导师姓名： 赵杰 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属第九人民医院 三级学科/
专业领域： 骨外
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海市制造局路639号7号楼13楼
邮编： 200011 邮箱地址： prof.zhao@133sh.com

研究方向 (点击浏览详细信息)
生物材料
生物力学
分子生物学
脊柱外科疾病

社会任职
上海市中西医结合学会脊柱专业委员会胸腰椎学组名誉组长
国际矫形与创伤外科协会(SICOT)中国部脊柱外科学委员会常务委员
国际腰椎研究协会（ISSLS）会员
《国际骨科学杂志》编委
上海医学会骨科分会副主任委员
《Journal of Orthopaedic Translation》编委
上海市医学会医疗鉴定专家委员会成员
《脊柱外科杂志》编委
中国医师协会骨科医师分会胸腰椎专业委员会副主任委员
上海市骨科临床质量控制中心专家委员会委员
上海市医师协会骨科分会副会长
《医用生物力学杂志》编委
中国医疗保健国际交流促进会骨科疾病防治专业委员会委员
中国博士后科学基金评审专家
北美脊柱协会（NASS）会员
中国医师协会骨科分会委员
AOSpine协会会员
中国康复医学会脊柱脊髓专业委员会腰椎研究学组荣誉主任委员
中国研究型医院学会骨科创新与转化专业委员会常务委员
中华医学会骨科学分会委员会委员及脊柱专业学组委员
《中国矫形外科杂志》编委
上海市科学技术专家库成员
上海市康复医学会骨科康复专业委员会主任委员
上海市医学会疼痛学分会副主任委员、腰背疼痛学组组长

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** DDRGK1介导类泛素化修饰RPS3调控椎间盘退变的作用和机制研究 国家自然科学基金面上项目 2019-01~2022-12 58万元 课题负责人
2017YFB** “硬组织病损精准治疗的个性化医疗器械增材制造技术集成和应用示范”项目课题四个性化医疗器械精准治疗骨关节-脊柱疾病的临床应用研究 国家重点研发计划-“增材制造与激光制造”专项 2017-07~2021-06 610万元 课题负责人
16CR3030A 3D打印解剖适配型椎间融合器的临床应用研究 第一轮促进市级医院临床技能与临床创新三年行动计划 2016-12~2019-06 50万元 课题负责人
SHDC** 富集骨髓干细胞快速复合多孔生物材料用于腰椎多节段椎间融合的安全有效性的临床研究 （上海）市级医院新兴前沿技术联合攻关项目 2016-09~2019-09 180万元 课题负责人
** 不同矢状力线类型腰椎退变模式的生物力学研究 国家自然科学基金面上项目 2016-01~2019-12 51万元 课题负责人
2013ZYJB0502 老年脊柱退变性关节炎自然史及防治的研究 上海市卫生系统重要疾病联合攻关项目 2014-01~2016-12 12.5万元 子课题负责人
13DZ** 新型解剖适配型钛合金融合器的研究及产业化 市科委2013年度产学研医合作项目 2013-09~2016-09 50万元 课题负责人
** 瘦素在椎间盘细胞终末分化和椎间盘退变病理机制中的作用 国家自然科学基金面上项目 2011-01~2013-12 35万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Chen Han, Xunlin Li, Tangjun Zhou, Chen Chen, Kai Zhang, Shengbing Yang, Xin Wang, Haijun Tian, Changqing Zhao, Jie Zhao （通讯作者） A tranilast and BMP-2 based functional bilayer membrane is effective for the prevention of epidural fibrosis during spinal lamina reconstruction Journal of Materials Chemistry B 2019 7: 3075-3087
Wu A, Dong W, Liu S, Cheung JPY, Kwan KYH, Zeng X, Zhang K, Sun Z, Wang X, Cheung KMC, Zhou M, Zhao J （通讯作者） The prevalence and years lived with disability caused by low back pain in China, 1990 to 2016: findings from the global burden of disease study 2016 Pain 2019 160(1):237-245
Wang X, Chu W, Zhuang Y, Shi D, Tao H, Jin C, Dai K, Zhao J （通讯作者）, Gan Y. Bone Mesenchymal Stem Cell-Enriched β-Tricalcium Phosphate Scaffold Processed by the Screen-Enrich-Combine Circulating System Promotes Regeneration of Diaphyseal Bone Non-Union Cell Transplant 2019 28(2):212-223
Tian H, Zhou T, Chen H, Li C, Jiang Z, Lao L, Kahn SA, Duarte MEL, Zhao J （通讯作者）, Daubs MD, Buser Z, Brochmann EJ, Wang JC, Murray SS Bone morphogenetic protein-2 promotes osteosarcoma growth by promoting epithelial-mesenchymal transition (EMT) through the Wnt/β-catenin signaling pathway J Orthop Res 2019 37(7):1638-1648
Cheng X, Zhang L, Zhang K, Zhang G, Hu Y, Sun X, Zhao C, Li H, Li YM, Zhao J （通讯作者） Circular RNA VMA21 protects against intervertebral disc degeneration through targeting miR-200c and X linked inhibitor-of-apoptosis protein Ann. Rheum. Dis. 2018 77(5): 770-779
Wu AM, Li XL, Tian HJ, Zhang K, Zhao CQ, Sheng SR, Lin Y, Ni WF, Wang XY, Zhao J （通讯作者） Optimal medial transforaminal lumbar interbody fusion approach with five extensive options: A simulated study on three-dimensional digital reconstructed images J Orthop Translat 2018 6（15）:1-8
Tian H, Wu A, Guo M, Zhang K, Chen C, Li X, Cheng X, Zhou T, Murray SS, Sun X, Zhao J （通讯作者） Adequate Restoration of Disc Height and Segmental Lordosis by Lumbar Interbody Fusion Decreases Adjacent Segment Degeneration World Neurosurg 2018 118:e856-e864
Gu Q, Tian H, Zhang K, Chen D, Chen D, Wang X, Zhao J （通讯作者） Wnt5a/FZD4 Mediates the Mechanical Stretch-Induced Osteogenic Differentiation of Bone Mesenchymal Stem Cells Cell Physiol Biochem 2018 48(1):215-226
Wu AM, Lin JL, Kwan KYH, Wang XY, Zhao J （通讯作者） 3D-printing techniques in spine surgery: the future prospects and current challenges Expert Rev Med Devices 2018 15(6):399-401
Zhang F, Zhang K, Tian HJ, Wu AM, Cheng XF, Zhou TJ, Zhao J （通讯作者） Correlation between lumbar intervertebral disc height and lumbar spine sagittal alignment among asymptomatic Asian young adults J Orthop Surg Res 2018 13(1):34
Cheng X, Zhang G, Zhang L, Hu Y, Zhang K, Sun X, Zhao C, Li H, Li YM, Zhao J. （通讯作者） Mesenchymal stem cells deliver exogenous miR-21 via exosomes to inhibit nucleus pulposus cell apoptosis and reduce intervertebral disc degeneration J. Cell. Mol. Med 2018 22(1): 261-276
Wu AM, Zhang K, Li XL, Cheng XF, Zhou TJ, Du L, Chen C, Tian HJ, Sun XJ, Zhao CQ, Li YM, Zhao J （通讯作者） The compression of L5 nerve root, single or double sites?-radiographic graded signs, intra-operative detect technique and clinical outcomes Quant Imaging Med Surg 2018 8(4):383-390
Zhou T, Du L, Chen C, Han C, Li X, Qin A, Zhao C, Zhang K, Zhao J. （通讯作者） Lysophosphatidic Acid Induces Ligamentum Flavum Hypertrophy Through the LPAR1/Akt Pathway Cell. Physiol. Biochem. 2018 45(4): 1472-1486
Zhao X, Chen C, Zhou T, Mi J, Du L, Kang Z, Huang J, Zhang K, Sun X, Zhao J （通讯作者） Analysis of single cage position in transforaminal lumbar interbody fusion through digital images Int Orthop 2018 42(5):1091-1097
Zhao X, Du L, Xie Y, Zhao J （通讯作者） Effect of Lumbar Lordosis on the Adjacent Segment in Transforaminal Lumbar Interbody Fusion: A Finite Element Analysis World Neurosurg 2018 114:e114-e120
Zhao X, Zhao J, Guan J, Zeng J, Han C, He Y, Zhou T, Chen C, Xie Y Measurement of the nerve root of the lower lumbar region using digital images Medicine (Baltimore) 2018 97(8):e9848
Ma Z, Zhao C, Zhang K, Du L, Tian J, Sun X, Zhao J （通讯作者） Modified Lumbosacral Angle and Modified Pelvic Incidence as New Parameters for Management of Pediatric High-grade Spondylolisthesis Clin Spine Surg 2018 31(2):E133-E139
Li K, Li Y, Mi J, Mao L, Han X, Zhao J （通讯作者） Resveratrol protects against sodium nitroprusside induced nucleus pulposus cell apoptosis by scavenging ROS Int J Mol Med 2018 41(5):2485-2492
Wu AM, Li XL, Li XB, Zhang K, Sun XJ, Zhao CQ, Wang S, Huang QS, Lin Y, Ni WF, Wang XY, Zhao J （通讯作者） The outcomes of percutaneous kyphoplasty in treatment of the secondary osteoporotic vertebral compression factures: a case-control study Ann Transl Med 2018 6(6):107
Zhang K, Sun W, Liu XY, Zhao CQ, Li H, Sun XJ, You-Zhuan X, Ding W, Zhao J （通讯作者） Hypertrophy and Fibrosis of the Ligamentum Flavum in Lumbar Spinal Stenosis is Associated With Increased Expression of LPA and LPAR1. Clinical spine surgery 2017 30(3):E189-E191
Cheng X, Zhang K, Sun X, Zhao C, Li H, Zhao J （通讯作者） Analysis of compensatory mechanisms in the pelvis and lower extremities in patients with pelvic incidence and lumbar lordosis mismatch. Gait Posture 2017 56:14-18
Du L, Sun XJ, Zhou TJ, Li YC, Chen C, Zhao CQ, Zhang K, Zhao J. （通讯作者） The role of cage height on the flexibility and load sharing of lumbar spine after lumbar interbody fusion with unilateral and bilateral instrumentation: a biomechanical study BMC Musculoskelet Disord 2017 18(1):474.
Cheng X, Zhang K, Sun X, Zhao C, Li H, Ni B, Zhao J. （通讯作者） Clinical and radiographic outcomes of bilateral decompression via a unilateral approach with transforaminal lumbar interbody fusion for degenerative lumbar spondylolisthesis with stenosis. The spine journal : official journal of the North American Spine Society 2017 17(8):1127-1133
Tian H, Zhao J （通讯作者）, Brochmann EJ, Wang JC, Murray SS Bone morphogenetic protein-2 and tumor growth: Diverse effects and possibilities for therapy Cytokine Growth Factor Rev 2017 34:73-91
Cheng X, Zhang K, Sun X, Zhao C, Li H, Zhao J （通讯作者） Femoral head retroposition as a potential compensatory mechanism in patients with a severe mismatch between pelvic incidence and lumbar lordosis. Skeletal Radiol. Skeletal Radiol. 2017 1
Li Y, Li K, Mao L, Han X, Zhang K, Zhao C, Zhao J. （通讯作者） Cordycepin inhibits LPS-induced inflammatory and matrix degradation in the intervertebral disc. PeerJ 2016 4:e1992
Mi J, Li K, Zhao X, Zhao CQ, Li H, Zhao J. （通讯作者） Vertebral Body Hounsfield Units are Associated With Cage Subsidence After Transforaminal Lumbar Interbody Fusion With Unilateral Pedicle Screw Fixation. Clinical spine surgery. 2016 1
Cheng X, Ni B, Zhang F, Hu Y, Zhao J. （通讯作者） High Glucose-Induced Oxidative Stress Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances Possibly via p38 MAPK Activation in Rat Nucleus Pulposus Cells. Journal of diabetes research 2016 1
Mi J, Li K, Zhao X, Zhao CQ, Li H, Zhao J. （通讯作者） Vertebral Body Compressive Strength Evaluated by Dual-Energy X-Ray Absorptiometry and Hounsfield Units In Vitro. Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry. 2016 1
Li Y, Li K, Han X, Mao C, Zhang K, Zhao T, Zhao J. （通讯作者） The imbalance between TIMP3 and matrix-degrading enzymes plays an important role in intervertebral disc degeneration. Biochemical and biophysical research communications 2016 469(3):507-514
Zhao CQ, Ding W, Zhang K, Zhao J. （通讯作者） Transforaminal lumbar interbody fusion using one diagonal fusion cage with unilateral pedicle screw fixation for treatment of massive lumbar disc herniation. Indian journal of orthopaedics 2016 50(5):473-378
Zhang K, Ding W, Sun W, Sun XJ, Xie YZ, Zhao CQ, Zhao J. （通讯作者） Beta1 integrin inhibits apoptosis induced by cyclic stretch in annulus fibrosus cells via ERK1/2 MAPK pathway. Apoptosis : an international journal on programmed cell death. 2016 21(1):13-24
Li K, Li Y, Ma Z, Zhao J （通讯作者） Crocin exerts anti-inflammatory and anti-catabolic effects on rat intervertebral discs by suppressing the activation of JNK International Journal of Molecular Medicine 2015 36:1291-1299
Li Y, Li K, Hu Y, Xu B, Zhao J （通讯作者） Piperine mediates LPS induced inflammatory and catabolic effects in rat intervertebral disc International journal of clinical and experimental pathology 2015 8(6):6203-13
Mao L, Zhao J （通讯作者）, Dai KR, Hua L, Sun XJ Bilateral decompression using a unilateral pedicle construct for lumbar stenosis Int Orthop 2014 38(3):573-8
Sun W, Zhang K, Liu G, Ding W, Zhao C, Xie Y, Yuan J, Sun X, Li H, Liu C, Tang T, Zhao J （通讯作者） Sox9 gene transfer enhanced regenerative effect of bone marrow mesenchymal stem cells on the degenerated intervertebral disc in a rabbit model PLoS One 2014 9(4):e93570
Zhang K, Sun W, Zhao CQ, Li H, Ding W, Xie YZ, Sun XJ, Zhao J （通讯作者） Unilateral versus bilateral instrumented transforaminal lumbar interbody fusion in two-level degenerative lumbar disorders: a prospective randomised study Int Orthop 2014 38(1):111-6
Ding W, Zhao C, Cao L, Zhang K, Sun W, Xie Y, Li H, Zhao J （通讯作者） Leptin induces terminal differentiation of rat annulus fibrosus cells via activation of MAPK signaling Anat Rec 2013 296(12):1806-12
Sun W, Zhang K, Zhao CQ, Ding W, Yuan JJ, Sun Q, Sun XJ, Xie YZ, Li H, Zhao J （通讯作者） Quantitative T2 mapping to characterize the process of intervertebral disc degeneration in a rabbit model BMC Musculoskelet Disord 2013 14(1):357