导师姓名： 陆林 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 心血管病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海市瑞金二路197号瑞金医院心内科
邮编： 200025 邮箱地址： rjlulin1965@163.com

研究方向 (点击浏览详细信息)
糖尿病心血管病变、冠心病

社会任职
第八届中华医学会动脉粥样硬化组委员
中华医师协会转化型医院委员会理事
中国医师协会心血管分会代谢组组员
中华医学英文版编委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 脂肪因子CTRP5促动脉粥样硬化发生和机制研究 国家自然科学基金，面上项目 2018-01~2021-12 55万元 课题负责人
** Chromogranin A的关键降解肽段抗动脉粥样硬化机制研究 国家自然科学基金委员会,重大专项 2016-01~2018-12 80万元 课题负责人
2015CB553600 中国人代谢综合征的分子营养机制及干预研究 科技部973 2015-01~2019-12 125万元 课题参与人
** 脂肪因子CTRP1 致动脉粥样硬化及机制研究 国家自然基金，面上项目 2014-01~2017-12 70万元 课题负责人
建立小鼠动脉不稳定型斑块荧光示踪模型和HMGB2促糖尿病不稳定型斑块形成研究 上海市科委 2011-06~2014-06 20万元 课题负责人
** 14-3-3蛋白磷酸化修饰RhoGEF和RhoGAP对糖尿病支架术后再狭窄发生的作用研究 国家自然基金，面上项目 2011-01~2013-12 35万元 课题负责人
09JC** 14-3-3蛋白与糖尿病猪冠状动脉雷帕霉素支架术后再狭窄关系的研究 上海市科委"创新行动计划"基础研究重点项目 2009-09~2011-08 30万元 课题负责人
** Rho促RKIP磷酸化在糖尿病猪冠状动脉雷帕霉素支架术后再狭窄发生中的作用和机制研究 国家自然基金委,面上项目 2009-01~2011-12 33万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Gong DH, Dai Y, Chen S, Wang XQ, Yan XX, Shen Y, Liu J, Yang ZK, Hu J, Yu LJ, Liu LL, Zhang RY, Shen WF, Chen QJ, Ding FH, Lu L. （通讯作者） Secretory vimentin is associated with coronary artery disease in patients and induces atherogenesis in apoE-/- mice. Int J Cardiol 2019 283:9-16
Li C, Chen JW, Liu ZH, Shen Y, Ding FH, Gu G, Liu J, Qiu JP, Gao J, Zhang RY, Shen WF, Wang XQ, Lu L （通讯作者） CTRP5 promotes transcytosis and oxydative modification of low-density lipoprotein and the development of atherosclerosis Atherosclerosis 2018 278;197-209
Liu ZH, Li C, Chen JW, Shen Y, Gao J, Shen WF, Zhang RY, Wang XQ, Lu L （通讯作者） C1q/TNF-related protein 1 promotes endothelial barrier dysfunction under disturbed flow. Biochem Biophys Res Commun 2017 490:580-586
Dai Y, Shen Y, Li QR, Ding FH, Wang XQ, Liu HJ, Yan XX, Wang LJ, Yang K, Wang HB, Chen QJ, Shen WF, Zhang RY, Lu L. （通讯作者） Glycated Apolipoprotein A-IV Induces Atherogenesis in Patients With CAD in Type 2 Diabetes. J Am Coll Cardiol 2017 70:2006-2019
Xiong W, Wang X, Dai D, Zhang B, Lu L （通讯作者）, Tao R The anti-inflammatory vasostatin-2 attenuates atherosclerosis in ApoE-/- mice and inhibits monocyte/macrophage recruitment Thromb Haemost 2017 117:401-414
Yan X, Zhang H, Fan Q, Hu J, Tao R, Chen Q, Iwakura Y, Shen W, Lu L （通讯作者）, Zhang Q, Zhang R. Dectin-2 Deficiency Modulates Th1 Differentiation and Improves Wound Healing After Myocardial Infarction. Circ Res 2017 120:1116-1129
Wang F, Li C, Ding FH, Shen Y, Gao J, Liu ZH, Chen JW, Zhang RY, Shen WF, Wang XQ, Lu L （通讯作者） Increased serum TREM-1 level is associated with in-stent restenosis, and activation of TREM-1 promotes inflammation, proliferation and migration in vascular smooth muscle cells. Atherosclerosis 2017 267:10-18
Liu ZH, Dai DP, Ding FH, Pan WQ, Fang YH, Zhang Q, Li M, Yang P, Wang XQ, Shen Y, Wang LJ, Yan XX, He YH, Yang K, Zhang RY, Shen WF, Chen Y, Lu L. （通讯作者） ASSOCIATION OF SERUM HMGB2 LEVEL WITH MACE AT 1 MONTH OF MYOCARDIAL INFARCTION: AGGRAVATION OF MYOCARDIAL ISCHEMIC INJURY IN RAT BY HMGB2 VIA ROS. Am J Physiol Heart Circ Physiol 2017 312:H422-H436
He YH, Wang XQ, Zhang J, Liu ZH, Pan WQ, Shen Y, Zhu ZB, Wang LJ, Yan XX, Yang K, Zhang RY, Shen WF, Ding FH, Lu L. （通讯作者） Association of Serum HMGB2 Levels With In-Stent Restenosis: HMGB2 Promotes Neointimal Hyperplasia in Mice With Femoral Artery Injury and Proliferation and Migration of VSMCs. Arterioscler Thromb Vasc Biol 2017 37:717-729
Shen Y, Li C, Zhang RY, Zhang Q, Shen WF, Ding FH, Lu L. （通讯作者） Association of increased serum CTRP5 levels with in-stent restenosis after coronary drug-eluting stent implantation: CTRP5 promoting inflammation, migration and proliferation in vascular smooth muscle cells. Int J Cardiol 2016 228:129-136
Pan WQ, He YH, Su Q, Yang J, Fang YH, Ding FH, Yan XX, Liu ZH, Wang XQ, Yang K, Zhang RY, Shen WF, Zhang FR, Lu L （通讯作者） Association of decreased serum vasostatin-2 level with ischemic chronic heart failure and with MACE in 3-year follow-up: vasostatin-2 prevents heart failure in myocardial infarction rats Int J Cardiol 2016 221:1-11
Chen K, Chen QJ, Wang LJ, Liu ZH, Zhang Q, Yang K, Wang HB, Yan XX, Zhu ZB, Du R, Zhang RY, Shen WF, Lu L （通讯作者） Increment of HFABP level in coronary artery in-stent restenosis segements in diabetic and nondiabetic minipigs: HFABP overexpression promotes multiple pathway-related inflammation, growth and migration in human vascular smooth muscle cells. J Vasc Res 2016 53:27-38
Lu L （共同第一作者）, Zhang RY, Wang XQ, Liu ZH, Shen Y, Ding FH, Meng H, Wang LJ, Yan XX, Yang K, Wang HB, Pu LJ, Zhang Q, Chen QJ, De Caterina R, Shen WF. C1q/TNF-related protein-1: an adipokine marking and promoting atherosclerosis Eur Heart J 2015 2015Dec24
Shen Y, Ding FH, Sun JT, Pu LJ, Zhang RY, Zhang Q, Chen QJ, Shen WF, Lu L. （通讯作者） Association of elevated apoA-I glycation and reduced HDL-associated paraoxonase 1,3 activity, and their interaction with angiographic severity of coronary artery disease in patients with type 2 diabetes mellitus. Cardiovasc Diabetol 2015 14:52
Yang ZK, Shen Y, Shen WF, Pu LJ, Meng H, Zhang RY, Zhang Q, Chen QJ, De Caterina R, Lu L. （通讯作者） Elevated glycated albumin and reduced endogenous secretory receptor for advanced glycation end products levels in serum predict major adverse cardiocerebral events in patients with type 2 diabetes and stable coronary artery disease. Int J Cardiol 2015 197:241-247
Lu L （共同第一作者）, Wang YN, Sun WH, Liu ZH, Zhang Q, Pu LJ, Yang K, Zhu ZB, Meng H, Yang P, Du R, Chen QJ, Wang LS, Yu H, Shen WF. Two-dimensional fluorescence in-gel electrophoresis of coronary restenosis tissues in minipigs: increased adipocyte fatty acid binding protein induces reactive oxygen species-mediated growth and migration in smooth muscle cells. Arterioscler Thromb Vasc Biol 2013 33:572-580
Pu LJ, Lu L （共同第一作者）, Zhang RY, Du R, Shen Y, Zhang Q, Yang ZK, Chen QJ, Shen WF. Glycation of apoprotein a-I is associated with coronary artery disease plaque progression in type 2 diabetic patients. Diabetes Care 2013 36:1312-1320
Lu L （共同第一作者）, Wang YN, Li MC, Wang HB, Pu LJ, Niu WQ, Meng H, Yang EL, Zhang RY, Zhang Q, Zhao Q, Chen QJ, De Caterina R, Shen WF Reduced serum levels of vasostatin-2, an anti-inflammatory peptide derived from chromogranin A, are associated with the presence and severity of coronary artery disease. Eur Heart J 2012 33:2297-2306
Cai XY, Lu L （共同第一作者）, Wang YN, Jin C, Zhang RY, Zhang Q, Chen QJ, Shen WF Association of increased S100B, S100A6 and S100P in serum levels with acute coronary syndrome and also with the severity of myocardial infarction in cardiac tissue of rat models with ischemia-reperfusion injury. Atherosclerosis 2011 217:536-542
Wang LJ, Lu L （共同第一作者）, Zhang FR, Chen QJ, De Caterina R, Shen WF Increased serum high-mobility group box-1 and cleaved receptor for advanced glycatin endproducts levels and decreased endogenous secretory receptor for advanced glycation endproducts levels in diabetic and non-diabetic patients with heart failure. Eur J Heart Fail 2011 13:440-449
Zheng JL, Lu L, Hu J, Zhang RY, Zhang Q, Chen QJ, Shen WF Increased serum YKL-40 and C-reactive protein levels are associated with angiographic lesion progression in patients with coronary artery disease. Atherosclerosis 2010 210:590-595
Wang L, Lu L, Zhang F, Chen Q, Shen W Polymorphisms of beta-adrenoceptor and natriuretic peptide receptor genes influence the susceptibility to and the severity of idiopathic dilated cardiomyopathy in a Chinese cohort. J Card Fail 2010 16:36-44
Lu L （共同第一作者）, Zhang Q, Xu Y, Zhu ZB, Geng L, Wang LJ, Jin C, Chen QJ, Schmidt AM, Shen WF. Intra-coronary administration of sRAGE attenuates cardiac remodeling with decreased myocardial TGF-beta1 expression and fibrosis in minipigs with ischemia-reperfusion injury Chin Med J. 2010 123:594-598
Peng WH, Lu L （共同第一作者）, Hu J, Yan XX, Zhang Q, Zhang RY, Chen QJ, Shen WF. Decreased serum esRAGE level is associated with angiographically determined coronary plaque progression in diabetic patients. Clin Biochem 2009 42:1252-1259
Peng WH, Lu L （共同第一作者）, Zhang Q, Zhang RY, Wang LJ, Yan XX, Chen QJ, Shen WF. Chromosome 9p21 polymorphism is associated with myocardial infarction but not with clinical outcome in Han Chinese. Clin Chem Lab Med. 2009 47:917-922
Lu L （共同第一作者）, Pu LJ, Zhang Q, Wang LJ, Kang S, Zhang RY, Chen QJ, Wang JG, De Caterina, Shen WF. Increased glycated albumin and decreased esRAGE levels are related to angiographic severity and extent of coronary artery disease in patients with type 2 diabetes. Atherosclerosis 2009 206:540-545
Yan XX, Lu L （共同第一作者）, Peng WH, Wang LJ, Zhang Q, Zhang RY, Chen QJ, Shen WF. Increased serum HMGB1 level is associated with coronary artery disease in nondiabetic and type 2 diabetic patients. Atherosclerosis 2009 205:544-548
Chen QJ, Lu L （共同第一作者）, Peng WH, Hu J, Yan XX, Wang LJ, Zhang Q, Zhang RY, Shen WF. Polymorphisms of MMP-3 and TIMP4 genes affect angiographic coronary plaque progression in non-diabetic and type 2 diabetic patients. Clin Chim Acta 2009 405:97-103
Jin C, Lu L （共同第一作者）, Zhang RY, Zhang Q, Ding FH, Chen QJ, Shen WF. Association of serum glycated albumin, C-reactive protein and ICAM-1 levels with diffuse coronary artery disease in patients with type 2 diabetes mellitus. Clin Chem Acta 2009 408:45-49
Ruan W,Lu L （共同第一作者）,Zhang Q, Cao M, Zhu ZB, Wang LJ, Shen WF. Serial assessment of left ventricular remodeling and function by echo-tissue Doppler imaging after myocardial infarction in streptozotocin-induced diabetic swine. J Am Soc Echocardiogr 2009 22:530-536
Lu L （共同第一作者）, Zhang Q, Pu LJ, Peng WH, Yan XX, Wang LJ, Chen QJ, Zhu ZB, Michel JB, Shen WF. Dysregulation of matrix metalloproteinases and their tissue inhibitors is related to abnormality of left ventricular geometry and function in streptozotocin-induced diabetic minipigs. Int J Exp Pathol 2008 89:125-137
Lu L （共同第一作者）, Pu LJ, Chen QJ, Wang L, Peng WH, Yan X, Zhang Q, Zhang RY, Gong PH, Qiu JP, Shen WF. Increased glycated albumin and decreased esRAGE concentrations are associated with in-stent restenosis in Chinese diabetic patients. Clin Chim Acta 2008 396:33-37
Zhang Q, Lu L （共同第一作者）, Pu L, Zhang R, Shen J, Zhu Z, Hu J, Yang Z, Chen Q, Shen W. Neointimal hyperplasia persists at six months after sirolimus-eluting stent implantation in diabetic porcine Cardiovasc Diabetol 2007
Lu L （共同第一作者）, Zhang Q, Pu LJ, Xu XW, Zhang RY, Zhang JS, Hu J, Yang ZK, Lv AK, Ding FH, Chen QJ, Lou S, Fang DH, Shen WF. Elevation of tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 levels in aortic intima of Chinese Guizhou minipigs with streptozotocin-induced diabetes Chin Med J 2007 120:479-484
Pu LJ, Lu L （共同第一作者）, Shen WF, et al. Increased serum glycated albumin level is associated with the presence and severity of coronary artery disease in type 2 diabetic patients. Circ J 2007 71:1067-1073
Lu L （共同第一作者）, Pu LJ, Xu XW, Zhang Q, Zhang RY, Zhang JS, Hu J, Yang ZK, Lv AK, Ding FH, Shen J, Lou S, Fang DH, Shen WF. Association of serum levels of glycated albumin, C-reactive protein and tumor necrosis factor-alpha with severity of coronary artery disease. Clin Biochem 2007 40:810-816