导师姓名： 段胜仲 专业代码： 100301
性别： 男 专业名称： 口腔基础医学
培养单位： 附属第九人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： duansz2008@hotmail.com
邮编： 200125 邮箱地址： duansz2008@hotmail.com

研究方向 (点击浏览详细信息)
2. 心血管疾病和代谢病的转录调控机制
1. 口腔微生态与心血管疾病及代谢病

社会任职
中国病理生理学会血管医学专业委员会委员
Mediators of Inflammation客座编辑
中华口腔医学会口腔生物医学专业委员会委员
Nat Rev Immunol、Circulation、PLOS Biology、iScience等杂志审稿人
国际心脏研究会中国转化医学工作委员会委员
国家自然科学基金评审专家
欧洲研究理事会课题评审专家
中国生物化学与分子生物学会脂质与脂蛋白专业委员会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 牙周稳态在维持全身健康中的作用及机制研究 国家自然科学基金重大项目（课题） 2020-01~2024-12 350万元 课题负责人
** 巨噬细胞调控管周脂肪及干细胞分化在血管损伤中的机制研究 国家自然科学基金重大研究计划集成项目 2018-01~2020-12 260万元 课题参与人
** 核受体与代谢和心血管疾病 国家****科学基金 2018-01~2022-12 350万元 课题负责人
** T细胞盐皮质激素受体对血压的调控作用和机制研究 国家自然科学基金面上项目 2017-01~2020-12 61万元 课题负责人
段胜仲-引进 口腔微生物与系统性疾病 上海交通大学医学院第九人民医院 2016-08~2019-07 200万元 课题负责人
** 构建盐皮质激素受体基因敲入小鼠用于心血管疾病研究 上海市科学技术委员会动物专项 2015-07~2017-09 25万元 课题负责人
** 盐皮质激素受体调控内膜新生和血管重构 国家自然科学基金重大研究计划培育项目 2014-01~2016-12 85万元 课题负责人
** 核受体MR 的阻断和PPARg 的激活在心肌梗死与心肌肥厚中的各自以及协同作用 国家自然科学基金面上项目 2014-01~2017-12 81万元 课题负责人
2012OHTP06 中国科学院“****” 中国科学院 2012-07~2015-12 260万元 课题负责人
2012CB524902 营养失衡导致脂代谢紊乱疾病的病理生理学机制与早期干预研究 科技部国家重点基础研究发展计划（973计划） 2012-01~2016-12 120万元 课题参与人
** 髓样细胞盐皮质激素受体对肥胖和二型糖尿病的干预及其机制研究 国家自然科学基金面上项目 2012-01~2015-12 58万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Kong D, Wan Q, Li J, Zuo S, Liu G, Liu Q, Wang C, Bai P, Duan SZ, Zhou B, Gounari F, Lu A, Lazarus M, Breyer RM, Yu Y. DP1 Activation Reverses Age-Related Hypertension via NEDD4L-Mediated T-bet Degradation in T Cells. Circulation 2020 doi: 10.1161/CIRCULATIONAHA.119.042532
Xu K, Fu Y, Han Y, Xia R, Xu S, Duan S, Zhang Z, Li J. Fewer tumour-specific PD-1+ CD8+ TILs in high-risk "Infiltrating" HPV – HNSCC. Br J Cancer 2020 doi: 10.1038/s41416-020-0966-8. Online ahead of print.
Fu S, He K, Tian C, Sun H, Zhu C, Bai S, Liu J, Wu Q, Xie D, Yue T, Shen Z, Dai Q, Yu X, Zhu S, Liu G, Zhou R, Duan S, Tian Z, Xu T, Wang H, Bai L. Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells. Nat Commun 2020 11(1):438
Du LJ, Sun JY, Zhang WC, Wang YL, Zhu H, Liu T, Gao MZ, Zheng C, Zhang YY, Liu Y, Liu Y, Shao S, Zhang XQ, Leng Q, Auwerx J, Duan SZ. （通讯作者） Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice. J Am Heart Assoc. 2020 Jul 28;e015862.
Yuan X, Duan SZ, Cao J, Gao N, Xu J, Zhang L. Noninvasive inflammatory markers for assessing liver fibrosis stage in autoimmune hepatitis patients. Eur J Gastroenterol Hepatol 2019 31(11):1467-1474
Zhang L, Qi Z, Zou Y, Zhang J, Xia W, Zhang R, He Z, Cai X, Lin Y, Duan SZ, Li J, Wang L, Lu N, Tang Z. Engineering DNA-Nanozyme Interfaces for Rapid Detection of Dental Bacteria. ACS Appl Mater Interfaces 2019 11(34):30640-30647
Zheng XJ, Liu Y, Zhang WC, Liu Y, Li C, Sun XN, Zhang YY, Xu J, Jiang X, Zhang L, Yang W, Duan SZ*. （通讯作者） Mineralocorticoid receptor negatively regulates angiogenesis through repression of STAT3 activity in endothelial cells. J Pathol. 2019 248(4):438-451
Yi Y, Du L, Qin M, Chen XQ, Sun XN, Li C, Du LJ, Liu Y, Liu Y, Sun JY, Tang Z, Xu M, Fang B, Liu X*, Duan SZ*. （通讯作者） Regulation of atrial fibrosis by the bone. Hypertension 2019 73(2):379-389
Shi Y, Xia W, Liu S, Guo J, Qi Z, Zou Y, Wang L, Duan SZ, Zhou Y, Lin C, Shi J, Wang L, Fan C, Lv M, Tang Z. Impact of graphene exposure on microbial activity and community ecosystem in saliva. ACS Appl. Bio Mater. 2019 2, 1, 226-235
Li C, Sun XN, Chen BY, Zeng MR, Du LJ, Liu T, Gu HH, Liu Y, Li YL, Zhou LJ, Zheng XJ, Zhang YY, Zhang WC, Liu Y, Shi C, Shao S, Shi XR, Yi Y, Liu X, Wang J, Auwerx J, Wang ZV, Jia F*, Li RG*, Duan SZ* （通讯作者） Nuclear Receptor Corepressor 1 Represses Cardiac Hypertrophy EMBO Mol Med 2019 11(11):e9127
Lin S, Cao L, Wang Q, Du J, Jiao D, Duan S, Wu J, Gan Q, Jiang X. Tailored biomimetic hydrogel based on a photopolymerised DMP1/MCF/gelatin hybrid system for calvarial bone regeneration. J. Mater. Chem. B. 2018 6; 414-427
Ai TJ, Sun JY, Du LJ, Shi C, Li C, Sun XN, Liu Y, Li L, Xia Z, Jia L, Liu J*, Duan SZ*. （通讯作者） Inhibition of neddylation by MLN4924 improves neointimal hyperplasia and promotes apoptosis of vascular smooth muscle cells through p53 and p62. Cell Death Differ. 2018 25(2):319-329.
Shen ZX, Yang QZ, Li C, Du LJ, Sun XN, Liu Y, Sun JY, Gu HH, Sun YM, Wang J, Duan SZ*. （通讯作者） Myeloid peroxisome proliferator-activated receptor gamma deficiency aggravates myocardial infarction in mice. Atherosclerosis. 2018 274:199-205.
Zhang WC, Du LJ, Zheng XJ, Chen XQ, Shi C, Chen BY, Sun XN, Li C, Zhang YY, Liu Y, Xiao H, Leng Q, Jiang X, Zhang Z, Sun S*, Duan SZ*. （通讯作者） Elevated sodium chloride drives type I interferon signaling in macrophages and increases antiviral resistance. J Biol Chem. 2018 293(3):1030-1039.
Yu F, Shi G, Cheng S, Chen J, Wu SY, Wang Z, Xia N, Zhai Y, Wang Z, Peng Y, Wang D, Du JX, Liao L, Duan SZ, Shi T, Cheng J, Chiang CM, Li J, Wong J. SUMO suppresses and MYC amplifies transcription globally by regulating CDK9 sumoylation. Cell Res. 2018 28(6):670-685.
Wu Y, Dong Y, Duan S, Zhu D, Deng L. Metabolic Syndrome, Inflammation, and Cancer. Mediators Inflamm. 2017 2017:**.
Sun XN, Li C, Liu Y, Du LJ, Zeng MR, Zheng XJ, Zhang WC, Liu Y, Zhu M, Kong D, Zhou L, Lu L, Shen ZX, Yi Y, Du L, Qin M, Liu X, Hua Z, Sun S, Yin H, Zhou B, Yu Y, Zhang Z, Duan SZ*. （通讯作者） T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma. Circ Res 2017 120(10):1584-1597
Du L, Qin M, Yi Y, Chen X, Jiang W, Zhou L, Zhang D, Xu K, Yang Y, Li C, Liu Y, Liu X*, Duan SZ*. （通讯作者） Eplerenone Prevents Atrial Fibrosis via the TGF-β Signaling Pathway. Cardiology 2017 138(1):55-62
Wu Y, Lee S, Bobadilla S, Duan SZ, Liu X. High glucose-induced p53 phosphorylation contributes to impairment of endothelial antioxidant system. Biochim Biophys Acta 2017 1863(9):2355-2362
Li C, Sun XN, Zeng MR, Zheng XJ, Zhang YY, Wan Q, Zhang WC, Shi C, Du LJ, Ai TJ, Liu Y, Liu Y, Du LL, Yi Y, Yu Y, Duan SZ*. （通讯作者） Mineralocorticoid Receptor Deficiency in T Cells Attenuates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction Through Modulating T-Cell Activation. Hypertension 2017 70(1):137-147
Shan B, Wang X, Wu Y, Xu C, Xia Z, Dai J, Shao M, Zhao F, He S, Yang L, Zhang M, Nan F, Li J, Liu J, Liu J, Jia W, Qiu Y, Song B, Han JJ, Rui L, Duan SZ* （通讯作者）, Liu Y*. The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity. Nat Immunol 2017 18(5):519-529
Zhang YY, Li C, Yao GF, Du LJ, Liu Y, Zheng XJ, Yan S, Sun JY, Liu Y, Liu MZ, Zhang X, Wei G, Tong W, Chen X, Wu Y, Sun S, Liu S, Ding Q, Yu Y, Yin H, Duan SZ*. （通讯作者） Deletion of Macrophage Mineralocorticoid Receptor Protects Hepatic Steatosis and Insulin Resistance through ERα/HGF/MET Pathway. Diabetes 2017 66(6):1535-1547
Yan S, Tang J, Zhang Y, Wang Y, Zuo S, Shen Y, Zhang Q, Chen D, Yu Y, Wang K, Duan SZ* （通讯作者）, Yu Y*. Prostaglandin E2 promotes hepatic bile acid synthesis by an E prostanoid receptor 3-mediated hepatocyte nuclear receptor 4α/cholesterol 7α-hydroxylase pathway in mice. Hepatology 2017 65(3):999-1014
Shen ZX, Chen XQ, Sun XN, Sun JY, Zhang WC, Zheng XJ, Zhang YY, Shi HJ, Zhang JW, Li C, Wang J, Liu X, Duan SZ*. （通讯作者） Mineralocorticoid Receptor Deficiency in Macrophages Inhibits Atherosclerosis by Affecting Foam Cell Formation and Efferocytosis. J Biol Chem 2017 292(3):925-935
O'Donnell PE, Ye XZ, DeChellis MA, Davis VM, Duan SZ, Mortensen RM, Milstone DS. Lipodystrophy, Diabetes and Normal Serum Insulin in PPARγ-Deficient Neonatal Mice. PLoS One 2016 11(8):e**
Sun JY, Li C, Shen ZX, Zhang WC, Ai TJ, Du LJ, Zhang YY, Yao GF, Liu Y, Sun S, Naray-Fejes-Toth A, Fejes-Toth G, Peng Y, Chen M, Liu X, Tao J, Zhou B, Yu Y, Guo F, Du J, Duan SZ*. （通讯作者） Mineralocorticoid Receptor Deficiency in Macrophages Inhibits Neointimal Hyperplasia and Suppresses Macrophage Inflammation Through SGK1-AP1/NF-kB pathways. Arterioscler Thromb Vasc Biol 2016 36(5):874-85
Chen L, Ding ML, Wu F, He W, Li J, Zhang XY, Xie WL, Duan SZ, Xia WH, Tao J. . Impaired Endothelial Repair Capacity of Early Endothelial Progenitor Cells in Hypertensive Patients With Primary Hyperaldosteronemia: Role of 5,6,7,8-Tetrahydrobiopterin Oxidation and Endothelial Nitric Oxide Synthase Uncoupling. Hypertension 2016 67(2):430-9
Chen XQ, Wang Q, Du LL, Yi Y, Liu Y, Liu X*, Duan SZ*. （通讯作者） Eplerenone Inhibits Atrial Fibrosis in Mutant TGF-beta 1 Transgenic Mice. Sci China Life Sci 2016 59(10):1042-1047
Yu M, Jiang M, Chen Y, Zhang S, Zhang W, Yang X, Li X, Li Y, Duan S, Han J, Duan Y. Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)γ-DEPENDENT MECHANISM. J Biol Chem 2016 291(33): 16977-89
Shen Y, Zuo S, Wang Y, Shi H, Yan S, Chen D, Xiao B, Zhang J, Gong Y, Shi M, Tang J, Kong D, Lu L, Yu Y, Zhou B, Duan SZ, Schneider C, Funk CD, Yu Y. Thromboxane Governs the Differentiation of Adipose-Derived Stromal Cells Toward Endothelial Cells In Vitro and In Vivo. Circ Res 2016 118(8):1194-207
Mayo E, Llanos AA, Yi X, Duan SZ, Zhang L. Prognostic value of tumour deposit and perineural invasion status in colorectal cancer patients: a SEER-based population study. Histopathology 2016 69(2):230-8
Xu J, Li L, Yu G, Ying W, Gao Q, Zhang W, Li X, Ding C, Jiang Y, Wei D, Duan S, Lei Q, Li P, Shi T, Qian X, Qin J, Jia L. Neddylation-Cullin 2-RBX1 E3 ligase axis targets tumor suppressor RhoB for degradation in liver cancer. Mol Cell Proteomics. 2015 14(3):499-509
Zhu H, Zhang G, Yi X, Zhu X, Wu Y, Liang J, Zhang S, Zeng Y, Fan D, Yu X, He J, He G, Chen Z, Duan S, Zhang L. Histology subtypes and polyp size are associated with synchronous colorectal carcinoma of colorectal serrated polyps: a study of 499 serrated polyps. Am J Cancer Res 2015 5(1):363-74
Liu Q, Hu T, He L, Huang X, Tian X, Zhang H, He L, Pu W, Zhang L, Sun H, Fang J, Yu Y, Duan S, Hu C, Hui L, Zhang H, Quertermous T, Xu Q, Red-Horse K, Wythe JD, Zhou B. Genetic targeting of sprouting angiogenesis using Apln-CreER. Nat Commun 2015 6:6020
Yang X, Yao H, Chen Y, Sun L, Li Y, Ma X, Duan S, Li X, Xiang R, Han J, Duan Y. Inhibition of glutathione production induces macrophage CD36 expression and enhances cellular oxLDL uptake. J Biol Chem 2015 290(36):21788-99
Jiang L, Yin M, Wei X, Liu J, Wang X, Niu C, Kang X, Xu J, Zhou Z, Sun S, Wang X, Zheng X, Duan S, Yao K, Qian R, Sun N, Chen A, Wang R, Zhang J, Chen S, Meng D. Bach1 Represses Wnt/β-Catenin Signaling and Angiogenesis. Circ Res 2015 117(4): 364-75
Zhang WC, Zheng XJ, Du LJ, Sun JY, Shen ZX, Shi C, Sun S, Zhang Z, Chen XQ, Qin M, Liu X, Tao J, Jia L, Fan HY, Zhou B, Yu Y, Ying H, Hui L, Liu X, Yi X, Liu X, Zhang L, Duan SZ*. （通讯作者） High salt primes a specific activation state of macrophages, M(Na). Cell Res 2015 25(8):893-910
Hua W, Li C, Yang Z, Li L, Jiang Y, Yu G, Zhu W, Liu Z, Duan S, Chu Y, Yang M, Zhang Y, Mao Y, Jia L. Suppression of glioblastoma by targeting the overactivated protein neddylation pathway. Neuro Oncol 2015 17(10):1333-43
Lu A, Zuo C, He Y, Chen G, Piao L, Zhang J, Xiao B, Shen Y, Tang J, Kong D, Alberti S, Chen D, Zuo S, Zhang Q, Yan S, Fei X, Yuan F, Zhou B, Duan S, Yu Y, Lazarus M, Su Y, Breyer RM, Funk CD, Yu Y. EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling. J Clin Invest 2015 125(3):1228-42
Sun S, Liu S, Duan SZ, Zhang L, Zhou H, Hu Y, Zhou X, Shi C, Zhou R, Zhang Z. Targeting the c-Met/FZD8 signaling axis eliminates patient-derived cancer stem-like cells in head and neck squamous carcinomas. Cancer Res 2014 74(24): 7546-59
Liu Q, Huang X, Oh JH, Lin RZ, Duan S, Yu Y, Yang R, Qiu J, Melero-Martin JM, Pu WT, Zhou B. Epicardium-to-fat transition in injured heart. Cell Res 2014 24(11): 1367-9
He H, Tao H, Xiong H, Duan SZ, McGowan FX Jr, Mortensen RM, Balschi JA. Rosiglitazone Causes Cardiotoxicity via Peroxisome Proliferator-Activated Receptor γ-Independent Mitochondrial Oxidative Stress in Mouse Hearts. Toxicol Sci 2014 138(2): 468-81
Duan S*. （通讯作者） Mineralocorticoid receptor: a critical player in vascular remodeling. Sci China Life Sci 2014 57(8): 809-17
Li C, Zhang YY, Frieler RA, Zheng XJ, Zhang WC, Sun XN, Yang QZ, Ma SM, Huang B, Berger S, Wang W, Wu Y, Yu Y, Duan SZ* （通讯作者）, Mortensen RM*. Myeloid mineralocorticoid receptor deficiency inhibits aortic constriction-induced cardiac hypertrophy in mice. PLoS One 2014 9(10): e110950
沈竹夏,段胜仲*. （通讯作者） 巨噬细胞极化在2型糖尿病和心血管疾病中的作用. 生命科学 2013 25(2): 191-197
Duan SZ* （通讯作者）, Zhang WC, Zheng XJ. An Update on Actions of Mineralocorticoid Receptor in the cardiovascular System: From Clinical Studies to Basic Research. NAJMS 2013 6(2): 91-94
Shen Z, Li C, Frieler RA, Gerasimova AS, Lee SJ, Wu J, Wang MM, Lumeng CN, Brosius FC 3rd, Duan SZ* （通讯作者）, Mortensen RM*. Smooth muscle protein 22 alpha-Cre is expressed in myeloid cells in mice. Biochem Biophys Res Commun 2012 422(4): 639-42
Barbieri M, Di Filippo C, Esposito A, Marfella R, Rizzo MR, D'Amico M, Ferraraccio F, Di Ronza C, Duan SZ, Mortensen RM, Rossi F, Paolisso G. Effects of PPARs Agonists on Cardiac Metabolism in Littermate and Cardiomyocyte-Specific PPAR-γ-Knockout (CM-PGKO) Mice. PLoS One 2012 7(4): e35999
Frieler RA, Meng H, Duan SZ, Berger S, Schütz G, He Y, Xi G, Wang MM, Mortensen RM. Myeloid-specific deletion of the mineralocorticoid receptor reduces infarct volume and alters inflammation during cerebral ischemia. Stroke 2011 42(1): 179-85
Shen Z, Lu M, Duan S, Duan SZ*. （通讯作者） Macrophage Polarization and Inflammation at the Interface of Cardiovascular Disease and Metabolism. NAJMS 2011 4(4):191-195
Zhang J, Ouyang J, Wang G, Xia ZY, Duan SZ, Wu Y. Role of PKCζ translocation in the development of type 2 diabetes in rats following continuous glucose infusion. Diabetes Metab Res Rev 2010 26(1): 59-70
Duan SZ, Usher MG, Foley EL 4th, Milstone DS, Brosius FC 3rd, Mortensen RM. Sex dimorphic actions of rosiglitazone in generalised peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-deficient mice. Diabetologia 2010 53(7): 1493-505
Duan SZ* and Mortensen RM. （通讯作者） A New Connection: Myeloid Mineralocorticoid Receptor and Cardiovascular Disease. NAJMS 2010 3(4):167-170
Usher MG#, Duan SZ# （通讯作者）,*, Ivashchenko CY, Frieler RA, Berger S, Schütz G, Lumeng C, Mortensen RM*. Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice. J Clin Invest 2010 120(9): 3350-3364
Duan SZ, Usher MG, Mortensen RM. PPARs: the vasculature, inflammation and hypertension. Curr Opin Nephrol Hypertens 2009 18(2):128-133
Duan SZ, Ivashchenko CY, Usher MG, Mortensen RM. PPAR-gamma in the Cardiovascular System. PPAR Res 2008 745804
Ye CP#, Duan SZ# （共同第一作者）, Milstone DS, Mortensen RM. Go controls the hyperpolarization-activated current, If in ES cell-derived cardiocytes. Am J Physiol Heart and Circulatory Physiol 2008 294(2):H979-985
Duan SZ, Usher MG, Mortensen RM. Peroxisome proliferator-activated receptor-gamma-mediated effects in the vasculature. Circ Res 2008 102(3): 283-294
Gupta D, Jetton TL, Mortensen RM, Duan SZ, Peshavaria M, Leahy JL. In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse pdx-1 promoter. J Biol Chem 2008 283(47):32462-70
Duan SZ, Ivashchenko CY, Whitesall SE, D’Alecy LG, Mortensen RM. Direct monitoring pressure overload predicts cardiac hypertrophy in mice. Physiol Meas 2007 28(11): 1329-1339
Ivashchenko CY, Duan SZ, Usher MG, Mortensen RM. PPAR-gamma knockout in pancreatic epithelial cells abolishes the inhibitory effect of rosiglitazone on caerulein-induced acute pancreatitis. Am J Physiol Gastrointest Liver Physiol 2007 293(1): G319-326
Duan SZ, Christe M, Milstone DS, Mortensen RM. Go but not Gi2 or Gi3 is required for muscarinic regulation of heart rate and heart rate variability in mice. Biochem Biophys Res Commun 2007 357(1): 139-143
Duan SZ, Ivashchenko CY, Whitesall SE, D'Alecy LG, Duquaine DC, Brosius FC, Gonzalez FJ, Vinson C, Pierre MA, Milstone DS, Mortensen RM. Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality. J Clin Invest 2007 117(3): 812-822
Duan SZ, Ivashchenko CY, Russell MW, Milstone DS, Mortensen RM. Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice. Circ Res 2005 97(4): 372-379