摘要/Abstract

摘要： 吴茱萸碱是从中药吴茱萸中提取的天然生物碱。除具有较强的抗炎、镇痛等作用外，吴茱萸碱还能抑制肿瘤细胞活性与增殖、阻滞细胞周期、促进凋亡、促进自噬、抑制肿瘤微血管形成以及影响肿瘤表观遗传学修饰等。相关的通路如 PI3K-Akt和 JAK-STAT通路以及其对生存素、血管内皮生长因子和 miRNA的作用也陆续被揭示。随着吴茱萸碱相关衍生物和中药制剂不断地被合成与改进，研究人员对其抗肿瘤活性的认识逐步深入，推测其在未来具有较大的临床和药用开发价值。
关键词: 吴茱萸碱, 抗肿瘤活性, 作用机制, 衍生物, 联合用药
Abstract:
Evodiamine is the natural component extracted Euodiae Fructus. Recently, growing evidence has proved that evodiamine has great effects on suppressing cell viability and proliferation, arresting cell cycle, inducing apoptosis, promoting autophagy, inhibiting the formation of microvascular angiogenesis as well as affecting epigenetic modification in cancer. Recent studies have continuously revealed related signal pathways involved in evodiamine such as PI3K-Akt and JAK-STAT pathways, as well as the impact of evodiamine on survivin, vascular endothelial growth factor and miRNAs. With the development and synthesis of evodiamine derivatives and related herbal formulations, the understanding of antitumor activity of evodiamine is gradually deepening. The important clinical significance and market value of evodiamine can be prospected.
Key words: evodiamine, antitumor activity, mechanism, derivative, combined medication


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