KCJJ"受体和细胞功能调控是细胞和分子生物学的前沿分支。很多递质、激素、免疫因子、生长因子和药物都通过受体和后续信号转导实现对靶细胞功能的调控，其生理和病理意义已受到广泛重视。本课程概要介绍这已领域的基本知识及重要进展，包括它们的分类、分布、结构、功能、主要研究技术、生理和病理意义，对学生知识的现代化有重要意义。本课程包括以下四个部分：1．受体和受体后信号转导概论：内容主要是受体和受体后信号转导概念的发展过程；受体的基本特征；受体和受体后信号转导的主要研究方法；受体和配基结合反应的四大基本特征及基本规律；受体的分类原则及受体的亚型；受体后信号转导机制的几种主要类型；受体和和受体后信号转导的调节。2．膜受体：膜受体成员很多，在介绍膜受体的通性、分类、成员后将按四个大类分别讲授。第一大类是G-蛋白偶联受体，内容包括共同特征、成员、结构和功能域、G-蛋白的亚单位及亚型、G-蛋白的活化及失活过程；G-蛋白信息传递中的环一磷酸腺苷通路。第二大类是酶联受体，内容包括主要成员、特征及分类，酶联受体的主要信号转导通路，促进细胞增殖、分化的主要机理。第三大类是与可溶性酪氨酸激酶偶联受体，内容包括主要成员、特征、分类及主要信号转导通路，调节细胞增殖、分化的主要机理。第四大类是离子通道受体，内容包括主要成员、结构特点、调节离子流量的主要机理及对某些脏器功能的调节作用。3．核受体：内容包括核受体的通性、基本成员和生理作用、核受体的分类及分类的主要依据；结构功能域的分区、各区的主要作用、C区结构与功能的相互关系；与配基结合后对基因表达的调节、介导蛋白的作用、生理和病理意义。4．受体与疾病：目前国际上对受体及受体后信号转导和疾病的关系非常重视，研究进展很快。本课程拟对研究较成熟的几个方面作概要介绍。内容包括遗传基因突变引起的受体异常，遗传基因突变引起的G蛋白异常，受体抗体和疾病的关系，某些重要疾病中受体的变化作为重要的中间环节，如精神分裂症、老年痴呆症、帕金森症，溢出性结合引起的征候及机理，某些肿瘤时受体的变化与治疗方案和预后的关系，受体及受体后信号转导分子和癌基因的关系。通过本课程的学习使学员对受体和受体后的信号转导通路的分类、分布、结构、功能、它们的生理和病理意义，以及主要研究技术有概括性了解，使学员能开拓视野，更好地理解和掌握各基础和临床学科的现代化进展。"

KCJJY"Receptors and cell function regulation is a frontal sub-branch of cell biology and molecular biology. Many neuro-transmitters, hormones, cytokines, growth factors and drugs regulate target cell functions through their actions on receptors and post-receptor signal transduction. Therefore, the physiological and pathological significance of receptors and post-receptor signal transduction have attracted extensive attention. The main aim of this course is to introduce the basic knowledge and important progress of this field including classification, distribution, structure, function, main techniques as well as the physiological and pathological significance. These should be very important for the graduate students to modernize their knowledge. The course will involve the following four portions:1. Concept of receptor and post-receptor signal transduction; development of concept; basic characteristics of receptors, fundamental techniques for studying receptors and post-receptor signal transduction, basic laws of ligand receptor binding, classification of receptors and their sub-types, several important classes of post-receptor signal transduction cascades, and their regulation. 2. Membranous receptors: After introducing the common properties, classification and members, the four classes of membranous receptors will be lectured separately. The first is the G protein coupled receptors involving the activation of G protein and the signal transduction after G protein activation. The second is the enzyme-linked receptors and the regulation of cell division and differentiation by their specific post-receptor pathway. The third is the receptors coupled to soluble tyrosine kinase and the regulation of their target molecules especially cytokines. The fourth is the ligand gated ion channels, the specific molecular mechanism regulating the pass-through of ions and their consequences.3. Nuclear receptors: This will involve the general characteristics of nuclear receptors, their members, classification based on the molecular structure especially C domain, and their mechanism in regulating the gene expression of various target molecules.4. Receptors and diseases: In view of the extremely rapid progress of the investigations of this topic, only selected topics having abundant data will be lectured. These will involve the hereditary diseases due to mutations of receptors or G proteins, certain diseases due to abnormal auto-antibody, certain diseases where abnormal receptors acts as an important intermediate factor of pathogenesis, and the relation of receptors to certain malignancy.Taken together, it is expected that after studying this course students will have enough basic knowledge of receptors and post-receptor signal transduction as well as the physiological and pathological significance so that they will be able to share the continuous development of this field in the world."