导师姓名： 刘伟 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属第九人民医院 三级学科/
专业领域： 整形
导师类型： 博士生导师 专业学位导师： 兼
联系方式： liuwei_md@126.com
邮编： 200011 邮箱地址： liuwei_md@yahoo.com.cn

研究方向 (点击浏览详细信息)
组织工程研究，瘢痕研究和治疗

社会任职
上海市整形外科研究所副所长,中华整形外科杂志编委,中国生物医学工程学会组织工程分会副主任委员,中国生物材料委员会委员，中国解剖学会再生医学分会副主任委员，国际组织工程与再生医学学会(TERMIS) Member at large, Biomaterials 和 Journal of Tissue Engineering and Regenerative Medicine杂志编委, Tissue Engineering”杂志特刊编辑。Scar Club学术委员会委员， Founding Member of Global Scar Society, Fellow of Interntional Union Society of Biomeaterials Science and Technology

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 模拟肌腱发育时空调控机制促进组织工程肌腱胶原合成与重塑 国家自然基金面上项目 2019-01~2022-12 59万元 课题负责人
2018YFC** 生物力学调控组织再生核心技术研发及其临床应用转化 科技部2018年国家重点研发计划 2018-09~2021-07 1173万元 课题负责人
** 基于全基因组、转录组和甲基化测序的瘢痕疙瘩易感基因探索研究 2017年国家自然科学基金面上项目 2017-01~2020-12 52万元 课题负责人
瘢痕诊断分类及危险评估的临床研究 瘢痕诊断分类及危险评估的临床研究 瘢痕诊断分类及危险评估的临床研究 瘢痕诊断分类及危险评估的临床研究 2015年国家卫计委公益性行业基金 2015-06~2018-12 23万元 课题参与人
** 肌腱细胞外基质和拓扑结构诱导人脂肪干细胞成肌腱分化的实验研究 国家自然基金面上项目 2015-01~2018-12 90万元 课题负责人
2012AA020507 结构类组织的组织工程构建技术与产品研发 科技部863 2012-01~2015-12 1200万元 课题负责人
** 模拟肌腱细胞形态和力学微环境诱导ASC 成肌腱分化及机制 国家自然科学基金 2012-01~2015-12 60万元 课题负责人
** 细胞形态和力学刺激在皮肤成纤维细胞向肌腱细胞转分化中的作用及其分子机制 国家自然科学基金 2011-01~2014-12 35万元 课题负责人
** 阻断转化生长因子-beta 效应联合干细胞移植促进伤口皮肤再生 国家自然基金委,面上项目 2009-01~2011-12 34万元 课题负责人
2006AA02A127 组织工程肌腱体外构建及产品研制与开发 科技部863 2006-12~2010-12 450万元 课题负责人
2005CB522703 生物力学调节细胞分化和促进工程化组织形成的机理 科技部973子课题 2005-10~2010-09 450万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
刘伟 （通讯作者） 瘢痕疙瘩发生和发展的整体观机制探讨 组织工程与重建外科 2018 14（4）：181-183
Li Q, Zhang W, Zhou G, Cao Y, Liu W （通讯作者）, Zhang ZY. Demineralized bone matrix-based microcarrier scaffold favors vascularized large bone regeneration in vivo in a rat model. J Biomater Appl. 2018 33(2):182-195.
中国整形美容协会瘢痕医学分会常务委员会专家组 （通讯作者） 中国瘢痕疙瘩临床治疗推荐指南 中国整形美容外科杂志 2018 29（5）：前插1-5
Deng J, Shi Y, Gao Z, Zhang W, Wu X, Cao W, Liu W. （通讯作者） Inhibition of Pathological Phenotype of Hypertrophic Scar Fibroblasts Via Coculture with Adipose-Derived Stem Cells. Tissue Eng Part A. 2018 24(5-6):382-393.
Zhou K, Feng B, Wang W, Jiang Y, Zhang W, Zhou G, Jiang T, Cao Y, Liu W. （通讯作者） Nanoscaled and microscaled parallel topography promotes tenogenic differentiation of ASC and neotendon formation in vitro. Int J Nanomedicine. 2018 4;13:3867-3881.
Wang W, Deng D, Wang B, Zhou G, Zhang W, Cao Y, Zhang P, Liu W. （通讯作者） Comparison of Autologous, Allogeneic, and Cell-Free Scaffold Approaches for Engineered Tendon Repair in a Rabbit Model-A Pilot Study. Tissue Eng Part A, 2017 2017 DOI: 10.1089/ten.tea.2016.0447
Liu K, Gao Z, Zhou G, Zhang W, Wu X, Liu W. （通讯作者） Characterization of Smad3 knockout mouse derived skin cells. In Vitro Cell Dev Biol Anim. 2017 ;53(5):458-466
Lin X, Wang W, Zhang W, Zhang Z, Zhou G, Cao Y, Liu W （通讯作者） Hyaluronic acid coating enhances biocompatibility of non-woven PGA scaffold and cartilage formation. Tissue Eng Part C, 2017 23(2):86-97.
Shi Y, Zhou K, Zhang W, Zhang Z, Zhou G, Cao Y, Liu W. （通讯作者） Microgrooved topographical surface directs tenogenic lineage specific differentiation of mouse tendon derived stem cells. Biomed Mater. 2017 12(1):015013.
Shi Y, Xiong Y, Jiang Y, Zhang Z, Zhou G, Zhang W, Cao Y, He J, Liu W. （通讯作者） Conditional tenomodulin overexpression favors tenogenic lineage differentiation of transgenic mouse derived cells. Gene. 2017 598:9-19.
Deng J, Shi Y, Gao Z, Zhang W, Wu X, Cao W, Liu W. （通讯作者） Inhibition of Pathological Phenotype of Hypertrophic Scar Fibroblasts Via Coculture with Adipose-Derived Stem Cells Tissue Eng Part A, 2017 2017 DOI: 10.1089/ten.tea.2016.0550
Jiang Y, Shi Y, He J, Zhang Z, Zhou G, Zhang W, Cao Y, Liu W （通讯作者） Enhanced tenogenic differentiation and tendon-like tissue formation by tenomodulin overexpression in murine mesenchymal stem cells. J Tissue Eng Regen Med. 2016 2016 Apr 21. doi: 10.1002/term
Wang W, Qu M, Xu L, Wu X, Gao Z, Gu T, Zhang W, Ding X, Liu W （共同第一作者）, Chen YL Sorafenib exerts an anti-keloid activity by antagonizing TGF-β/Smad and MAPK/ERK signaling pathways. J Mol Med (Berl). 2016 94(10):1181-1194.
Wang W, Li J, Wang K, Zhang Z, Zhang W, Zhou G, Cao Y, Ye M, Zou H, Liu W （通讯作者） Induction of predominant tenogenic phenotype in human dermal fibroblasts via synergistic effect of TGF-β and elongated cell shape. Am J Physiol Cell Physiol. 2016 310(5):C357-72.
Wang W, He J, Feng B, Zhang Z, Zhang W, Zhou G, Cao Y, Fu W, Liu W. （通讯作者） Aligned nanofibers direct human dermal fibroblasts to tenogenic phenotype in vitro and enhance tendon regeneration in vivo. Nanomedicine (Lond). 2016 11(9):1055-72.
Lin X, Shi Y, Cao Y, Liu W. （通讯作者） Recent progress in stem cell differentiation directed by material and mechanical cues. Biomed Mater. 2016 ;11(1):014109.
Huang J, Lin X, Shi Y, Liu W. （通讯作者） Tissue engineering and regenerative medicine in basic research: a year in review of 2014. Tissue Eng Part B Rev 2015 21(2):167-76
Lin X, Huang J, Shi Y, Liu W. （通讯作者） Tissue engineering and regenerative medicine in applied research: a year in review of 2014. Tissue Eng Part B 2015 ;21(2):177-86
Wang W, He A, Zhang Z, Zhang W, Zhou G, Cao Y, Liu W. （通讯作者） Induction of transient tenogenic phenotype of high-density cultured human dermal fibroblasts. Connect Tissue Res 2015 56(4):288-99
Xiong Y, He J, Zhang W, Zhou G, Cao Y, Liu W. （通讯作者） Retention of the stemness of mouse adipose-derived stem cells by their expansion on human bone marrow stromal cell-derived extracellular matrix. Tissue Eng Part A. 2015 21(11-12):1886-94
Wang X, Gao Z, Wu X, Zhang W, Zhou G, Liu W. （通讯作者） Inhibitory effect of TGF-β peptide antagonist on the fibrotic phenotype of human hypertrophic scar fibroblasts. Pharm Biol 2015 2:1-9
Liu W （通讯作者）, Burdick JA, van Osch GJ. egulation Policy on Tissue Engineering and Regenerative Medicine in Asian-Pacific Region. Tissue Eng Part A. 2015 21(23-24):2779-80.
Deng D, Wang W, Wang B, Zhang P, Zhou G, Zhang WJ, Cao Y, Liu W. （通讯作者） Repair of Achilles tendon defect with autologous ASCs engineered tendon in a rabbit model. Biomaterials 2014 35(31):8801-9
Xiong Y, He J, Zhang W, Zhou G, Cao Y, Liu W. （通讯作者） Potent Osteogenesis and Chondrogenesis of CD34-Enriched Mouse Adipose-Derived Stem Cells. J Med Bio Eng 2014 34:230-237
Deng D, Liu W （通讯作者）, Cheema U, Mudera V, Hadjipanayi E, Brown RA. Less is more: new biomimetic approach to control spatial and temporal cell loading for tissue engineering. J Biomed Mater Res A. 2014 102(11):4108-17
Liu K, Gao Z, Wu X, Zhou G, Zhang WJ, Yang X, Liu W. （通讯作者） Knocking out Smad3 favors allogeneic mouse fetal skin development in adult wounds. Wound Repair Regen. 2014 ;22(2):265-71
Qu M, Song N, Chai G, Wu X, Liu W （通讯作者） Pathological niche environment transforms dermal stem cells to keloid stem cells: A hypothesis of keloid formation and development. Med Hypotheses. 2013 81(5):807-12
Chen B, Wang B, Zhang WJ, Zhou G, Cao Y, Liu W. （通讯作者） Macromolecular Crowding Effect on Cartilaginous Matrix Production: A Comparison of Two-Dimensional and Three-Dimensional Models Tissue Eng Part C 2013 19(8):586-95
Liu W （通讯作者）, Burdick JA, van Osch GJ. Plant-derived recombinant human collagen: a strategic approach for generating safe human ECM-based scaffold. Tissue Eng Part A 2013 19(13-14):1489-90
He J, Duan H, Xiong Y, Zhang W, Zhou G, Cao Y, Liu W （通讯作者） Potent osteogenesis and chondrogenesis of CD34-enriched mouse adipose-derived stem cells Mol Med Rep 2013 7(4):1111-6
Wang W, Deng D, Li J, Liu W. （通讯作者） Elongated cell morphology and uniaxial mechanical stretch contribute to physical attributes of niche environment for MSC tenogenic differentiation. Cell Biol Int 2013 37(7):755-60
Chen B, Wang B, Zhang WJ, Zhou G, Cao Y, Liu W. （通讯作者） In vivo tendon engineering with skeletal muscle derived cells in a mouse model Biomaterials 2012 33(26):6086-97
Xia L, Liu Q, Zhang W, Zhou G, Cao Y, Liu W. （通讯作者） Enhanced proliferation and functions of in vitro expanded human hair follicle outer root sheath cells by low oxygen tension culture Tissue Eng Part C Methods 2012 18(8):603-13
Zhang Y, Li J, Zhu J, Zhou G, Zhang WJ, Cao Y, Liu W. （通讯作者） Enhanced cartilage formation by inhibiting cathepsin K expression in chondrocytes expanded in vitro. Biomaterials 2012 33(30):7394-404
Yuan J, Cao Y, Liu W （通讯作者） Biomimetic scaffolds: implications for craniofacial regeneration J Craniofac Surg 2012 23(1):294-7
Song N, Wu X, Gao Z, Zhou G, Zhang WJ, Liu W. （通讯作者） Enhanced expression of membrane transporter and drug resistance in keloid fibroblasts Hum Pathol 2012 43(11):2024-32
Jiang Y, Liu H, Li H, Wang F, Cheng K, Zhou G, Zhang W, Ye M, Cao Y, Liu W （通讯作者）, Zou H. A proteomic analysis of engineered tendon formation under dynamic mechanical loading in vitro. Biomaterials. 2011 32(17):4085-95.
Xia L, Liu Q, Zhou G, Zhang W, Cao Y, Liu W （通讯作者） A proteomic analysis of engineered Mouse out root sheath cells cultured on E-cadherin-coateddishes exhibit neuronal cell morphology Asia-Pacific J Chem Eng ING 2011 6: 816–822
Liu W （通讯作者）, Wu X, Gao Z. New potential antiscarring approaches. Wound Repair Regen. 2011 19 Suppl 1:s22-31
Zhu J, Li J, Wang B, Zhang WJ, Zhou G, Cao Y, Liu W. （通讯作者） Enhanced proliferation capacity of The regulation of phenotype of cultured tenocytes by microgrooved surface structure. Biomaterials. 2010 31(27):6952-6958
Hu K, Shi H, Zhu J, Deng D, Zhou G, Zhang W, Cao Y, Liu W. （通讯作者） Compressed collagen gel as the scaffold for skin engineering. Biomed Microdevices. 2010 12(4):627-35.
Gao Z, Wu X, Song N, Zhang L, Liu W. （通讯作者） Engineering human neo-tendon tissue in Differential expression of growth differentiation factor-9 inkeloids Burns 2010 36(8):1289-95
Liu W. （通讯作者） Engineered in vitro models of tumor angiogenesis: introduction to a new special issue format of Tissue Engineering. Tissue Eng Part A. 2010 16(7):2129-31.
Xu L, Cao D, Liu W （通讯作者）, Zhou G, Zhang WJ, Cao Y. Engineered in vitro models of tumor angiogenesis: introduction to a new In vivo engineering of a functional tendon sheath in a hen model. Tissue Eng Part A. 2010 31(14):3894-902.
Zhang Y, Wang B, Zhang WJ, Zhou G, Cao Y, Liu W. （通讯作者） Enhanced proliferation capacity of porcine tenocytes in low O(2) tension culture. Biotechnol Lett. 2010 32(2):181-7.
Deng D, Liu W （通讯作者）, Xu F, Yang Y, Zhou G, Zhang WJ, Cui L, Cao Y. Engineering human neo-tendon tissue in vitro with human dermal fibroblasts under static mechanical strain. Biomaterials 2009 30(35):6724-30.