章永春 长聘教轨副教授

电话：+86-021
邮箱：yongchun_zhang@sjtu.edu.cn
地址：上海市东川路800号, 上海交通大学生命科学技术学院
博士生导师，本课题组主要利用人多能干细胞、3D类器官培养、小鼠模型和分子生物信息学技术研究器官的再生、癌症的形成以及治疗。目前已在Nature，Cell Stem Cell和Developmental Cell等杂志发表了多篇论文。





学术经历
教育和研究经历
2020-今上海交通大学生命科学技术学院，长聘教轨副教授
2018-2019 美国哥伦比亚大学Columbia University，Associate Research Scientist
2015-2018 美国哥伦比亚大学Columbia University，博士后
2010-2015 美国罗彻斯特大学University of Rochester，博士
2006-2010 南开大学生命科学学院，学士


教育和研究经历
2020-今上海交通大学生命科学技术学院，长聘教轨副教授
2018-2019 美国哥伦比亚大学Columbia University，Associate Research Scientist
2015-2018 美国哥伦比亚大学Columbia University，博士后
2010-2015 美国罗彻斯特大学University of Rochester，博士
2006-2010 南开大学生命科学学院，学士





研究方向

消化道（包括食管、胃和肠）的干细胞、肿瘤和类器官






1）消化道3D类器官的建立;
2）消化道肿瘤的形成与治疗研究;
3）人诱导多能干细胞分化和器官再生;
4）器官发育的分子和细胞调节机制






研究方向


消化道（包括食管、胃和肠）的干细胞、肿瘤和类器官 1）消化道3D类器官的建立;
2）消化道肿瘤的形成与治疗研究;
3）人诱导多能干细胞分化和器官再生;
4）器官发育的分子和细胞调节机制











代表论著
? 3D Modeling of Esophageal Development using Human PSC-Derived Bas al Progenitors Reveals a Critical Role for Notch Signaling. 2018Cell Stem Cell. 4;23(4):516-529.Yongchun Zhang, Ying Yang, Ming Jian g, Sarah Xuelian Huang, Wanwei Zhang, Denise Al Alam, Soula Danopoulos, Munemasa Mori, Ya-Wen Chen, Revathi Balasubramanian, Susan a M. Chuva de Sousa Lopes, Carlos Serra, Monika Bialecka, Eugene Kim, Sijie Lin, Ana Luisa Rodrigues Toste de Carvalho, Paul N. Riccio, Wellington V. Cardoso, Xin Zhang, Hans-Willem Snoeck, Jianwen Que.

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? BMP signaling in development, stem cells, and diseases of the gastrointestinal tract. 2020Annual Review of Physiology. 82:251-273.Yongchun Zhang, Jianwen Que.

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? Use of hPSC-derived 3D organoids and mouse genetics to define the roles of YAP in the development of the esophagus.2019 Development. Dominique D Bailey#,Yongchun Zhang#, Benjamin J van Soldt#, Ming Jiang, Supriya Suresh, Hiroshi Nakagawa, Anil K Rustgi, Seema S Aceves, Wellington V Cardoso, Jianwen Que. (#co-first authors)

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? • CCN1 Regulates Chondrocyte Maturation and Cartilage Development. 2016 Journal of Bone and Mineral Research. 31 (3), 549-559. Yongchun Zhang, Tzong-jen Sheu, Donna Hoak, Jie Shen, Matthew J Hilton, Michael J Zuscik, Jennifer H Jonason, Regis J O'Keefe.

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? Development and stem cells of the esophagus.2017Seminars in Cell & Developmental Biology. 66, 25-35.Yongchun Zhang,Ming Jiang, Eugene Kim, Sijie Lin, Kuancan Liu, Xiaopeng Lan, Jianwen Que.

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? BMP-TAK1 (MAP3K7) induces adipocyte differentiation through PPARγ signaling. 2017Journal of Cellular Biochemistry. 118 (1), 204-210.Yongchun Zhang, Regis J O'Keefe, Jennifer H Jonason.

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? Transitional basal cells at the squamous-columnar junction generate Barrett's esophagus. 2017Nature.26;550(7677):529-533. Ming Jiang, Haiyan Li,Yongchun Zhang, Ying Yang, Rong Lu, Kuancan Liu, Sijie Lin, Xiaopeng Lan, Haikun Wang, Han Wu, Jian Zhu, Zhongren Zhou, Jianming Xu, Dong-Kee Lee, Lanjing Zhang, Yuan-Cho Lee, Jingsong Yuan, Julian A. Abrams, Timothy C. Wang, Antonia R. Sepulveda, Qi Wu, Huaiyong Chen, Xin Sun, Junjun She, Xiaoxin Chen, Jianwen Que.

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? Isl1 regulation of Nkx2. 1 in the early foregut epithelium is required for trachea-esophageal separation and lung lobation. 2019Developmental Cell. Eugene Kim, Ming Jiang, Huachao Huang,Yongchun Zhang, Natalie Tjota, Xia Gao, Jacques Robert, Nikesha Gilmore, Lin Gan, Jianwen Que.

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? • Wnt/Fgf crosstalk is required for the specification of basal cells in the mouse trachea. 2019 Development. 146 (3), dev171496.Zhili Hou, Qi Wu, Xin Sun, Huaiyong Chen, Yu Li, Yongchun Zhang, Munemasa Mori, Ying Yang, Jianwen Que, Ming Jiang.

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? Pharmacological targeting of p38 MAP-Kinase 6 (MAP2K6) inhibits the growth of esophageal adenocarcinoma. 2018Cellular Signalling. 51, 222-232.Sijie Lin, Kuancan Liu,Yongchun Zhang, Ming Jiang, Rong Lu, Christopher J Folts, Xia Gao, Mark D Noble, Tingting Zhao, Zhongren Zhou, Xiaopeng Lan, Jianwen Que.

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