摘要/Abstract

摘要： RNA修饰在生命活动和疾病的发生和发展中发挥着重要的作用。氮6-甲基腺嘌呤（N⁶-methyladenine， m⁶A）修饰是信使RNA中广泛存在的甲基化修饰，是动态变化的。近年来在肿瘤中发现m⁶A修饰酶和结合蛋白表达异常，可通过改变靶基因的RNA m⁶A修饰水平来调控肿瘤的进展。该文综述了m⁶A的去甲基化酶和甲基转移酶，包括α-酮戊二酸依赖的加双氧酶FTO（FTO α-ketoglutarate dependent dioxygenase）、AlkB同源蛋白5（AlkB homolog 5，ALKBH5），甲基转移酶样3（methyltransferase like 3，METTL3）在多种肿瘤中发挥的重要功能，以及m⁶A修饰酶的小分子抑制剂的研究进展。
关键词: 氮6-甲基腺嘌呤（m⁶A）, 肿瘤, 抑制剂, α-酮戊二酸依赖的加双氧酶FTO
Abstract:
RNA modifications play an important role in physiology and pathology. N⁶-methyladenine (m⁶A) has been identified as a prevalent methylation modification on eukaryotic RNAs. RNA m⁶A can be reversible. In recent years, abnormal expression of the RNA m⁶A modification enzymes and binding proteins have been found in tumors, and they promote or inhibit the tumor progression by altering the mRNA m⁶A modification levels of the target genes. This paper reviews the important functions of FTO α-ketoglutarate dependent dioxygenase, AlkB homolog 5 (ALKBH5) and methyltransferase like 3 (METTL3) in a variety of tumors, and also reports their small molecule inhibitors.
Key words: RNA N⁶-methyladenine (m⁶A), tumor, inhibitor, FTO α-ketoglutarate dependent dioxygenase


PDF全文下载地址:

点我下载PDF