摘要/Abstract

摘要： TRIM28是一个包含多个结构域的大分子蛋白，属于人类三聚体蛋白家族中的一员。该家族共计包含60余种蛋白，以存在4个保守结构域即RING指、B-box 1型和2型以及亮氨酸卷曲螺旋结构为主要特征。TRIM28主要与含KRAB结构域（Kruppelassociated box domain）的转录因子相互作用，从而发挥转录共激活或共抑制作用，并在肿瘤发生、细胞分化、胚胎发育的调控中发挥重要作用。
关键词: 转录调节, 共激活子, 共抑制子, 肿瘤, 表观遗传, 甲基化
Abstract:
TRIM28, known as a kind of macro-molecules, consists of multiple domains and belongs to one of human tripartite motif-containing proteins families. This superfamily contains more than 60 proteins in total and is characterizedfour conservative domains, also referred to the RBCC domain, which is a RING (really interesting new gene) finger, two B-boxes (type 1 and type 2) and a leucine zipper coiled-coil region. TRIM28 plays its pivotal roles in transcriptional co-activation or co-repressioninteracting directly with transcription factors, within which is a Kruppel-associated box domain (KRAB domain). Moreover, itis critical during the development of embryos, thedifferentiation of cells and the regulation of cancers.
Key words: transcriptional regulation, co-activator, co-repressor, cancer, epigenetics, methylation


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