导师姓名： 栾洋 专业代码： 100400
性别： 女 专业名称： 公共卫生与预防医学
培养单位： 公共卫生学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： yluan@sjtu.edu.cn
邮编： 200025 邮箱地址： yluan@sjtu.edu.cn

研究方向 (点击浏览详细信息)
外源化合物遗传毒性与肝毒性评价与研究

社会任职
中国环境诱变剂学会理事
国际遗传毒性测试专家工作组成员
Mutagenesis杂志编委会成员
上海市环境诱变剂学会理事
中国毒理学会遗传毒理委员会 副主任委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
马兜铃酸物质基础与致癌毒性研究 国家自然科学基金面上项目 2019-01~2022-12 57万元 课题负责人
ZH2018ZDA22 基于微流控芯片的线虫发育毒性高通量测试及新型农药毒性筛选研究 交大医学院医工交叉重点项目 2019-01~2021-12 50万元 课题负责人
** 多溴联苯醚（PBDEs）的生殖遗传毒性研究 国家自然科学基金 2015-01~2018-12 80万元 课题负责人
** 建立新的动物模型研究肝脏P450酶对致癌物遗传毒性的影响 国家自然科学基金 2011-01~2013-12 35万元 课题负责人
** 新的遗传毒性分子生物标志物的探索与研究 国家自然科学基金 2009-01~2011-12 17万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Weiying Liu, Jing Xi, Yiyi Cao, Xinyue You, Ruixue Chen, Xinyu Zhang, Li Han, Guoyu Pan and Yang Luan （通讯作者） An Adaption of Human-Induced Hepatocytes to In Vitro Genetic Toxicity Tests Mutagenesis 2019 34:165-171
Hao Xu, Chao Feng, Yiyi Cao, Ying Lu, Jing Xi, Jieyun Ji, Dasheng Lu, Xin-Yu Zhang, Yang Luan. Distribution of the parent compound and its metabolites in serum, urine, and feces of mice administered 2,20,4,40-tetrabromodiphenylether. Chemosphere 2019 225: 217-225
Wang Y, Yu YX, Luan Y, An J, Yin DG, Zhang XY Bioactivation of 1-chloro-2-hydroxy-3-butene, an in vitro metabolite of 1,3-butadiene, by rat liver microsomes Chem Biol Interact. 2018 282:36-44
Wei Z, Xi J, Gao S, You X, Li N, Cao Y, Wang L, Luan Y （通讯作者）, Dong X. Metabolomics coupled with pathway analysis characterizes metabolic changes in response to BDE-3 induced reproductive toxicity in mice. Sci Rep. 2018 8(1):5423
Yang Luan, Shuangcheng, MaYimin Mao Is it really the“dark side”of herbal medicine? SCIENCE CHINA Life Sciences 2018 doi: 10.1007/s11427-018-9351-0
Xinyue You, Jing Xi, Weiying Liu, Yiyi Cao, Weifeng Tang, Xinyu Zhang, Yingxin Yu, Yang Luan （通讯作者） 2,2',4,4'-Tetrabromodiphenyl Ether Induces Germ Cell Apoptosis through Oxidative Stress by a MAPK-mediated p53-independent Pathway Environmental Pollution 2018 242:887-93
You X, Ando T, Xi J, Cao Y, Liu W, Zhang X, Honma M, Masumura K, Luan Y. （通讯作者） Gene mutation and micronucleus assays in gpt delta mice treated with 2,2',4,4'-tetrabromodiphenyl ether Mutagenesis 2018 33(2):153-160
Xinyue You, Jing Xi, Yiyi Cao, Jinfu Zhang, Yang Luan （通讯作者） 4-Bromodiphenyl Ether (BDE-3) Induces Germ Cell Apoptosis by Induction of ROS and DNA Damage in Caenorhabditis elegans TOXICOLOGICAL SCIENCES 2017 157(2) 510–518
Liupeng Wang, Wenwei Xu, Leilei Ma, Suxing Zhang, Kezhi Zhang, Peizhen Ye, Guozhen Xing, Xuefeng Zhang, Yiyi Cao, Jing Xi, Jun Gu, Yang Luan （通讯作者） Detoxification of Benzo[a]pyrene primarily depends on cytochrome 450, while bioactivation involves additional oxidoreductases including 5-lipoxygenase, cyclooxygenase and aldo-keto reductase in the liver J Biochem Mol Toxicol. 2017 31(7)e21902
Ma LL, Wu ZT, Wang L, Zhang XF, Wang J, Chen C, Ni X, Lin YF, Cao YY, Luan Y （通讯作者）, Pan GY. Inhibition of hepatic cytochrome P450 enzymes and sodium/bile acid cotransporter exacerbates leflunomide-induced hepatotoxicity Acta Pharmacol Sin. 2016 37: 1– 10
Yiyi Cao,Li Yang, Nannan Feng, Oumin Shi, Jing Xi, Xinyue You, Chunrong Yin, Huan Yang, Katsuyoshi Horibata, Masamitsu Honma, Biyun Qian,Wei Weng, Yang Luan （通讯作者） A Population Study Using the Human Erythrocyte PIG-A Assay Environ Mol Mutagen. 2016 57(8):605-614
Wang Y, Zhang X, Wang M, Cao Y, Wang X, Liu Y, Wang J, Wang J, Wu L, Hei TK, Luan Y （通讯作者）, Xu A Mutagenic effects of perfluorooctanesulfonic acid in gpt delta transgenic system are mediated by hydrogen peroxide Environ Sci Technol 2015 49(10):6294-303
Luan Y （通讯作者）, Xing G, Ren J,Gu J, Role of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formation Genes and Environment. 2015 37:11
Wang K, Feng C, Li C, Yao J, Xie X, Gong L, Luan Y, Xing G, Zhu X, Qi X, Ren J Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor Int J Mol Sci. 2015 16(7):16454-68
Luan Y,Qi X, Xu L, Ren J, Chen T Absence of mature miRNAs inactivates the response of gene expression to carcinogenesis induced by N-ethyl-N-nitrosourea in mouse liver J Appl. Toxicol. 2014 (1):2973-73
Chang Y, Zhou C, Huang F, Torous DK, Luan Y, Shi C, Wang H, Wang X, Wei N, Xia Z, Zhong Z, Zhang M, An F, Cao Y, Geng X, Jiang Y, Ju Q, Yu Y, Zhu J, Dertinger SD, Li B, Liao M, Yuan B, Zhang T, Yu J, Zhang Z, Wang Q, Ma J Inter-laboratory validation of the in-vivo flow cytometric micronucleus analysis method (MicroFlow?) in China Mutat Res Genet Toxicol Environ Mutagen. 2014 772:6-13
Xia Liu, Xiang Xue, Likun Gong, Xinming Qi, Yuanfeng Wu, Guozhen Xing; Yang Luan, Ying Xiao, Xiongfei Wu, Yan Li, Min Chen, Lingling Miao, Jun Yao, Jun Gu, Donghai Lin, Jin Ren. 1H NMR-based metabolomic analysis of triptolide-induced toxicity in liver-specific cytochrome P450 reductase knockout mice Metabonomics 2012 8(5):907-18
Guozhen Xing, Xinming Qi, Min Chen, Yuanfeng Wu, Jun Yao, Likun Gong, Takehiko Nohmi, Luan Y （通讯作者）, Ren J Comparison of the mutagenicity of aristolochic acid I and aristolochic acid II in the gptdeltatransgenic mouse kidney Mutation Research. 2012 743(1-2):52-8
Wu Y, Qi X, Gong L, Xing G, Xue X, Li Y, Chen M, Yao J, Miao L, Luan Y （通讯作者）, Ren J Identification of BC005512 as a DNA damage responsive murine endogenous retrovirus of GLN family involved in cell growth regulation. Plos one 2012 7(4): 35010-35016
Mengjun Wu, Guozhen Xing, Xinming Qi, Chenchen Feng, Mingxia Liu, Likun Gong, Yang Luan （通讯作者）, Jin Ren Assessment of the mutagenic potential of arecoline in gpt delta transgenic mice Mutation Research 2012 748(1-2):65-9
Luan Y, Xing G, Qi X, Wu M, Li C, Yao J, Gong L, Nohmi T, Gu J, Zhou W, Zheng S, Ren J The application of hepatic P450 reductase null gpt delta mice in studying the role of hepatic P450 in genotoxic carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mutagenesis Arch Toxicol. 2012 86(1):1753-1761
Luan Y, Kogi Mieko, Rajaguru P, Ren J, Yamaguchi T, Suzuki K. Microarray analysis of responsible genes in increased growth rate in the subline of HL60 (HL60RG) cells Mutation Research. 2012 731(1-2):20-6
Xia Liu, Xiang Xue, Likun Gong, Xinming Qi, Yuanfeng Wu, Guozhen Xing; Yang Luan, Ying Xiao, Xiongfei Wu, Yan Li, Min Chen, Lingling Miao, Jun Yao, Jun Gu, Donghai Lin, Jin Ren. 1H NMR-based metabolomic analysis of triptolide-induced toxicity in liver-specific cytochrome P450 reductase knockout mice Metabonomics 2012 8(5):907-18
Xue X, Gong LK, Maeda K, Luan Y, Qi XM, Sugiyama Y, Ren J Critical Role of Organic Anion Transporters 1 and 3 in Kidney Accumulation and Toxicity of Aristolochic Acid I Mol Pharm. 2011 8(6): 2183-92
Xue X, Gong L, Qi X, Wu Y, Xing G, Yao J, Luan Y, Xiao Y, Li Y, Wu X, Chen M, Gu J, Ren J. Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity Toxicol Lett. 2011 205(1):47-54
Chen M, Gong L, Qi X, Xing G, Luan Y, Wu Y, Xiao Y, Yao J, Li Y, Xue X, Pan G, Ren J. Inhibition of renal NQO1 activity by dicoumarol suppresses nitroreduction of aristolochic acid I and attenuates its nephrotoxicity. Toxicol. Sci. 2011 122(2):288-96
Xue X, Gong L, Qi X, Wu Y, Xing G, Yao J, Luan Y, Xiao Y, Li Y, Wu X, Chen M, Gu J, Ren J. Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity Toxicol Lett. 2011 205(1):47-54
Mei N, Guo L, Fu PP, Fuscoe JC, Luan Y （共同第一作者）, Chen T. Metabolism, genotoxicity, and carcinogenicity of comfrey Toxicol Environ Health B Crit Rev 2010 13:509-26
Li Y, Luan Y （共同第一作者）, Qi X, Li M, Gong L, Xue X, Wu X, Wu Y, Chen M, Xing G, Yao J, Ren J. Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II. Toxicol. Sci. 2010 118(2):435-43