导师姓名： 钟来平 专业代码： 100302
性别： 男 专业名称： 口腔临床医学
培养单位： 附属第九人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海市黄浦区制造局路639号1号楼13楼
邮编： 200011 邮箱地址： zhonglaiping@163.com

研究方向 (点击浏览详细信息)
口腔颌面头颈部肿瘤的发病机制和临床研究

社会任职
美国临床肿瘤协会会员
中国临床肿瘤学会转化医学专委会委员
《Journal of Oral Pathology and Medicine》Reviewer
《Scientific Reports》Reviewer
中华口腔医学会会员、口腔颌面头颈肿瘤专委会委员
《Molecular and Cellular Biochemistry》Reviewer
《Advances in Modern Oncology Research》Editorial Board Member
《Annals of Hematology and Oncology》Editorial Board Member
中国临床肿瘤学会头颈肿瘤专委会常委
《BMC Oral Health》Reviewer
《Oral Oncology》Reviewer
《Oral Diseases》Reviewer
《Oncology Reports》Reviewer
上海市头颈肿瘤诊治和转化医学中心秘书长
国家自然科学基金评审专家
《Archive of Oral Biology》Reviewer
上海市口腔医学会会员、口腔基础医学专委会委员、口腔颌面头颈肿瘤专委会委员、口腔颌面科专委会青年委员
亚洲口腔颌面外科医师协会会员
国际口腔颌面外科医师协会会员
《Journal of Cell Biology and Genetics》Reviewer
中国生物工程学会转化医学分会委员
《Annuals of Otolaryngology》Editorial Board Member
《European Journal of Surgical Oncology》Reviewer
《India Journal of Dental Research》Reviewer
中国医疗保健国际交流促进会肿瘤整形外科与功能性外科分会委员
《Head Neck》Reviewer
《Pathology-Research and Practice》Reviewer
《Archives of Otolaryngology and Rhinology》Editorial Board Member

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
201916 口腔/口咽鳞癌个体化诊疗团队 上海九院临床研究型MDT项目 2020-01~2022-12 45万元 课题负责人
** 研究型医师 上海交大医学院双**** 2020-01~2022-12 100万元 课题负责人
** ErbB2和重组GDF15在GDF15指导口腔鳞癌个体化治疗中的机制研究 国家自然科学基金,面上项目 2020-01~2023-12 54万元 课题负责人
19XD** 外源性GDF15抑制口腔鳞癌进展的分子机制研究 上海市科委,优秀学术带头人计划 2019-01~2021-12 40万元 课题负责人
2018BR41 生物标志物指导口腔鳞癌个体化治疗的转化研究 上海市卫计委,优秀学科带头人计划 2018-07~2021-06 45万元 课题负责人
17SG18 Stathmin在口腔鳞癌TPF诱导化疗中的转化研究 上海市教委,曙光计划 2018-01~2020-12 15万元 课题负责人
SHDC12017X02 Stathmin指导口腔鳞癌TPF诱导化疗的II期临床试验 上海市申康中心 2017-12~2020-11 30万元 课题负责人
** Stathmin 1在口腔鳞癌诱导化疗及p53、PI3K/AKT信号通路中的机制研究 国家自然科学基金面上项目 2017-01~2020-12 57万元 课题负责人
Y-MT2015-036 EGFR突变在口腔/口咽鳞癌西妥昔单抗联合TP诱导化疗临床试验中的研究 中国临床肿瘤协会 2015-10~2017-10 5万元 课题负责人
15ZH2008 GDF15在口腔鳞癌个体化治疗中的转化医学研究 上海交通大学医学院转化医学创新基金 2015-06~2017-05 20万元 课题负责人
** GDF15在口腔鳞癌TPF诱导化疗和调控AKT/ERK信号通路中的机制研究 国家自然科学基金面上项目 2015-01~2018-12 80万元 课题负责人
201447 生物标志物指导口腔/口咽鳞癌个体化治疗方案选择的转化医学研究 上海市人力资源和社会保障局 2014-12~2016-12 10万元 课题负责人
13QH** Annexin A1与病理分化程度对口腔鳞癌诱导化疗的影响及其机制研究 上海市科委 2013-09~2015-08 15万元 课题负责人
** Annexin A1在头颈鳞癌EGF相关ERK/MAPK信号通路中的作用机制 国家自然科学基金,面上项目 2013-01~2016-12 65万元 课题负责人
建立基于口腔鳞癌体外细胞癌变模型的动物模型 上海市科委,动物专项 2010-05~2012-03 20万元 课题负责人
1052nm04700 血清多肽的纳米磁珠质谱在口腔癌早期诊断中的研究 上海市科委,纳米专项 2010-03~2012-06 30万元 课题负责人
** 口腔鳞癌发生发展中GDF15与p53、ERK1/2信号通路作用关系的研究 国家自然基金委,面上项目 2010-01~2012-12 31万元 课题负责人
08QA** 膜联蛋白A1在口腔鳞癌发生发展中的机制研究 上海市科委,启明星计划 2008-07~2010-07 15万元 课题负责人
** IGFBP3及相关基因在口腔上皮细胞恶性转化中作用的研究 国家自然基金委,青年基金 2008-01~2010-12 17万元 课题负责人
2007CG22 应用比较蛋白质组学筛选口腔黏膜上皮癌变相关蛋白的研究 上海市教委,晨光计划 2007-11~2009-12 6万元 课题负责人
应用比较蛋白质组学筛选口腔鳞癌形成过程中的肿瘤标志物 中国博士后科学基金委 2006-12~2008-12 5万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Ju WT, Ma HL, Zhao TC, Liang SY, Liu Y, Tan YR, Zhu DW, Wang LZ, Li J, Zhang ZY, Zhou G, Zhong LP （通讯作者） Stathmin guides personalized therapy in oral squamous cell carcinoma Cancer Sci 2020 111(4): 1303-1313
Liu Y, Fan BH, Tan YR, Zhu DW, Dong MJ, Wang LZ, Li J, Sun J, Zhang CP, Ji T, Yang WJ, Abdelrehem A, Wu YQ, Zhong LP （通讯作者） Diffuse-type tenosynovial giant cell tumor of the temporomandibular joint with skull base invasion: a report of 22 cases with literature review Oral Surg Oral Med Oral Pathol Oral Radiol 2020 accepted
Zhao TC, Liang SY, Fu Y, Ju WT, Zhou ZH, Wang LZ, Li J, Zhang CP, Zhang ZY, Zhong LP （通讯作者） High-risk lymph node ratio predicts worse prognosis in patients with locally advanced oral cancer J Oral Pathol Med 2020 in press
Hu YJ, Sun WW, Zhao TC, Liu Y, Zhu DW, Wang LZ, Li J, Zhang CP, Zhang ZY, Zhong LP （通讯作者） Cyclin D1 overexpression enhances chemosensitivity to TPF chemotherapeutic agents via caspase-3 pathway in oral cancer Oncol Lett 2020 in press
Yin XL, Tan YR, Liu Y, Sun WW, Zhang XY, Hu YJ, Sun J, Zhang CP, Zhong LP （通讯作者） Clinical application of temporary external fixator for immediate mandibular reconstruction J Craniofac Surg 2019 30(4): e337-e342
Ju WT, Zhao TC, Liu Y, Tan YR, Sun WW, Dong MJ, Sun Q, Wang LZ, Li J, Zhong LP （通讯作者） Computed tomographic features of adenoid cystic carcinoma in the palate Cancer Imaging 2019 19(1): 3
Zhao TC, Liang SY, Ju WT, Liu Y, Tan YR, Zhu DW, Zhang CP, Zhang ZY, Zhong LP （通讯作者） Normal BMI predicts the survival benefits of inductive docetaxel, cisplatin, and 5-fluorouracil in patients with locally advanced oral squamous cell carcinoma Clin Nutr 2019 in press
Liu Y, Tan YR, Sun WW, Ju WT, Fu Y, Wang LZ, Li J, Zhang CP, Zhang ZY, Zhong LP （通讯作者） Identification of SCARA5 as a potential biomarker for oral squamous cell carcinoma through MALDI TOF MS analysis Proteom Clin Appl 2018 12(5): e**
Ju WT, Fu Y, Liu Y, Tan YR, Dong MJ, Wang LZ, Li J, Zhong LP （通讯作者） Clinical and pathological analyses of tuberculosis in the oral cavity: report of 11 cases Oral Surg Oral Med Oral Pathol Oral Radiol 2018 125(1): 44-51
Ma J, Fu Y, Tu YY, Liu Y, Tan YR, Ju WT, Pickering CR, Myers JN, Zhang ZY, Zhong LP （通讯作者） Mutation allele frequency threshold does not affect prognostic analysis using next-generation sequencing in oral squamous cell carcinoma BMC Cancer 2018 18:758
Tang X, Hu YJ, Ju WT, Fu Y, Sun WW, Liu Y, Tan YR, Wang LZ, Li J, Tu YY, Zhang CP, Zhang ZY, Zhong LP （通讯作者） Elevated GDF15 expression predicts long-term benefit of TPF induction chemotherapy in patients with oral cancer Oncol Lett 2018 15(5): 8118-8124
Ma HL, Jin SF, Ju WT, Fu Y, Tu YY, Wang LZ, Li J, Zhang ZY, Zhong LP （通讯作者） Stathmin is overexpressed and regulated by mutant p53 in oral squamous cell carcinoma J Exp Clin Cancer Res 2017 36:109
Ma J, Tang X, Sun WW, Liu Y, Tan YR, Ma HL, Zhu DW, Wang M, Wang LZ, Li J, Tu YY, Zhang CP, Zhang ZY, Zhong LP （通讯作者） Mutant GDF15 presents a poor prognostic outcome for patients with oral squamous cell carcinoma Oncotarget 2016 7(2): 2113-2122
Zhong LP, Zhang CP, Ren GX, Guo W, William Jr WN, Hong CS, Sun J, Zhu HG, Tu WY, Li J, Cai YL, Yin QM, Wang LZ, Wang ZH, Hu YJ, Ji T, Yang WJ, Ye WM, Li J, He Y, Wang YA, Xu LQ, Zhuang ZP, Lee JJ, Myers JN, Zhang ZY Long-term results of a randomized phase III trial of TPF induction chemotherapy followed by surgery and radiation in locally advanced oral squamous cell carcinoma Oncotarget 2015 6(21): 18707-18714
Ma HL, Yu C, Liu Y, Tan YR, Qiao JK, Yuan YX, Wang LZ, Li J, Chen Q, Chen FX, Zhang ZY, Zhong LP （通讯作者） Decreased expression of glutathione S-transferase pi correlates with poorly differentiated grade in patients with oral squamous cell carcinoma J Oral Pathol Med 2015 44(3): 193-200
Liu Y, Li J, Tan YR, Xiong P, Zhong LP （通讯作者） Accuracy of diagnosis of salivary gland tumors with the use of ultrasonography, computed tomography, and magnetic resonance imaging: a meta-analysis Oral Surg Oral Med Oral Pathol Oral Radiol 2015 119(2): 238-245.
Zhu DW, Yuan YX, Qiao JK, Yu C, Yang X, Wang LZ, Zhang ZY, Zhong LP （通讯作者） Enhanced anticancer activity of a protein phosphatase 2A inhibitor on chemotherapy and radiation in head and neck squamous cell carcinoma Cancer Lett 2015 356(2): 773-780
Ye G, Liu Y, Yin P, Zeng Z, Huang Q, Kong H, Lu X, Zhong L （通讯作者）, Zhang Z, Xu G Study of induction chemotherapy efficacy in oral squamous cell carcinoma using pseudotargeted metabolomics J Proteome Res 2014 13(4): 1994-2004
Zhu DW, Tan YR, Yang X, Qiao JK, Yu C, Wang LZ, Li J, Zhang ZY, Zhong LP （通讯作者） Phospholipase C gamma 1 is a potential prognostic biomarker for patients with locally advance and resectable oral squamous cell carcinoma Int J Oral Maxillofac Surg 2014 43(12): 1418-1426
Yang CZ, Ma J, Luo QQ, Neskey DM, Zhu DW, Liu Y, Myers JN, Zhang CP, Zhang ZY, Zhong LP （通讯作者） Elevated level of serum growth differentiation factor 15 is associated with precancerous oral mucosal lesions and oral squamous cell carcinoma J Oral Pathol Med 2014 43(1): 28-34
Yang CZ, Ma J, Zhu DW, Liu Y, Montgomery B, Wang LZ, Li J, Zhang ZY, Zhang CP, Zhong LP （通讯作者） GDF15 is a potential predictive biomarker for TPF induction chemotherapy and promotes tumorigenesis and progression in oral squamous cell carcinoma Ann Oncol 2014 25(6): 1215-1222
Zhu DW, Yang X, Yang CZ, Ma J, Liu Y, Yan M, Wang LZ, Li J, Zhang CP, Zhang ZY, Zhong LP （通讯作者） Annexin A1 down-regulation in oral squamous cell carcinoma correlates to pathologic differentiation grade Oral Oncol 2013 49(6):542-550
Zhu DW, Liu Y, Yang X, Yang CZ, Ma J, Yang X, Qiao JK, Wang LZ, Li J, Zhang CP, Zhang ZY, Zhong LP （通讯作者） Low Annexin A1 expression predicts benefit from induction chemotherapy in oral cancer patients with moderate or poor pathologic differentiation grade BMC Cancer 2013 13(1): 301
Ma J, Liu Y, Yang X, Zhang CP, Zhang ZY, Zhong LP （通讯作者） Induction chemotherapy in patients with resectable head and neck squamous cell carcinoma: a meta-analysis World J Surg Oncol 2013 11(1): 67
Zhong LP, Zhang CP, Ren GX, Guo W, William Jr WN, Sun J, Zhu HG, Tu WY, Li J, Cai YL, Wang LZ, Fang XD, Wang ZH, Hu YJ, Ji T, Yang WJ, Ye WM, Li J, He Y, Wang YA, Xu LQ, Wang BS, Kies MS, Lee JJ, Myers JN, Zhang ZY Randomized phase III trial of induction chemotherapy with docetaxel, cisplatin and fluorouracil followed by surgery versus up-front surgery in locally advanced resectable oral squamous cell carcinoma J Clin Oncol 2013 31(6):744-751
Zhong LP, Zhu DW, William Jr. WN, Liu Y, Ma J, Yang CZ, Yang X, Wang LZ, Li J, Myers JN, Lee JJ, Zhang CP, Zhang ZY Elevated cyclin D1 expression is predictive for a benefit from TPF induction chemotherapy in oral squamous cell carcinoma patients with advanced nodal disease Mol Cancer Ther 2013 12(6):1112-1121
Zhong LP, Zhang ZY Neoadjuvant versus induction chemotherapy: more than semantics reply J Clin Oncol 2013 31(23):2972-2973
Zhong LP, Ow A, Yang WJ, Hu YJ, Wang LZ, Zhang CP Surgical management of solitary venous malformation in the mid-cheek region Oral Surg Oral Med Oral Pathol Oral Radiol 2012 114(2):160-166
Yang X, Ow A, Zhang CP, Wang LZ, Yang WJ, Hu YJ, Zhong LP （通讯作者） Clinical analysis of 120 cases of intraoral lymphoepithelial cyst Oral Surg Oral Med Oral Pathol Oral Radiol 2012 113(4):448-452
Ma J, Liu Y, Huang XL, Zhang ZY, Myers JN, Neskey DM, Zhong LP （通讯作者） Induction chemotherapy decreases the rate of distant metastasis in patients with head and neck squamous cell carcinoma but does not improve survival or locoregional control: a meta-analysis Oral Oncol 2012 48(11):1076-1084
Zhong LP, Zhang ZY, Zhu HG, Fu HH, He Y Clinical management of peripheral ameloblastoma J Craniofac Surg 2011 22(5):1929-1932
Yang X, Ji T, Wang LZ, Yang WJ, Hu YJ, Zhong LP （通讯作者）, Zhang CP, Zhang ZY Clinical analysis of masses arising from the accessory parotid gland Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011 112(3):291-298
Zhong LP, Wang LZ, Ji T, Yang WJ, Zhang CP Management of facial nerve schwannoma in the accessory parotid region J Oral Maxillofac Surg 2011 69(5):1390-1397
Yang X, Wei KJ, Zhang L, Pan HY, Zhou XJ, Zhong LP （通讯作者）, Li J, Chen WT, Zhang ZY Increased expression of Cathepsin B in oral squamous cell carcinoma Int J Oral Maxillofac Surg 2010 39(2):174-181
Jiang Q, Pan HY, Ye DX, Zhang P, Zhong LP （通讯作者）, Zhang ZY Downregulation of tapasin expression in primary human oral squamous cell carcinoma: association with clinical outcome Tumor Biol 2010 31(5):451-459
Zhong LP, Wei KJ, Yang X, Pan HY, Wang LZ, Zhang ZY Overexpression of Galectin-1 is positively correlated with pathologic differentiation grade in oral squamous cell carcinoma J Cancer Res Clin Oncol 2010 136(10):1527-1535
Zhong LP, Wang LZ, Ji T, Hu YJ, Ye WM, Li J, Sun J, Zhu HG, Li Jiang, Zhang CP Clinical analysis of Castleman disease hyaline vascular type in parotid and neck region Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010 109(3):432-440
Yu ZW, Zhong LP （通讯作者）, Ji T, Zhang P, Chen WT, Zhang CP MicroRNAs contribute to the chemoresistance of cisplatin in tongue squamous cell carcinoma lines Oral Oncol 2010 46(4):317-322
Yang X, Wei KJ, Zhang L, Pan HY, Ye DX, Zhong LP （通讯作者）, Zhang ZY Decreased expression of S100A6 in oral squamous cell carcinoma Oncol Rep 2010 24(2):479-488
Yang X, Ren GX, Zhang CP, Zhou GY, Hu YJ, Yang WJ, Guo W, Li J, Zhong LP （通讯作者） Neck dissection and post-operative chemotherapy with dimethyl triazeno imidazole carboxamide and cisplatin protocol are useful for oral mucosal melanoma BMC Cancer 2010 10(1):623-623
Zhong LP, Zhang L, Yang X, Pan HY, Zhou XJ, Wei KJ, Ye DX, Jiang Q, Chen WT, Zhang ZY Comparative proteomic analysis of differentially expressed proteins in an in vitro cellular carcinogenesis model of oral squamous cell carcinoma Proteomics Clin Appl 2009 3(3):322-337
Zhang L, Yang X, Pan HY, Li JZ, Zhou XJ, Li J, Chen WT, Zhong LP （通讯作者）, Zhang ZY Expression of growth differentiation factor 15 is positively correlated with histopathological malignant grade and in vitro cell proliferation in oral squamous cell carcinoma Oral Oncol 2009 45(7):627-632
Zhang L, Yang X, Zhong LP （通讯作者）, Zhou XJ, Pan HY, Wei KJ, Li J, Chen WT, Zhang ZY Decreased expression of Annexin A1 correlates with pathologic differentiation grade in oral squamous cell carcinoma J Oral Pathol Med 2009 38(4):362-370
Wei KJ, Zhang L, Yang X, Zhong LP （通讯作者）, Zhou XJ, Pan HY, Li J, Chen WT, Zhang ZY Overexpression of cytokeratin 17 protein in oral squamous cell carcinoma in vitro and in vivo Oral Dis 2009 19(1):111-117
Zhong LP, Wei KJ, Yang X, Zhang L, Zhou XJ, Pan HY, Li J, Chen WT, Zhang ZY Increased expression of Annexin A2 in oral squamous cell carcinoma Arch Oral Biol 2009 54(1):17-25
Zhong LP, Zheng JW, Zhang WL, Zhang SY, Zhu HG, Ye WM, Wang YA, Zhang ZY Multicentric Gorham disease in the oral and maxillofacial region: report of a case and review of the literature J Oral Maxillofac Surg 2008 66(5):1073-1076
Zhang CP, Zhong LP （共同第一作者）, Hu YJ, Zhang ZY Three-flap reconstruction of a large defect caused by radical resection of advanced oral cancer J Oral Maxillofac Surg 2008 66(6):1269-1277
Zhong LP, Yang X, Zhang L, Wei KJ, Pan HY, Zhou XJ, Li J, Chen WT, Zhang ZY Overexpression of insulin-like growth factor binding protein 3 in oral squamous cell carcinoma Oncol Rep 2008 20(6):1441-1447
Zhong LP, Pan HY, Zhou XJ, Ye DX, Zhang L, Yang X, Chen WT, Zhang ZY Characteristics of a cancerous cell line, HIOEC-B(a)P-96, induced by benzo(a)pyrene from human immortalized oral epithelial cell line Arch Oral Biol 2008 53(5):443-452
Zheng JW, Zhong LP （共同第一作者）, Zhang ZY, Zhang CP, Zhu HG, Sun J, Fan XD, Hu YJ, Ye WM, Li J, Suen J Carotid artery resection and reconstruction: A clinical experience on 28 consecutive cases Int J Oral Maxillofac Surg 2007 36(6):514-521
Zhong LP, Li J, Zhang CP, Zhu HG, Sun J, Zhang ZY Expression of E-cadherin in cervical lymph nodes from primary oral squamous cell carcinoma patients Arch Oral Biol 2007 52(8):740-747
Zhong LP, Zhu HG, Zhang CP, Chen WT, Zhang ZY Detection of serum Cyfra 21-1 in patients with primary oral squamous cell carcinoma Int J Oral Maxillofac Surg 2007 36(3):230-234
Zhong LP, Zhang CP, Li J, Chen WT, Zhang ZY Increase of Cyfra 21-1 concentration in saliva from oral squamous cell carcinoma patients Arch Oral Biol 2007 52(11):1079-1087
Zhong LP, Chen WT, Zhang CP, Zhang ZY Increased CK19 expression correlated with pathological differentiation grade and prognosis in oral squamous cell carcinoma patients Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 104(3):377-384
Zhong LP （通讯作者）, Zhao SF, Chen GF, Ping FY, Xu ZF, Hu JA Increase of CK19 mRNA level in oral squamous cell carcinoma tissues detected by relative quantification with real-time PCR technique Arch Oral Biol 2006 51(12):1112-1119
Chen GF, Zhong LP （通讯作者） Functional reconstruction of maxilla with Titanium mesh and pedicled buccal fat pad flap Plast Reconstr Surg 2005 115(1):334-336
Zhong LP, Chen GF, Xu ZF, Zhang X, Ping FY, Zhao SF Detection of telomerase activity in saliva from oral squamous cell carcinoma patients Int J Oral Maxillofac Surg 2005 34(5):566-570
Zhong LP, Chen GF, Zhao SF Cervical Castleman disease in children Br J Oral Maxillofac Surg 2004 42(1):69-71
Zhong LP, Zhao SF, Chen GF, Ping FY Ultrasonographic appearance of lipoma in oral and maxillofacial region Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004 98(6):738-740
Zhong LP, Chen GF, Fan LJ, Zhao SF Immediate reconstruction of maxilla with bone grafts supported by pedicled buccal fat pad graft Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004 97(2):147-154
Zhong LP （通讯作者）, Chen GF Chondroblastoma of the temporomandibular region: report of 3 cases Chin Med J 2003 116(10):1591-1593
Chen GF, Zhong LP （通讯作者） A bilateral musculomucosal buccal flap method for cleft palate surgery J Oral Maxillofac Surg 2003 61(12):1399-1404