导师姓名： 贾仁兵 专业代码： 100212
性别： 男 专业名称： 眼科学
培养单位： 附属第九人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： renbingjia@sjtu.edu.cn
邮编： 邮箱地址： renbingjia@sjtu.edu.cn

研究方向 (点击浏览详细信息)
眼肿瘤、眼眶病、眼整形

社会任职
中国医师协会眼科医师分会葡萄膜炎与免疫专业委员会委员
亚太眼肿瘤眼病理学会委员
海医会眼科专委会视网膜母细胞瘤学组委员、秘书
中华医学会眼科学会眼免疫学组委员
中华医学会眼科分会青年委员
上海市黄浦区侨联青年委员
上海市眼科学会眼整形眼眶病学组委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** BMP9在眼眶静脉畸形发生中的作用及其机制研究 国家自然科学基金 2018-01~2021-12 56万元 课题负责人
** lncRNA-OVM1调控α-SMA在眼眶静脉畸形形成中的机制研究 国家自然科学基金 2016-01~2019-12 70万元 课题负责人
—— 视网膜母细胞瘤动脉联合静脉化疗的前瞻性、随机、对照临床试验 上海交通大学医学院高峰高原计划—“研究型医师”项目 2015-10~2018-09 100万元 课题负责人
—— 常见眼恶性肿瘤预后相关靶标筛查及其作用研究 上海交通大学医学院转化医学创新基金 2015-06~2017-05 40万元 课题负责人
14SG18 MiR181abcd-CTDSPL-pRB-E2F1信号通路在脉络膜黑色素瘤生长转移中的作用机制研究 上海市教育委员会“曙光”计划 2015-01~2017-12 15万元 课题负责人
** 常见眼恶性肿瘤诊疗新技术、规范及其应用研究 国家卫计委 2014-01~2017-12 1500万元 子课题负责人
** STAT3-miR-181-NLK-Wnt/β-catenin信号通路在视网膜母细胞瘤生长转移中的作用机制 国家自然科学基金 2014-01~2017-12 70万元 课题负责人
11QA** 表达耐药基因小干扰RNA溶瘤腺病毒治疗视网膜母细胞瘤研究 上海市科委“启明星”计划 2011-04~2013-03 15万元 课题负责人
** 缺氧调控微小RNA181b表达对视网膜母细胞瘤生长的影响及其作用机制 国家自然科学基金青年基金 2010-01~2012-12 20万元 课题负责人
2006Y20 基于端粒酶靶向表达EpCAM小干扰RNA抑制视网膜母细胞瘤浸润和转移 上海市卫生局青年基金 2007-01~2009-12 5万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Xu Y, Li F, Jia R （通讯作者）, Fan X Updates on the clinical diagnosis and management of ocular sebaceous carcinoma: a brief review of the literature Onco Targets Ther 2018 11:3713-3720
Ruan J, Wang Y, Li F, Jia R, Zhou G, Shao C, Zhu L, Cui M, Yang DP, Ge S Graphene Quantum Dots for Radiotherapy ACS Appl Mater Interfaces（IF 8.097） 2018 10(17):14342-14355
Wang S, Chai P, Jia R, Jia R （通讯作者） Novel insights on m6A RNA methylation in tumorigenesis: a double-edged sword. Mol Cancer(IF 7.776) 2018 17(1):101
Li Y, Shang Q, Li P, Cao J, Zhu L, Jager MJ, Fan X, Ge S, Jia R. （通讯作者） Characterization of a conjunctival melanoma cell line CM-AS16, newly-established from a metastatic Han Chinese patient. Exp Eye Res 2018 173:51-63.
Chai P, Jia R, Jia R, Pan H, Wang S, Ni H, Wang H, Zhou C, Shi Y, Ge S, Zhang H, Fan X Dynamic chromosomal tuning of a novel GAU1 lncing driver at chr12p13.32 accelerates tumorigenesis Nucleic Acids Res（IF 11.561） 2018 46(12):6041-6056
Li F, Chai P, Fan J, Wang X, Lu W, Li J, Ge S, Jia R, Zhang H, Fan X A Novel FOXL2 Mutation Implying Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Type I Cell Physiol Biochem 2018 45(1):203-211
Fan J, Li Y, Jia R （通讯作者）, Fan X. An inherited FGFR2 mutation increased osteogenesis gene expression and result in Crouzon syndrome BMC Med Genet 2018 19(1):91
Zhang L, He X, Li F, Pan H, Huang X, Wen X, Zhang H, Li B, Ge S, Xu X, Jia R （通讯作者）, Fan X The miR-181 family promotes cell cycle by targeting CTDSPL, a phosphatase-like tumor suppressor in uveal melanoma J Exp Clin Cancer Res 2018 37(1):15
Xu XL, Li Z, Liu A, Fan X, Hu DN, Qi DL, Chitty DW, Jia R, Qui J, Wang JQ, Sharaf J, Zou J, Weiss R, Huang H, Joseph WJ, Ng L, Rosen R, Shen B, Reid MW, Forrest D, Abramson DH, Singer S, Cobrinik D, Jhanwar SC SKP2 Activation by Thyroid Hormone Receptor β2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells Cancer Res(IF 9.13) 2017 77(24):6838-6850
Xing Y, Wen X, Ding X, Fan J, Chai P, Jia R, Ge S, Qian G, Zhang H, Fan X 16. CANT1 lncRNA Triggers Efficient Therapeutic Efficacy by Correcting Aberrant lncing Cascade in Malignant Uveal Melanoma Mol Ther(IF 7.008） 2017 25(5):1209-1221
Shi Y, Jia R, Fan X Ocular basal cell carcinoma: a brief literature review of clinical diagnosis and treatment Onco Targets Ther 2017 10:2483-2489
Lu L, Yu X, Zhang L, Ding X, Pan H, Wen X, Xu S, Xing Y, Fan J, Ge S, Zhang H, Jia R, Fan X The Long Non-Coding RNA RHPN1-AS1 Promotes Uveal Melanoma Progression nt J Mol Sci 2017 18(1). pii: E226.
Xie J, Xu S, Shi Y, Li T, Jia R, Fan X. Comprehensive Treatment of Primary Orbital Arteriovenous Malformation. J Craniofac Surg 2017 28(6):e557-e559
Zhou C, Wang Y, Jia R （通讯作者）, Fan X. Conjunctival Melanoma in Chinese Patients: Local Recurrence, Metastasis, Mortality, and Comparisons With Caucasian Patients. Invest Ophthalmol Vis Sci 2017 58(12):5452-5459
Li Y, Jia R （通讯作者）, Ge S Role of Epigenetics in Uveal Melanoma. Int J Biol Sci 2017 13(4):426-433
Zhang L, He J, Han B, Lu L, Fan J, Zhang H, Ge S, Zhou Y, Jia R# （通讯作者）, Fan X Novel FOXC2 Mutation in Hereditary Distichiasis Impairs DNA-Binding Activity and Transcriptional Activation Int J Biol Sci 2016 6;12(9):1114-20
Qiu C, Li P, Bi J, Wu Q, Lu L, Qian G, Jia R#. （通讯作者） Differential expression of TYRP1 in adult human retinal pigment epithelium and uveal melanoma cells Oncol Lett 2016 11(4):2379-2383
Leilei Zhang, Xiaolin Huang, Xiaowei Zhu, Shengfang Ge, Eric Gilson, Renbing Jia# （通讯作者）, Jing Ye and Xianqun Fan Differential senescence capacities in meibomian gland carcinoma and basal cell carcinoma International Journal of Cancer 2016 138(6):1442–1452
Xu S, Wang H, Pan H, Shi Y, Li T, Ge S, Jia R# （通讯作者）, Zhang H,Fan X ANRIL lncRNA triggers efficient therapeutic efficacy by reprogramming the aberrant INK4-hub in melanoma Cancer Lett 2016 381(1):41-8
Xin Song, Renbing Jia （共同第一作者）, Huimin Zhu,Yixiong Zhou,Ying Sun, Ming Lin, Yao Fu, Jin Li, Zhengkang Li, Linna Lu, Yundun Shen, Shengfang Ge, and Xianqun Fan A Modified Staged Surgical Intervention for Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Annals of Plastic Surgery 2015 74(4):410-7
Jiayan Fan, Yue Xing, Xuyang Wen, Renbin Jia （共同第一作者）, Hongyan Ni, Jie He, Xia Ding, Hui Pan, Guanxiang Qian,Shengfang Ge, Andrew R. Hoffman, He Zhang and Xianqun Fan Long non-coding RNA ROR decoys genespecific histone methylation to promote tumorigenesis Genome Biology 2015 16:139
XIAOFANG XU, SHENGFANG GE, RENBING JIA （通讯作者）, YIXIONG ZHOU, XIN SONG,HE ZHANG and XIANQUN FAN Hypoxia-induced miR-181b enhances angiogenesis of retinoblastoma cells by targeting PDCD10 and GATA6 ONCOLOGY REPORTS 2015 33(6):2789-96
Hui Pana, RenbingJia （共同第一作者）, LeileiZhanga, ShiqiongXua, QingWua, XinSonga, HeZhanga,Shengfang Gea,XiaoliangLeonXub,XianqunFana BAP1 regulates cell cycle progression through E2F1 target genes and mediates transcriptional silencing via H2A monoubiquitinationin uveal melanoma cells The International Journal of Biochemistry & Cell Biology 2015 60:176–184
Leilei Zhang, Xiaolin Huang, Xiaowei Zhu, Shengfang Ge, Eric Gilson, Renbing Jia （通讯作者）, Jing Ye and Xianqun Fan Differential senescence capacities in meibomian gland carcinoma and basal cell carcinoma International Journal of Cancer 2015 published online
Zhang L, Jia R （共同第一作者）, Zhao J, Fan J, Zhou Y, Han B, Song X, Wu L, Zhang H, Song H, Ge S, Fan X. Novel mutations in the RB1 gene from Chinese families with a history of retinoblastoma Tumor Biology 2015 36(4):2409-20
Renbing Jia, Shiqiong Xu, Xiaolin Huang, Xin Song, Hui Pan, Leilei Zhang, Fanglin He, Ming Lin, Shengfang Ge, Xianqun Fan Pingyangmycin as First-Line Treatment for Low-FlowOrbital or Periorbital Venous Malformations Original Investigation 2014 132(8):942-948
Wang J, Jia R （共同第一作者）, Zhang Y, Xu X, Song X, Zhou Y, Zhang H, Ge S, Fan X. The role of Bax and Bcl-2 in gemcitabine-mediated cytotoxicity in uveal melanoma cells Tumor Biol. 2014 35(2):1169-75
Shiqiong Xu, Renbing Jia （共同第一作者）, Shengfang Ge, Ming Lin and Xianqun Fan Treatment of periorbital infantile haemangiomas: A systematic literature review on propranolol or steroids Journal of Paediatrics and Child Health 2014 50(4):271-279
Zhang Y, Jia R （共同第一作者）, Wang J, Xu X, Yao Y, Ge S,Fan X Targeted Silencing of MART-1 Gene Expression by RNA Interference Enhances the Migration Ability of Uveal Melanoma Cells Int. J. Mol. Sci. 2013 14(4):15092-15104
Cun B, Song X, Jia R, Wang H, Zhao X, Liu B, Ge S, Fan X Cell growth inhibition in HPV 18 positive uveal melanoma cells by E6/E7 siRNA. Tumour Biol. 2013 34(3):1801-6
Xu SQ, Jia RB# （共同第一作者）, Zhang W, Zhu H, Ge SF, Fan XQ Beta-blockers versus corticosteroids in the treatment of infantile hemangioma: anevidence-based systematic review World J Pediatr 2013 9(3):221-9
Shi W, Jia R, Li Z, He D, Fan X. Combination of transorbital and endoscopic transnasal approaches to repair orbital medial wall and floor fractures. J Craniofac Surg. 2012 23(1):71-4
Jia R, Zhu H, Lin M, Li Z, Sun Y, Luo M, Fan X. Clinicopathological characteristics and surgical outcomes of divided nevus of the eyelids: a decade's experience on 73 cases. Ann Plast Surg. 2012 68(2):166-70
Jia RB, Fan XQ, Xu YY, Dong ED. Continuous funding of National Natural Science Foundation of China has boosted the development of the discipline of ophthalmology over the past 25 years Zhonghua Yan Ke Za Zhi. (Chinese). 2012 48(2):164-9.
Zhang P, Jia R （共同第一作者）, Ying L, Liu B, Qian G, Fan X, Ge S. WWOX-mediated apoptosis in A549 cells mainly involves the mitochondrial pathway. Mol Med Rep. 2012 6(1):121-4
Cun B, Song X, Jia R, Zhao X, Wang H, Ge S, Fan X. Combination of oncolytic adenovirus and dacarbazine attenuates antitumor ability against uveal melanoma cells via cell cycle block. Cancer Biol Ther. 2012 13(2):77-84
Song X, Wang H, Jia R, Cun B, Zhao X, Zhou Y, Xu X, Qian G, Ge S, Fan X. Combined Treatment with an Oncolytic Adenovirus and Antitumor Activity of Vincristine against Retinoblastoma Cells. Int J Mol Sci. 2012 13(9):10736-49
Wang Z, Jia R, Ge S, He T, Zhang Y, Yang Y, Wang Y, Shi W, Ji Y, Ye F, Chen P, Lu J, Sun J, Xu X, Zhou Y, Gu P, Luo M, Lu H, Fan X. Ocular complications of human immunodeficiency virus infection in eastern china. Am J Ophthalmol. 2012 153(2):363-369
Yao Y, Li L, Zhang H, Jia R, Liu B, Zhao X, Zhang L, Qian G, Fan X, Ge S. Enhanced therapeutic efficacy of vitamin K2 by silencing BCL-2 expression in SMMC-7721 hepatocellular carcinoma cells. Oncol Lett. 2012 4(1):163-167
Huang X, Jia R （共同第一作者）, Zhao X, Liu B, Wang H, Wang J, Zhou Y, Cun B, Ge S, Fan X Recombinant oncolytic adenovirus H101 combined with siBCL2: cytotoxic effect on uveal melanoma cell lines. Br J Ophthalmol. 2012 96(10):1331-8
Jia R, Jiao Z, Xu X, Wang J, Zhou Y, Song X, Ge S, Fan X. Functional significance of B7-H1 expressed by human uveal melanoma cells. Mol Med Rep. 2011 4(1):163-7
Xu X, Jia R （共同第一作者）, Zhou Y, Song X, Wang J, Qian G, Ge S, Fan X. Microarray-based analysis: identification of hypoxia-regulated microRNAs in retinoblastoma cells. Int J Oncol. 2011 38(5):1385-93
Wang J, Jia R （共同第一作者）, Yao Y, Cun B, Huang X, Gu P, Ge S, Fan X. Differential expression of Mart-1 in human uveal melanoma cells. Mol Med Rep. 2011 4(5):799-803
Li J, Lin M, Zhou H, Jia R （通讯作者）, Fan X. Double-eyelid blepharoplasty incorporating blepharoptosis surgery for 'latent' aponeurotic ptosis. J Plast Reconstr Aesthet Surg. 2011 64(8):993-9
Li L, Qi Z, Qian J, Bi F, Lv J, Xu L, Zhang L, Chen H, Jia R. （通讯作者） Induction of apoptosis in hepatocellular carcinoma Smmc-7721 cells by vitamin K(2) is associated with p53 and independent of the intrinsic apoptotic pathway. Mol Cell Biochem. 2010 342(1-2):125-31
Song X, Zhou Y, Jia R, Xu X, Wang H, Hu J, Ge S, Fan X. Inhibition of retinoblastoma in vitro and in vivo with conditionally replicating oncolytic adenovirus H101. Invest Ophthalmol Vis Sci. 2010 51(5):2626-35
Zhou Y, Song X, Jia R, Wang H, Dai L, Xu X, Gu P, Ge S, Fan X. Radiation-inducible human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene therapy: a novel treatment for radioresistant uveal melanoma. Pigment Cell Melanoma Res. 2010 23(5):661-74
Xu X, Jia R （共同第一作者）, Zhou Y, Song X, Fan X. Investigation of vasculogenic mimicry in sebaceous carcinoma of the eyelid. Acta Ophthalmol. 2010 88(5):160-4
Jiao Z, Wang W, Jia R, Li J, You H, Chen L, Wang Y. Accumulation of FoxP3-expressing CD4+CD25+ T cells with distinct chemokine receptors in synovial fluid of patients with active rheumatoid arthritis. Scand J Rheumatol. 2007 36(6):428-33.
Jia RB, Zhang P, Zhou YX, Song X, Liu HY, Wang LZ, Luo M, Lu J, Ge SF, Fan XQ. VEGF-targeted RNA interference suppresses angiogenesis and tumor growth of retinoblastoma. Ophthalmic Res. 2007 39(2):108-15.