KCJJ"细胞微生物学是一门研究微生物和宿主细胞相互作用的交叉学科，本课程重点介绍有关病原体－宿主相互作用的研究进展，讲述微生物从粘附到宿主细胞受体，直至与细胞发生各类作用，例如调节细胞信号转导途径，调节基因表达，等等。掌握细胞微生物学知识有助于更深入地理解微生物病原体的致病过程，以及宿主和病原体的相互关系。为了引领微生物学及相关专业学生进入这一新的领域，使他们得到更多的训练，在将来的科研工作中具备更高的专业水准，我们开设了“细胞微生物学”这门课程。这是一门跨专业、跨学科的研究生课程，主要包括5个专题，共20个学时：1.细胞微生物学入门。重点介绍微生物的致病过程：细菌的粘附；细菌内在化的机制；胞外菌蛋白分泌的机制；致病菌如何破坏真核细胞功能，包括细菌在感染过程中对细胞骨架的作用，打破细胞凋亡与细胞增生的平衡，诱导免疫应答，破坏或逃逸宿主天然和获得性免疫应答；细菌对宿主环境的应答，这一应答过程有助于细菌在不利的环境中得以生存。2.细胞生物学概述，为学习和研究细胞微生物学提供基础知识。3.细菌分泌系统；致病岛（毒力岛）。4.细胞介导的免疫：病原体的诱导和调节。5.细胞微生物学研究方法，这些方法将为寻找新的微生物致病因子和研究微生物－宿主相互作用提供强有力的技术支持。例如，笔记标识突变, 体内表达技术（IVET），体内诱导的抗原技术（IVIAT），芯片技术，差减杂交技术，抑制差减杂交技术，酵母双杂交技术，噬菌体展示技术，等等。"

KCJJY"Cellular Microbiology introduce the intersection of microbial and host-cell biology, emphasizing most recent researches that probes pathogen-host interactions, which start at the point of microbial adhesion to cellular receptors and include the variety of interactions that occur inside the cell, such as how cells alter signaling pathways and gene regulation. Knowledge of cellular microbiology will provide a deeper understanding of the evolution of pathogenicity and host-parasite relationships. To draw students into this field and create opportunities for them to get more training and be capable of a high level of competence and professionalism in their postgraduate careers, we offer the interdepartmental graduate course called ""Cellular Microbiology"". Course content includes 5 special topics (20 semester hours): 1.Introduction to cellular microbiology, emphasizing on microbial pathogenecity: microbe adherence; mechanisms of bacterial internalization; protein secretion of extracellular bacterial pathogens; hijacking of eukaryotic functions by bacterial pathogens, including targeting of the cytoskeleton during infection, disrupting the balance between apoptosis and proliferation, induction of immune response and bacterial strategies for overcoming host innate and adaptive immune responses; bacterial responses to host environment, helping the bacteria survive the unfavorable environment.2.Overview of cell biology that provides fundamental knowledge for the study of cellular microbiology.3.Bacterial secretion system; pathogenicity or virulence island.4.Cell-Mediated Immunity: induction and regulation by pathogenic agents. 5.Methods for study of cellular microbiology, which provides potent technological backup for the seeking of new microbial virulence factors and the research on pathogen-host interactions, for example, signature tagged mutagenesis (STM), in vivo expression technology (IVET), in vivo induced antigen technology (IVIAT), microarray technology, subtractive hybridisation (SH), suppression subtractive hybridisation (SSH), yeast two-hybrid, phage display, etc."