导师姓名： 张文杰 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属第九人民医院 三级学科/
专业领域： 整形
导师类型： 博士生导师 专业学位导师：
联系方式： wenjieboshi@aliyun.com
邮编： wenjieboshi@aliyun.com 邮箱地址： wenjieboshi@yahoo.com.cn

研究方向 (点击浏览详细信息)
干细胞分化、再生医学

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
2019CXJQ01 重大疾病的干细胞治疗研发与临床转化体系建立 上海市卫生计生委 2019-01~2023-12 1000万元 课题负责人
** miR-21在间充质干细胞来源微泡促血管生成中的作用与机制研究 国家自然科学基金面上项目 2018-01~2021-12 55万元 课题负责人
2016YFC** 人类器官的构建及工程化技术体系建立 国家重点研发计划 2016-07~2020-12 50万元 子课题负责人
15JC** 基于纳米探针和双模式成像动态监测体内PLGA降解与骨再生的研究 上海市科学技术委员会 2015-09~2018-08 50万元 课题负责人
** 局部高密度培养扩增骨髓血管内皮祖细胞及其机理 国家自然科学基金面上项目 2013-01~2016-12 75万元 课题负责人
** 基于 PECAM-1 标记的全能性干细胞研究 国家自然科学基金，面上项目 2012-01~2015-12 60万元 课题负责人
2011CB964704 基于干细胞的骨质疏松治疗和相关骨再生机理 国家重点基础研究发展计划 2011-01~2015-08 348万元 子课题负责人
应用脐带血干细胞修复骨组织缺损研究 上海市科委,国际合作 2007-12~2010-12 15万元 课题负责人
** 共培养诱导人胚胎干细胞向软骨细胞分化作用与机制 国家自然基金委,面上项目 2007-01~2009-12 30万元 课题负责人
06SG22 利用骨髓来源干细胞构建组织工程化血管 上海市教委,曙光计划 2007-01~2009-12 12万元 课题负责人
** 利用胚胎干细胞体外构建组织工程化血管 国家自然基金委,面上项目 2006-01~2008-12 28万元 课题负责人
05PJ14054 诱导分化人胚胎干细胞构建组织工程化软骨 上海市科委,浦江人才 2005-12~2007-09 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Deng M, Wang X, Yu Z, Cai Y, Liu W, Zhou G, Wang X, Yu Z, Li W, Zhang WJ. （通讯作者） Cell-free fat extract promotes tissue regeneration in a tissue expansion model. Stem Cell Res Ther. 2020 11(1):50.
Wang X, Ai A, Yu Z, Deng M, Liu W, Zhou G, Li W, Zhang W （通讯作者）, Cao Y, Wang X. Dual-modal non-invasive imaging in vitro and in vivo monitoring degradation of PLGA scaffold based gold nanoclusters. Mater Sci Eng C Mater Biol App 2020 2020, 107:110307
Xu Y, Deng M, Cai Y, Zheng H, Wang X, Yu Z, Zhang W （通讯作者）, Li W. Cell-Free Fat Extract Increases Dermal Thickness by Enhancing Angiogenesis and Extracellular Matrix Production in Nude Mice. Aesthet Surg J. 2020 40(8):904-913
Hongjie Zheng, Ziyou Yu, Mingwu Deng, Yizuo Cai, Xiangsheng Wang, Yuda Xu, Lu Zhang, Wenjie Zhang and Wei Li. （通讯作者） Fat extract improves fat graft survival via proangiogenic, anti-apoptotic and pro-proliferative activities. Stem Cell Res Ther. 2019 2019, 10(1): 174.
Deng M, Xu Y, Yu Z, Wang X, Cai Y, Zheng H, Li W, Zhang W. （通讯作者） Protective Effect of Fat Extract on UVB-Induced Photoaging In Vitro and In Vivo. Oxid Med Cell Longev. 2019 2019:**
Cai Y, Yu Z, Yu Q, Zheng H, Xu Y, Deng M, Wang X, Zhang L, Zhang W （通讯作者）, Li W. Fat Extract Improves Random Pattern Skin Flap Survival in a Rat Model. Aesthet Surg J. 2019 39(12):NP504-NP514
Yu Z, Witman N, Wang W, Li D, Yan B, Deng M, Wang X, Wang H, Zhou G, Liu W, Sahara M, Cao Y, Fritsche-Danielson R, Zhang W （通讯作者）, Fu W, Chien KR. Cell-mediated delivery of VEGF modified mRNA enhances blood vessel regeneration and ameliorates murine critical limb ischemia. J Control Release. 2019 310:103-114
Mingwu Deng, Dong Li, Yichen Zhang, Guangdong Zhou, Wei Liu, Yilin Cao, Wenjie Zhang. （通讯作者） Protective effect of crocin on ultraviolet B-induced dermal fibroblast photoaging. Mol Med Rep. 2018 2018 Aug; 18(2): 1439–1446.
Qian Yu, Yizuo Cai, He Huang, Zhenxing Wang, Peng Xu, Xiangsheng Wang, Lu Zhang, Wenjie Zhang, Wei Li. Co-Transplantation of Nanofat Enhances Neovascularization and Fat Graft Survival in Nude Mice. Aesthetic Surgery Journal. 2018 2018;38(6):667-675
Ziyou Yu, Yizuo Cai, Mingwu Deng, Dong Li, Xiangsheng Wang, Hongjie Zheng, Yuda Xu, Wei Li, Wenjie Zhang. （通讯作者） Fat extract promotes angiogenesis in a murine model of limb ischemia: a novel cell-free therapeutic strategy. Stem Cell Res Ther. 2018 2018; 9: 294
Dong Li, Mingwu Deng, Ziyou Yu, Wei Liu, Guangdong Zhou, Wei Li, Xiansong Wang , Da-Peng Yang , and Wenjie Zhang. （通讯作者） Biocompatible and Stable GO-Coated Fe3O4 Nanocomposite: A Robust Drug Delivery Carrier for Simultaneous Tumor MR Imaging and Targeted Therapy. ACS Biomater. Sci. Eng. 2018 2018, 4, 2143?2154
Peng Xu, Qian Yu, Huizhen Huang, Wen Jie Zhang* （通讯作者）, Wei Li*. Nanofat increases dermis thickness and neovascularization in photoaged nude mouse skin. Aesthetic Plastic Surgery. 2018 2018;42:343-351.
Ziyou Yu, Yizuo Cai, Mingwu Deng, Dong Li, Xiangsheng Wang, Hongjie Zheng, Yuda Xu, Wei Li, Wenjie Zhang. （通讯作者） Fat extract promotes angiogenesis in a murine model of limb ischemia: a novel cell-free therapeutic strategy. Stem Cell Res Ther. 2018 2018; 9: 294.
Hui Xie, Zhenxing Wang, Liming Zhang, Qian Lei, Aiqi Zhao, Hongxiang Wang, Qiubai Li, Yilin Cao, Wen Jie Zhang （通讯作者）, Zhichao Chen. Extracellular Vesicle-functionalized Decalcified Bone Matrix Scaffolds with Enhanced Pro-angiogenic and Pro-bone Regeneration Activities. Sci Rep. 2017 2017; 7: 45622.
He Huang, Da-Peng Yang, Minghuan Liu, Xiangsheng Wang, Zhiyong Zhang, Guangdong Zhou, Wei Liu, Yilin Cao, Wen Jie Zhang （通讯作者）, Xiansong Wang . pH-sensitive Au–BSA–DOX–FA nanocomposites for combined CT imaging and targeted drug delivery. Int J Nanomedicine. 2017 2017; 12: 2829–2843.
He Huang, Shaoqing Feng, Wenjie Zhang （通讯作者）, Wei Li, Peng Xu, Xiangsheng Wang, Ai Ai. Bone marrow mesenchymal stem cell-derived extracellular vesicles improve the survival of transplanted fat grafts. Mol Med Rep. 2017 2017 Sep; 16(3): 3069–3078.
Xie H, Wang Z, Zhang L, Lei Q, Zhao A, Wang H, Li Q, Chen Z, Zhang W. （通讯作者） Development of an angiogenesis-promoting microvesicle-alginate-polycaprolactone composite graft for bone tissue engineering applications. Peer J. 2016 2016;4:e2040.
Xu P, Lu Y, Wang Z, Lian J, Zhou G, Liu W, Cao Y, Zhang WJ. （通讯作者） Comparison of Bone Marrow-derived Mononuclear Cells vs. Mesenchymal Stem Cells in Protecting Random-pattern Skin Flap Survival in Rats. J Stem Cell Res Ther. 2016 2016;6: 355.
Feng S, Chen J, Wo Y, Li Y, Chen S, Zhang Y, Zhang W. （通讯作者） Real-time and long-time in vivo imaging in the shortwave infrared window of perforator vessels for more precise evaluation of flap perfusion. Biomaterials. 2016 2016;103:256-64.
Ma XY, Zhang Y, Zhu D, Lu Y, Zhou G, Liu W, Cao Y, Zhang WJ. （通讯作者） Corneal Stroma Regeneration with Acellular Corneal Stroma Sheets and Keratocytes in a Rabbit Model. PLoS One 2015 10(7):e**
Fu X, Chen Y, Xie FN, Dong P, Liu WB, Cao Y, Zhang WJ （通讯作者）, Xiao R. Comparison of immunological characteristics of mesenchymal stem cells derived from human embryonic stem cells and bone marrow. Tissue Eng Part A. 2015 21(3-4):616-26
Wang ZX, Chen C, Zhou Q, Wang XS, Zhou G, Liu W, Zhang ZY, Cao Y, Zhang WJ. （通讯作者） The Treatment Efficacy of Bone Tissue Engineering Strategy for Repairing Segmental Bone Defects Under Osteoporotic Conditions. Tissue Eng Part A 2015 21(17-18):2346-55
Lu Y, Gong Y, Lian J, Wang L, Kretlow JD, Zhou G, Cao Y, Liu W, Zhang WJ. （通讯作者） Expansion of endothelial progenitor cells in high density dot culture of rat bone marrow cells. PLoS One. 2014 9(9):e107127
Lian J, Lu Y, Xu P, Ai A, Zhou G, Liu W, Cao Y, Zhang WJ. （通讯作者） Prevention of liver fibrosis by intrasplenic injection of high-density cultured bone marrow cells in a rat chronic liver injury model. PLoS One. 2014 9(9):e103603
Xue J, Feng B, Zheng R, Lu Y, Zhou G, Liu W, Cao Y, Zhang Y, Zhang WJ. （通讯作者） Engineering ear-shaped cartilage using electrospun fibrous membranes of gelatin/polycaprolactone. Biomaterials. 2013 34(11):2624-31.
Duan H, Feng B, Guo X, Wang J, Zhao L, Zhou G, Liu W, Cao Y, Zhang WJ. （通讯作者） Engineering of epidermis skin grafts using electrospun nanofibrous gelatin/ polycaprolactone membranes. Int J Nanomedicine 2013 8:2077-84
Fu W, Wang SJ, Zhou GD, Liu W, Cao Y, Zhang WJ. （通讯作者） Residual Undifferentiated Cells During Differentiation of Induced Pluripotent Stem Cells In Vitro and In Vivo. Stem Cells Dev. 2012 21(4):521-9
Xue JX, Gong YY, Zhou GD, Liu W, Cao Y, Zhang WJ. （通讯作者） Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells induced by acellular cartilage sheets. Biomaterials 2012 33(24):5832-40
Chen Y, Ai A, Tang ZY, Zhou GD, Liu W, Cao Y, Zhang WJ. （通讯作者） Mesenchymal-Like Stem Cells Derived from Human Parthenogenetic Embryonic Stem Cells. Stem Cells Dev. 2012 21(1):143-51
Gong YY, Xue JX, Zhang WJ （通讯作者）, Zhou GD, Liu W, Cao Y. A sandwich model for engineering cartilage with acellular cartilage sheets and chondrocytes. Biomaterials. 2011 32(9):2265-73
Pi QM, Zhang WJ （通讯作者）, Zhou GD, Liu W, Cao Y. Degradation or excretion of quantum dots in mouse embryonic stem cells. BMC Biotechnol. 2010
Bi D, Chen FG, Zhang WJ （通讯作者）, Zhou GD, Cui L, Liu W, Cao Y. Differentiation of human multipotent dermal fibroblasts into islet-like cell clusters. BMC Cell Biol. 2010
Yue W, Pi QM, Zhang WJ （通讯作者）, Zhou GD, Cui L, Liu W, Cao Y. PECAM-1, SSEA-1 and Flk-1 mark distinct populations of mouse embryonic stem cells during differentiation towards hematopoietic/endothelial cells. Stem Cells Dev. 2010 19(12):1937-48
Zhang YQ, Zhang WJ （共同第一作者）, Lui W, Zhou GD, Cui L, Cao Y. Tissue engineering of corneal stroma layer with dermal fibroblasts: phenotypic and functional switch of differentiated cells in cornea. Tissue Eng Part A 2008 14(2):295-303
Xu ZC, Zhang WJ （共同第一作者）, Li H, Cui L, Cen L, Zhou GD, Liu W, Cao Y. Engineering of an elastic large muscular vessel wall with pulsatile stimulation in bioreactor. Biomaterials. 2008 29(10):1464-72
Zhang WJ （共同第一作者）, Lui W, Cui L, Cao Y. Tissue engineering of blood vessel. J Cell Mol Med 2007 11(5):945-57
Chen FG, Zhang WJ （共同第一作者）, Bi D, Liu W, Wei X, Chen FF, Zhu L, Cui L, Cao Y. Clonal analysis of nestin- vimentin+ multipotent fibroblasts isolated from human dermis. J Cell Sci 2007 120:2875-2883
Wu CF, Tsung HC, Zhang WJ （共同第一作者）, Wang Y, Lu JH, Tang ZY, Kuang YP, Jin W, Cui L, Liu W, Cao YL. Improved cryopreservation of human embryonic stem cells with trehalose. 2005, . Reproductive Biomedicine Online 2005 11(6): 733-739