摘要/Abstract

摘要： 干细胞来源的细胞外囊泡（stem cell-derived extracellular vesicles，SC-EVs）能够调节病变细胞功能及微环境，且不具有干细胞移植的风险，能更安全地用于疾病治疗。在中枢神经系统损伤病灶中，SC-EVs能够促进神经血管再生并抑制炎症损伤，有利于神经功能康复。SC-EVs可减少Aβ蛋白相关的神经损伤，缓解阿尔茨海默病。SC-EVs还可以作为微RNA及化疗药物的运输载体治疗神经胶质瘤。该文就SC-EVs在中枢神经系统疾病治疗中应用的研究成果进行综述。
关键词: 干细胞来源的细胞外囊泡, 中枢神经系统损伤, 阿尔茨海默病, 神经胶质瘤
Abstract:
Stem cell-derived extracellular vesicles can regulate functions of targeting cells in lesions and have fewer risks in treating diseases. In central nervous injury lesions, stem cell-derived extracellular vesicles can promote neurogenesis and angiogenesis and regulate nervous inflammation, which promotes the recovery of the nerve injury. Stem cell-derived extracellular vesicles can ease Aβ protein-related neuron damage in Alzheimers disease. Stem cell-derived extracellular vesicles also can deliver microRNA and chemotherapeutic agents to neuroglioma cells. This review introduces recent advances in using stem cell-derived extracellular vesicles in treating central nervous system diseases.
Key words: stem cell-derived extracellular vesicles (SC-EVs), central nervous system injury, Alzheimer’s disease, neuroglioma


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