导师姓名： 陶永 专业代码： 100213
性别： 男 专业名称： 耳鼻咽喉科学
培养单位： 附属第九人民医院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： taoyent@foxmail.com

研究方向 (点击浏览详细信息)
耳聋基因治疗
老年性聋和噪音性聋的药物治疗
非人灵长类动物的听觉及内耳治疗

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 上海交通大学医学院双百人 上海交通大学医学院 2019-12~2022-12 100万元 课题负责人
DF **** 上海市教委 2019-11~2022-10 100万元 课题负责人
** 核糖核酸蛋白介导的CRISPR/Cas9精准治疗Pmca2基因突变耳聋小鼠的研究 国家自然科学基金青年项目 2019-01~2021-12 21万元 课题负责人
2018YQ59 内耳基因治疗 上海市卫生系统优秀人才培养计划 2018-07~2021-06 30万元 课题负责人
** 核糖核酸蛋白介导的CRISPR/Cas9精准治疗遗传性耳聋小鼠的研究 上海市科技创新行动计划 2018-06~2021-06 20万元 课题负责人
18PJ** 利用单碱基编辑工具治疗遗传性耳聋小鼠模型 上海浦江人才 2018-06~2020-06 20万元 课题负责人
18ZR** 应用CRISPR/Cas9定向基因编辑技术精准治疗遗传性耳聋模型小鼠听力 上海自然基金面上项目 2018-05~2021-05 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wen Kang,Xingle Zhao,Zhuoer Sun,Tingting Dong,Chenxi Jin,Ling Tong,Weidong Zhu,Yong Tao （通讯作者）,Hao Wu Adeno-associated virus vector enables safe and efficient Cas9 Gene Therapy 2020 无
Xingle Zhao, Chenxi Jin, Tingting Dong, Zhuoer Sun, xiaofei Zheng, Baiyi Feng, Zhenzhe Cheng, Xiang Li, YongTao （通讯作者）, HaoWuabc Characterization of Promoters for Adeno-associated Virus Mediated Efficient Cas9 Activation in Adult Cas9 Knock-In Murine Cochleae Hearing Research 2020 394
Yilai Shu, Wenyan Li, Mingqian Huang, Yi-Zhou Quan, Deborah Scheffer,Chunjie Tian, Yong Tao, Xuezhong Liu, Konrad Hochedlinger, Artur A. Indzhykulian,Zhengmin Wang, Huawei Li,Zheng-Yi Chen Renewed proliferation in adult mouse cochlea and regeneration of hair cells Nature Communications 2019 10(1):5530
Jingrong Lu,Lingxiang Hu,Bin Ye,Haixia Hu,Yong Tao, Yilai Shu,HaoChiang,Vikrant Borse,Mingliang Xiang,Hao Wu,Albert S. B. Edge,Fuxin Shi Increased Type I and Decreased Type II Hair Cells after Deletion of Sox2 in the Developing Mouse Utricle Neuroscience 2019 422:146-160
Wen Kanga,Zhuoer Suna,Xingle Zhao,Xueling Wanga, Yong Tao （通讯作者）, Hao Wu Gene editing based hearing impairment research and therapeutics Neuroscience Letters 2019 709:134326
Xueling Wang,Yuming chen,Yong Tao,Yunge gao,Dehong Yu,hao Wu A666-conjugated nanoparticles target prestin of outer hair cells preventing cisplatin-induced hearing loss International Journal of Nanomedicine 2018 13:7517-753
Xue Gao1, Yong Tao （共同第一作者）, Veronica Lamas, Mingqian Huang, Wei-Hsi Yeh,Bifeng Pan, Yu-Juan Hu, Johnny H. Hu, David B.Thompson, Yilai Shu, Yamin Li, Hongyang Wang, Shiming Yang,Qiaobing Xu, Daniel B. Polley, M. Charles Liberman, Wei-Jia Kong, Jeffrey R. Holt, Zheng-Yi Chen, and David R. Liu Treatment of autosomal dominant progressive hearing loss by in vivo delivery of genome editing agents Nature 2018 553(7687);217-221
Yong Tao, Mingqian Huang, Yilai Shu, Adam Ruprecht, Hongyang Wang, Yong Tang, Luk H. Vandenberghe, Qiuju Wang, Guangping Gao, Wei-Jia Kong,Zheng-Yi Chen Delivery of Adeno-Associated Viral Vectors in Adult Mammalian Inner Ear Cell Subtypes without Auditory Dysfunction. Human Gene Therapy 2018 29(4);492-506.
Yilai Shu,Yong Tao,Zhengmin Wang,Yong Tang,Huawei Li,Pu Dai,Guangping Gao,Zheng-Yi Chen Identification of Adeno-Associated Viral Vectors That Target Neonatal and Adult Mammal Human Gene Therapy 2016 27(9);687-99
Yilai Shu, Yong Tao （共同第一作者）, Wenyan Li,Jun Shen,Zhengmin Wang, Zheng-Yi Chen Adenovirus Vectors Target Several Cell Subtypes of Mammalian Inner Ear In Vivo Neural Plasticity 2016 **
Bing Zou, Rahul Mittal, M'hamed Grati, Zhongmin Lu , Yilai Shu, Yong Tao,Youg Feng, Dinghua Xie, Weijia Kong, Shiming Yang, Zheng-Yi Chen,Xuezhong Liu The application of genome editing in studying hearing loss Hearing Research 2015 327;102-8.
Margie Li, Yong Tao, Yilai Shu, Jonathan R. LaRochelle, Angela Steinauer, David Thompson, AlannaSchepartz, Zheng-Yi Chen, David R. Liu Discovery and characterization of a peptide that enhances endosomal escape of delivered proteins in vitro and in vivo Journal of the American Chemical Society. 2015 137(44):14084-93