摘要/Abstract

摘要： 生命早期营养影响妊娠结局和子代终身健康。类胡萝卜素缺乏与先兆子痫、早产和宫内生长受限等不良妊娠结局的发生有关。类胡萝卜素在体内可以发挥抗氧化、炎症调节和免疫促进作用，并可以促进子代的视力、认知和呼吸系统健康。在类胡萝卜素中， α-胡萝卜素、 β-胡萝卜素和 β-隐黄质可以在体内转化生成维生素 A，其转化效率受到机体维生素 A营养状况的影响；叶黄素和玉米黄质高度富集于婴幼儿大脑和视网膜，与视敏度和认知功能的发育密切相关。母乳含有充足的叶黄素且其吸收率明显高于配方乳粉，人工喂养的婴儿尤其是早产儿需要注意补充叶黄素。该文综述了类胡萝卜素与不良妊娠结局及子代发育相关的功能研究进展，以及其在配方乳粉中的添加现状。
关键词: 生命早期, 类胡萝卜素, 不良妊娠结局, 子代发育
Abstract:
Early life nutrition plays an important role in determining the pregnancy outcomes and offspring lifelong health. Carotenoids deficiency is associated with adverse pregnancy outcomes such as preeclampsia, premature delivery and intrauterine growth restriction. Carotenoids possess antioxidant, inflammation modulating and immune-enhancing properties and promote visual, cognitive and respiratory health in offsprings. Among carotenoids, α-carotene, β-carotene and β-cryptoxanthin can be transformed into vitamin A in vivo, and their conversion rates are affectedthe nutritional status of vitamin A. Lutein and zeaxanthin are highly enriched in the brain and retina of infants and young children, which are closely related to the development of visual acuity and cognitive function. Breast milk contains an adequate level of lutein and its absorption rate is significantly higher than that of infant formulas. Consequently lutein supplementation is necessary for artificially fed infants, especially premature infants. In this paper, the functional research progresses of carotenoids related to adverse pregnancy outcomes and offspring development, as well as the present situation of carotenoids supplementation in formula were reviewed.
Key words: early life, carotenoids, adverse pregnancy outcomes, offspring development


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