导师姓名： 糜坚青 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 血液病
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： jianqingmi@shsmu.edu.cn 邮箱地址： jianqingmi@shsmu.edu.cn

研究方向 (点击浏览详细信息)
血液恶性疾病及血小板疾病的临床与基础研究

社会任职
国家自然科学基金面上项目、上海市科委项目管理及绩效评估、上海市医学科技奖等评审专家
中国老年医学学会血液分会常务委员
中国抗癌协会血液肿瘤医学专业委员会委员
中国抗癌协会血液转化医学专业委员会常务委员
中国初级卫生保健基金会血液病专家委员会主任委员
上海市抗癌协会理事
上海市司法鉴定专家委员会专家
中华医学会血液专业委员会全国委员
中华医学会上海分会血液专业委员会委员，国家自然科学基金委项目评议专家
上海医药行业协会血液医学转化专业委员会主任委员
上海市抗癌协会血液肿瘤专业委员会副主任委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** PI3Kp85亚基及其调控途径异常在BCR-ABL1阳性急性淋巴细胞白血病TKI耐药中的作用研究 国家自然科学基金面上项目 2017-01~2020-12 55万元 课题负责人
16CR3008A 新建的“瑞金急淋方案”治疗初发急性淋巴细胞白血病的疗效评估和预后判断 申康专科疾病临床“五新”转化项目 2016-09~2019-08 50万元 课题负责人
16XD** 三氧化二砷联合酪氨酸激酶抑制剂靶向治疗Ph阳性急性淋巴细胞白血病的分子机制 上海市科技人才计划项目 2016-05~2019-04 40万元 课题负责人
** 三氧化二砷联合达沙替尼靶向治疗BCR-ABL1阳 性急性淋巴细胞白血病的疗效观察及分子机制研究 上海市科委政府间国际科技合作基金项目 2015-10~2018-09 50万元 课题负责人
13zz088 靶向NOXA/mcl-1途径治疗套细胞淋巴瘤的机制研究 上海市教委科研创新重点计划 2013-01~2015-12 16万元 课题负责人
开发白血病分子分型新标志探索个体化治疗新路径之子课题“慢性粒细胞性白血病的靶向治疗” 卫生行业科研专项项目 2012-01~2015-12 150万元 子课题负责人
2010CB529203 基于系统生物医学的白血病临床转化研究 973国家重点基础研究发展计划 2010-01~2014-12 640万元 课题负责人
** 白血病患者外周血CD4-CD8-双阴性细胞杀伤自体白血病细胞的研究 国家自然科学基金面上项目 2009-01~2011-12 32万元 课题负责人
06PJ14067 血小板活化机制及其临床意义的研究 上海市科委浦江人才计划 2006-01~2008-01 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Xu, J., L. J. Chen, S. S. Yang, Y. Sun, W. Wu, Y. F. Liu, J. Xu, Y. Zhuang, W. Zhang, X. Q. Weng, J. Wu, Y. Wang, J. Wang, H. Yan, W. B. Xu, H. Jiang, J. Du, X. Y. Ding, B. Li, J. M. Li, W. J. Fu, J. Zhu, L. Zhu, Z. Chen, X. F. Fan, J. Hou, J. Y. Li, J. Q. Mi （通讯作者）, S. J. Chen Exploratory trial of a biepitopic CAR T-targeting B cell maturation antigen in relapsed/refractory multiple myeloma Proc Natl Acad Sci U S A 2019 116, 9543-9551
Cui W, Wang J, Nie RM, Zhao LL, Gao MQ, Zhu HM, Chen L, Hu J, Li JM, Shen ZX, WangZY, Chen SJ, Chen Z, Wang KK, Xi XD, Mi JQ* （通讯作者） Arsenic trioxide at conventional dosage does not aggravate hemorrhage in the first-line treatment of adult acute promyelocytic leukaemia. Eur J Haematol. 2018 100(4):344-350
Tao Wang, Chunyan Cheng, Lijun Peng, Mengqing Gao, Mengping Xi, Sophie Rousseaux, Saadi Khochbin, Jin Wang a, Jian-Qing Mi （通讯作者） Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia Journal of Cellular and Molecular Medicine 2018 Vol 22, No 3, 2018 pp. 1614-1626
Cheng C, Wang T, Song Z, Peng L, Gao M, Hermine O, Rousseaux S, Khochbin S, Mi JQ （通讯作者）, Wang J. Induction of autophagy and autophagy-dependent apoptosis in diffuse large B-cell lymphoma by a new antimalarial artemisinin derivative, SM1044. Cancer Med. 2018 2018 Feb;7(2):380-396. doi: 10.1002/cam4.1276. Epub 2017 Dec 26.
Wu C, Huang J, Xu WB, Guan YJ, Ling HW, Mi JQ （通讯作者）, Yan H. Discriminating Depth of Response to Therapy in Multiple Myeloma Using Whole-body Diffusion-weighted MRI with Apparent Diffusion Coefficient: Preliminary Results From a Single-center Study. Acad Radiol. 2018 2018 Jul;25(7):904-914.
Chen B, Jiang L, Zhong ML, Li JF, Li BS, Peng LJ, Dai YT, Cui BW, Yan TQ, Zhang WN, Weng XQ, Xie YY, Lu J, Ren RB, Chen SN, Hu JD, Wu DP, Chen Z, Tang JY, Huang JY, Mi JQ （通讯作者）, Chen SJ. Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2018 2018 Jan 9;115(2):373-378.
Yu WY, Geng M, Hao J, Chen M, Zhang SJ, Wang J, Mi JQ （通讯作者） Clinical Features and Prognosis Analysis of Hodgkin Lymphoma: A Multicenter Retrospective Study Over a Decade of Patients in China Clin Lymphoma Myeloma Leuk 2017 May;17(5):274-282
Dai YJ, Wang YY, Huang JY, Xia L, Shi XD, Xu J, Lu J, Su XB, Yang Y, Zhang WN, Wang PP, Wu SF, Huang T, Mi JQ, Han ZG, Chen Z, Chen SJ. Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement. Proceedings of the National Academy of Sciences of the United States of America 2017 2017 May 16;114(20):5237-5242.
Liu YF,Wang BY,Zhang WN,Huang JY, Li BS, Zhang M, Jiang L,Li JF,Wang MJ,Dai YJ,Zhang ZG,Wang Q,Kong J,Chen B,Zhu YM,Weng XQ,Shen ZX,Li JM, Wang J,Yan XJ,Li Y,Liang YM,Liu L,Chen XQ,Zhang WG,Yan JS,Hu JD,Shen SH,Chen J,Gu LJ,Pei D,Li Y,Wu G,Zhou X,Ren RB,Cheng C,Yang JJ,Wang KK, Wang SY,Zhang J,Mi JQ （通讯作者）,Pui CH,Tang JY,Chen Z,Chen SJ Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia EBioMedicine 2016 Jun;8:173-83
ZHAO LL, LIU YF, PENG LJ, FEI AM, CUI W, MIAO SC, HERMINE O, GRESSIN R, KHOCHBIN S, CHEN SJ, WANG J, MI JQ. （通讯作者） Arsenic Trioxide rewires Mantle Cell Lymphoma response to Bortezomib Cancer Medicine 2015 in press
Mi JQ, Chen SJ, Zhou GB, Yan XJ, Chen Z. Synergistic targeted therapy for acute promyelocytic leukaemia: a model of translational research in human cancer Journal of Interne Medicine 2015 2015 Jun 9. doi: 10.1111/joim.12376
Wang J, Mi JQ （通讯作者）, Debernardi A, Vitte AL, Emadali A, Meyer JA, Charmpi K, Ycart B, Callanan MB, Carroll WL, Khochbin S, Rousseaux S. A six gene expression signature defines aggressive subtypes and predicts outcome in childhood and adult acute lymphoblastic leukemia Oncotarget 2015 Jun 30;6(18):16527-42.
Duan CW, Shi J, Chen J, Wang B, Yu YH, Qin X, Zhou XC, Cai YJ, Li ZQ, Zhang F, Yin MZ, Tao Y, Mi JQ, Li LH, Enver T, Chen GQ, Hong DL Leukemia propagating cells rebuild an evolving niche in response to therapy Cancer Cell 2014 Jun 16;25(6):778-93
Chen WL, Wang JH, Zhao AH, Xu X, Wang YH, Chen TL, Li JM, Mi JQ, Zhu YM, Liu YF, Wang YY, Jin J, Huang H, Wu DP, Li Y, Yan XJ, Yan JS, Li JY, Wang S, Huang XJ, Wang BS, Chen Z, Chen SJ, Jia W. A distinct glucose metabolism signature of acute myeloid leukemia with prognostic value Blood 2014 Oct 30;124(18):2893
Hui Zhang, Jian-Qing Mi （共同第一作者）, Hai Fang, Zhao Wang, Chun Wang, Lin Wu, Bin Zhang, Mark Mindend,Wen-Tao Yang, Huan-Wei Wang, Jun-Min Li, Xiaodong Xi, Sai-Juan Chen, Ji Zhang, Zhu Chen,and Kan-Kan Wang Preferential eradication of acute myelogenousleukemia stem cells by fenretinide Proc Natl Acad Sci U S A 2013 Apr 2;110(14):5606-11
Mi JQ *, Li JM, Shen ZX, Chen SJ, Chen Z How to manage acute promyelocytic leukemia Leukemia 2012 26(8):1743-51
Mi JQ, Wang X, Yao Y, Lu HJ, Jiang XX, Zhou JF, Wang JH, Jiao B, Shen SH, Tang JY, Gu LJ, Jiang H, Ma LY, Hao SG, Chen FY, Xiong SM, Shen ZX, Chen Z, Chen B, Chen SJ Newly diagnosed acute lymphoblastic leukemia in China (II): Prognosis related to genetic abnormalities in a series of 1 091 cases Leukemia 2012 26(7):1507-16
Chen B, Wang YY, Zhang WN, He HY, Zhu YM, Chen HM, Gu CH, Fan X, Chen JM, Cao Q, Yang G, Jiang CL, Weng XQ, Zhang XX, Xiong SM, Shen ZX, Jiang H, Gu LJ, Chen Z, Mi JQ * （通讯作者）, Chen SJ Newly diagnosed acute lymphoblastic leukemia in China(I):Abnormal genrtic patterns in 1346 childhood and adult cases and their comparison to the reports from western countries Leukemia 2012 26(7):1608-16
Mi J Current treatment strategy of acute promyelocytic leukemia Front Med 2011 5(4):341-7
Yan XJ, Xu J, Gu ZH, Pan CM, Lu G, Shen Y, Shi JY, Zhu YM, Tang L, Zhang XW, Liang WX, Mi JQ, Song HD, Li KQ, Chen Z, Chen SJ Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia Nat Genet 2011 43(4):309-15
Wang YY, Zhao LJ, Wu CF, Liu P, Shi L, Liang Y, Xiong SM, Mi JQ, Chen Z, Ren R, Chen SJ C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice Proc Natl Acad Sci U S A 2011 108(6):2450-5
Wang K, Wang P, Shi J, Zhu X, He M, Jia X, Yang X, Qiu F, Jin W, Qian M, Fang H, Mi JQ, Yang X, Xiao H, Minden M, Du Y, Chen Z, Zhang J PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia Cancer Cell 2010 17(2):186-97
Fu CT, Zhu KY, Mi JQ, Liu YF, Murray ST, Fu YF, Ren CG, Dong ZW, Liu YJ, Dong M, Jin Y, Chen Y, Deng M, Zhang W, Chen B, Breslin P, Chen SJ, Chen Z, Becker MW, Zhu J, Zhang JW, Liu TX An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 axis controls myeloid development and transformation Blood 2010 115(23):4715-24
Zhang ZR, Mi JQ, Gu LJ, Tang JY, Shen SH, Wen ZJ, Chen SJ, Chen Z. Using sound Clinical Paths and Diagnosis-related Groups (DRGs)-based payment reform to bring benefits to patient care: A case study of leukemia therapy Frontiers of Medicine in China 2010 4(1):8–15
Su X, Mi J （共同第一作者）, Yan J, Flevaris P, Lu Y, Liu H, Ruan Z, Wang X, Kieffer N, Chen SJ, Du X, and Xi X RGT, a synthetic peptide corresponding to the integrin β3 cytoplasmic C-terminal sequence Blood 2008 112(3):592-602
He S, Cao Q, Qiu Y, Mi JQ, Zhang JZ, Jin M, Ge H, Emerson SG, Zhang Y, Zhang Y A new approach to the blocking of alloreactive T cell-mediated graft-versus-host disease by in vivo administration of anti-CXCR3 neutralizing antibody. J Immunol. 2008 181(11):7581-92.
糜坚青,王振义. 急性白血病细胞遗传及分子发病机制以及相关靶向治疗. 内科理论与实践杂志 2006 1(1):23-29
Mi JQ* （通讯作者）, Manches O, Wang J, Perron P, Weisbuch S, Marche P, Renversez JC, Bensa JC, Sotto JJ, Leroux D, Bonnefoix T. Development of autologous cytotoxic CD4+ T clones in a human model of B-cell non-Hodgkin follicular lymphoma. Br J Haematol 2006 135(3): 324-35.
Bonnefoix T, Bonnefoix P, Perron P, Mi JQ, Ng WF, Lechler R, Bensa JC, Cahn JY, Leroux D. Quantitating effector and regulatory T lymphocytes in immune responses by limiting dilution analysis modeling. J Immunol 2005 174(6):3421-31
Bonnefoix T, Mi JQ, Perron P, Callanan M, Semoun C, Favre M, Renversez JC, Sotto MF, Leroux D, Sotto JJ Terminal plasmocytoid differentiation of malignant B cells induced by autotumor-reactive CD4(+) T cells in one case of splenic marginal zone B-cell lymphoma blood 2002 Jan 1;99(1):388-91.
Mi JQ, Blanc-Jouvan F, Wang J, Sotto MF, Cousin F, Castinel A, Chauvet M, Sotto JJ, Polack B, Mossuz P Endogenous megakaryocytic colony formation and thrombopoietin sensitivity of megakaryocytic progenitor cells are useful to distinguish between essential thrombocythemia and reactive thrombocytosis J Hematother Stem Cell Res 2001 Jun;10(3):405-9.