"医学遗传学经过半个多世纪的发展，已经成为一门涉及数千种遗传性疾病的基础理论和临床实践的科学。尤其在近十几年中发展尤为迅速，随着人类基因组计划的完成，极大地推动了医学遗传学的发展，研究领域拓展到分子层面，新的致病基因不断被检出并定位，其致病机理的研究也日益加速。面向二十一世纪遗传学的飞速发展，医学院校的医学遗传学教学也面临着严峻的挑战。以往医学院“医学遗传学”课程只对本科生开设，为了进一步深化研究生的教学改革，提高研究生培养的质量，适应社会发展对高层次医药卫生人才的需要，为此新开设针对硕士研究生的“医学分子遗传学”课程。本课程由上海交通大学基础医学院医学遗传学教研室主任、上海高校模式生物E-研究院首席研究员王铸钢教授主讲，邀请上海高校模式生物E-研究院的特聘研究员参与讲授，其中2位为教育部“****特聘教授”、3位为国家杰出青年基金获得者。课程内容包括模式生物技术在生物医学研究中的应用、利用条件基因剔除技术研制人类疾病小鼠模型、基因捕获技术在功能基因组研究中的应用、转录因子AP-2的调节和功能分析、MyD88途径受抑制引起转基因心脏肥厚和心脏损害、神经退行性疾病的分子遗传学研究进展等。该课程采取全新的理念设计，通过各位特聘研究员紧密结合各自科研工作的理论与实践介绍，指导学生如何选择科研题目、如何设计技术路线、如何判断实验结果、如何解决研究中遇到的问题，最终目的是提高研究生的创新意识、创新思维及创新能力。"

KCJJY"Up to now, human and mouse genome sequences are known. The scientific interest has turned to elucidating gene function and identifying gene products that might have therapeutic values. The laboratory mouse has had a prominent role in the study of human disease mechanisms throughout the rich, 100-year history of classical mouse genetics. Appreciation of the power of mouse genetics to inform the study of mammalian physiology and disease, coupled with the advent of the mouse genome sequence and the ease of producing mutated alleles, has catalyzed public and private sector initiatives to produce mouse mutants on a large scale, with the goal of eventually knocking out a substantial portion of the mouse genome. However, the total number of knockout mice described in the literature is relatively modest, corresponding to only ~10% of the ~25,000 mouse genes. The curated Mouse Knockout & Mutation Database lists 2,669 unique genes, the curated Mouse Genome Database lists 2,847 unique genes. Most of these knockouts are not readily available to scientists who may want to use them in their research.In order to improve the research on functional genomics, it is necessary to setup a new course which is named Medical Molecular Genetics for graduate students in Shanghai Jiao Tong University School of Medicine. This course will be hosted by Dept. of Medical Genetics of above-mentioned the University. Prof. Wang, who is director of this Department, will be in charge of this course. Topics include: Generation of the conditional gene targeted mouse models for human diseases, Four stones hit one bird--the identification of Rig-I partner, Regulation and functional analysis of transcription factor AP-2, Inhibition of MyD88 pathway causes heart hypertrophy and heart failure in transgenic mice, Genetics of Neurodegenerative Disorders and so on. Of course, it will be give some lectures by seven famous professors from Model Organism Division, E-institutes of Shanghai Universities. Thank you to care this course."