摘要/Abstract

摘要： 抑郁症是一种严重的精神疾病，给个人和社会带来了严重的健康风险与经济负担。目前有关抑郁症发病机制的理论众多，如神经递质紊乱、内分泌失调、神经元适应性和可塑性损害、氧化应激和线粒体功能障碍等。近年来，关于免疫功能异常在抑郁症发病中的研究日益增多，该文就天然免疫因子 NLRP3 炎症小体在抑郁症发病机制中作用的研究进展进行综述.
关键词: 抑郁症, 发病机制, NLRP3 炎症小体, 细胞因子
Abstract:
Depression disorder is a kind of serious mental illness which poses high health risks and heavy financial burden to individuals and the society. Currently, there are many theories on the pathogenesis of depression disorder, such as neurotransmitter disorders, endocrine disorders, abnormal neuronal adaptability and plasticity, oxidative stress and mitochondrial dysfunction and so on. In the lately decade, the research of immune dysfunction in the pathogenesis of depression has become a newly hot-point. This review summarizes NLRP3 inflammasome in the pathogenesis of depression disorder.
Key words:  depression disorder, pathogenesis mechanism, NLRP3 inflammasome, cytokine


PDF全文下载地址:

点我下载PDF