摘要/Abstract

摘要： 目的 ·研究不同认知功能水平老人之间的脑微出血差异。方法 ·以 18例阿尔茨海默病患者（ AD组）、 28例遗忘型轻度认知功能损害患者（ aMCI组）以及 30例志愿入组的年龄匹配的正常对照老人（ NC组）为研究对象。利用磁敏感加权成像技术，寻找并记录脑微出血点的数量及位置，勾画出左右大脑的额叶、颞叶、顶叶、枕叶、丘脑等与认知功能密切相关的脑区。 χ2检验分析各组微出血点例次和各脑区及全脑存在微出血点例次的组间差异，并对以上各脑区及全脑的微出血点数量进行组间方差分析。结果 ·对脑区存在微出血点例次的 χ2检验中， AD组与 NC组在额叶（ P0.005）、颞叶（ P0.005）和全脑（ P0.004），aMCI组与 NC组在额叶（ P0.048），3组间在额叶（ P0.006）、颞叶（ P0.006）和全脑（ P0.016）差异均具有统计学意义。对微出血点数量的方差分析中， AD组与 NC组在额叶（ P0.004）、颞叶（ P0.049），aMCI组与 NC组在额叶（ P0.044），3组间在额叶（ P0.016）、颞叶（P0.038）和全脑（P0.048）差异均具有统计学意义。结论 ·阿尔茨海默病患者较正常对照老人在额叶和颞叶存在较重的脑微出血表现，脑微出血的量化有望成为阿尔茨海默病诊断的候选指标。
关键词: 轻度认知功能损害, 阿尔茨海默病, 磁敏感加权成像, 脑微出血
Abstract:
Objective · Toevaluatethedifferencesof brain microbleedsamongAlzheimer′s disease(AD),amnesia mild cognitiveimpairment (aMCI)and normal control (NC). Methods · Eighteen AD patients, 28 aMCI patients and 30 age-matched NC were recruited in the study. The location and number of microbleeds was recorded in the brain according to the susceptibility-weighted images. The bilateral frontal lobe, parietal lobe, occipital lobe, temporal lobe, and thalamus were manually mapped on 3D-MR imaging. The number of cases with microbleeds and the number of microbleeds in each lobe were calculated and compared among three groups using the chi-square test and ANOVA. Results · Significant differences on case number with microbleeds were found betweenAD group and NC group in the frontal lobe (P0.005), the temporal lobe (P0.005) and whole brain (P0.004), and between aMCI group and NC group in the frontal lobe (P0.048). It also showed significant differences among three groups in the frontal lobe (P0.006), the temporal lobe (P0.006) and whole brain (P0.016). For the microbleeds counts, significant differences were found betweenAD group and NC group in the frontal lobe (P0.004) and the temporal lobe (P0.049), and between AD group and NC group in the frontal lobe (P0.044). It also had significant differences among three groups in the frontal lobe (P0.016), the temporal lobe (P0.038) and whole brain (P0.048). Conclusion · The AD group has more significantmicrobleeds in frontal and parietal lobes incomparison toNC group.The quantization of cerebral microbleedsmay be apotential biomarker for AD diagnosis.
Key words: mild cognitive impairment (MCI), Alzheimer&, prime, sdisease, susceptibility-weighted image (SWI), brainmicrobleed


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