导师姓名： 宋雷 专业代码： 100213
性别： 男 专业名称： 耳鼻咽喉科学
培养单位： 附属第九人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： lei.song@yale.edu
邮编： 200120 邮箱地址： Lei.song@vip.126.com

研究方向 (点击浏览详细信息)
听觉电生理

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
外毛细胞功能调控机理的研究 国家自然科学基金-面上项目 2018-01~2021-12 78.16万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Jingjing Zhao#, Gen Li#, Xuan Zhao, Xin Lin, Yunge Gao, Nuno Raimundo, Geng-Lin Li, Wei Shang*, Hao Wu*, Lei Song* （通讯作者） Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss Aging 2020 12(7):5590-5611
Xin Lin#, Gen Li#, Yu Zhang, Jingjing Zhao, Jiawen Lu, Yunge Gao, Huihui Liu, Geng-Lin Li, Tao Yang, Lei Song* （通讯作者）, Hao Wu* Hearing consequences in Gjb2 knock-in mice: implications for human p.V37I mutation Aging 2019 11(18):7416-7441
Lynda El-Hassar, Lei Song, Winston J T Tan, Charles H Large, Giuseppe Alvaro, Joseph Santos-Sacchi, Leonard K Kaczmarek Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice. Journal of Neuroscience 2019 39(24):4797-4813
Zhang H, Pan H, Zhou C, Wei Y, Ying W, Li S, Wang G, Li C, Ren Y, Li G, Ding X, Sun Y, Li GL, Song L, Li Y, Yang H, Liu Z. Simultaneous zygotic inactivation of multiple genes in mouse through CRISPR/Cas9-mediated base editing. Development 2018 145(20). pii: dev168906
Li C, Shu Y, Wang G, Zhang H, Lu Y, Li X, Li G, Song L, Liu Z. Characterizing a novel vGlut3-P2A-iCreER knockin mouse strain in cochlea. Hearing Research 2018 364:12-24.
Tan WJT, Song L （通讯作者）, Graham M, Schettino A, Navaratnam D, Yarbrough WG, Santos-Sacchi J, Ivanova AV. Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear. Antioxidants & Redox Signaling 2017 27(8):489-509
Song L,Santos-Sacchi J An electrical inspection of the subsurface cisternae of the outer hair cell. Biophysical Journal 2015 108(3):568-77
McKay SE, Yan W, Nouws J, Thormann MJ, Raimundo N, Khan A, Santos-Sacchi J, Song L （通讯作者）, Shadel GS. Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness. American Journal of Pathology 2015 185(12):3132-40
Joseph Santos-Sacchi and Lei Song Chloride and salicylate influence prestin-dependent specific membrane capacitance: support for the area motor model J Biol Chem 2014 289(15):10823-30
Joseph Santos-Sacchi and Lei Song Chloride-driven electromechanical phase lags at acoustic frequencies are generated by SLC26a5, the outer hair cell motor protein Biophys J 2014 107(1):126-33
Song L,Santos-Sacchi J Disparities in voltage-sensor charge and electromotility imply slow chloride-driven state transitions in the solute carrier SLC26a5. Proceedings of the National Academy of Sciences of the United 2013 110(10):3883-8
Ricci AJ, Bai JP, Song L, Lv C, Zenisek D, Santos-Sacchi J. Patch-clamp recordings from lateral line neuromast hair cells of the living zebrafish. Journal of Neuroscience 2013 33(7):3131-4
Raimundo N, Song L, Shutt TE, McKay SE, Cotney J, Guan MX, Gilliland TC, Hohuan D, Santos-Sacchi J, Shadel GS Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness Cell 2012 148(4):716-26
Tao Wu, Lei Song, Xiaorui Shi, Zhigeng Jiang, Santos-Sacchi and Alfred Nuttall Effect of capsaicin on potassium conductance and electromotility of the guinea pig outer hair cell Hearing Research 2011 272(1-2): 117-24
Song L,Santos-Sacchi J Conformational State-Dependent Anion Binding in Prestin: Evidence for Allosteric Modulation Biophysical Journal 2010 98(3): 371–376
Song L,McGee JA,Walsh EJ The Influence of Thyroid Hormone Deficiency on the Development of Cochlear Nonlinearities Journal of the Association for Research in Otolaryngology 2008 9(4): 464–476
Song L,McGee JA,Walsh EJ Development of cochlear amplification, frequency tuning, and two-tone suppression in the mouse. Journal of Neurophysiology 2007 99(1):344-55
Song L,McGee JA,Walsh EJ Frequency-and Level-Dependent Changes in Auditory Brainstem Responses in Developing Mice Journal of Acoustical Society of America 2006 119(4):2242-57
Song L,McGee JA,Walsh EJ Consequences of combined maternal, fetal and persistent postnatal hypothyroidism on the development of auditory function in Tshr(hyt) mutant mice Brain Research 2006 1101(1):59-72
Santos-Sacchi J, Song L, Zheng J, Nuttall AL Control of mammalian cochlear amplification by chloride anions. Journal of Neuroscience 2006 26(15):3992-8
Carlo Spirlì, Romina Fiorotto, Lei Song, Joseph Santos-Sacchi, Lajos Okolicsanyi, Sara Masier, Loretta Rocchi, Maria Pia Vairetti, Marina De Bernard, Saida Melero, Tullio Pozzan, Mario Strazzabosco Glibenclamide stimulates fluid secretion in rodent cholangiocytes through a CFTR-independent mechanism. Gastroenterology 2005 129(1):220-33
Song L,Seeger A,Santos-Sacchi J On membrane motor activity and chloride flux in the outer hair cell of Corti’s organ: lessons learned from the environmental toxin tributyltin Biophysical Journal 2005 88(3):2350-62