导师姓名： 王琛 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属第九人民医院 三级学科/
专业领域： 整形
导师类型： 硕士生导师 专业学位导师：
联系方式： wangchen2369@163.com
邮编： 200011 邮箱地址： wangchen2369@163.com

研究方向 (点击浏览详细信息)
干细胞与组织再生；瘢痕的基础和临床

社会任职
中华医学会医学美学与美容学分会干细胞学组委员
中华医学会整形外科分会干细胞转化应用学组委员
中国整形美容协会抗衰老分会青年委员
中整协瘢痕医学分会青年委员
上海市医学会 医学美学与美容 第七届 委员会青年委员会副主任委员
中国医师协会美容与整形医师分会青年委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 长链非编码RNA-ANHS抑制增生性瘢痕的作用机制研究 国家自然科学基金面上项目 2020-01~2023-12 55万元 课题负责人
YG2015QN09 应用脂肪干细胞与纳米电纺丝构建 上海交通大学“医工交叉研究基金” 2016-01~2018-12 12万元 课题负责人
ZZjdyx12100 miR-21调控Smad7基因表达在增生性瘢痕形成中的作用及机制 上海高校青年教师科研专项基金 2013-09~2016-08 4万元 课题负责人
~ miR-31/FIH轴调控HIF-1α通路促进增生性瘢痕发展的机制研究 上海交大医学院优秀青年教师人才计划 2013-09~2016-08 10万元 课题负责人
~ miR-21调控TGF-β通路在增生性疤痕形成中的作用及机制 第五届“九院优青培养计划” 2013-06~2016-05 6万元 课题负责人
力学刺激诱导miR-100诱导脂肪干细胞向平滑肌细胞分化的作用和机制 国家自然科学基金青年基金 2013-01~2015-12 23万元 课题负责人
11ZR** 应用脂肪干细胞构建双层结构的组织工程化血管修复小口径动脉缺损的实验研究 上海市自然科学基金 2011-04~2014-03 10万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Yechi Qin, Guifei Li, Chen Wang （通讯作者）, Danqing Zhang, Lili Zhang, Haowei Fang, Shifeng Yan, Kunxi Zhang, and Jingbo Yin Biomimetic Bilayer Scaffold as an Incubator to Induce Sequential Chondrogenesis and Osteogenesis of Adipose Derived Stem Cells for Construction of Osteochondral Tissue ACS Biomater Sci Eng 2020 6,5,3070-3080
Yingying Zhang, Xueqin Li, Chen Wang （共同第一作者）, Mengying Zhang, Hui Yang, and Kun Lv LncRNA AK085865 promotes macrophage M2 polarization in CVB3-induced viral myocarditis by regulating ILF2-ILF3 complex-mediated miRNA-192 biogenesis Mol Ther Nucleic Acids 2020 21:441-451
Hong Y, Chen J, Fang H, Li G, Yan S, Zhang K, Wang C （通讯作者）, Yin J All-in-One Hydrogel Realizing Adipose-Derived Stem Cell Spheroid Production and In Vivo Injection via "Gel-Sol" Transition for Angiogenesis in Hind Limb Ischemia ACS Appl Mater Interfaces 2020 12(10):11375-11387
Zhou R, Wang C （共同第一作者）, Liang Y, Li X, Li Q Anti-miR-200b promotes wound healing by regulating fibroblast functions in a novel mouse model Acta Biochim Biophys Sin (Shanghai) 2019 51(10):1049-1055.
Chen J, Zhou R, Liang Y, Fu X, Wang D, Wang C （通讯作者） Blockade of lncRNA-ASLNCS5088-enriched exosome generation in M2 macrophages by GW4869 dampens the effect of M2 macrophages on orchestrating fibroblast activation FASEB J 2019 33(11):12200-12212
Wang X, Zhang Y, Jiang B, Zhang Q, Zhou R, Zhang L, Wang C （通讯作者） Study on the role of Hsa-miR-31-5p in hypertrophic scar formation and the mechanism Exp Cell Res 2017 361(2):201-209
Aji K, Zhang Y, Aimaiti A, Wang Y, Rexiati M, Azhati B, Tusong H, Cui L, Wang C. （通讯作者） MicroRNA-145 regulates the differentiation of human adipose-derived stem cells to smooth muscle cells via targeting Krüppel-like factor 4 Mol Med Rep 2017 15(6):3787-3795
Li G, Zhou R, Zhang Q, Jiang B, Wu Q, Wang C （通讯作者） Fibroproliferative effect of microRNA-21 in hypertrophic scar derived fibroblasts Exp Cell Res 2016 345(1):93-9
Zhou R, Zhu L, Fu S, Qian Y, Wang D, Wang C （通讯作者） Small diameter blood vessels bioengineered from human adipose-derived stem cells Scientific Reports 2016 6:35422
Wen C, Yan H, Fu S, Qian Y, Wang D, Wang C （通讯作者） Allogeneic Adipose-derived Stem Cells Regenerate Bone in a Critical-sized Ulna Segmental Defect Exp Biol Med 2016 241(13):1401-9
Wang X, Chu J, Wen C, Fu S, Qian Y, Wo Y, Wang C （通讯作者）, Wang D Functional characterization of TRAP1-like protein involved in modulating fibrotic processes mediated by TGF-β/Smad signaling in hypertrophic scar fibroblasts Exp Cell Res 2015 332(2):202-11
Lv Y, Cao D, Guo F, Qian Y, Wang C （通讯作者）, Wang D Abdominal wall reconstruction using a combination of free tensor fasciae lata and anterolateral thigh myocutaneous flap: a prospective study in 16 patients Am J Surg 2015 210(2):365-73
Zhou R, Zhang Q, Zhang Y, Fu S, Wang C （通讯作者） Aberrant miR-21 and miR-200b expression and its pro-fibrotic potential in hypertrophic scars Exp Cell Res 2015 339(2):360-6
Gong L, Wang C （共同第一作者）, Sun Q, Li G, Wang D. Effects of human adipose derived stem cells on the viability of rabbit random pattern flaps Cytotherapy 2014 16(4):496-507
Gu H, Xiong Z, Yin X, Li B, Mei N, Li G, Wang C （通讯作者） Bone regeneration in a rabbit ulna defect model: use of allogeneic adipose-derived stem cells with low immunogenicity Cell Tissue Res 2014 358(2):453-64
Wang C, Cai Y, Zhang Y, Xiong Z, Li G, Cui L Local injection of deferoxamine improves neovascularization in ischemic diabetic random flap by increasing HIF-1α and VEGF expression PLoS One 2014 9(6):e100818
Wang C, Xiong Z, Xu J, Zhang L, Huang H, Li G The distally based lateral sural neuro-lesser saphenous veno-fasciocutaneous flap: anatomical basis and clinical applications J Orthop Traumatol 2014 15(3):215-23
Wang C, Guo F, Zhou H, Zhang Y, Xiao Z, Cui L Proteomic profiling of tissue-engineered blood vessel walls constructed by adipose-derived stem cells Tissue Eng Part A 2013 19(3-4):415-425
Gu H, Xiong Z, Xu J, Li G, Wang C （通讯作者） Clinical and anatomical study of the distally based lesser saphenous veno-lateral sural neurocutaneous flap for lower extremity coverage J Orthop Sci 2013 18(5):740-748
Wang C, Yin S, Cen L, Liu Q, Liu W, Cao Y, Cui L Differentiation of adipose derived stem cells into contractile smooth muscle cells induced by TGF-β1 and BMP4 Tissue Eng Part A 2010 16(4):1201-1213
Wang C, Cen L, Yin S, Liu Q, Liu W, Cao Y, Cui L A small diameter elastic blood vessel wall prepared under pulsatile conditions from polyglycolic acid mesh and smooth muscle cells differentiated from adipose-derived stem cells Biomaterials 2010 31(4):621-630.