摘要： 目的·对英文版脑转移瘤症状评估量表（Brain Metastases Symptom Checklist，BMSC）进行汉化并检验其信度和效度。方法·遵循Brislin模型对英文版BMSC进行翻译和跨文化调适，形成中文版BMSC。于2017年1月—2019年6月，采用便利抽样选取上海交通大学医学院附属瑞金医院神经外科功能神经外科中心和山东第一医科大学附属省立医院伽玛刀治疗科符合纳入标准的239例脑转移瘤患者进行调查。采用Cronbach
's
α 系数评价量表的内部一致性，采用组内相关系数（intra-class correlation coefficient，ICC）评价量表的重测信度，分别采用条目水平的内容效度指数（item-level content validity index，I-CVI）、量表平均内容效度指数（scale-level average content validity index，S-CVI/Ave）评价量表的内容效度。计算中文版BMSC的效应值（effective size，ES）以评价量表的反应度，分别采用基于校标法和基于分布法的最小临床重要差异（minimal clinical important difference，MCID）值分析BMSC评分。结果·中文版BMSC的Cronbach
's
α系数为0.85，重测信度ICC为0.72，I-CVI为0.8~1.0，S-CVI/Ave为0.97。伽玛刀治疗前后BMSC评分的差异有统计学意义（
P<0.05），BMSC评分的ES为0.01~0.35；基于校标法获得BMSC评分的MCID值介于0.07~1.28，基于分布法获得的MCID值介于0.01~0.60。结论·中文版BMSC具有较好的信度和效度。
关键词: 脑转移瘤, 症状, 量表, 信度, 效度 Abstract: Objective·To translate the English version of Brain Metastases Symptom Checklist (BMSC) into Chinese version and test its reliability and validity.
Methods·The translation and adaption of BMSC for the Chinese population were generated by Brislin translation and back-translation model. From January 2017 to June 2019, a sample of 239 brain metastases patients matched with the inclusion criteria were selected via convenience sampling from the Center for Functional Neurosurgery, Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine and Gamma Knife Center, Shandong Provincial Hospital affiliated to Shandong First Medical University. The Cronbach's α coefficient was used to evaluate the internal consistency, and the intra-class correlation coefficient (ICC) was used to determine the retest reliability. The item-related content validity index (ICV) and the scale-level average content validity index (S-CVI/Ave) were applied to assess the content validity of the Chinese version of BMSC. The effective size (ES) was calculated to evaluate the responsiveness of the Chinese version of BMSC, and the minimal clinical important difference (MCID) of the Chinese version of BMSC was evaluated by using anchor-based approach and distribution-based approach respectively.
Results·The Cronbach's α coefficient of the Chinese version of BMSC was 0.85, and the ICC reflecting retest reliability was 0.72. The I-CVI was 0.8?1.0, and the S-CVI/Ave was 0.97. The scores of the Chinese version of BMSC before and after gamma knife treatment showed significant differences (P<0.05), and the ES of the Chinese version of BMSC was 0.01?0.35. The MCID value of BMSC score obtained by anchor-based method was 0.07?1.28, and the value obtained by distribution-based method was 0.01?0.60.
Conclusion·The Chinese version of BMSC has good validity and reliability.
Key words: brain metastases, symptom, scale, reliability, validity PDF全文下载地址:
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