导师姓名： 朱振安 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属第九人民医院 三级学科/
专业领域： 骨外
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 邮箱地址： zhuzhenan2006@126.com

研究方向 (点击浏览详细信息)
人工关节感染的防治研究
人工关节无菌性松动的机理和防治研究
复杂人工关节技术和方法的改进和创新
个体化定制型人工关节处理巨大骨缺损

社会任职
中华医学会骨科学分会关节外科学组委员
中华骨科杂志编委
华裔骨科学会理事
中国骨伤杂志编委
医用生物力学杂志编委
中华医学会骨科学分会委员
中华肩肘外科电子杂志第一届编辑委员会委员
《中国骨与关节外科》第三届编委会常务编委
上海医学会骨科分会副主任委员兼关节外科学组组长
《中华解剖与临床杂志》第六届编辑委员会编委
生物骨科材料与临床研究杂志副主编
中欧骨科学术交流学会理事
上海市医师协会骨科医师分会第一届学委会副会长
国际骨科学杂志副主编
中国医师协会骨科医师分会常委
SICOT中国学会上海分会主任委员
生物医学工程学会第九届理事会理事

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 靶向调控Notch通路的 Cell Sheet 联合PTH促进异体骨修复骨缺损的作用及机制研究 国家自然科学基金面上项目 2016-01~2019-12 57万元 课题负责人
临床新技术安全性与效果评价——关节置换安全性与效果评价 公益性行业科研专项 2013-03~2016-06 77万元 子课题负责人
12JC** 碳纤维增强磁性介孔磷灰石三维多孔支架的构建机制及生物学性能研究 上海市科委基础研究重点项目 2013-01~2015-12 40万元 课题负责人
** OPG/RANKL/RANK系统在关节软骨细胞分化阻滞解除及骨性关节炎发病中的作用 国家自然科学基金 2010-01~2012-12 32万元 课题负责人
髋关节假体设计与临床应用研究 市科委 2009-07~2012-06 20万元 子课题负责人
11DZ** 芪麝丸治疗神经根型颈椎病的再评价研究 市科委 2009-07~2012-06 143.1万元 子课题负责人
** 特异性阻断CN/NFAT信号通路对磨损颗粒诱导假体周围骨溶解影响的实验研究 国家自然基金委,面上项目 2008-01~2010-12 29万元 课题负责人
2006aa02a137 个体化人工关节的生物学优化及快速化制作和应用 国家科技部,863项目 2007-01~2010-12 190万元 课题负责人
06XD14033 人工关节磨损颗粒对破骨细胞分化影响的分子信号研究 上海市科委,学科带头人 2006-09~2008-09 20万元 课题负责人
04JC14042 聚乙烯颗粒对破骨细胞CN/NFAT信号转导通路的影响 上海市科委,重点基础研究 2004-10~2007-06 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Mao Y, Xu C, Xu J, Li H, Liu F, Yu D, Zhu Z （通讯作者） The use of customized cages in revision total hip arthroplasty for Paprosky type III acetabular bone defects. Int Orthop 2015 39: 2023-2030
Jun-Jie Guan,Bo Tian, Sha Tanga, Qin-Fei Ke, Chang-Qing Zhang, Zhen-An Zhu （通讯作者）,Ya-Ping Guo Hydroxyapatite coatings with oriented nanoplate arrays: synthesis, formation mechanism and cytocompatibility J. Mater. Chem. B, 2015 3, 1655–1666
徐辰,毛远青,朱振安 （通讯作者） 老年股骨颈骨折治疗进展 国际骨科学杂志 2015 36(2)109-113
Chuanlong Wu, Wengang Wang, Bo Tian, Xuqiang Liu, Xinhua Qu, Zanjing Zhai, Haowei Li, Fengxiang Liu, Qiming Fan, Tingting Tang, An Qin, Zhenan Zhu. （通讯作者） Myricetin prevents titanium particle-induced osteolysis in vivo and inhibits RANKL-induced osteoclastogenesis in vitro. Biochem Pharmacol 2015 Jan 1;93(1):59-71.
Hui feng Ding, Yuanqing Mao, Bin Yu, Zhu Z （通讯作者）, Huiwu Li, Baoqing Yu, Jianming Huang。 The use of morselized allografts without impaction and cemented cage support in acetabular revision surgery: a 4- to 9-year follow-up Journal of Orthopaedic Surgery and Research 2015 10:77
Zhang J, Wei J, Mao Y, Li H, Xie Y, Zhu Z. （通讯作者） Range of Hip Joint Motion in Developmental Dysplasia of the Hip Patients Following Total Hip Arthroplasty With the Surgical Technique Using the Concept of Combined Anteversion: A Study of Crowe I and II Patients. J Arthroplasty 2015 30: 2248-2255.
Wei Chen, Teng Long, Ya-Jun Guo, Ya-Ping Guo,Zhen-An Zhu. （通讯作者） Hydrothermal synthesis of hydroxyapatite coatings with oriented nanorod arrays. Royal Society of Chemistry Advances. Hydrothermal synthesis of hydroxyapatite coatings with oriented nanorod arrays. Royal Society of Chemistry Advances. 2014 4(1):185-191
Wu C, Tian B, Qu X, Liu F, Tang T, Qin A, Zhu Z （通讯作者）, Dai K MicroRNAs play a role in chondrogenesis and osteoarthritis Int J Mol Med. 2014 Jul;34(1):13-23
Wu C, Qu X, Mao Y, Li H, Liu F, Zhu Z （通讯作者） Developmental dysplasia of the hip, age, BMI, place of residence and tobacco abuse increase the odds of aseptic loosening in Chinese patients PLoS One 2014 Jan 15;9(1):e85562
吴传龙,曲新华,毛远青,刘凤祥,李慧武,朱振安 （通讯作者） 糖尿病与关节假体感染发病率的相关性研究 中华关节外科杂志（电子版） 2014 8(1)4-9
Bo Tian, Tao Jiang, Zhanying Shao, Zanjing Zhai, Haowei Li, Qiming Fan,Xuqiang Liu, Zhengxiao Ouyang, Tingting Tang, Qing Jiang,Minghao Zheng,Kerong Dai, An Qin, Yongping Yu, Zhenan Zhu （通讯作者） The prevention of titanium-particle-induced osteolysis by OA-14 through the suppression of the p38 signaling pathway and inhibition of osteoclastogenesis Biomaterials. 2014 Oct;35(32):8937-50
Wang L,Pan HH, Zhu Z （通讯作者） A genetic pedigree analysis to identify gene mutations involved in femoral head necrosis. Mol Med Rep 2014 Oct;10(4):1835-8
Mao Y, Yu D, Xu C, Liu F, Li H, Zhu Z （通讯作者） The Fate of Osteophytes in the Superolateral Region of the Acetabulum After Total Hip Arthroplasty. The Journal of Arthroplasty 2014 29: 2262–2266
Li H,Wang Y,Oni JK, Qu X, Li T, Zeng Y, Liu F, Zhu Z （通讯作者） The role of femoral neck anteversion in the development of|osteoarthritis in dysplastic hips Bone Joint J. 2014 Dec;96-B(12):1586-93
Jun Yang, Teng Long, Nan-Fei He, Ya-Ping Guo, Zhen-An Zhu （通讯作者）,Qin-Fei Ke. Fabrication of chitosan/bioglass three-dimensional porous scaffold for bone tissue engineering application. Journal of Materials Chemistry B. 2014 2:6611-6618
Wei Chen, Teng Long, Ya-Jun Guo, Zhen-An Zhu （通讯作者）,Ya-Ping Guo. Magnetic hydroxyapatite coatings with oriented nanorod arrays: hydrothermal synthesis, structure and biocompatibility. Journal of Materials Chemistry B. 2014 2:1653-1660
吴传龙,朱振安 （通讯作者） 抗骨质疏松类药物在全髋关节置换术后的应用 中华关节外科杂志（电子版） 2014 8(3)373-375
Ya-Ping Guo, Teng Long, Zhen-Fu Song, Zhen-An Zhu （通讯作者） Hydrothermal fabrication of ZSM-5 zeolites: Biocompatibility, drug delivery property, and bactericidal property J Biomed Mater Res B Appl Biomater. 2014 Apr;102(3):583-91.
Tian B, Tang S, Li Y, Long T, Qu XH, Yu DG, Guo YJ, Guo YP, Zhu ZA （通讯作者） Fabrication, characterization, and biocompatibility of ethyl cellulose/carbonated hydroxyapatite composite coatings on Ti6Al4V J Mater Sci Mater Med. 2014 Sep;25(9):2059-68
Zhang J, Wang L, Mao Y, Li H, Ding H, Zhu Z （通讯作者） The Use of Combined Anteversion in Total Hip Arthroplasty for Patients With Developmental Dysplasia of the Hip. J Arthroplasty. 2014 Mar;29(3):621-5
Teng Long, Yu-Tai Liu, Sha Tang, Jin-Liang Sun, Ya-Ping Guo, Zhen-An Zhu （通讯作者） Hydrothermal fabrication of hydroxyapatite/chitosan/carbon porous scaffolds for bone tissue engineering. JBMR-B: Applied Biomaterials. 2014 102:1740-1748
毛远青,徐嘉炜,张经纬,徐辰,于德刚,李慧武,王林,朱振安 （通讯作者） 髋关节表面置换术治疗髋关节发育不良的临床疗效 中华骨科杂志 2014 34(12)1198-1204
Ya-Ping Guo, Teng Long, Sha Tang, Ya-Jun Guo,Zhen-An Zhu （通讯作者） Hydrothermal fabrication of magnetic mesoporous carbonated hydroxyapatite microspheres: biocompatibility, osteoinductivity, drug delivery property and bactericidal property. Journal of Materials Chemistry B 2014 2:2899-2909
Long T1, Liu YT, Tang S, Sun JL, Guo YP, Zhu ZA （通讯作者） Hydrothermal fabrication of hydroxyapatite/chitosan/carbon porous scaffolds for bone tissue engineering J Biomed Mater Res B Appl Biomater. 2014 Nov;102(8):1740-8.
Wang L, Zhu Z （通讯作者） Nitric oxide show its survival role by NO-PKC pathway through cGMP-dependent or independent on the culture of cerebella granular neurons. Neurosci Lett 2014 Nov 7;583:165-9
Teng Long, Zhenan Zhu （共同第一作者）, Hani A. Awad, Edward M. Schwarz, Matthew J. Hilton,Yufeng Dong The effect of mesenchymal stem cell sheets on structural allograft healing of critical sized femoral defects in mice Biomaterials 2014 35 (2014) 2752-2759
Tian B, Tang S, Wang CD, Wang WG, Wu CL, Guo YJ, Guo YP, Z Zhu Z （通讯作者） Bactericidal properties and biocompatibility of a gentamicin-loaded Fe3O4/carbonated hydroxyapatite coating. Colloids and Surfaces B: Biointerfaces 2014 123: 403–412
Wu C, Qu X, Liu F, Li H, Mao Y, Zhu Z （通讯作者） Risk factors for periprosthetic joint infection after total hip arthroplasty and total knee arthroplasty in Chinese patients PLoS One. 2014 Apr 18;9(4):e95300
Tian B, Qin A, Shao ZY, Jiang T, Zhai ZJ, Li HW, Tang TT, Jiang Q, Dai KR, Zheng MH, Yu YP, Zhu ZA （通讯作者） OA-4 inhibits osteoclast formation and bone resorption via suppressing RANKL induced P38 signaling pathway Curr Med Chem. 2014 21(5):641-9
Teng Long,Ya-Ping Guo, Sha Tang, Ya-Jun Guo, Zhen-An Zhu. （通讯作者） Emulsion Fabrication of Magnetic Mesoporous Carbonated Hydroxyapatite Microspheres for Treatment of Bone Infection Royal Society of Chemistry Advances 2014 4:11816-11825
李慧武,朱振安 （通讯作者）,毛远青,严孟宁,岳冰 非截骨全髋关节置换术治疗单侧Crowe IV型髋关节发育不良 中华骨科杂志 2014 34(12)1205-1211
Yu-Tai Liu, Teng Long, Sha Tang, Jin-Liang Sun, Zhen-An Zhu （通讯作者）, Ya-PingGuo Biomimetic fabrication and biocompatibility of hydroxyapatite/chitosan nanohybrid coatings on porous carbon fiber felts. Materials Letters. 2014 128:31-34
Wu C, Qu X, Mao Y, Li H, Dai K, Liu F, Zhu Z （通讯作者） Utility of intraoperative frozen section in the diagnosis of periprosthetic joint infection PLoS One. 2014 Jul 15;9(7):e102346
Ya-Ping Guo, Teng Long, Zhen-Fu Song, Zhen-An Zhu （通讯作者） Hydrothermal fabrication of ZSM-5 zeolites: Biocompatibility, drug delivery property, and bactericidal property J Biomed Mater Res B Appl Biomater. 2014 Apr;102(3):583-91.
Li Y, Liu YZ, Long T, Yu XB, Tang TT, Dai KR, Tian B, Guo YP, Zhu ZA （通讯作者） Mesoporous bioactive glass as a drug delivery system: fabrication, bactericidal properties and biocompatibility J Mater Sci Mater Med. 2013 Aug;24(8):1951-61
李扬,刘怡卓,郭亚平,刘李娜,朱振安 （通讯作者） 介孔生物玻璃对人骨髓问充质干细胞早期黏附增殖行为的影响 生物骨科材料与临床研究 2013 10(4)8-11,16
Tao J, Li X, Zhou Z, Zhu Z. （通讯作者） Acute single-stage reconstruction of multiligament knee injuries using the ligament advanced reinforcement system. Med Princ Pract. 2013 22(4):373-8
Li H, Wang L, Mao Y, Wang Y, Dai K, Zhu Z （通讯作者） Revision of Complex Acetabular Defects Using Cages with the Aid of Rapid Prototyping. J Arthroplasty 2013 28(10):1770-5
Wang J, Wang X, Holz JD, Rutkowski T, Wang Y, Zhu Z （通讯作者）, Dong Y. Runx1 Is Critical for PTH-induced Onset of Mesenchymal Progenitor Cell Chondrogenic Differentiation PLoS One 2013 2013;8-9:e74255.
Liu FX, Wu CL, Zhu ZA （通讯作者）, Li MQ, Mao YQ, Liu M, Wang XQ, Yu DG, Tang TT. Calcineurin/NFAT pathway mediates wear particle-induced TNF-a release and osteoclastogenesis from mice bone marrow macrophages in vitro. Acta Pharmacol Sin. 2013 Nov 5;34(11):1457-66.
Qu X, Zhai Z, Wu C, Jin F, Li H, Wang L, Liu G, Liu X, Wang W, Li H, Zhang X, Zhu Z （通讯作者）, Dai K. Preoperative aspiration culture for preoperative diagnosis of infection in total hip or knee arthroplasty J Clin Microbiol 2013 2013;51-11:3830-4
刘铭,吴莉,朱振安 （通讯作者）,汤亭亭,郝永强,于志锋 辛伐他汀对去卵巢大鼠脊椎椎体骨形成功能影响的实验研究 中国骨质疏松杂志 2013 19( 4):330-335
吴传龙, 孙蕊心, 朱振安 （通讯作者） 金属对金属髋关节置换术后金属离子相关问题研究进展 生物骨科材料与临床研究 2013 10(3)33-36
Wang X, Sadovskaya I, Leterme D, Watier D, Chokr A, Zhu Z* （通讯作者）, Jabbouri S. A comparative study of antibodies against proteins extracted from staphylococcal biofilm for the diagnosis of orthopedic prosthesis-related infections in an animal model and in humans. Diagn Microbiol Infect Dis 2013 2013;75-2:124-9.
俞超,杨飞,戴尅戎,张晓玲,唐坚,朱振安 （通讯作者） 周期性张应变通过活性氧生成促进膝关节骨关节炎患者的软骨细胞发生凋亡 医用生物力学 2013 28(3):350-356
龚伟华,曾一鸣,唐坚,朱振安 （通讯作者） 髋部骨折的发生与股骨近端三维几何解剖形态的相关性研究 医用生物力学 2013 28(1):109-114
Ya-Jun Guo , Teng Long , Wei Chen , Cong-Qin Ning , Zhen-An Zhu （通讯作者）, Ya-Ping Guo Bactericidal property and biocompatibility of gentamicin-loaded mesoporous carbonated hydroxyapatite microspheres Mater Sci Eng C Mater Biol Appl 2013 Oct;33(7):3583-91.
Zhao X,Zhu ZA （通讯作者）,Sun YH,Wang Y,Zhao J, Zhang YJ, Dai KR. kel-titanium shape-memory sawtooth-arm embracing fixator for periprosthetic femoral fractures. Int Orthop 2012 Mar;36(3):619-26
Ding H,Zhu Z （通讯作者）,Tang T,Yu D,Yu B,Dai K. Comparison of the cytotoxic and inflammatory responses of titanium particles with different methods for endotoxin removal in RAW264.7 macrophages. J Mater Sci Mater Med. 2012 Apr;23(4):1055-62
Yu DG,Yu B,Mao YQ, Zhao X,Wang XQ, Ding HF, Cao L, Liu GW, Nie SB, Liu S, Zhu ZA （通讯作者） Efficacy of zoledronic acid in treatment of teoarthritis is dependent on the disease progression stage in rat medial meniscal tear model. Acta Pharmacol Sin 2012 Jul;33(7):924-34
刘铭,朱振安 （通讯作者）,汤亭亭,于志锋 辛伐他汀对增龄大鼠椎体骨形成功能的影响 医用生物力学杂志 2012 27（6）619-62
侯长举,朱振安 （通讯作者）,赵鑫,毛远青,于德刚 骨折后外周血间充质干细胞浓度变化的实验研究 中国矫形外科杂志 2012 20(2):160-164
Zhao X, Zhu ZA （通讯作者）, Sun YH, Wang Y, Zhao J, Zhang YJ, Dai KR Nickel-titanium shape-memory sawtooth-arm embracing fixator for periprosthetic femoral fractures Int Orthop 2012 Mar;36(3):619-26
Wang G, Zhu Z （通讯作者）, Lei C, Li M, Liu F, Mao Y, Yu Z, Liu M, Zhao X, Tang T Low-dose Risedronate Sodium Protects Bone Cells after Abrupt Oestrogen Withdrawal. J Int Med Res. 2012 40(5):1761-74
Yu B,Yu D,Cao L,Zhao X,Long T,Liu G, Tang T,Zhu Z （通讯作者） Simulated microgravity using a rotary cell culture system promotes chondrogenesis of human adipose-derived mesenchymal stem cells via the p38 MAPK pathway Biochem Biophys Res Commun. 2011 Oct 22;414(2):412-8.
于波,朱振安 （通讯作者） 力学因素在间充质干细胞构建功能性组织工程化软骨中的作用 医用生物力学杂志 2011 26(5):476-482
Xin Zhao, Zhen-An Zhu （通讯作者）, Jie Zhao, Mao-Qiang Li, Gang Wang, De-Gang Yu, Bo Yu The utility of digital templating in Total Hip Arthroplasty with Crowe type II and III dysplastic hips Int Orthop. 2011 May;35(5):631-8
X.Zhao, Z.A. Zhu （通讯作者）, Y.Z.Xie, B.Yu, D.G. Yu Total hip arthroplasty for high dislocated hips without femoral shortening osteotomy J Bone Joint Surg Br 2011 93-B:1189–93
Zhou X,Zhang P,Zhu Z （通讯作者） Tetracyclines Inhibit Rat Osteoclast Formation and Activity in vitro and Affect Bone Turnover in Young Rats in vivo Calcified Tissue International. 2010 86:163-171
Yuan Zhen,Mao Yuan-qing,Zhu zhen-an （通讯作者） Effect of impaction on gene-modiffied cells seeded on granular bone allografts in vitro and in vivo Chinese Medical Journal 2010 123(21):3055-3060
Zhou X,Zhang P,Zhang C,Zhu Z （通讯作者） Promotion of bone formation by naringin in a titanium particle-induced diabetic murine calvarial osteolysis model. J Orthop Res 2010 28(4):451-6
Maoqiang L,Zhenan Z （通讯作者）,Fengxiang L,Gang W,Yuanqing M,Ming L,Xin Z,Tingting T. Enhancement of osteoblast differentiation that is inhibited by titanium. particles through inactivation of NFATc1 by VIVIT peptide. J Biomed Mater Res A 2010 Dec 1;95(3):727-34
Wang X,Qiu S,Yao X,Tang T,Dai K,Zhu Z （通讯作者） Berberine inhibits Staphylococcus epidermidis adhesion and biofilm formation on the surface of titanium alloy J Orthop Res 2009 Nov;27(11):1487-92
Wang X,Yao X, Zhu Z （通讯作者）,Tang T,Dai K, Sadovskaya I,Flahaut S, Jabbouri S Effect of berberine on Staphylococcus epidermidis biofilm formation. Int J Antimicrob Agents 2009 Jul;34(1):60-6
Cao X,Ren F,Zhang P, Zhu Z （通讯作者） Osteoclast injection:a promising approach of cell therapy to obtain higher bone union ratio. Med Hypotheses 2009 Aug;73(2):161-2
Ming Liu, Kemin Wang, Tingting Tang, Keron Dai, Zhenan Zhu. （通讯作者） The effect of simvastatin on the differentiation of marrow stromal cells from aging rats. Pharmazie 2009 64(1):43-48
Ding H,Zhu ZA （通讯作者）,Dai KR. Evaluation of damage to trabecular bone of the osteoporotic human acetabulum at small strains using nonlinear micro-finite element analyses. Chin Med J (Engl) 2009 Sep 5;122(17):2041-7
Fengxiang Liu, Zhenan Zhu （通讯作者）, Yuanqing Mao, Ming Liu, Tingting Tang, Shijing Qiu. Inhibition of titanium particle-induced osteoclastogenesis through inactivation of NFATc1 by VIVIT peptide Biomaterials 2009 30(9):1756-1762
Yu Z,Zhu Z （通讯作者）,Tang T,Dai K,Qiu S Effect of body fat stores on total and regional bone mineral density in perimenopausal Chinese women. J Bone Miner Metab. 2009 27(3):341-6.
Ding Hai, Zhu zhenan （通讯作者）, Dai Kerong,Ye Ming, Wang Cheng-tao. Research on damage in trabecular bone of the healthy human acetabulum at small strains using nonlinear micro-finite element anyalysis. J. Shanghai Jiaotong Univ. 2008 13(5):623-628