导师姓名： 周广东 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属第九人民医院 三级学科/
专业领域： 整形
导师类型： 博士生导师 专业学位导师：
联系方式： guangdongzhou@126.com
邮编： 200241 邮箱地址： guangdongzhou@126.com

研究方向 (点击浏览详细信息)
干细胞与组织工程，软骨再生核心技术及其临床转化研究

社会任职
中国生物医学工程学会组织工程与再生医学分会副主任委员
中国研究型医院学会运动医学分会副主任委员
中国生物医学工程学会组织工程与再生医学分会-秘书长
国家863计划产业开发类项目-评审专家
中国生物医学工程学会组织工程与再生医学分会-常务委员
《Biomaterials》杂志-审稿专家
国家863计划项目评审专家
中国生物3D打印产业联盟-理事
中国生物材料学会再生材料分会-常委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** JNK信号通路调控体外软骨再生机制及其应用 7)国家自然科学基金面上项目：、、2019/01-2022/12、57万、在研、项目负责人。 2019-01~2022-12 57万元 课题负责人
18XD** 软骨再生核心技术及其临床转化 1)上海市优秀技术带头人：、、2018/01-2020/12、40万元、在研、项目负责人。 2018-01~2020-12 40万元 课题负责人
2017YFC** 软骨-骨一体化功能支架研制及生物关节再生 国家重点研发计划 2017-07~2020-12 1200万元 课题负责人
201512 组织工程软骨临床应用转化研究 上海市卫生和计划生育委员会 2016-01~2020-12 45万元 课题负责人
2016GGB14002 自体骨髓基质干细胞构建组织工程软骨修复 关节软骨缺损的基础研究及临床应用 山东省重点研发计划 2016-01~2018-12 10万元 课题负责人
** 人残耳软骨细胞体外构建人耳形态软骨及其体内转归 国家自然科学基金面上项目 2016-01~2019-12 58万元 课题负责人
15DZ** 组织工程耳廓形态软骨耳再造临床新技术 上海市科委产学研医合作 2015-07~2018-06 100万元 课题负责人
201501 泰山******** 山东省人民政府 2015-01~2020-12 200万元 课题负责人
** LOX激活及力学刺激提高体外构建软骨的力学强度 国家自然科学基金面上项目 2014-01~2017-12 70万元 课题负责人
13DZ** 临床组织工程技术平台设置标准研究 上海市科委标准专项课题 2013-07~2016-06 40万元 课题负责人
201214 组织工程化软骨的基础及临床转化研究 上海市领军人才后备队培养计划 2013-01~2015-12 30万元 课题负责人
2012AA020507 结构类组织的组织工程构建技术与产品开发 科技部，国家863计划重大课题 2012-01~2015-12 1294万元 子课题负责人
XBR** 基于体外构建技术的组织工程软骨临床应用转化 上海市卫生局，优秀学科带头人 2011-01~2015-12 100万元 课题负责人
NCET-09-0561 骨髓基质干细胞体外构建人耳廓形态软骨 教育部，新世纪优秀人才 2010-01~2012-12 50万元 课题负责人
** 骨髓基质干细胞体外构建人耳廓形态软骨 国家自然基金委,面上项目 2010-01~2012-12 35万元 课题负责人
09QH** 骨髓基质干细胞体外构建人耳廓形态软骨 上海市科委,启明星跟踪 2009-07~2011-06 20万元 课题负责人
** 组织工程功能支架材料及有序血管网络的构建 国家自然基金委,重点项目 2009-01~2012-12 180万元 子课题负责人
08SG19 应用干细胞体外构建个性化人耳廓形态软骨 上海市教育发展基金会 2009-01~2011-12 15万元 课题负责人
** 脂肪干细胞软骨潜能亚群的特异性分子标志 国家自然基金委,面上项目 2008-01~2010-12 28万元 课题负责人
2006AA02A126 基于成体干细胞体外构建的组织工程软骨产品研发 科技部，国家863计划重大课题 2006-12~2010-12 474万元 课题负责人
05QMX1427 脂肪干细胞生物学特性及纯化技术研究 上海市科委,启明星 2005-09~2008-09 10万元 课题负责人
2005CB522702 组织微环境对干细胞形成特定组织的影响及其作用机制 科技部，国家973计划课题 2005-09~2010-10 560万元 课题负责人
2002AA205021 组织微环境对干细胞形成组织工程化软骨构建的相关技术研究与产品开发 科技部，国家863计划重大课题 2002-11~2005-12 560万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Jia L,Zhang Y,Yao L,Zhang P,Ci Z, Zhang W,Miao C, Liang X, He A, Liu Y,Tang S, Zhang R,*Wang X, *Cao Y, *Zhou G （通讯作者） Regeneration of human-ear-shaped cartilage with acellular cartilage matrix-based biomimetic scaffolds Applied Materials Today 2020 20:p.10063
Xu Y,Jia L,Wang Z,Jiang G,*Zhou G （通讯作者）,*Chen W,*Chen R Injectable photo-crosslinking cartilage decellularized extracellular matrix for cartilage tissue regeneration Materials Letters 2020 268:127609
Chen W, Xu Y, Li Y, Jia L, *Mo X, *Jiang G, *Zhou G （通讯作者） 3D printing electrospinning fiber-reinforced decellularized extracellular matrix for cartilage regeneration Chemical Engineering Journal 2020 382: p. 122986
Xu Y,Guo Y, Li Y,Huo Y, She Y,Li H, Jia Z, Jiang G,*Zhou G （通讯作者）,* You Z,*Duan L Biomimetic Trachea Regeneration Using a Modular Ring Strategy Based on Poly(Sebacoyl Diglyceride)/ Polycaprolactone for Segmental Trachea Defect Repair.Advanced Functional Materials Biomimetic Trachea Regeneration Using a Modular Ring Strategy Based on Poly(Sebacoyl Diglyceride)/ Polycaprolactone for Segmental Trachea Defect Repair.Advanced Functional Materials 2020 **:P.1-14
Xu Y,Xu Y,Bi B, Hou M, Yao L, Du Q, He A,Liu Y, Miao C,Liang X,*Jiang X,*Zhou G （通讯作者）,*Cao Y A moldable thermosensitive hydroxypropyl chitin hydrogel for 3D cartilage regeneration in vitro and in vivo Acta Biomaterialia 2020 108:87-96
Yin Z,Li D,Liu Y,Feng S,Yao L,Liang X,Miao C,Xu Y,Hou M,Zhang R,Zhang W,Liu W,*Liu Y,*Zhou G （通讯作者）,*Cao Y Regeneration of elastic cartilage with accurate human-ear shape based on PCL strengthened biodegradable scaffold and expanded microtia chondrocytes. Applied Materials Today 2020 20:100724
Chen WM , Xu Y , Liu YQ,Wang ZX , Li YQ , Jiang GN , Mo XM ,Zhou （通讯作者）,GD Three-dimensional printed electrospun fiber-based scaffold for cartilage regeneration MATERIALS & DESIGN 2019 179(2019)107886
Liu Y,Xu Y,Zhang Z, Huo Y , Chen D , Ma W , Sun K , Tonga GY , *Zhou G （通讯作者）, Kohane DS , Tao K . A Simple, Yet Multifunctional, Nanoformulation for Eradicating Tumors and Preventing Recurrence with Safely Low Administration Dose Nano letters 2019 19(8):5515-5523
Li D, Yin Z, Liu Y , Feng S, Liu Y , Lu F , Xu Y , Min P , Hou M , Li K , He A , Zhang W , Liu W , *Zhang Y , *Zhou G ,*Cao Y . Regeneration of trachea graft with cartilage support, vascularization, and epithelization Acta biomaterialia 2019 89():206-216
Wang F, Hu Y, He D, Zhou G （通讯作者）, Edward III Ellis Scaffold-free cartilage cell sheet combined with bone-phase BMSCs-scaffold regenerate osteochondral construct in mini-pig model. Am J Transl Res 2018 10(10):2997-3010.
Xue J, He A, Zhu Y, Liu Y, Li D, Yin Z, Zhang W, Liu W, Cao Y, *Zhou G. （通讯作者） Repair of articular cartilage defects with acellular cartilage sheets in a swine model Biomed Mater 2018 13(2):025016
Zhang Y, Xu Y, Liu Y, Dan Li, Yin Z, Huo Y, Jiang G, Yang Y, Wang Z, Li Y, Lu F, Liu Y, *Duan L, *Zhou G. （通讯作者） Porous decellularized trachea scaffold prepared by a laser micropore technique J Mech Behav Biomed Mater 2018 90:96-103
Liu Y, Xu Y, Geng X, Huo Y, Chen D, *Sun K, *Zhou G （通讯作者）, Chen B, *Tao K. Synergistic Targeting and Efficient Photodynamic Therapy Based on Graphene Oxide Quantum Dot-Upconversion Nanocrystal Hybrid Nanoparticles Small 2018 14(19):e**
Xia H, Zhao D, Zhu H, Hua Y, Xiao K, Xu Y, Liu Y, Chen W, Liu Y, Zhang W, Liu W, Tang S, Cao Y, *Wang X, *Chen H, *Zhou G. （通讯作者） Lyophilized Scaffolds Fabricated from 3D-Printed Photocurable Natural Hydrogel for Cartilage Regeneration ACS Appl Mater Interfaces 2018 10(37):31704-31715.
Feng C, Luo X, He N, Xia H, Lv X, Zhang X, Li D, Wang F, He J, Zhang L, Lin X, Lin L, Yin H, He J, Wang J , Cao W, Wang R, *Zhou G （通讯作者）, *Wang W. . Efficacy and Persistence of Allogeneic Adipose-Derived Mesenchymal Stem Cells Combined with Hyaluronic Acid in Osteoarthritis After Intra-articular Injection in a Sheep Model Tissue Eng Part A. 2018 24(3-4):219-233
Zhou G, Jiang H, Yin Z, Liu Y, Zhang Q, Zhang C, Pan B, Zhou J, Zhou X, Sun H, Li D, He A, Zhang Z, Zhang W, Liu W, Cao Y. In Vitro Regeneration of Patient-specific Ear-shaped Cartilage and Its First Clinical Application for Auricular Reconstruction. EBioMedicine 2018 28:287-302.
He A, Xia H, Xiao K, Wang T, Liu Y, Xue J, Li D, Tang S, Liu F, *Wang X, Zhang W, Liu W, *Cao Y, *Zhou G. （通讯作者） Cell yield, chondrogenic potential, and regenerated cartilage type of chondrocytes derived from ear, nasoseptal, and costal cartilage J Tissue Eng Regen Med 2018 12(4):1123-1132
Wang H, Dai T, Li S, Zhou S, Yuan X, You J, Wang C, Mukwaya V, *Zhou G （通讯作者）, Liu G,Wei X, *Dou H. Scalable and cleavable polysaccharide nanocarriers for the delivery of chemotherapy drugs Acta Biomater 2018 72:206-216
Li D, Zhu L, Liu Y, Yin Z, Liu Y, Liu F, He A, Feng S, Zhang Y, Zhang Z, Zhang W, Liu W, Cao Y,*Zhou G （通讯作者） Stable subcutaneous cartilage regeneration of bone marrow stromal cells directed by chondrocyte sheet Acta Biomater 2017 54:321-332
Chen D, Tao R, Tao K, Chen B, Choi SK, Tian Q, Xu Y, *Zhou G （通讯作者）, *Sun K Efficacy Dependence of Photodynamic Therapy Mediated by Upconversion Nanoparticles: Subcellular Positioning and Irradiation Productivity Small 2017 13(13)
Xu Y, Li D, Yin Z, He A, Lin M, Jiang G, Song X, Hu X, Liu Y, Wang J, *Wang X, *Duan L, *Zhou G. （通讯作者） Tissue-engineered trachea regeneration using decellularized trachea matrix treated with laser micropore technique Acta Biomater 2017 58:113-121
He A, Liu L, Luo X, Liu Y, Liu Y, Liu F, Wang X*, Zhang Z, Zhang W, Liu W, *Cao Y,*Zhou G （通讯作者） Repair of osteochondral defects with in vitro engineered cartilage based on autologous bone marrow stromal cells in a swine model Scientific Reports 2017 7:40489
Feng C, Luo X, He N, Xia H, Lv X, Zhang X, Li D, Wang F, He J, Zhang L, Lin X, Lin L, Yin H, He J, Wang J, Cao W, Wang R,*Zhou G （通讯作者）, *Wang W Efficacy and persistence of allogeneic adipose-derived mesenchymal stem cells combined with hyaluronic acid in osteoarthritis after intra-articular injection in a sheep model Tissue Eng Part A 2017 1-36
Wang H, Dai T, Zhou S, Huang X, Li S, Sun K,*Zhou G （通讯作者）, *Dou H Self-Assembly Assisted Fabrication of Dextran-Based Nanohydrogels with Reduction-Cleavable Junctions for Applications as Efficient Drug Delivery Systems Sci Rep 2017 7:40011
Chen J,Yuan Z, Liu Y, Zheng R, Dai Y, Tao R, Xia H, Liu H, Zhang Z, Zhang W, Liu W, Cao Y, *Zhou G （通讯作者） Improvement of In Vitro Three-Dimensional Cartilage Regeneration by a Novel Hydrostatic Pressure Bioreactor Stem Cells Transl Med 2016 6(3):982-991
Liao HT, Zheng R, Liu W, Zhang WJ, *Cao Y, *Zhou G. （通讯作者） Prefabricated, Ear-shaped Cartilage Tissue Engineering by Scaffold-free Porcine Chondrocytes Membrane Plast Reconstr Surg 2015 135(2): 313-321
Zhu Y, Zhang Y, Liu Y, Tao R, Xia H, Zheng R, Shi Y, Tang S, Zhang W, Liu W, *Cao Y, *Zhou G. （通讯作者） Influence of Chm-I knockout on ectopic cartilage regeneration and homeostasis maintenance Tissue Eng Part A 2015 21(3-4):782-792
Dai T, Zhou S, Yin C, Li S, Cao W, Liu W, Sun K, *Dou H, *Cao Y, *Zhou G. Dextran-based fluorescent nanoprobes for sentinel lymph node mapping Biomaterials 2014 35(28):8227-35
Zhang L, He A, Yin Z, Yu Z, Luo X, Liu W, Zhang W, Cao Y, *Liu Y, *Zhou G （通讯作者） Regeneration of human-ear-shaped cartilage by co-culturing human microtia chondrocytes with BMSCs Biomaterials 2014 35(18):4878-87
Luo X, Liu Y, Zhang Z, Tao R, Liu Y, He A, Yin Z, Li D, Zhang W, Liu W, *Cao Y, *Zhou G. （通讯作者） Long-term functional reconstruction of segmental tracheal defect by pedicled tissue-engineered trachea in rabbits Biomaterials 2013 34(13):3336-44
Ding C, Qiao Z, Jiang W, Li H, Wei J,* Zhou G （通讯作者）, *Dai K Regeneration of a goat femoral head using a tissue-specific, biphasic scaffold fabricated with CAD/CAM technology. Biomaterials 2013 34(28):6706-16
Zheng R, Duan H, Xue J, Liu Y, Feng B, Zhao S, Zhu Y, Liu Y, He A, Zhang W, Liu W, *Cao Y, *Zhou G. （通讯作者） The influence of Gelatin/PCL ratio and 3-D construct shape of electrospun membranes on cartilage regeneration Biomaterials 2013 35(1):152-64
Zhang Y, Yang F, Liu K, Shen H, Zhu Y, Zhang W, Liu W, Wang S, Cao Y, Zhou G. （通讯作者） The impact of PLGA scaffold orientation on in vitro cartilage regeneration. Biomaterials. 2012 33(10):2926-35
Spiller KL, Liu Y, Holloway JL, Maher SA, Cao Y, Liu W, *Zhou G （通讯作者）, Lowman AM A novel method for the direct fabrication of growth factor-loaded microspheres within porous PVA hydrogels: Controlled release for cartilage tissue engineering. J Control Release. 2012 157(1):39-45
Jiang Y, Liu H, Li H, Wang F, Cheng K, Zhou G, Zhang W, Ye M, Cao Y, Liu W, Zou H. A proteomic analysis of engineered tendon formation under dynamic mechanical loading in vitro. Biomaterials. 2011 32(17):4085-95.
Sun H, Liu W, Zhou G, Zhang W, Cui L, Cao Y. Tissue engineering of cartilage, tendon and bone. Front Med. 2011 5(1):61-9.
Gong YY, Xue JX, Zhang WJ, Zhou G, Liu W, Cao Y. A sandwich model for engineering cartilage with acellular cartilage sheets and chondrocytes. Biomaterials. 2011 32(9):2265-73.
Li Q, Liu T, Zhang L, Liu Y, Zhang W, Liu W, Cao Y, *Zhou G. （通讯作者） The role of bFGF in down-regulating α-SMA expression of chondrogenically induced BMSCs and preventing the shrinkage of BMSC engineered cartilage. Biomaterials. 2011 32(21):4773-81.
Liu Y, Zhang L, Zhou G （共同第一作者）, Li Q, Liu W, Yu Z, Luo X, Jiang T, Zhang W, Cao Y. In vitro engineering of human ear-shaped cartilage assisted with CAD/CAM technology Biomaterials 2010 31(8):2176-83
Yue W, Pi QM, Zhang WJ, Zhou G, Cui L, Liu W, Cao Y. Platelet endothelial cell adhesion molecule-1, stage-specific embryonic antigen-1, and Flk-1 mark distinct populations of mouse embryonic stem cells during differentiation toward hematopoietic/endothelial cells. Stem Cells Dev. 2010 19(12):1937-48.
Zhu J, Li J, Wang B, Zhang WJ, Zhou G, Cao Y, Liu W. The regulation of phenotype of cultured tenocytes by microgrooved surface structure. Biomaterials. 2010 31(27):6952-6958.
Liu X, Sun H, Yan D, Zhang L, Lv X, Liu T, Zhang W, Liu W, Cao Y, Zhou G. （通讯作者） In vivo ectopic chondrogenesis of BMSCs directed by mature chondrocytes. Biomaterials. 2010 31(36):9406-14
Wu Y, Zhu L, Jiang H, Liu W, Liu Y, Cao Y, Zhou G. （通讯作者） Engineering cartilage substitute with a specific size and shape using porous high-density polyethylene (HDPE) as internal support. J Plast Reconstr Aesthet Surg. 2010 63(4):e370-5.
Dai T, Jiang Z, Li S, Zhou G, Kretlow JD, Cao W, Liu W, Cao Y. Reconstruction of lymph vessel by lymphatic endothelial cells combined with polyglycolic acid scaffolds: a pilot study. J Biotechnol. 2010 150(1):182-9.
Jiang T, Liu W, Lv X, Sun H, Zhang L, Liu Y, Zhang WJ, Cao Y, Zhou G （通讯作者） Potent in vitro chondrogenesis of CD105 enriched human adipose-derived stem cells. Biomaterials 2010 31(13):3564-71
Zhu L, Wu Y, Jiang H, Liu W, Cao Y, Zhou G. （通讯作者） Engineered cartilage with internal porous high-density polyethylene support from bone marrow stromal cells: A preliminary study in nude mice. Br J Oral Maxillofac Surg. 2010 48(6):462-5.
Luo X, Zhou G （通讯作者）, Liu W, Zhang WJ, Cen L, Cui L, Cao Y In vitro precultivation alleviates post-implantation inflammation and enhances development of tissue-engineered tubular cartilage. Biomed Mater. 2009 4(2):025006.
Yan D, Zhou G （通讯作者）, Zhou X, Liu W, Zhang WJ, Luo X, Zhang L, Jiang T, Cui L, Cao Y. The impact of low levels of collagen IX and pyridinoline on the mechanical properties of in vitro engineered cartilage. Biomaterials. 2009 30(5):814-21.
Liu K, Zhou G （共同第一作者）, Liu W, Zhang WJ, Cui L, Liu X, Liu TY, Cao Y. The dependence of in vivo stable ectopic chondrogenesis by human mesenchymal stem cells on chondrogenic differentiation in vitro. Biomaterials. 2008 29(14):2183-92.
Liu K, Zhou G （共同第一作者）, Liu W, Zhang WJ, Cui L, Liu X, Liu TY, Cao Y. In vitro formation of lacuna structure by human dermal fibroblasts co-cultured with porcine chondrocytes on a 3D biodegradable scaffold. Biotechnol Lett. 2007 29(11):1685-90.
Zhou G, Liu W, Cui L, Wang X, Liu T, Cao Y. Repair of porcine articular osteochondral defects in non-weightbearing areas with autologous bone marrow stromal cells. Tissue Eng. 2006 12(11):3209-21
Lu M, Zhou G （通讯作者）, Liu W, Wang Z, Zhu Y, Yu B, Zhang W, Cao Y. Remodeling of buccal mucosa by bladder microenvironment. Key Eng Mater. 2005 3(6): 288-289