导师姓名： 林开利 专业代码： 100301
性别： 男 专业名称： 口腔基础医学
培养单位： 附属第九人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 电子邮箱：lklecnu@aliyun.com
邮编： 200011 邮箱地址： lklecnu@aliyun.com

研究方向 (点击浏览详细信息)
生物医用材料与组织再生、口腔基础

社会任职
上海生物医学工程学会第七届口腔生物医学专委会?委员
中国食品药品监督管理局医疗器械技术审评咨询专家
中国生物材料学会骨修复材料与器械分会?委员
中国医疗器械行业协会3D打印医疗器械专业委会?专家委员会专家
中华口腔医学会口腔材料专委会?委员
中华医促会骨科生物材料分委会?委员
上海市硅酸盐学会第十届理事会无机生物与环保材料专委会?委员
中国医药生物技术协会3D打印分会?常委
中国医药教育协会医用生物材料与技术专业委员会?委员
The Open Biomedical Engineering Journal ? 副主编
上海市口腔医学会第三届理事会?理事
中华口腔医学会口腔基础医学专委会?委员
上海市实验动物标准化技术委员会?委员
上海市口腔医学会口腔生物材料专委会?委员
Frontiers in Tissue Engineering and Regenerative Medicine ? Editor Board Member
上海市口腔医学会口腔基础医学专委会?常委
中国机械工程学会生物制造工程分会?委员
RSC Advances ? 副主编（2015-2017）
中国生物材料青年委员会?委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 上海交通大学医学院双**** 上海交通大学医学院 2019-10~2022-09 130万元 课题负责人
19XD** 基于微纳结构和功能元素设计和制备生物活性骨修复陶瓷 上海市优秀学术/技术带头人 2019-04~2022-04 40万元 课题负责人
** 激活内源性干细胞的骨修复材料构建及其原位诱导骨再生机制研究 国家自然科学基金 2019-01~2022-12 57万元 课题负责人
2018YFB** 3D打印关节单元高通量筛选药物模型构建 国家重点研发计划课题 2018-05~2021-04 340万元 课题负责人
2018 上海交通大学医学院附属第九人民医院引进人才计划 上海高校高峰学科（口腔医学） 2018-03~2021-12 200万元 课题负责人
** 基于3D打印的个性化生物活性牙种植体研制 上海市科委国际科技合作（重点）项目 2017-07~2020-06 50万元 课题负责人
** 三维打印多级微纳结构生物陶瓷调控成骨/成血管机制及其促颌骨 节段性缺损修复研究 国家自然科学基金 2017-01~2020-12 60万元 课题负责人
16DZ** 医用3D打印聚乳酸材料标准体系研究与建设 上海市科委标准化（重点）项目（子课题） 2016-08~2019-07 60万元 课题参与人
锶/硅掺杂高结晶度纳米构羟基磷灰石生物涂层的制备及促骨整合性能研究 上海市卫计委（重点）项目 2016-01~2018-12 15万元 课题负责人
** 可降解微纳结构双相磷酸钙生物陶瓷调控成骨/成血管及其应用研究 上海市科委生物医药支撑（重点）项目 2015-07~2018-09 50万元 课题负责人
13NM** 羟基磷灰石及其复合骨修复材料的自组装制备 上海市科委基础研究（重点）项目 2013-09~2016-08 40万元 课题负责人
** 羟基磷灰石表面微纳米结构及组成的可控制备与生物学效应研究 国家自然科学基金 2012-12~2015-12 58万元 课题负责人
** 多孔硅酸钙生物陶瓷的成骨与降解机理研究 国家自然科学基金 2010-01~2012-12 22万元 课题负责人
09JC** 掺锶/锌生物活性硅酸钙骨修复陶瓷的制备与生物学性能研究 上海市科委基础研究（重点）项目 2009-09~2011-09 35万元 课题负责人
07ZD05012 生物玻璃和玻璃陶瓷粉体检测方法标准研究 上海市科委标准化（重点）项目 2007-10~2009-09 60万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
[5]Cancan Zhao, Anfeng Shen, Liangzhu Zhang, Kaili Lin,* and Xudong Wang* （通讯作者） Borocarbonitrides Nanosheets Engineered 3D-printed Scaffolds for Integrated Strategy of Osteosarcoma Therapy and Bone Regeneration Chemical Engineering Journal 2020 2020;401:125989
Cancan Zhao, Kaili Lin （通讯作者）,* Xudong Wang* Maintenance and modulation of stem cells stemness based on biomaterial designing via chemical and physical signals Applied Materials Today 2020 2020;19:100614
Yitong Wang#, Ting Ying#, Jinxiu Li#, Yafeng Xu, Qinfei Ke, Steve G.F. Shen,* He Xu,* and Kaili Lin （通讯作者）,* Hierarchical micro/nanofibrous scaffolds incorporated with curcumin and zinc ion eutectic metal organic frameworks for enhanced diabetic wound healing via anti-oxidant and anti-inflammatory activities Chemical Engineering Journal 2020 2020;402:126273
Jinkai Zhang#, Jiaqiang Liu#, Chengtao Wang, Fengshan Chen*, Xudong Wang*, Kaili Lin （通讯作者）,* A comparative study of the osteogenic performance between the hierarchical micro/submicro-textured 3D-printed Ti6Al4V surface and the SLA surface Bioactive Materials 2020 2020;5:9-16.
Jiajie Chen#, Yitong Wang#, Baoyuan Ma#, Lei Guan, Zhengfang Tian, Kaili Lin,* Yufang Zhu* （通讯作者） Biodegradable hollow mesoporous organosilica-based nanosystems with dual stimuli-responsive drug delivery for efficient tumor inhibition by synergistic chemo- and photothermal therapy Applied Materials Today 2020 2020;19:100655
Shaojie Dong, Yu Chen,* Luodan Yu, Kaili Lin （通讯作者）,* and Xudong Wang* Magnetic Hyperthermia–Synergistic H2O2 Self-Sufficient Catalytic Suppression of Osteosarcoma with Enhanced Bone-Regeneration by 3D-Printing Composite Scaffolds Advanced Functional Materials 2020 2020;30:**
Junkai Zeng#, Yitong Wang#, Zhenyu Sun#, Haishang Chang, Mi Cao, Jie Zhao*, Kaili Lin*, Youzhuan Xie* （通讯作者） A novel biocompatible PDA/IR820/DAP coating for antibiotic/photodynamic/photothermal triple therapy to inhibit and eliminate Staphylococcus aureus biofilm Chemical Engineering Journal 2020 2020;394:125017
Anting Jin#, Yitong Wang#, Kaili Lin （通讯作者）,* Lingyong Jiang* Nanoparticles modified by polydopamine: working as “drug” carriers Bioactive Materials 2020 2020;5:522-541.
Shaojie Dong,# Ya-nan Zhang,# Jianyu Wan, Rongrong Cui, Xingge Yu, Guohua Zhao,* Kaili Lin （通讯作者）,* A Novel Multifunctional Carbon Aerogel Coated Platform for Osteosarcoma Therapy and Enhanced Bone Regeneration Journal of Materials Chemistry. B 2020 2020;8:368-379.
Ranjith Kumar Kankala, Hongbo Zhang, Chen-Guang Liu, Kiran Reddy Kanubaddi, Chia-Hung Lee, Shi-Bin Wang, Wenguo Cui,* Hélder A. Santos,* Kaili Lin （通讯作者）,* and Ai-Zheng Chen* Metal Species–Encapsulated Mesoporous Silica Nanoparticles: Current Advancements and Latest Breakthroughs Advanced Functional Materials 2020 2019;29:**
张欣然, 林开利* （通讯作者） 自噬在骨稳态与骨质疏松症中的作用及机制研究进展 骨科 2019 10(2):162-166.
Hui Wang,# Chucheng Lin,# Xinran Zhang, Kaili Lin* （通讯作者）, Xudong Wang*, Steve Guofang Shen* Mussel inspired polydopamine coating: a general strategy to enhance osteogenic differentiation and osseointegration for diverse implants ACS Applied Materials & Interfaces 2019 11(7):7615-7625.
Kaili Lin#, Dawei Zhang#, Maria Helena Macedo, Wenguo Cui*, Bruno Sarmento*, Guofang Shen* Advanced collagen-based biomaterials for regenerative biomedicine Advanced Functional Materials 2019 29:**.
Jinkai Zhang, Wenhui Zhou, Hui Wang, Kaili Lin* （通讯作者）, Fengshan Chen* 3D-printed surface promoting osteogenic differentiation and angiogenetic factor expression of BMSCs on Ti6Al4V implants and early osseointegration in vivo Journal of Materials Science & Technology 2019 35:336-343.
Panyu Zhou, Jianghong Wu, Yan Xia, Ye Yuan, Hongyue Zhang, Shuogui Xu, Kaili Lin （通讯作者） Loading BMP-2 on nanostructured hydroxyapatite microspheres for rapid bone regeneration International Journal of Nanomedicine 2018 2018;13:4083-4092.
Dawei Zhang, Xiaowei Wu, Jingdi Chen, Kaili Lin （通讯作者） The development of collagen based composite scaffolds for bone regeneration Bioactive Materials 2018 2018;3:129-138.
Hui Wang, Xinran Zhang, Haicheng Wang, Jinkai Zhang, Changshun Ruan, Rui Zhu, Kaili Lin （通讯作者） Enhancing the Osteogenic Differentiation and Rapid Osseointegration of 3D Printed Ti6Al4V Implants via Nano-topographic Modification Journal of Biomedical Nanotechnology 2018 2018;14:707-715.
Xinran Zhang, Haotian Li, Chucheng Lin, Congqin Ning, Kaili Lin （通讯作者） The synergistic effects of micro-pattern and strontium ion doping on the osteogenic differentiation of bone marrow stromal cells through the ERK1/2 and p38 MAPK signaling pathway Biomaterials Science 2018 2018;6:418-430.
Xiaojing Guo, Silong Wei, Mengmeng Lu, Zhengwei Shao, Jiayu Lu, Lunguo Xia, Kaili Lin （通讯作者）, Derong Zou RNA-Seq investigation and in vivo study of the effect of strontium ranelate on ovariectomized rat via the involvement of ROCK1 Artificial Cells, Nanomedicine, and Biotechnology 2018 https://doi.org/10.1080/**.2018.**.
Wenjun Sun, Yuning Zhou, Xinran Zhang, Wei Xia, Yuanjin Xu, Kaili Lin （通讯作者） Fabricating of injectable nano-structured silicon containing hydroxyapatite microspheres with enhanced osteogenic differentiation and angiogenic factor expression for carriers Ceramics International 2018 https://doi.org/10.1016/j.ceramint.2018.08.040
Lunguo Xia, Youtao Xie, Bing Fang, Xiuhui Wang, Kaili Lin （通讯作者） In situ Modulation of Crystallinity and Nano-structures to Enhance the Stability and Osseointegration of Hydroxyapatite Coatings on Ti-6Al-4V Implants Chemical Engineering Journal 2018 2018;347: 711-720.
Xiaowei Wu, Shang Zheng, Yuanzhou Ye, Yuchen Wu, Kaili Lin （通讯作者）, Jiansheng Su Enhanced osteogenic di?erentiation and bone regeneration of poly(lactic-co-glycolic acid) by graphene via activation of PI3K/Akt/GSK3β/β-catenin signal circuit Biomaterials Science 2018 2018;6:1147-1158.
Wenhui Zhou, Jinkai Zhang, Kaili Lin （通讯作者）, Fengshan Chen Comparison between mandibular and femur derived bone marrow stromal cells: osteogenic and angiogenic potentials in vitro and bone repairing ability in vivo RSC Advances 2017 2017;7:56220-56228.
林开利 （通讯作者） 改善磷酸钙陶瓷生物活性的途径 口腔材料器械杂志 2017 2017;26(2):57-61.
Xiaowei Wu, Shinn-Jyh Ding, Kaili Lin （通讯作者）, Jiansheng Su A Review on the biocompatibility and potential applications of graphene in inducing cell differentiation and tissue regeneration Journal of Materials Chemistry B 2017 2017;5:3084-3102.
Ling-Yan Meng, Bin Wang, Ming-Guo Ma, Kaili Lin （通讯作者） The progress of microwave-assisted hydrothermal method in the synthesis of functional nanomaterials Materials Today Chemistry 2016 2016;1-2:63-83.
Cancan Zhao, Lunguo Xia, Dong Zhai, Bing Fang, Jiang Chang, Kaili Lin （通讯作者） Designing the ordered micropatterned hydroxyapatite bioceramics to promote the growth and osteogenic differentiation of bone marrow stromal cells Journal of Materials Chemistry. B 2015 2015;3:968-976.
Xiaohong Wang, Yao Sun, Kaili Lin （通讯作者） Facile Synthesis of Dental Enamel-like Hydroxyapatite Nanorod Arrays via Hydrothermal Transformation of Hillebrandite Nanobelts Journal of Materials Chemistry B 2015 2015;3:7334-7339.
Zhilan Yin, Xiaoya Wang, Xiuhui Wang, Na Zhang, Lei Chen, Haiyun Qu, Jiang Chang, Zhongming Ren, Kaili Lin （通讯作者） Facile Synthesis of Element-substituted Hydroxyapatite Whiskers using α-tricalcium Phosphate as Precursors International Journal of Applied Ceramic Technology 2015 2015;12(5):1000-1007.
Kaili Lin （通讯作者）, Chengtie Wu, Jiang Chang Advances in synthesis of calcium phosphate crystals with controlled size and shape Acta Biomaterialia 2014 2014;10:4071-4102.
Lunguo Xia, Kaili Lin （共同第一作者）, Zhiyuan Zhang, Xinquan Jiang, Jiang Chang Enhanced osteogenesis through nano-structured surface design of macroporous hydroxyapatite bioceramic scaffolds via activation of ERK and p38 MAPK signaling pathways Journal of Materials Chemistry. B 2013 2013;1(40):5403-5416.
Kaili Lin, Peiyi Liu, Weibin Zhang, Li Wei, Zhaoyong Zou, Ying Qian, Yuhui Shen, Jiang Chang Mesoporous strontium substituted hydroxyapatite microspheres: surfactant-free hydrothermal synthesis, enhanced biological response and sustained drug releas Chemical Engineering Journal 2013 2013;222:49-59.
Kaili Lin, Wei Yuan, Lu Wang, Lei Chen, Jianxi Lu, Zhen Wang, Jiang Chang Evaluation of host inflammatory responses of β-tricalcium phosphate bioceramics caused by calcium pyrophosphate impurity using a subcutaneous mode Journal of Biomedical Materials Research, Part B-Applied Biomaterials 2011 2011;99B(2):350-358.
Kaili Lin （通讯作者）, Jiang Chang, Xiaoguo Liu, Lei Chen, Yanling Zhou Synthesis of the element-substituted hydroxyapatite with controllable morphologies and chemical compositions using calcium silicate as precursor CrystEngComm 2011 2011;13(15):4850-4855.
Kaili Lin （通讯作者）, Jiayong Pan, Yiwei Chen, Rongming Cheng, Xuecheng Xu Study the adsorption of phenol from aqueous solution on hydroxyapatite nanopowders Journal of Hazardous Materials 2009 2009;161:231-240.
Songfeng Xu, Kaili Lin （共同第一作者）, Yunyu Hu, Zhen Wang, Jiang Chang, Lin Wang, Jianxi Lu, Congqin Ning Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics Biomaterials 2008 2008;29(17):2588-2596.