摘要/Abstract

摘要： 抗中性粒细胞胞浆抗体（anti-neutrophil cytoplasmic antibody，ANCA）相关性血管炎（ANCA associated vasculitis，AAV）是一类全身性自身免疫性疾病。AAV以小血管壁的炎症或纤维素样坏死为病理基础，可累及多个器官系统，严重时可危及生命。单核 - 巨噬细胞是机体固有免疫系统中重要的细胞组分，包括血液中的单核细胞和组织中固定或游走的巨噬细胞。在不同组织器官中的单核 - 巨噬细胞参与AAV发病和疾病进展。文章就单核 - 巨噬细胞在AAV中的研究进展予以综述。
关键词: 抗中性粒细胞胞浆抗体, 抗中性粒细胞胞浆抗体相关性血管炎, 单核细胞, 巨噬细胞
Abstract:
Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) constitues a group of autoimmune diseases with poor prognosis. Inflammation and fibrinoid necrosis of the small vessels are the pathological features of the disease, and many organs and systems can be involved. Monocyte-macrophages are important to innate immune system. Monocyte-macrophage can respond rapidly to inflammation and participate in the progression of AAV. Recently, the role of monocyte-macrophage in AAV has been studied with great detail. This article reviews recent research progress of monocyte-macrophage in AAV so as to further understand the disease.
Key words: anti-neutrophil cytoplasmic antibody (ANCA), ANCA associated vasculitis, monocyte, macrophage


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