导师姓名： 郭晓奎 专业代码： 100400
性别： 男 专业名称： 公共卫生与预防医学
培养单位： 公共卫生学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： xkguo@shsmu.edu.cn
邮编： 200025 邮箱地址： Microbiology@sjtu.edu.cn

研究方向 (点击浏览详细信息)
耐药菌噬菌体控制；益生菌的安全性；微生态学

社会任职
中国微生物学会组织委员会副主任委员
中国微生物学会普及与教育工作委员会副主任委员
《医学参考报》（微生物学与免疫学）编委
《微生物与感染杂志》编委
中国微生物学会理事会理事
中华预防医学会微生态学分会副主任委员
《中国微生态学杂志》编委
中国微生物学会医学微生物学与免疫学委员会医学细菌学组主任委员
《中国人兽共患病学报》副主编
上海市预防医学会微生态学专业委员会主任委员
中国医学微生物学和免疫学专业委员会委员
中国健康医学教育PBL联盟常务理事
上海市微生物学会微生物组学专业委员会主任委员
中国人兽共患病病原专业委员会委员
《国际生物制品学杂志》副主编
上海市医学病毒学专科学会委员
上海市食品学会理事兼乳酸菌专业委员会主任委员
中国微生物学会医学微生物学与免疫学委员会副主任委员
《上海交通大学学报》（医学版）编委
上海市微生物学会理事会秘书长

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
15GWZK0102 上海市公共卫生三年行动计划重点学科建设项目传染病与卫生微生物学 上海市卫计委 2016-01~2017-12 22.5万元 子课题负责人
钩端螺旋体与宿主细胞相互作用及其分子致病机制的研究 国家自然科学基金 2013-01~2015-12 52万元 子课题负责人
** 不同动物源性致病性钩端螺旋体遗传变异规律和致病差异的分子机制研究 国家自然科学基金 2013-01~2016-12 60万元 课题负责人
2012EP001004 超级细菌的预警监控和临床防治综合评价信息化平台的建立 科技部支撑计划 2012-01~2015-12 75万元 子课题负责人
** 基于Pan-genome技术探究问号钩端螺旋体不同血清型致病性差异的遗传基础 国家自然科学基金 2012-01~2015-12 58万元 课题负责人
2011AA02A100 自动化临床微生物分析检测仪器的研制 863重大专项 2011-09~2015-12 300万元 课题负责人
10JC** 重要人兽共患病钩端螺旋体病通用疫苗的基础研究 上海市科委 2010-10~2012-09 30万元 课题负责人
09XD** 钩端螺旋体rel基因致病机理的研究 上海市科委 2009-07~2011-06 40万元 课题负责人
2008ZX10004-002 呼吸道感染和感染性腹泻病原体诊断和组合检测技术 “十一五”重大专项子课题 2008-01~2010-12 300万元 子课题负责人
** 钩端螺旋体比较蛋白质组学研究 国家自然科学基金 2008-01~2010-12 30万元 课题负责人
** 钩体血清型相关基因的研究 国家自然科学基金 2007-01~2009-12 26万元 课题负责人
2006AA02Z176 钩端螺旋体重要功能基因的发掘、鉴定和应用 国家科技部 “863”计划 2006-01~2008-12 330万元 课题负责人
2003AA223030 钩端螺旋体致病及免疫机理的功能基因组学研究 国家科技部 “863”计划 2004-01~2005-12 157.3万元 课题负责人
** 钩端螺旋体溶血素基因结构、表达及功能的研究 国家自然科学基金 2004-01~2006-12 20万元 课题负责人
2001AA223030 钩端螺旋体致病及免疫机理的功能基因组学研究 国家科技部 “863”计划 2001-01~2003-12 141.1万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Li XM, Kang YX, Lin L, Jia EH, Piao DR, Jiang H, Zhang CC, He J, Chang YF, Guo XK （通讯作者）, Zhu Y Genomic Characterization Provides New Insights for Detailed Phage- Resistant Mechanism for Brucella abortus Front Microbiol. 2019 10:917
Zhu L, Luo F, Hu W, Han Y, Wang Y, Zheng H, Guo X （通讯作者）, Qin J Bacterial Communities in the Womb During Healthy Pregnancy Front Microbiol. 2018 9:2163
Bili Xia, Le Sun, Xia Fan,Haihan Xiao, Yongzhang Zhu, Jinhong Qin, Chengsong Cai, Wei Zhao,Yung-Fu Chang, Yan Zhang,Xiaokui Guo （通讯作者）, Ping He A new model of self-resolving leptospirosis in mice infected with a strain of L. interrogansserovarAutumnalis harboring LPS signaling only through TLR4 Emerging Microbes & Infections 2017 6(5):e36
Zeng L, Wang D, Hu N, Zhu Q, Chen K, Dong K, Zhang Y, Yao Y, Guo X （通讯作者）, Chang YF, Zhu Y A Novel Pan-Genome Reverse Vaccinology Approach Employing a Negative-Selection Strategy for Screening Surface-Exposed Antigens against leptospirosis Front Microbiol. 2017 8:396
Mingquan Guo, Chunyan Feng, Jie Ren, Xuran Zhuang, Yan Zhang, Yongzhang Zhu, Ke Dong, Ping He, Xiaokui Guo （通讯作者）, Jinhong Qin A Novel Antimicrobial Endolysin LysPA26 against Pseudomonas aeruginosa Front Microbiol. 2017 8:293
Zelin Cui; Tingting Feng; Feifei Gu; Qingtian Li; Ke Dong; Yan Zhang; YongzhangZhu; Lizhong Han; jinhong Qin; Xiaokui Guo Characterization and complete genome of the virulent Myoviridae phage JD007 active against a variety of Staphylococcus aureus isolates from different hospitals in Shanghai, China Virology Journal 2017 14:26
Yinghua Xu, Yongzhang Zhu,Yuezhu Wang, Yung-Fu Chang, Ying Zhang, Xiugao Jiang, Xuran Zhuang, Yongqiang Zhu, Jinlong Zhang, Lingbing Zeng, Minjun Yang, Shijun Li, Shengyue Wang, Qiang Ye, Xiaofang Xin, Guoping Zhao, Huajun Zheng, Xiaokui Guo （通讯作者）, Junzhi Wang Whole genome sequencing revealed virulence-relatedproteins expansion and host adaptation of pathogenic Leptospira Scitific Reports 2016 6:20020
Yao Wang, Xiali Ding, Yuan Chen, Mingquan Guo, Yan Zhang, Xiaokui Guo （通讯作者）, Hongchen Gua Antibiotic-loaded, silver core-embedded mesoporous silica nanovehicles as a synergistic antibacterial agent for the treatment of drug-resistant infections Biomaterials 2016 101:207-216
Zhu W, Wang J, Zhu Y, Tang B, Zhang Y, He P, Zhang Y, Liu B, Guo X （通讯作者）, Zhao G, Qin J Identification of three extra-chromosomal replicons in Leptospira pathogenic strain and development of new shuttle vectors BMC Genomics 2015 16:90
Yanzhuo Wang, Xuran Zhuang, Yi Zhong, Cuicai Zhang, Yan Zhang, Lingbing Zeng, Yongzhang Zhu, Ping He, Dong Ke, Utpal Pal, Xiaokui Guo （通讯作者）, Jinhong Qin Distribution of Plasmids in Distinct Leptospira Pathogenic Species PLoS Negl Trop Dis 2015 9(11):e**
Zhang C, Yang H, Li X, Cao Z, Zhou H, Zeng L, Xu J, Xu Y, Chang YF, Guo X （通讯作者）, Zhu YZ, Jiang X Molecular Typing of Pathogenic Leptospira Serogroup Icterohaemorrhagiae Strains Circulating in China during the Past 50 Years PLoS Negl Trop Dis 2015 9(5):e**
Wei YX, Ye L, Liu DB, Zhang ZY, Liu C, Guo XK （通讯作者） Activation of the chromosomally encoded mazEF(Bif) locus of Bifidobacterium longum under acid stress Int J Food Microbiol 2015 207:16-22
Zhao JW, Sun ZQ, Zhang XY, Zhang Y, Liu J, Ye J, Chen CC, Samten B, Wang HH, Guo XK （通讯作者）, Zhang SL Mycobacterial 3-hydroxyacyl-l-thioester dehydratase Y derived from Mycobacterium tuberculosis induces COX-2 expression in mouse macrophages through MAPK-NF-κB pathway Immunol Lett 2014 161(1):125-132
Ling-Bing Zeng, Xu-Ran Zhuang, Li-Li Huanga, Yun-Yi Zhang, Chun-Yan Che,Ke Dong, Yan Zhang, Ze-Lin Cui, Xia-Li Ding, Yung-Fu Chang, Xiao-Kui Guo （通讯作者）, Yong-Zhang Zhu Comparative subproteome analysis of three representative Leptospira interrogans vaccine strains reveals cross-reactive antigens and novel virulence determinants J Proteomics 2014 112C:27-37
Yuan L, Cui Z, Wang Y, Guo X （通讯作者）, Zhao Y Complete genome sequence of virulent bacteriophage SHOU24, which infects foodborne pathogenic Vibrio parahaemolyticus Arch Virol 2014 159(11):3089-3093
Jiyun Fan, Ying Wang, Hui Xiong, Xiaokui Guo and Yung-chi Cheng （通讯作者） Impact of the rtI187V polymerase substitution of hepatitis B virus on viral replication and antiviral drug susceptibility J Gen Virol 2014 95(Pt 11):2523-2530
Wei-Nan Zhu, Li-Li Huang, Ling-Bing Zeng, Xu-Ran Zhuang, Chun-Yan Chen, Yan-Zhuo Wang, Jin-Hong Qin, Yong-Zhang Zhu, Xiao-Kui Guo （通讯作者） Isolation and Characterization of Two Novel Plasmids from Pathogenic Leptospira interrogans Serogroup Canicola Serovar Canicola Strain Gui44 PLoS Negl Trop Dis 2014 8(8):e3103
Zhang ZY, Sun ZQ, Wang ZL, Hu HR, Wen ZL, Song YZ, Zhao JW, Wang HH, Guo XK （通讯作者）,Zhang SL Identification and pathogenicity analysis of a novel non-tuberculous mycobacterium clinical isolate with nine-antibiotic resistance Clin Microbiol Infect 2013 19:91-3
Yaoxia Kang, Enhou Jia, Liang Lin, Xiangyang Duan, Pei Xiao, Jingxian Peng, Wei Gao, Chaobao Zhang, Xiaokui Guo （通讯作者）, Buyun Cui, and Xiangqi Li Simultaneous emergence of several biotypes of Brucella among Baotou’s brucellosis patients by combined diagnostic strategy Acta Biochim Biophys Sin (Shanghai) 2013 45: 893–895
Zhang Y, Dong K, Zeng L, Li Q, Liu C, Wang J, Guo X （通讯作者）, Zhao GP .Genetic and molecular biological characterization of two homologous cheR genes from Leptospira interrogans Acta Biochim Biophys Sin (Shanghai) 2013 45(10):806-816
Zelin Cui, Yuhua Zhou, Hong Li, Yan Zhang, Shenjie Tang, Xiaokui Guo （通讯作者） Complex sputum microbial composition in patients with pulmonary tuberculosis BMC microbiology 2012 12:276
Zelin Cui, Zhen Song, Yanchun Wang, LingbingZeng, WenbinShen, Zheng Wang, Qingtian Li, Ping He, Jinhong Qin, and Xiao-Kui Guo （通讯作者） Complete Genome Sequence of wide host-range Staphylococcus aureus phage JD007 Journal of Virology 2012 86(24):13880
Zhou Y, Tao J, Yu H, Ni JJ, Zeng LB, Teng QH, Kim K, Zhao GP, Guo XK （通讯作者）, and Yao YF Hcp-family proteins secreted via type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cells Infection and Immunity 2012 80(3):1243-51
Zhang ZY, Liu C, Zhu YZ, Wei YX, Tian F, Zhao GP, Guo XK （通讯作者） Safety assessment of Lactobacillus plantarumJDM1 based on the complete genome Int J Food Microbiol 2012 153(1-2):166-70
Zelin Cui, WenbinShen, Zheng Wang, Haotian Zhang, Rao Me, Yanchun Wang, LingbingZeng, Yongzhang Zhu, Jinhong Qin, Ping He, and Xiao-Kui Guo （通讯作者） Complete Genome Sequence of Klebsiellapneumoniae phage JD001 Journal of Virology 2012 86(24):13843
Wei YX, Zhang ZY, Liu C, Malakar PK, Guo XK （通讯作者） Safety assessment of Bifidobacterium longum JDM301 based on complete genome sequences World J Gastroenterol 2012 18(5):479-88
Zhong Y, Chang X, Cao XJ, Zhang Y, Zheng H, Zhu Y, Cai C, Cui Z, Zhang Y, Li YY, Jiang XG, Zhao GP, Wang S, Li Y, Zeng R, Li X, Guo XK （通讯作者） Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601 Cell Research 2011 21(8):1210-1229
Zhang ZY, Sun ZQ, Wang ZL, Wen ZL, Sun QW, Zhu ZQ, Song YZ, Zhao JW, Wang HH, Zhang SL, Guo XK （通讯作者） Complete genome of a novel clinical isolated non-tuberculous mycobacterium strain JDM601.. 2011, 193 (16): 4300-1 J Bacteriol 2011 193 (16):4300-4301
Zhang SM, Tian F, Huang QF, Zhao YF, Guo XK （通讯作者）, Zhang FQ Bacterial diversity of subgingival plaque in 6 healthy Chinese individuals Exp Ther Med 2011 2(5):1023-1029
Li QT, Zhou YH, Dong K, Guo XK. （通讯作者） Potential therapeutic efficacy of a bactericidal-immunomodulatory fusion peptide against methicillin-resistant Staphylococcus aureus skin infection. Appl Microbiol Biotechnol. 2010 86(1):305-9
Yan-Xia Wei, Zhuo-Yang Zhang, Chang Liu,Yong-Zhang Zhu, Yong-Qiang Zhu, Hua-Jun Zheng, Guo-Ping Zhao, Sheng-Yue Wang, and Xiao-Kui Guo （通讯作者） Complete Genome Sequence of Bifidobacterium longum JDM301. J. Bacteriol 2010 192(15):4076-4077
Liu C, Zhang ZY, Dong K, Guo XK （通讯作者） Adhesion and immunomodulatory properties of Bifidobacterium lactis HN019 to intestinal epithelial cells INT-407. World Journal of Gastroenterology 2010 16 (18):2283-2290
Dong K, Li QT, Liu C, Zhang YY, Zhao GP, Guo XK. （通讯作者） Cloning and characterization of three cheB genes in Leptospira interrogans Acta Biochim Biophys Sin (Shanghai) 2010 42 (3):216-223
Yuhua Zhou, Qingtian Li, Lizhong Han, Ping Lin, Huajun Zheng, Yanxia Wei, Zelin Cui, Yuxing Ni, Xiaokui Guo （通讯作者） The microbiota analyses of sputum from the patients of lower respiratory tract infection using 16S rDNA pyro-sequencing. 42 :754-761 Acta Biochim Biophys Sin 2010 42:754-761
Zhu YZ, Cai CS, Zhang W, Guo HX, Zhang JP, Ma GY, Ji YY, Wu JL, Li QT, Lu CP, Guo XK （通讯作者） Immunoproteomic Analysis of Human Serological Antibody Responses to Vaccination with Whole-Cell Pertussis Vaccine (WCV) PLoS ONE 2010 5(11):13915-13915
Cai CS, Zhu YZ, Zhong Y, Xin XF, Jiang XG, Lou XL, He P, Qin JH, Zhao GP, Wang SY, Guo XK （通讯作者） Development of O-antigen gene cluster-specific PCRs for rapid typing six epidemic serogroups of Leptospira in China. BMC microbiology 2010 10(67):1230-1236
Yuan JP, Li P, Tao J, Shi XD, Hu BY, Chen HB, Guo XK （通讯作者） H.pylori Escape Host Immunoreaction Through Inhibiting ILK Expression By VacA. Cellular & Molecular Immunology 2009 6(3):91-97
Zhao W, Chen CY, Zhang XY, Lai WQ, Hu BY, Zhao GP, Qin JH, Guo XK （通讯作者） Molecular characterization of the pL40 protein in Leptospira interrogans Can. J. Microbiol 2009 55 (6):739-749
Zhang SM, Tian F, Jiang XQ, Li J, Xu C,Guo XK （通讯作者）, Zhang FQ. Evidence for calcifying nanoparticles in gingival crevicular fluid and dental calculus in periodontitis. Journal of Periodontology 2009 80 (9):1462-1470
Tian F, Yu Y, Chen B, Li HR, Yao YF, Guo XK （通讯作者） Bacterial, archaeal and eukaryotic diversity in Arctic sediment as revealed by 16S rRNA and 18S rRNA gene clone libraries analysis. Polar Biology 2009 32 (1):93-103
Zhang ZY, Liu C, Zhu YZ, Zhong Y, Zhu YQ, Zheng HJ, Zhao GP, Wang SY, Guo XK （通讯作者） Complete genome sequence of Lactobacillus plantarum JDM1. J. Bacteriol. 2009 191(15):5020-5021
Liu C, Zhang ZY, Dong K, Yuan JP,Guo XK （通讯作者） Antibiotic resistance of probiotic strains of lactic acid bacteria isolated from marketing food and drugs. Biomedical and Enviromental Science 2009 22(5):401-412
Feng CY, Li QT, Zhang XY, Dong K, Hu BY, Guo XK （通讯作者） Immune strategies on single component LipL32 and multi-components recombinant LipL32-41-OmpL1 vaccines against Leptospira. Brazilian Journal of Medical and Biological Research 2009 42(9):796-803
He P, Sheng YY, Shi YZ, Jiang XG, Qin JH, Zhang ZM, Zhang GP, Guo XK （通讯作者） Genetic diversity among major endemic strains of Leptospira interrogans in China BMC Genomics 2008 8(14):204-7
Qin JH, Zhang Q, Zhang ZM, Zhong Y, Yang Y, Hu BY, Zhao GP, Guo XK （通讯作者） Identification of a novel prophage-like gene cluster actively expressed in both virulent and avirulent strains of Leptospira interrogans serovar lai. Infect Immun 2008 76(6):2411-9
Zhu YZ, Li QT, Wang L, Zhong Y, Ding GH, Li G, Jia PL, Shi TL, Guo XK （通讯作者） Gene Expression Profiling-Based In Silico Approach to Identify Potential Vaccine Candidates and Drug Targets against B. pertussis and B. parapertussis. OMICS 2008 12 (3):161-169
Guo XK （共同第一作者）, Zhao WQ, Kondo C, Shimojo N, Yamashita K, Aoki T, Hayakawa T Tissue inhibitors of metalloproteinases-1 (TIMP-1) and-2(TIMP-2) are major serum factors that stimulate the TIMP-1 gene in human gingival fibroblasts. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2007 1763(3):296-304
Li ZH, Dong K, Yuan JP, Hu BY, Liu JX, Zhao GP, Guo XK （通讯作者） Characterization of the cheY genes from Leptospira interrogans and their effects on the behavior of Escherichia coli. Biochem Biophys Res Commun 2006 345(2):858-866
Li QT, Zhu YZ, Chu JY, Wang YY, Xu YH, Hou QM, Zhang SM, Guo XK （通讯作者） Protective immunity against Bordetella pertussis by a recombinant DNA vaccine and the effect of coinjection with a granulocyte-macrophage colony stimulating factor gene. Microbiol Immunol 2006 50(12):929-36.
Sun JC, Xu JL, Cao JP, Liu Q, Guo XK （通讯作者）, Shi TL Prediction and systematic study of protein-protein interaction networks of Leptospira interrogans. Chinese science Bulletin 2006 51(1):1-10
Li QT, Zhu YZ, Chu JY, Dong K, He P, Feng CY, Hu BY, Zhang SM, Guo XK （通讯作者） Granulocyte-macrophage Colony-stimulating Factor DNA Prime-protein Boost Strategy to Enhance the Efficacy of a Recombinant Pertussis DNA Vaccine Acta Pharmacologica Sinica 2006 27 (11):1487-1494
Li ZH, Dong K, Sun JC, Yuan JP, Hu BY, Liu JX, Zhao GP, Guo XK （通讯作者） Characterization of cheW Genes of Leptospira interrogans and Their Effects in Escherichia coli. Acta Biochim Biophys Sin 2006 38(2):79-88
Yang HL, Jiang XC, Zhang XY, Li WJ, Hu BY, Zhao GP, Guo XK （通讯作者） Thrombocytopenia in the experimental leptospirosis of guinea pig is not related to disseminated intravascular coagulation. BMC Infect Dis 2006 6(1):19-25
Yang HL, Zhu YZ, Qin JH, He P, Jiang XC, Zhao GP, Guo XK （通讯作者） In silico and microarray-based genomic approaches to identifying potential vaccine candidates against Leptospira interrogans. BMC Genomics 2006 16(7):239-240
Qin JH, Sheng YY, Zhang ZM, Shi XZ, He P, Hu BY, Yang Y, Liu SG, Zhao GP, Guo XK （通讯作者） Genome-wide transcriptional analysis of temperature shift in L. interrogans serovar lai strain 56601 BMC Microbiology 2006 6(51):1-10