导师姓名： 沈键锋 专业代码： 100212
性别： 男 专业名称： 眼科学
培养单位： 附属第九人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市眼眶病眼肿瘤重点实验室，黄浦区制造局路833弄12号楼3楼309室，电子邮件： jfshen@shsmu.edu.cn 实验室网页（建设中）：www.shenlab.org.cn
邮编： 200011 邮箱地址： darkingfeng@hotmail.com

研究方向 (点击浏览详细信息)
方向一：SWI/SNF染色质重塑复合体调控肿瘤发生与进展
方向二：DNA损伤修复与肿瘤免疫调控的相互作用机制与应用
方向三：肿瘤靶向和免疫治疗新方法

社会任职
上海市医学会眼科专科分会视觉研究学组委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
001 DNA损伤修复与肿瘤免疫调控 国家高层次人才计划 2020-01~2022-12 300万元 课题负责人
** 聚ADP核糖聚合酶1调控STING信号通路影响肿瘤免疫的机理研究 国家自然科学基金面上项目 2020-01~2023-12 55万元 课题负责人
** "双百人”-临床专职科研队伍 上海交通大学医学院 2019-10~2022-09 100万元 课题负责人
002 上海交通大学医学院基金 引进人才启动经费 2019-04~2024-03 300万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Jianfeng Shen, Wei Zhao, Zhenlin Ju, Lulu Wang, Yang Peng, Marilyne Labrie, Timothy A. Yap, Gordon B. Mills,Guang Peng PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness Cancer Research 2019 79(2) January 15
Jianfeng Shen, Zhenlin Ju, Wei Zhao, Lulu Wang, Yang Peng, Zhongqi Ge, Zachary D. Nagel, Jun Zou, Chen Wang, Prabodh Kapoor, Xiangyi Ma, Ding Ma, Jiyong Liang, Jingsong Liu, Leona D. Samson, Guo-Min Li, Han Liang, Xuetong Shen, Gordon B. Mills, Guang Peng ARID1A deficiency promotes mutability and potentiates anti-tumor immunity unleashed by immune checkpoint blockade Nature Medicine 2018 Vol 24, 556-562
Xiaojuan Lin, Jianfeng Shen （共同第一作者）, Dan Peng, Janos L Tanyi, Kathleen Montone, Qihong Huang, Yi Fan, Lin Zhang, Xiaomin Zhong RNA-binding protein LIN28B inhibits apoptosis through regulating the AKT2/FOXO3A/Bim axis in ovarian cancer cells Signal Transduction and Targeted Therapy 2018 3:23
Hui-Ju Hsieh, Wei Zhang, Shu-Hong Lin, Wen-Hao Yang, Jun-Zhong Wang, Jianfeng Shen, Yiran Zhang, Yiling Lu, Hua Wang, Jane Yu, Gordon B. Mills,Guang Peng Systems biology approach reveals that mTORC1 regulates G2/M DNA damage checkpoint recovery, creating a therapeutic vulnerability in mTOR-hyperactivated tumors Nature Communications 2018 9:3982
Kumar S, Peng X, Daley J, Yang L, Shen J, Nguyen N, Bae G, Niu H, Peng Y, Hsieh HJ, Wang L, Rao C, Stephan CC, Sung P, Ira G, Peng G Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells Oncogenesis 2017 6(4):e319
Lihong Zhang, Yang Peng, Ivan P.Uray, Jianfeng Shen, Lulu Wang, Xiangdong Peng, Powel H.Brown, Wei Tu, Guang Peng Natural product beta-thujaplicin inhibits homologous recombination repair and sensitizes cancer cells to radiation therapy DNA Repair 2017 60:89-101
Zhang L, Shen J, Yin Y, Peng Y, Wang L, Hsieh HJ, Shen Q, Brown PH, Tao K, Uray IP, Peng G Identifying Cell Cycle Modulators That Selectively Target ARID1A Deficiency Using High-Throughput Image-Based Screening SLAS Discov 2017 22(7):813-826
Zhong X, Zheng L, Shen J, Zhang D, Xiong M, Zhang Y, He X, Tanyi JL, Yang F, Montone KT, Chen X, Xu C, Xiang AP, Huang Q, Xu X, Zhang L Suppression of MicroRNA 200 Family Expression by Oncogenic KRAS Activation Promotes Cell Survival and Epithelial-Mesenchymal Transition in KRAS-Driven Cancer Mol Cell Biol 2016 36(21):2742-2754
Kapoor P, Bao Y, Xiao J, Luo J, Shen J, Persinger J, Peng G, Ranish J, Bartholomew B, Shen X Regulation of Mec1 kinase activity by the SWI/SNF chromatin remodeling complex Genes Dev 2015 29(6):591-602
Shen J, Peng Y, Wei L, Zhang W, Yang L, Lan L, Kapoor P, Ju Z, Mo Q, Shih IeM, Uray IP, Wu X, Brown PH, Shen X, Mills GB, Peng G ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors Cancer Discovery 2015 5(7):752-67
Jiang Y, Qian X, Shen J, Wang Y, Li X, Liu R, Xia Y, Chen Q, Peng G, Lin SY, Lu Z Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation Nat Cell Biol 2015 17(9):1158-68
Zhang B, Wang E, Dai H, Shen J, Hsieh HJ, Lu X, Peng G Phosphorylation of the BRCA1 C terminus (BRCT) repeat inhibitor of hTERT (BRIT1) protein coordinates TopBP1 protein recruitment and amplifies ataxia telangiectasia-mutated and Rad3-related (ATR) Signaling J Biol Chem 2014 289(49):34284-95