导师姓名： 李彪 专业代码： 100207
性别： 男 专业名称： 影像医学与核医学
培养单位： 附属瑞金医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 200025 邮箱地址： biaoli63@hotmail.com

研究方向 (点击浏览详细信息)
肿瘤分子核医学

社会任职
上海市核学会放射和治疗专业副主任委员
中国医学影像学杂志编委
国际放射医学核医学杂志编委
中华核医学杂志编委
上海市抗癌学会影像医学委员会常委
上海核学会理事
标记免疫与分析杂志编委
中华医学会核医学分会委员
诊断学理论与实践编委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 分子影像监测乳腺癌吉西他滨耐药的多重逆转 国家自然科学基金面上项目 2019-01~2022-12 57万元 课题负责人
** PET/MR在上腹部肿瘤诊断评估中的价值 市科委科技专项 2017-07~2020-06 20万元 课题负责人
** 细胞递送载体介导基因及金纳米棒精准协同放射治疗肿瘤的分子影像学研究 国家自然科学基金面上项目 2017-01~2020-12 56万元 课题负责人
16CR3110B PET/MR操作常规的建立及在头颈部、上腹部和盆腔肿瘤中的应用 上海申康医院发展中心 2016-12~2019-06 30万元 课题负责人
2016YFC** 全数字高性能PET/CT 性能检测、临床验证与高级应用开发 国家重点研发计划 2016-07~2020-12 110万元 课题负责人
** 基于脑胶质瘤骨髓间充质干细胞靶向介导双基因治疗的可视化研究 国家自然科学基金面上项目 2015-01~2018-12 72万元 课题负责人
瑞金医院学科带头人攀登计划 瑞金医院学科带头人攀登计划 2013-01~2015-12 150万元 课题负责人
** miRNA-143靶向调控己糖激酶-2肿瘤治疗的分子影像可视化评估 国家自然科学基金面上项目 2013-01~2016-12 80万元 课题负责人
11XD** 核素正反馈调控NIS基因治疗甲状腺癌的研究 上海市优秀学科带头人 2011-06~2013-05 40万元 课题负责人
** 双启动子杆状病毒介导188Re肿瘤靶向治疗及抗肿瘤新生血管调控的实验研究 国家自然科学基金面上项目 2011-01~2013-12 35万元 课题负责人
核素标记人纤溶酶原kringle5对肿瘤显像、治疗和疗效评价的临床前研究 上海市科委生物医药重点科技攻关项目 2009-07~2011-06 50万元 课题负责人
YG08PETZD01 18F-FDG micro PET/CT评价188Re-kringle5抗肿瘤血管生成治疗疗效的实验研究 上海交通大学“医工(理)交叉研究基金”小动物PET/CT平台专项重点项目 2008-11~2010-10 10万元 课题负责人
07jc14039 生物影像动态监测新技术及相关标志物预测肿瘤化疗疗效的应用基础研究 (二) 上海市科委重点项目 2007-11~2009-11 50万元 子课题负责人
** 188Re标记人纤溶酶原Kringle 5在肿瘤显像和治疗中的研究 国家自然科学基金面上项目 2006-01~2008-12 25万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Shi S,Zhang M,Guo R,Miao Y,Li B （通讯作者） Human sodium iodide transporter gene mediated imaging and therapy of mouse glioma by 188Re: a comparing study with 131I Hum Gene Ther 2019 30(1):106-117
Miao Y,Zhang LF,Zhang M,Guo R,Liu MF,Li B （通讯作者） Therapeutic Delivery of miR-143 Targeting Tumor Metabolism in Poorly Differentiated Thyroid Cancer Xenografts and Efficacy Evaluation Using 18F-FDG MicroPET-CT Hum Gene Ther 2019 30(7):882-892
Hu J,Shen W,Qu Q,Fei X,Miao Y,Huang X,Liu J,Wu Y,Li B （通讯作者） NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation inhibition Front Med 2019 May 22
Zhang M,Sun L,Rui W,Guo R,He H,Miao Y,Meng H,Liu J,Biao L （通讯作者） Semi-quantitative analysis of 99mTc-sestamibi retention level for preoperative differential diagnosis of parathyroid carcinoma Quant Imaging Med Surg 2019 9(8):1394-1401
Shangguan C, Gan G, Zhang J, Wu J, Miao Y, Zhang M, Li B （通讯作者）, Mi J Cancer-associated fibroblasts enhance tumor 18F-FDG uptake and contribute to the intratumor heterogeneity of PET-CT Theranostics 2018 Feb 2;8(5):1376-1388
Guo R, Xi Y, Zhang M, Miao Y, Zhang M, Li B （通讯作者） Human sodium iodide transporter gene mediated imaging and therapy of mouse glioma by 188Re: a comparing study with 131I Oncol Lett 2018 Mar;15(3):3911-3917
Guo R, Wang J, Zhang M, Zhang M, Meng H, Zhang Y, Li B （通讯作者） Value of 99mTc-MIBI SPECT/CT parathyroid imaging and ultrasonography for concomitant thyroid carcinoma. Nucl Med Commun 2017 Aug;38(8):676-682
Zhang M, Shi S, Guo R, Miao Y, Li B （通讯作者） Use of rhenium-188 for in vivo imaging and treatment of human cervical cancer cells transfected with lentivirus expressing sodium iodide symporter Oncol Rep 2016 Oct;36(4):2289-2297
Miao Y, Zhang LF, Guo R, Liang S, Zhang M, Shi S, Shang-Guan CF, Liu MF, Li B （通讯作者） (18)F-FDG PET/CT for Monitoring the Response of Breast Cancer to miR-143-Based Therapeutics by Targeting Tumor Glycolysis Mol Ther Nucleic Acids 2016 Aug 30;5(8):e357
Shi S, Zhang M, Guo R, Zhang M, Hu J, Xi Y, Miao Y, Li B （通讯作者） 131I therapy mediated by sodium/iodide symporter combined with kringle 5 has a synergistic therapeutic effect on glioma Oncol Rep 2016 Feb;35(2):691-698
Hu J, Lei H, Fei X, Liang S, Xu H, Qin D, Wang Y, Wu Y, Li B （通讯作者） NES1/KLK10 gene represses proliferation, enhances apoptosis and down-regulates glucose metabolism of PC3 prostate cancer cells Sci Rep 2015 Nov 30;5:17426.
Shi S, Zhang M, Guo R, Miao Y, Hu J, Xi Y, Li B （通讯作者） In vivo molecular imaging and radionuclide (131I) therapy of human nasopharyngeal carcinoma cells transfected with a lentivirus expressing sodium iodide symporter PLoS One 2015 Jan 26;10(1):e**.
Shi S, Zhang M, Guo R, Miao Y, Zhang X, Li B （通讯作者） Molecular Imaging to Monitor Repair of Myocardial Infarction Using Genetically Engineered Bone Marrow-Derived Mesenchymal Stem Cells Curr Gene Ther 2015 2015 Apr 20
Miao Zhang, Lihua Wang, Rui Guo, Sheng Liang, Xufeng Jiang, Min Zhang, Biao Li. （通讯作者） Molecular In Vivo Imaging Using a Noninvasive Cardiac-Specific MLC-2v Promoter Driven Dual-Gene Recombinant Lentivirus Monitoring System PLoS One 2015 31;10(7):e**
Xi Y, Guo R, Hu J, Zhang M, Zhang X, Li B. （通讯作者） 18F-fluoro-2-deoxy-D-glucose retention index as a prognostic parameter in patients with pancreatic cancer. Nucl Med Commun 2014 35(11):1112-8
Guo R, Zhang M, Xi Y, Ma Y, Liang S, Shi S, Miao Y, Li B. （通讯作者） Theranostic Studies of Human Sodium Iodide Symporter Imaging and Therapy Using 188Re: A Human Glioma Study in Mice PLoS ONE 2014 9(7) e102011
Shi S, Zhang M, Guo R, Miao Y, Zhang M, Hu J, Xi Y, Li B. （通讯作者） Feasibility of lentiviral?mediated sodium iodide symporter gene delivery for the efficient monitoring of bone marrow?derived mesenchymal stem cell transplantation and survival. Int J Mol Med 2014 34(6):1547-54
Zhang M, Guo R, Shi S, Miao Y, Zhang Y, Li B. （通讯作者） Baculovirus Vector-Mediated Transfer of Sodium Iodide Symporter and Plasminogen Kringle 5 Genes for Tumor Radioiodide Therapy PLoS ONE 2014 (3) e92326
Zhang M, Zhang Y, Huang W, Li B. （通讯作者） False-Positive I-131 Uptake by a temporomandibular joint effusion Clin Nucl Med 2013 38(10)823-825
Xu HP, Guo R, Li B （通讯作者） Baculovirus Mediated Experimental Research on Targeted Egr1-Kringle 5 Gene Radiotherapy in Lung Adenocarcinoma Journal of Cancer Therapy 2012 3:397-405
Zhang M, Zhang M, Wang LH, Hu JJ, Li B （通讯作者） Combined 18F-FDG PET/CT with Enhanced CT Perform One-Stop Shop Imaging for Assessing Pancreatic Carcinoma Journal of Cancer Therapy 2012 3:546-552
Xi Y, Zhang M, Guo R, Zhang M, Hu JJ, Li B （通讯作者） Meta-Analysis: 18F-FDG PET or PET/CT for the Evaluation of Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer Journal of Cancer Therapy 2012 3:662-672
Liang S, Lan X, Zhang Y, Xu X, Li B （通讯作者） Fully automatic synthesis of [18F]FES for reporter gene hERL expression imaging Nucl Med Commun 2012 33(1):29-33
Guo R, Liang S, Ma YF, Shen H, Xu HP, Li B （通讯作者） Evaluation of biodistribution and anti-tumor effect of 188Re-rhk5 in mice with lung adenocarcinoma Oncology Letters 2011 2:865-870
Guo R, Ma YF, Zhang RY, Liang S, Shen H, Xu HP, Li B （通讯作者） 188Rhenium labeled recombinant human plasminogen kringle5 (rhk5) and preliminary biodistribution evaluation in mice bearing A549 tumors Nuklearmedizin 2011 50(6):234-239
Guo R, Tian LP, Han B, Xu HP, Zhang M, Li B （通讯作者） Feasibility of a novel positive feedback effect of 131I promoted Bac-Egr1-hNIS expression in malignant glioma via baculovirus Nucl Med Biol 2011 38:599-604
Zhang M, Guo R, Xu HP, Zhang M, Li B （通讯作者） Retinoic acid and tributyrin induce in-vitro radioiodine uptake and inhibition of cell proliferation in a poorly differentiated follicular thyroid carcinoma. Nucl Med Commun Nucl Med Commun 2011 32(7):605-610
Guo R, Zhang RY, Pan YX, Xu HP, Zhang M, Liang S, Wang LH, Zhang YF, Li B （通讯作者） Feasibility of a novel positive feedback effect of 131I promoted Bac-Egr1-hNIS expression in malignant glioma via baculovirus: a comparing study with Bac-CMV-hNIS Nucl Med Commun 2011 32:402-409
Guo Rui, Zhang Yifan, Liang Sheng, Zhang Miao, Jiang Xufeng, Li Biao. （通讯作者） Human sodium/iodide symporter gene induced iodine uptake in human lung adenocarcinoma via baculovirus. Nuclear Science and Technique 2010 21(2):99-105
Guo R, Zhang YF, Liang S, Xu HP, Zhang M, Li B （通讯作者） Sodium butyrate enhances the expression of baculovirus-mediated sodium/iodide symporter gene in A549 lung adenocarcinoma cells Nucl Med Commun 2010 31(10):916-21
Xu H, Zhang M, Zhai G, Li B. （通讯作者） The clinical significance of 18F-FDG PET/CT in early detection of second primary malignancy in cancer patients. Journal of Cancer Research and Clinical Oncology 2010 136(8):1125-34
Zhai G, Zhang M, Xu H, Zhu C, Li B. （通讯作者） The role of 18F-fluorodeoxyglucose PET/CT whole body imaging in the evaluation of focal thyroid incidentaloma. J Endocrinol Invest 2010 33(3):151-155
Xu H, Zhang M, Zhai G, Zhang M, Ning G, Li B （通讯作者） The role of integrated 18F-FDG PET/CT in identification of ectopic ACTH secretion tumors. Endocr 2009 36:385-391
Miao Zhang, Xufeng Jiang, Min Zhang, Haoping Xu, Ge Zhai, Biao Li （通讯作者） The role of 18F-FDG PET/CT in the evaluation of ascites with undetermined origin. J Nucl Med 2009 50(4):506-512
Huang W, Tian XL, Wu YL, Zhong J, Yu LF, Hu SP, Li B （通讯作者） Suppression of gastric cancer growth by baculovirus vector-mediated transfer of normal epithelial cell specific-1 gene. World J Gastroenterol 2008 14(38):5810-5815
Zhang M, Li B （通讯作者）, Jiang X. PET/CT imaging in a case of cardiac liposarcoma. J Nucl Cardiol 2008 15(3):473-475
Zhang J, Kong Y, Zhou J, Zhang J, Zhang L, Wang C, Zhu C, Li B. （通讯作者） The clinical significance of 18F-FDG PET/CT in early detection of second primary malignancy in cancer patients. Nuclear Science and Technique 2008 (19):32-38
Huang W, Zhong J, Wu LY, Yu LF, Tian XL, Zhang YF, Li B （通讯作者） Downregulation and CpG island hypermethylation of NES1/hK10 gene in the pathogenesis of human gastric cancer. Cancer Lett 2007 251(1):78-85
Hui Yang, Hai-Yan Zhou, Biao Li, Guo-Zhong Niu, Sheng-Di Chen Downregulation of Parkin Damages Antioxidant Defenses and Enhances Proteasome Inhibition-Induced Toxicity in PC12 Cells J Neuroimmune Pharmacol 2007 2:276-283
Wei-Guo Liu, Xi-Jing Wang, Guo-Qiang Lu, Biao Li, Gang Wang and Sheng-Di Chen Dopaminergic regeneration by neurturin-overexpressing c17.2 neural stem cells in a rat model of Parkinson's disease Molecular Neurodegeneration 2007
Yifan Zhang, Shiquan Jia, Yong Liu, Biao Li, Zhaohui Wang, Hui Lu, Chengmo Zhu A clinical study of all-trans-retinoid-induced differentiation therapy of advanced thyroid cancer Nuclear Medicine Communications 2007 28:251-255
Hui Yang, Hai-Yan Zhou, Biao Li, Sheng-Di Chen Neuroprotection of Parkin against apoptosis is independent of inclusion body formation NEUROREPORT 2005 16(10):1117-1121.
Wei-Guo Liu, Yan Chen, Biao Li, Guo-Qiang Lu, Sheng-Di Chen Neuroprotection by Pergolide Against Levodopa-Induced Cytotoxicity of Neural Stem Cells Neurochemical Research 2004 29(12):2207-2214.
Li B, Goyal J, Dhar S, Dimri G, Evron E, Sukumar S, Wazer DE, Band V CpG methylation as a basis for breast tumor-specific loss of NES1/kallikrein 10 expression Cancer Res 2001 Nov 1;61(21):8014-21