导师姓名： 葛盛芳 专业代码： 100212
性别： 男 专业名称： 眼科学
培养单位： 附属第九人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： geshengfang@hotmail.com
邮编： 200011 邮箱地址： geshengfang@hotmail.com

研究方向 (点击浏览详细信息)
眼恶性肿瘤发生机制及其靶向治疗

社会任职
中国生物物理学会 辐射与环境专业委员会委员
上海市眼眶病眼肿瘤重点实验室副主任
上海法院知识产权技术咨询专家
曾兼任上海市生物化学与分子生物学学会理事。任<转化医学杂志>编委，《上海交通大学学报（医学版）》审稿人。
教育部学位与研究生教育发展中心评审专家

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
U** 富氧碳基纳米材料协同重离子放疗杀伤肿瘤的作用及机理研究 国家自然科学基金项目 2020-01~2023-12 60万元 课题负责人
** LncRNA L12–PTPRZ1通路在葡萄膜黑色素瘤靶向治疗中的作用机理研究 国家自然科学基金项目 2018-01~2021-12 55万元 课题负责人
U** lncRNA-**-CCNB2通路在重离子放疗中的辐射增敏机理研究 国家自然科学基金 2015-01~2017-12 68万元 课题负责人
常见眼恶性肿瘤诊疗新技术、规范及其应用研究 国家卫计委公益性行业科研专项项目 2014-06~2017-06 1262万元 课题参与人
13JC** lncRNA-15:**通过调控有关蛋白参与低氧诱导的癌细胞恶性转化过程 上海市基础研究重点 2013-09~2016-08 30万元 课题负责人
XDA** 肿瘤干细胞分离、鉴定及特异标记物的研究及基于肿瘤干细胞特征的靶向药物研究 中国科学院战略性先导科技专项资助A类 2013-01~2017-12 200万元 课题参与人
** 导入PRC2基因修复肿瘤细胞IGF2遗传印迹丢失的作用及其机制研究 国家自然科学基金项目 2012-01~2015-12 64万元 课题负责人
** 重离子协同腺病毒载体靶向杀灭肿瘤细胞的机理研究 国家自然科学基金 2010-01~2012-12 54万元 课题负责人
2010CB529902 靶向基因治疗的应用基础研究 973计划 2010-01~2014-12 144万元 课题参与人
基因-MicroRNA共表达新型腺病毒对荷瘤鼠肿瘤生长的影响 第三期国家大学生创新性实验计划项目 2009-11~2011-06 3万元 课题负责人
09ZZ110 基因－小干扰RNA共表达肿瘤基因治疗新策略的研究 上海市教委 2009-01~2011-12 15万元 课题负责人
08ZR** 基因－小干扰RNA共表达策略在肿瘤基因治疗中的应用研究 上海市科委 2008-11~2010-12 10万元 课题负责人
ZD0702 Trail-siPROM1共表达双靶点胃肠肿瘤干细胞基因治疗新策略研究 仁济医院合作研究项目 2007-10~2010-09 25万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Chai P, Yu J, Ge S* （通讯作者）, Jia R*, Fan X*. Genetic alteration, RNA expression, and DNA methylation profiling of coronavirus disease 2019 (COVID-19) receptor ACE2 in malignancies: a pan-cancer analysis. J Hematol Oncol (IF 8.731) 2020 13(1):43
Li Y, He J, Qiu C, Shang Q, Qian G, Fan X*, Ge S* （通讯作者）, Jia R*. The oncolytic virus H101 combined with GNAQ siRNA-mediated knockdown reduces uveal melanoma cell viability. J Cell Biochem. 2019 120(4):5766-5776.
Ding Y, Yang J, Ma Y, Yao T, Chen X, Ge S* （通讯作者）, Wang L*, Fan X*. MYCN and PRC1 cooperatively repress docosahexaenoic acid synthesis in neuroblastoma via ELOVL2. J Exp Clin Cancer Res(IF 5.646) 2019 38(1):498
Shang Q, Li Y, Wang H, Ge S （通讯作者）, Jia R. Altered expression profile of circular RNAs in conjunctival melanoma. Epigenomics. 2019 11(7):787-804.
Zhao H, Pan H, Wang H, Chai P, Ge S （通讯作者）, Jia R, Fan X. SKP2 targeted inhibition suppresses human uveal melanoma progression by blocking ubiquitylation of p27. Onco Targets Ther. 2019 12:4297-4308
Shang Q, Yang Z, Jia R, Ge S （通讯作者） The novel roles of circRNAs in human cancer. Mol Cancer (IF 10.679) 2019 18(1):6
Chai P, Jia R, Jia R, Pan H, Wang S, Ni H, Wang H, Zhou C, Shi Y, Ge S, Zhang H, Fan X. Dynamic chromosomal tuning of a novel GAU1 lncing driver at chr12p13.32 accelerates tumorigenesis. Nucleic Acids Res(IF 11.561) 2018 46(12):6041-6056
Li Y, Shang Q, Li P, Cao J, Zhu L, Jager MJ, Fan X, Ge S, Jia R Characterization of a conjunctival melanoma cell line CM-AS16, newly-established from a metastatic Han Chinese patient. Exp Eye Res 2018 173:51-63
Ruan J, Wang Y, Li F, Jia R, Zhou G, Shao C, Zhu L, Cui M, Yang DP, Ge S. （通讯作者） Graphene Quantum Dots for Radiotherapy. ACS Appl Mater Interfaces.(IF8.097) 2018 10(17):14342-14355
Li P, Li Y, Zhu L, Yang Z, He J, Wang L, Shang Q, Pan H, Wang H, Ma X, Li B, Fan X, Ge S* （通讯作者）, Jia R*, Zhang H*. Targeting secreted cytokine BMP9 gates the attenuation of hepatic fibrosis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2017 864(3):709-720
Li G, Wang L, Jiang Y, Kong X, Fan Q, Ge S, Hao Y. Upregulation of Akt signaling enhances femoral fracture healing by accelerating atrophic quadriceps recovery. Biochim Biophys Acta 2017 2017 Nov;1863(11):2848-2861
Li Y, Jia R, Ge S （通讯作者） Role of Epigenetics in Uveal Melanoma. Int J Mol Med 2017 2017 Oct;40(4):979-986
Bi J, Li P, Li C, He J, Wang Y, Zhang H, Fan X, Jia R, Ge S （通讯作者） The SDF-1/CXCR4 chemokine axis in uveal melanoma cell proliferation and migration Tumour Biol 2016 37(3):4175-82
Zhang L, Jia R, Zhao J, Fan J, Zhou Y, Han B, Song X, Wu L, Zhang H, Song H, Ge S* （通讯作者）, Fan X* Novel mutations in the RB1 gene from Chinese families with a history of retinoblastoma Tumour Biol. 2015 36(4):2409-20
Pan H, Jia R, Zhang L, Xu S, Wu Q, Song X, Zhang H, Ge S* （通讯作者）, Xu XL*, Fan X* BAP1 regulates cell cycle progression through E2F1 target genes and mediates transcriptional silencing via H2A monoubiquitination in uveal melanoma cells. Int J Biochem Cell Biol 2015 60(3):176-84
Fan J, Xing Y, Wen X, Jia R, Ni H, He J, Ding X, Pan H, Qian G, Ge S （通讯作者）, Hoffman AR, Zhang H, Fan X Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis Genome Biol (IF 13.214) 2015 16(1):139-156
Bi J, Ge S （通讯作者） Potential roles of BMP9 in liver fibrosis Int J Mol Sci 2014 15(11):20656-67
Zhang H, Zeitz MJ, Wang H, Niu B, Ge S, Li W, Cui J, Wang G, Qian G, Higgins MJ, Fan X, Hoffman AR, Hu JF. Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus J Cell Biol （IF10.822） 2014 204(1):61-75
Jia R, Xu S, Huang X, Song X, Pan H, Zhang L, He F, Lin M, Ge S* （通讯作者）, Fan X*. Pingyangmycin as First-Line Treatment for Low-Flow Orbital or Periorbital Venous Malformations: Evaluation of 33 Consecutive Patients JAMA Ophthalmol (IF 6.669) 2014 132(8):942-8
Wang J, Jia R, Zhang Y, Xu X, Song X, Zhou Y, Zhang H, Ge S* （通讯作者）, Fan X*. The role of Bax and Bcl-2 in gemcitabine-mediated cytotoxicity in uveal melanoma cells Tumour Biol 2014 35(2):1169-75
Ye L, Zhao X, Lu J, Qian G, Zheng JC, Ge S. （通讯作者） Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells. Biochem Biophys Res Commun 2013 436(9):1-6
Zhang H, Jiao W, Sun L, Fan J, Chen M, Wang H, Xu X, Shen A, Li T, Niu B, Ge S, Li W, Cui J, Wang G, Sun J, Fan X, Hu X, Mrsny RJ, Hoffman AR, Hu JF Intrachromosomal Looping Is Required for Activation of Endogenous Pluripotency Genes during Reprogramming Cell Stem Cell (IF25.315) 2013 13(1):30-5
Cun B, Song X, Jia R, Wang H, Zhao X, Liu B, Ge S （通讯作者）, Fan X Cell growth inhibition in HPV 18 positive uveal melanoma cells by E6/E7 siRNA Tumour Biol 2013 34(3):1801-6
Zhang Y, Jia R, Wang J, Xu X, Yao Y, Ge S* （通讯作者）, Fan X* Targeted Silencing of MART-1 Gene Expression by RNA Interference Enhances the Migration Ability of Uveal Melanoma Cells Int. J. Mol. Sci 2013 14(4):15092-15104
Li C, Chen P, Zhang J, Zhang L, Huang X, Yao Y, Che X, Fan X, Ge S （通讯作者）, Wang Z. Enzyme-induced vitreolysis can alleviate the progression of diabetic retinopathy through the HIF-1α pathway. Invest Ophthalmol Vis Sci 2013 54(12):1-12
Li C, Wu Q, Liu B, Yao Y, Chen Y, Zhang H, Wang C, Cao J, Ge S （通讯作者） Detection and Validation of Circulating Endothelial Cells, a Blood-based Diagnostic Marker of Acute Myocardial Infarction PLoS ONE 2013 8(3):58478-0
Zhang J, Sun Q, Zhang Z, Ge S[葛盛芳], Han ZG, Chen WT Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop Oncogene (IF 7.357) 2012 0(0):01-8
Hao Y, Ma Y, Wang X, Jin F, Ge S. Short-term muscle atrophy caused by botulinum toxin-A local injection impairs fracture healing in the rat femur. J Orthop Res 2012 30(4):574-80
Xin Song, Haibo Wang, Renbing Jia, Biyun Cun, Xiaoping Zhao, Yixiong Zhou, Xiaofang Xu, Guanxiang Qian, Shengfang Ge(通讯作者) and Xianqun Fan （通讯作者） Combined treatment with an oncolytic adenovirus and vincristine antitumor activity against retinoblastoma cells Int. J. Mol. Sci. 2012 13(0):10736-10749
Wang H, Song X, Zhang H, Zhang J, Shen X, Zhou Y, Fan X, Dai L, Qian G, Hoffman AR, Hu JF, Ge S [葛盛芳(通讯作者)] （通讯作者） Potentiation of tumor radiotherapy by a radiation-inducible oncolytic and oncoapoptotic adenovirus in cervical cancer xenografts Int J Cancer(IF 6.198) 2012 15;130 (2):443-53
Sun J, Zhou J, Zhao P, Lian J, Zhu H, Zhou Y, Sun Y, Wang Y, Zhao L, Wei Y, Wang L, Cun B, Ge S, Fan X High Prevalence of Myopia and High Myopia in 5060 Chinese University Students in Shanghai Invest Ophthalmol Vis Sci. 2012 53(12):7504-9
Huang X, Jia R, Zhao X, Liu B, Wang H, Wang J, Zhou Y, Cun B, Ge S （通讯作者）, Fan X. Recombinant oncolytic adenovirus H101 combined with siBCL2: cytotoxic effect on uveal melanoma cell lines Br J Ophthalmol 2012 96(10):1331-8
Wang Z, Jia R, Ge S(葛盛芳), He T, Zhang Y, Yang Y, Wang Y, Shi W, Ji Y, Ye F, Chen P, Lu J, Sun J, Xu X, Zhou Y, Gu P, Luo M, Lu H, Fan X Ocular Complications of Human Immunodeficiency Virus Infection in Eastern China Am J Ophthalmol 2012 153(2):363-369
Cun B, Song X, Jia R, Zhao X, Wang H, Ge S [葛盛芳], Fan X Combination of oncolytic adenovirus and dacarbazine enhances antitumor ability against uveal melanoma cells via cell cycle block Cancer Biology & Therapy 2012 13(2):77-84
Guo H, Hu X, Ge S[葛盛芳], Qian G, Zhang J Regulation of RAP1B by miR-139 suppresses human colorectal carcinoma cell proliferation Int J Biochem Cell Biol 2012 44(9):1465-72
Huang X, Wang L, Zhang H, Wang H, Zhao X, Qian G, Hu J, Ge S(通讯作者) （通讯作者）, Fan X Therapeutic efficacy by targeting correction of notch1-induced aberrants in uveal tumors PLoS ONE 2012 7(8):44301-0
Yao Y, Wang L, Zhang H, Wang H, Zhao X, Zhang Y, Zhang L, Fan X, Qian G, Hu J, Ge S （通讯作者） A Novel Anticancer Therapy That Simultaneously Targets Aberrant p53 and Notch Activities in Tumors PLoS ONE 2012 7(10):46627-0
Fan J, Zhou Y, Huang X, Zhang L, Yao Y, Song X, Chen J, Hu J, Ge S, Song H, Fan X. The combination of polyalanine expansion mutation and a novel missense substitution in transcription factor FOXL2 leads to different ovarian phenotypes in blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) patients. Hum Reprod 2012 27(11):3347-57
Zhang H, Niu B, Hu JF, Ge S（葛盛芳）, Wang H, Li T, Ling J, Steelman BN, Qian G, Hoffman AR. Interruption of intrachromosomal looping by CTCF decoy proteins abrogates genomic imprinting of human insulin-like growth factor II Journal of Cell biology (IF 10.822) 2011 193(3):475-87
Zhang J, Guo H, Zhang H, Wang H, Qian G, Fan X, Hoffman AR, Hu JF, Ge S [葛盛芳(通讯作者)] （通讯作者） Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1. Cancer (IF 6.537) 2011 117(1):86-95
Xu H, Ni P, Chen C, Yao Y, Zhao X, Qian G, Fan X, Ge S[葛盛芳(通讯作者)] （通讯作者） SP1 suppresses phorbol 12-myristate 13-acetate induced up-regulation of human regucalcin expression in liver cancer cells. Mol Cell Biochem 2011 355(1):9-15
Song X, Zhou Y, Jia R, Xu X, Wang H, Hu J, Ge S, Fan X Inhibition of retinoblastoma in vitro and in vivo with conditionally replicating oncolytic adenovirus H101. Investigative Ophthalmology and Vision Science(IF 3.466) 2010 51(5):2626-35
Zhang P, Ying L, Xu R, Ge S[葛盛芳(通讯作者之一)] （通讯作者）, Mei W, Li F, Dai B, Lu J, Qian G Tumor-Specific, Hypoxia-Regulated WWOX Expression Adenovirus Inhibits Human Non-Small Cell Lung Cancer Growth in Vivo. Human Gene Therapy 2010 21(1):27-39
Zhang J, Huang S, Zhang H, Wang H, Guo H, Qian G, Fan X, Lu J, Hoffman AR, Hu JF, Ge S[葛盛芳(通讯作者)]. （通讯作者） Targeted knockdown of Bcl2 in tumor cells using a synthetic TRAIL 3’-UTR microRNA. Int J Cancer (IF 7.36) 2010 126(9):2229-2239
Zhang J, Guo H, Qian G, Ge S, Ji H, Hu X, Chen W. MiR-145, a new regulator of the DNA Fragmentation Factor-45 (DFF45)-mediated apoptotic network Mol Cancer(IF 7.776) 2010 9(1):211-220
Zhou Y, Song X, Jia R, Wang H, Dai L, Xu X, Gu P, Ge S （通讯作者）, Fan X Radiation-inducible human tumor necrosis factor-related apoptosis inducing ligand (TRAIL) gene therapy：a novel treatment for radioresistant uveal melanoma. Pigment Cell & Melanoma Research(IF 6.115) 2010 23:661-674
Zhang H, Wang H, Zhang J, Qian G, Niu B, Fan X, Lu J, Hoffman AR, Hu JF, Ge S[葛盛芳(通讯作者)]. （通讯作者） Enhanced Therapeutic Efficacy by Simultaneously Targeting Two Genetic Defects in Tumors. Mol Ther(IF 7.008) 2009 17 (1):57-64
Zhang X, Mei W, Zhang L, Yu H, Zhao X, Fan X, Qian G, Ge S[葛盛芳(通讯作者)]. （通讯作者） Co-expression of P1A35-43/β2m fusion protein and co-stimulatory molecule CD80 elicits effective anti-tumor immunity in the P815 mouse mastocytoma tumor model. Oncol Rep. 2009 22（5）:1213-1220
Fang L, Wang K, Liu X, Zhang L, Zhang X, Qian L, Lu J, Qian G, Ge S[葛盛芳(通讯作者)]. （通讯作者） A Study on the Anti-Tumor Immunity Induced by Gene-Modified Melanoma B16 Cells. Oncol Rep. 2008 19(6):1589-95
Zhao X, Wang L, Sun Y, Ye L, Lu J, Yuan Y, Qian G, Ge S[葛盛芳(通讯作者)]. （通讯作者） The endoplasmic reticulum (ER)-target protein Bik induces Hep3B cells apoptosis by the depletion of the ER Ca(2+) stores. Mol Cell Biochem. 2008 312(1-2):33-8
Zhao X, Sun Y, Yu H, Ye L, Zhang L, Lu J, Yuan Y, Qian G, Ge S[葛盛芳(通讯作者)]. （通讯作者） Apoptosis induced by BIK was decreased with RNA interference of caspase-12. Biochem Biophys Res Commun. 2007 359(4):896-901.
X. Liu, L. Zhang, X. Zhang, H. Yu, X. Zhao, J. Lu, G. Qian ,S. Ge[葛盛芳(通讯作者)]. （通讯作者） The effect of co-expression costimulatory molecule CD80 on uptake of antigen peptide-MHC class I-GFP complex by specific T cells. Int J Oncol. 2007 30（6）:1389-1396
Yu H, Zhao X, Huang S, Lu J, Qian G, Ge S[葛盛芳(通讯作者）] . （通讯作者） Blocking Notch1 Signaling by RNA Interference can Induce Growth Inhibition in Hela Cells. Int J Gynecol Cancer. 2007 17(2):511-6.
Jia RB, Zhang P, Zhou YX, Song X, Liu HY, Wang LZ, Luo M, Lu J, Ge SF[葛盛芳(共同通讯作者)] （通讯作者）, Fan XQ. VEGF-Targeted RNA Interference Suppresses Angiogenesis and Tumor Growth of Retinoblastoma. Ophthalmic Res. 2007 39(2):108-115.