导师姓名： 沈伟利 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 心血管病
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 邮箱地址： weili_shen@hotmail.com

研究方向 (点击浏览详细信息)
基于线粒体为靶点的高血压病的预防和治疗

社会任职
中国高血压联盟第五届理事会理事
上海市药理学会学术委员会委员
中国线粒体研究会学术委员会委员
上海市生物物理学会第九届理事会理事

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** SIRT3介导心脏成纤维细胞代谢重塑在高血压心脏重构中的作用研究 国家自然科学基金面上项目 2020-01~2023-12 55万元 课题负责人
19ZR** 肌肉因子CTRP15在运动干预高血压血管内皮损伤中的作用及其机制 上海市科学技术委员会 2019-07~2022-06 20万元 课题负责人
** 线粒体介导的NLRP3炎症小体活化在高血压血管外膜重塑中的作用 国家自然科学基金重大研究计划培育项目 2015-01~2017-12 80万元 课题负责人
** SIRT3在高血压血管内皮损伤与修复中的作用及机制研究 国家自然科学基金面上项目 2014-01~2017-12 70万元 课题负责人
2012AA02A516 高血压分子分型和个体化诊疗技术 863 2012-01~2015-12 470万元 课题参与人
** Frataxin在铁和酒精诱导肝损伤中的作用及机制 国家自然科学基金面上项目 2011-01~2013-12 35万元 课题负责人
10DZ** Rg3抗缺氧及神经疲劳的机制暨高效运动营养补剂研究 上海市科委中药现代化专项 2010-11~2013-12 150万元 课题参与人
** 脂肪因子Chemerin在骨骼肌胰岛素抵抗发生中的作用及其机制 国家自然科学基金面上项目 2008-01~2011-12 31万元 课题负责人
运动性疲劳的线粒体损伤与修复机制 上海市科委生物医药科技攻关重点项目 2007-09~2010-09 70万元 课题参与人

学术论文 作者论文标题期刊名出版年卷期页码
Gao J#, Xie Q#, Wei T, Huang C, Zhou W, Shen W （通讯作者） Nebivolol improves obesity-induced vascular remodelling by suppressing NLRP3 activation. J Cardiovasc Pharmacol. 2019 14. doi: 10.1097/FJC.0667.
Wei T#, Huang G#, Liu P#, Gao J, Huang C, Sun M, Shen W. （通讯作者） Sirtuin 3-mediated pyruvate dehydrogenase activity determines brown adipocytes phenotype under high-salt conditions. Cell Death & Disease 2019 10:614
Liu P, Huang G, Wei T, Gao J, Huang C, Sun M, Zhu L, Shen W. （通讯作者） Sirtuin 3-induced macrophage autophagy in regulating NLRP3 inflammasome activation. Biochim Biophys Acta 2018 1864:764-777.
Gao J, Feng Z, Wang X, Zeng M, Liu J, Han S, Xu J, Chen L, Cao K, Long J, Li Z, Shen W （通讯作者）, Liu J*. SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress. Cell Death Differ. 2018 25:229-240.
Liu P, Huang G, Cao Z, Xie Q, Wei T, Huang C, Li Q, Sun M, Shen W （通讯作者）, Gao P Haematopoietic TLR4 deletion attenuates perivascular brown adipose tissue inflammation in atherosclerotic mice. Biochim Biophys Acta 2017 1862:946-957
Wei T, Huang G, Gao J, Huang C, Sun M, Wu J, Bu J, Shen W （通讯作者） SIRT3 deficiency accelerates hypertensive cardiac remodeling by impairing angiogenesis J Am Heart Assoc 2017 6:e006114.
Xie Q, Wei T, Huang C, Liu P, Sun M, Shen W （通讯作者）, Gao P Nebivolol Ameliorates Cardiac NLRP3 Inflammasome Activation in a Juvenile-Adolescent Animal Model of Diet-Induced Obesity Sci Rep 2016 6:34326.
Chen X, An X, Chen D, Ye M, Shen W, Han W, Zhang Y, Gao P Chronic Exercise Training Improved Aortic Endothelial and Mitochondrial Function via an AMPKα2-Dependent Manner. Front Physiol 2016 21;7: 631
Li W, Jin D, Hata M, Takai S, Yamanishi K, Shen W, El-Darawish Y, Yamanishi H, Okamura H. Dysfunction of mitochondria and deformed gap junctions in the heart of IL-18-deficient mice Am J Physiol Heart Circ Physiol 2016 311:H313-325
Liu P, Xie Q, Wei T, Chen Y, Chen H, Shen W. （通讯作者） Activation of the NLRP3 inflammasome induces vascular dysfunction in obese OLETF rats Biochem Biophys Res Commun 2015 468:319-325
Lin JR, Shen WL, Yan C, Gao PJ. Downregulation of dynamin-related protein 1 contributes to impaired autophagic flux and angiogenic function in senescent endothelial cells. Arterioscler Thromb Vasc Biol. 2015 35:1413-1422.
Xie Q, Deng Y, Huang C, Liu P, Yang Y, Shen W （通讯作者）, Gao P. Chemerin-induced mitochondrial dysfunction in skeletal muscle. J Cell Mol Med 2015 19:986-995.
Deng Y, Xu J, Zhang X, Yang J, Zhang D, Huang J, Lv P, Shen W# （通讯作者）, Yang Y#. Berberine attenuates autophagy in adipocytes by targeting BECN1. Autophagy. 2014 10(10):1776-1786.
Liu J, Tang Y, Feng Z, Hou C, Wang H, Yan J, Liu J, Shen W, Zang W, Liu J, Long J. Acetylated FoxO1 mediates high-glucose induced autophagy in H9c2 cardiomyoblasts: regulation by a polyphenol -(-)-epigallocatechin-3-gallate. Metabolism 2014 63(10):1314-1323.
Huang C, Chen D, Xie Q, Yang Y#, Shen W#. （通讯作者） Nebivolol stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2013 438(1):211-217
Shen W （通讯作者）, Tian C, Chen H, Yang Y, Zhu D, Gao P, Liu J Oxidative stress mediates chemerin-induced autophagy in endothelial cells Free Radic Biol Med 2013 55(2):73-82
Sun M, Shen W （通讯作者）, Zhong M, Wu P, Chen H, Lu A Nandrolone attenuates aortic adaptation to exercise in rats Cardiovasc Res 2013 97(4):686-695
Sun M, Qian F, Shen W, Tian C, Hao J, Sun L, Liu J Mitochondrial nutrients stimulate Performance and mitochondrial biogenesis in exhaustively exercised rats Scandinavian Journal of Medicine & Science in Sports 2012 22(6):764-775.
Yan J, Feng Z, Liu Jia, Shen W, Wang Y, Wertz K, Weber P, Long J and Liu J Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto-Kakizaki (GK) rats: Ameliorating effects of (–)-epigallocatechin-3-gallate J Nutr Biochem 2012 23(7):716-724
Feng Z, Bai L, Yan J, Li Y, Shen W, Wang Y, Wertz K, Weber P, Zhang Y, Chen Y, Liu J Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction: Regulatory effects of hydroxytyrosol Free Radic Biol Med 2011 50(10):1437-1446.
Shen W, Hao J, Feng Z, Tian C, Chen W, Packer L, Shi X, Zang W, Liu J Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway Br J Pharmacol 2011 162(5):1213-1224
Zhong M, Shen W （共同第一作者）, Wang J, Yang J, He J, Yuan W, Higashino H, Chen H Paradoxical effects of streptozocin-induced diabetes on endothelium dysfunction in stroke-prone spontaneously hypertensive rats J physiol 2011 589(Pt 21):5153-5165
Hao J, Shen W （共同第一作者）, Sun L, Long J, Sharman E, Shi X, Liu J Mitochondrial dysfunction in the liver of the type 2 diabetic Goto–Kakizaki rats: Improvement by a combination of nutrients Brit J Nutr 2011 106(5):648-655
Zheng L, Xu CC, Chen WD, Shen WL, Ruan CC, Zhu LM, Zhu DL, and Gao PJ MicroRNA-155 regulates angiotensin II type 1 receptor expression and phenotypic differentiation in vascular adventitial fibroblasts Biochem Biophys Res Commun 2010 4009(4):483-488.
Jia H, Liu Z, Li X, Feng Z, Hao J, Li X, Shen W, Zhang H, Liu J Anti-Parkinsonism activity of high doses of B vitamins in a chronic cellular model and an α-synuclein transgenic Drosophila model Neuorbiol Aging 2010 31(4):636-646.
Zhu L, Liu Z, Feng Z, Hao J, Shen W, Li X, Sun L, Sharman E, Wang Y, Wertz K, Beber P, Shi X, Liu J Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells J Nutr Biochem 2010 21(11):1089-98.
Zhang H, Jia H, Liu J, Ao N, Yan B, Shen W, Wang X, Li X, Luo C, Liu J Combination of R-?Lipoic acid and acetyl-L-carnitine prevents mitochondrial dysfunction and oxidative damage in a rotenone-treated human neuroblastoma cellular model of Parkinson’s disease J Cell Mol Med 2010 14(1-2):215-225.
Hao J, Shen W, Yu G, Jia H, Li X, Feng Z, Wang Y, Weber P, Wertz K, Sharman E, Liu J Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes J Nutr Biochem 2009 21(7):634-644.
Sun L, Shen W, Liu Z, Guan S, Liu J, Ding S Endurance exercise causes mitochondrial and oxidative stress in rat liver: Effects of a combination of mitochondrial targeting nutrients Life Sci 2009 86(1-2):39-44.
Liu J, Shen W, Zhao B, Wang Y, Wertz K, Weber P, Zhang P Targeting mitochondrial biogenesis for preventing and treating insulin resistance in diabetes and obesity: Hope from natural mitochondrial nutrients Adv Drug Deliv Rev 2009 61(14):1343-1352.
Hao J, Shen W, Tian C, Liu Z, Ren J, Luo C, Long J, Sharman E, Liu J Mechanisms and improvement of immune dysfunction in the type 2 diabetic Goto–Kakizaki rats J Cell Mol Med 2009 13(4):701-711.
Shen W, Hao J, Tian C, Ren J, Yang L, Li X, Luo C, Cotma CW, Liu J A combination of mitochondrial nutriments improves mitochondrial biogenesis and function in skeletal muscle of type 2 diabetic Goto–Kakizaki rats PLoSONE 2008 3(6):e2328.
Che Z, Gao PJ, Shen WL, Fan CL, Liu JJ, Zhu DL Angiotensin II- stimulated collagen synthesis in aortic adventitial fibroblasts is mediated by connective tissue growth factor Hypertens Res 2008 31(6):1233-1240
Shen WL, Zhong MF, Ding W, Wang J, Zheng L, Zhu P, Wang B, Higashino H, Chen H Enhanced endogenous antioxidants may contribute to improved post-ischaemic cardiac function in rats surviving long-term hyperglycaemia Clin Exp Pharmacol Physiol 2008 35(7):820-826
Li X, Liu Z, Luo C, Jia H, Sun L, Hou B, Shen W, Packer L, Cotman CW, Liu J Lipoamide protects RPE cells from oxidative stress and mitochondrial dysfunction Free Radic Biol Med 2008 44(7):1465-1474.
Zhang J, Fang NY, Gao PJ, Wu LY, Han WQ, Guo SJ, Shen WL （通讯作者）, Zhu DL Peroxisome proliferator-activated receptor-gamma agonists attenuate angiotensin II-induced collagen type I expression in adventitial fibroblasts Clin Exp Pharmacol Physiol 2008 35(1):72-77
Shen W, Liu K, Tian C, Yang L, Li X, Ren J, Packer L, Head E, Sharman E, Liu J Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid J Cell Biochem 2008 104(4):1232-1243.
Shen W, Liu K, Tian C, Yang L, Li X, Ren J, Packer L, Cotman CW, Liu J R-alpha-Lipoic acid and acetyl-L: -carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes Diabetologia 2008 51(1):165-174.
Li L, Zhu DL, Shen WL, Gao PJHigashino H Increased migration of vascular adventitial fibroblasts from spontaneously hypertensive rats Hypertens Res 2006 29(2):95-103
Chen H, Shen WL （共同第一作者）, Wang XH, Chen HZ, Gu JZ, Fu J, Ni YF, Gao PJ, Zhu DL, Higashino H Enhanced endogenous antioxidants may contribute to improved post-ischaemic cardiac function in rats surviving long-term hyperglycaemia Clin Exp Pharmacol Physiol 2006 33(10):910-6
Shen WL, Gao PJ, Che ZQ, Ji KD, Yin M, Yan C, Berk BC, Zhu DL NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation Biochem Biophys Res Commun 2006 339(1):337-343
Viedt C, Shen W, Fei J, Kamimura M, Hansch GM, Katus HA, Kreuzer J HMG-CoA reductase inhibition reduces the proinflammatory activation of human vascular smooth muscle cells by the terminal complement factor C5b-9 Basic Res Cardiol 2003 98(6):353-361
Gao PJ, Li Y, Sun AJ, Liu JJ, Ji KD, Zhang YZ, Shen WL, Marche P, Zhu DL Differentiation of vascular myofibroblasts induced by transforming growth factor-beta1 requires the involvement of protein kinase Calpha J Mol Cell Cardiol 2003 35(9):1105-1112
Zhang Y, Shen WL Bcl-2 antisense oligodeoxynucleotide increases the sensitivity of leukemic cells to arsenic trioxide Cell Biol Int 2003 27(12):953-958
Viedt C, Vogel J, Athanasiou T, Shen W, Orth SR, Kubler W, Kreuzer J Monocyte chemoattractant protein-1 induces proliferation and interleukin-6 production in human smooth muscle cells by differential activation of nuclear factor-kappaB and activator protein-1 Arterioscler Thromb Vasc Biol 2002 22(6):914-920