Mao Z, Ke Z, Gorbunova V, Seluanov A. Replicatively senescent cells are arrested in G1 and G2 phases.Aging (Albany NY).Jun;4(6):431-5.
3. Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, Seluanov A, Gorbunova V. SIRT6 promotes DNA repair under stress by activating PARP1.Science.17 June 2011: 1443-1446.
4. Mao Z^#, Jiang Y^#, Liu X, Seluanov A, Gorbunova V. DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells. Neoplasia.2009 Jul; 11(7):683-691. # These authors contributed equally to this work.
5. Mao Z^#, Bozzella M^#, Seluanov A, Gorbunova V. DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle.2008 Sep 15; 7:18, 1-5. #These authors contributed equally to this work.
6. Mao Z, Bozzella M, Seluanov A, Gorbunova V. Comparison of nonhomologous end joining and homologous recombination in human cells. DNA Repair (Amst).2008 Oct 1;7(10):1765-71.
7. Mao Z, Seluanov A, Jiang Y, Gorbunova V. TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination. Proc Natl Acad Sci U S A.2007 Aug 7;104(32):13068-73.