导师姓名： 陈冰 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 血液病
导师类型： 博士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： chenbing.rjsih@yahoo.com

研究方向 (点击浏览详细信息)
白血病发病机制与分子分型研究

社会任职
中国医药生物技术协会组织生物样本库分会第三届专业委员会委员，中国抗癌协会血液病理学组委员，中国抗癌协会第一届肿瘤样本整合研究分会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 急性髓细胞白血病（AML）分子分型与个体化精准诊疗研究 上海交通大学医学院高峰高原计划——临床专职科研队伍（第二轮） 2019-01~2021-12 100万元 课题负责人
201802 血液疾病骨髓细胞形态学与染色体核型分析人工智能诊断系统开发 医学基因组学国家重点实验室开放课题 2018-07~2021-06 30万元 课题负责人
** 白血病罕见染色体易位与相关新融合基因的鉴定及其发病机制研究 国家自然科学基金（面上项目） 2017-01~2020-12 55万元 课题负责人
** 基于深度测序技术的急性髓细胞白血病（AML）分子分型研 国家自然科学基金（面上项目） 2015-01~2018-12 75万元 课题负责人
** M2b 型急性髓细胞白血病的靶向联合治疗机制研究 国家自然科学基金（面上项目） 2013-01~2016-12 75万元 课题负责人
2012AA02A505 急性粒细胞白血病的分子分型和个体化诊疗技术 国家高技术研究发展计划（863） 2012-01~2015-12 990万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Xin-Jie Chen, Wei-Na Zhang, Bing Chen （通讯作者）, Wen-Da Xi, Ying Lu, Jin-Yan Huang, Yue-Ying Wang, Jun Long, Song-Fang Wu, Yun-Xiang Zhang, Shu Wang, Si-Xing Li, Tong Yin, Min Lu, Xiao-Dong Xi, Jun-Min Li, Kan-Kan Wang, Zhu Chen, Sai-Juan Chen. Homoharringtonine deregulates MYC transcriptional expression by directly binding NF-κB repressing factor. Proc Natl Acad Sci U S A. 2019 116(6):2220-2225
Sui JN, Chen QS, Zhang YX, Sheng Y, Wu J, Li JM, Weng XQ, Chen B. （通讯作者） Identifying Leukemia-Associated Immunophenotype-based Individualized Minimal Residual Disease in Acute Myeloid Leukemia and its Prognostic Significance. Am J Hematol. 2019 94(5):528-538.
Bing Chen, Lu Jiang, Meng-Ling Zhong, Jian-Feng Li, Ben-Shang Lib, Li-Jun Peng, Yu-Ting Dai, Bo-Wen Cui, Tian-Qi Yan, Wei-Na Zhang, Xiang-Qin Weng, Yin-Yin Xie, Jing Lu, Rui-Bao Ren, Su-Ning Chen, Jian-Da Hu, De-Pei Wu, Zhu Chen, Jing-Yan Tang, Jin-Yan Huang, Jian-Qing Mi, Sai-Juan Chen. Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2018 115(2):373-378
Wang S, Zhang YX, Huang T, Sui JN, Lu J, Chen XJ, Wang KK, Xi XD, Li JM, Huang JY, Chen B. （通讯作者） Mutation profile and associated clinical features in Chinese patients with cytogenetically normal acute myeloid leukemia. Int J Lab Hematol. 2018 40(4):408-418
Yu C, Kong QL, Zhang YX, Weng XQ, Wu J, Sheng Y, Jiang CL, Zhu YM, Cao Q, Xiong SM, Li JM, Xi XD, Chen SJ, Chen B （通讯作者） Clinical significance of day 5 peripheral blast clearance rate in the evaluation of early treatment response and prognosis of patients with acute myeloid leukemia. J Hematol Oncol 2015 2015 May 10;8:48
Lu Y, Chen B （共同第一作者）, Song JH, Zhen T, Wang BY, Li X, Liu P, Yang X, Zhang QL, Xi XD, Chen SD, Zuo JP, Chen Z, Chen SJ. Eriocalyxin B ameliorates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells. Proc Natl Acad Sci U S A 2013 2013 Feb 5;110(6):2258-63.
B Chen, Y-Y Wang, Y Shen, W-N Zhang, H-Y He, Y-M Zhu, H-M Chen, C-H Gu, X Fan, J-m Chen, Q Cao, G Yang, C-L Jiang, X-Q Weng, X-X Zhang, S-M Xiong, Z-X Shen, H Jiang, L-J Gu, Z Chen, J-Q Mi and S-J Chen Newly diagnosed acute lymphoblastic leukemia in China (I):abnormal genetic patterns in 1346 childhood and adult cases and their comparison with the reports from Western countries. Leukemia 2012 2012 Jul;26(7):1608-16
Mi JQ, Wang X, Yao Y, Lu HJ, Jiang XX, Zhou JF, Wang JH, Jiao B, Shen SH, Tang JY, Gu LJ, Jiang H, Ma LY, Hao SG, Chen FY, Xiong SM, Shen ZX, Chen Z, Chen B （通讯作者）, Chen SJ. Newly diagnosed acute lymphoblastic leukemia in China (II): Prognosis related to genetic abnormalities in a series of 1 091 cases. Leukemia 2012 2012 Jul;26(7):1507-16
Shi JY, Ren ZH, Jiao B, Xiao R, Yun HY, Chen B, Zhao WL, Zhu Q, Chen Z, Chen SJ. Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia. Int J Cancer. 2011 2011 Jan 1;128(1):233-8.
Shen Y, Zhu YM, Fan X, Shi JY, Wang QR, Yan XJ, Gu ZH, Wang YY, Chen B, Jiang CL, Yan H, Chen FF, Chen HM, Chen Z, Jin J, Chen SJ. Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia. Blood 2011 2011 Nov 17;118(20):5593-603.
Fu CT, Zhu KY, Mi JQ, Liu YF, Murray ST, Fu YF, Ren CG, Dong ZW, Liu YJ, Dong M, Jin Y, Chen Y, Deng M, Zhang W, Chen B, Breslin P, Chen SJ, Chen Z, Becker MW, Zhu J, Zhang JW, Liu TX. An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 axis controls myeloid development and transformation. Blood 2010 2010 Jun 10;115(23):4715-24.
Jiao B, Wu CF, Liang Y, Chen HM, Xiong SM, Chen B, Shi JY, Wang YY, Wang JH, Chen Y, Li JM, Gu LJ, Tang JY, Shen ZX, Gu BW, Zhao WL, Chen Z, Chen SJ. AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2. Leukemia 2009 2009 Sep;23(9):1598-604.
Hu J, Liu YF, Wu CF, Xu F, Shen ZX, Zhu YM, Li JM, Tang W, Zhao WL, Wu W, Sun HP, Chen QS, Chen B, Zhou GB, Zelent A, Waxman S, Wang ZY, Chen SJ, Chen Z. Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci U S A. 2009 2009 Mar 3;106(9):3342-7.
Pan Q, Zhu YJ, Gu BW, Cai X, Bai XT, Yun HY, Zhu J, Chen B, Weng L, Chen Z, Xue YQ, Chen SJ. A new fusion gene NUP98-IQCG identified in an acute T-lymphoid/myeloid leukemia with a t(3;11)(q29q13;p15)del(3)(q29) translocation. Oncogene 2008 2008 May 29;27(24):3414-23.
Ma LH, Liu H, Xiong H, Chen B, Zhang XW, Wang YY, Le HY, Huang QH, Zhang QH, Li BL, Chen Z, Chen SJ. Aberrant transcriptional regulation of the MLL fusion partner EEN by AML1-ETO and its implication in leukemogenesis. Blood 2007 2007 Jan 15;109(2):769-77.
Xia HL, Chen LJ, Chen B, Jin XL, Chen SJ. The molecular cytogenetic aberration analyzed by comparative genomic hybridization and its significance in diffuse large B-cell lymphoma. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 2006 Feb;23(1):12-5.
Zhu YM, Zhao WL, Fu JF, Shi JY, Pan Q, Hu J, Gao XD, Chen B, Li JM, Xiong SM, Gu LJ, Tang JY, Liang H, Jiang H, Xue YQ, Shen ZX, Chen Z, Chen SJ. NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis. Clin Cancer Res. 2006 2006 May 15;12(10):3043-9.
Chen B, Zhao WL, Jin J, Xue YQ, Cheng X, Chen XT, Cui J, Chen ZM, Cao Q, Yang G, Yao Y, Xia HL, Tong JH, Li JM, Chen J, Xiong SM, Shen ZX, Waxman S, Chen Z, Chen SJ. Clinical and cytogenetic features of 508 Chinese patients with myelodysplastic syndrome and comparison with those in Western countries. Leukemia 2005 2005 May;19(5):767-75.
Wang YY, Zhou GB, Yin T, Chen B, Shi JY, Liang WX, Jin XL, You JH, Yang G, Shen ZX, Chen J, Xiong SM, Chen GQ, Xu F, Liu YW, Chen Z, Chen SJ. AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec. Proc Natl Acad Sci U S A. 2005 2005 Jan 25;102(4):1104-9.
Chen LJ, Dong Y, Chen SY, Zhang L, Zhou GB, Chen B, Wang L, Chen Z, Chen SJ. [hCG-PLZF-RARalpha/hCG-RARalpha-PLZF transgenic mice developing into leukemia] Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2005 2005 Dec;13(6):924-31.
Liu H, Chen B （共同第一作者）, Xiong H, Huang QH, Zhang QH, Wang ZG, Li BL, Chen Z, Chen SJ. Functional contribution of EEN to leukemogenic transformation by MLL-EEN fusion protein. Oncogene 2004 2004 Apr 22;23(19):3385-94.
Gu BW, Wang Q, Wang JM, Xue YQ, Fang J, Wong KF, Chen B, Shi ZZ, Shi JY, Bai XT, Wu DH, Chen Z, Chen SJ. Major form of NUP98/HOXC11 fusion in adult AML with t(11;12)(p15;q13) translocation exhibits aberrant trans-regulatory activity. Leukemia. 2003 2003 Sep;17(9):1858-64.
Gu BW, Xiong H, Zhou Y, Chen B （共同第一作者）, Wang L, Dong S, Yu ZY, Lu LF, Zhong M, Yin HF, Zhu GF, Huang W, Ren SX, Gallagher RE, Waxman S, Chen GQ, Wang ZG, Chen Z, Fu G, Chen SJ. Variant-type PML-RAR(alpha) fusion transcript in acute promyelocytic leukemia: use of a cryptic coding sequence from intron 2 of the RAR(alpha) gene and identification of a new clinical subtype resistant to retinoic acid therapy. Proc Natl Acad Sci U S A 2002 2002 May 28;99(11):7640-5.
Zhao M, Chen B, Wang L, Xu L, Cao Q, Su X, Chen SJ. [Establishment and application of multiplex FISH in detection of the complex chromosome abnormalities in leukemia] Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002 2002 Oct;19(5):375-8.