导师姓名： 张新宇 专业代码： 100400
性别： 男 专业名称： 公共卫生与预防医学
培养单位： 公共卫生学院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式： 邮箱：xyzhang999@shsmu.edu.cn，xyzhang999@sjtu.edu.cn
邮编： 200336 邮箱地址： xyzhang999@shsmu.edu.cn

研究方向 (点击浏览详细信息)
外源性和内源性化合物的代谢、遗传毒性、DNA加合物、生物标志以及毒性和致癌性的分子机理

社会任职
Toxicology and Applied Pharmacology杂志编委
美国化学会会员（2001-2015）
中国毒理学会终身会员
中国药理学会药物代谢专业委员会委员
中国环境科学学会高级会员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 丁二烯髓过氧化酶代谢产物、产物毒性和生物标志研究 国家自然科学基金 2020-01~2023-12 66万元 课题负责人
** 马兜铃酸物质基础与致癌毒性研究 国家自然科学基金 2019-01~2022-12 55万元 课题参与人
** 抗抑郁类精神药物在典型城市水体中的污染特性及其生态风险分析 国家自然科学基金 2015-01~2019-12 360万元 课题参与人
** 两种新型丁二烯代谢产物毒性、尿中生物标志物以及在暴露人体中的存在研究 国家自然科学基金 2014-01~2017-12 82万元 课题负责人
** 丁二烯代谢产物1-氯-3-丁烯-2-醇和1-氯-3-丁烯-2-酮与DNA碱基反应的研究 国家自然科学基金 2011-01~2013-12 35万元 课题负责人
** 长三角地区典型内分泌干扰物环境暴露水平与生态风险 国家自然科学基金 2009-01~2012-12 110万元 课题参与人

学术论文 作者论文标题期刊名出版年卷期页码
Hao Xu, Chao Feng, Yiyi Cao, Ying Lu, Jing Xi, Jieyun Ji, Dasheng Lu*, Xin-Yu Zhang* （通讯作者）, Yang Luan Distribution of the parent compound and its metabolites in serum, urine, and feces of mice administered 2,2‘,4,4’-tetrabromodiphenyl ether Chemosphere 2019 225, 217-225
Wen-Jing Wu, Wei-Feng Tang, Ming-Hui Xiang*, Jianshe Yan, Xiumei Cao, Chang-Hui Zhou, Yan Chang, Jing Xi, Yi-Yi Cao, Yang Luan, Xin-Yu Zhang* （通讯作者） Isotope dilution LC/ESI--MS-MS quantitation of urinary 1,4-bis(N-acetyl-S-cysteinyl)-2-butanone in mice and rats as the biomarker of 1-chloro-2-hydroxy-3-butene, an in vitro metabolite of 1,3-butadiene Chemico-Biological Interactions 2019 311, 108760
Ye Wang, Ying-Xin Yu, Yang Luan, Jing An, Dong-Guang Yin, Xin-Yu Zhang* （通讯作者） Bioactivation of 1-chloro-2-hydroxy-3-butene, an in vitro metabolite of 1,3-butadiene, by rat liver microsomes Chemico-Biological Interactions 2018 282, 36-44
Xin-Yu Zhang, Adnan A Elfarra* Toxicity mechanism-based prodrugs: glutathione-dependent bioactivation as a strategy for anticancer prodrug design Expert Opinion on Drug Discovery 2018 13, 815-824
Xin-Yu Zhang* （通讯作者）, Adnan A Elfarra* Myeloperoxidase-mediated bioactivation of olefins Advances in Molecular Toxicology 2018 12, 123-150
Xin-Yu Zhang* （通讯作者）, Adnan A. Elfarra* Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties Expert Opinion on Drug Metabolism & Toxicology 2017 13, 513-524
Ling-Yan Liu, Jin Zheng, Cong Kong, Jing An, Ying-Xin Yu, Xin-Yu Zhang* （通讯作者）, Adnan A. Elfarra* Characterization of the major purine and pyrimidine adducts formed after incubations of 1-chloro-3-buten-2-one with single-/double-stranded DNA and human cells Chemical Research in Toxicology 2017 30, 552-563
Fang-Mao Zeng, Ling-Yan Liu, Jin Zheng, Cong Kong, Jing An, Ying-Xin Yu, Xin-Yu Zhang* （通讯作者）, Adnan A. Elfarra* Identification of a fused-ring 2?-deoxyadenosine adduct formed in human cells incubated with 1-chloro-3-buten-2-one, a potential reactive metabolite of 1,3-butadiene Chemical Research in Toxicology 2016 29, 1041-1050
Jin Zheng, Yan Li, Ying-Xin Yu, Jing An, Xin-Yu Zhang* （通讯作者）, Adnan A. Elfarra* Novel adducts from the reaction of 1-chloro-3-buten-2-one with 2?-deoxyguanosine. Structural characterization and potential as tools to investigate 1,3-butadiene carcinogenicity Chemico-Biological Interactions 2015 226, 40-48
Yan Li, Avishay Pelah, Jing An, Ying-Xin Yu, Xin-Yu Zhang* （通讯作者） Concentration- and time-dependent genotoxicity profiles of isoprene monoepoxides and diepoxide, and the cross-linking potential of isoprene diepoxide in cells Toxicology Reports 2014 1, 36-45
Ying Wen, Keyin Liu, Huiran Yang, Yi Li, Haichuang Lan, Xinyu Zhang* （通讯作者）, Tao Yi* A highly sensitive ratiometric fluorescent probe for the detection of cytoplasmic and nuclear hydrogen peroxide Analytical Chemistry 2014 86, 9970-9976
Xin-Jie Liu, Fang-Mao Zeng, Jing An, Ying-Xin Yu, Xin-Yu Zhang* （通讯作者）, Adnan A. Elfarra* Cytotoxicity, genotoxicity, and mutagenicity of 1-chloro-2-hydroxy-3-butene and 1-chloro-3-buten-2-one, two alternative metabolites of 1,3-butadiene Toxicology and Applied Pharmacology 2013 271, 13-19
Liang Sun, Avishay Pelah, Dong-Ping Zhang, Yu-Fang Zhong, Jing An, Ying-Xin Yu, Xin-Yu Zhang* （通讯作者）, Adnan A. Elfarra* Formation of fused-ring 2'-deoxycytidine adducts from 1-chloro-3-buten-2-one, an in vitro 1,3-butadiene metabolite, under in vitro physiological conditions Chemical Research in Toxicology 2013 26, 1545-1553
Pan-Pan Zhang, Ying Wen, Jing An, Ying-Xin Yu*, Ming-Hong Wu, Xin-Yu Zhang* （通讯作者） DNA damage induced by three major metabolites of 1,3-butadiene in human hepatocyte L02 cells Mutation Research 2012 747, 240-245
Ying-Xin Yu, Yu-Ping Pang, Chen Li, Jun-Ling Li, Xin-Yu Zhang* （通讯作者）, Zhi-Qiang Yu, Jia-Liang Feng, Ming-Hong Wu, Guo-Ying Sheng, Jia-Mo Fu Concentrations and seasonal variations of polybrominated diphenyl ethers (PBDEs) in in- and out-house dust and human daily intake via dust ingestion corrected with bioaccessibility of PBDEs Environment International 2012 42, 124-131
Ying Wen, Pan-Pan Zhang, Jing An, Ying-Xin Yu, Ming-Hong Wu, Guo-Ying Sheng, Jia-Mo Fu, Xin-Yu Zhang* （通讯作者） Diepoxybutane induces the formation of DNA-DNA rather than DNA-protein cross-links, and single-strand breaks and alkali-labile sites in human hepatocyte L02 cells Mutation Research 2011 716, 84-91