导师姓名： 裘正军 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属第一人民医院 三级学科/
专业领域： 普外
导师类型： 博士生导师 专业学位导师： 兼
联系方式： qiuwryb@126.com
邮编： 200080 邮箱地址： qiuwryb@online.sh.cn

研究方向 (点击浏览详细信息)
胰腺癌和胃肠肿瘤的临床和基础研究

社会任职
中国医师协会结直肠肿瘤专业委员会委员
上海市医师协会普外科专委会委员
上海市抗癌协会胰腺癌专委会副主委
中国研究型医院学会微创外科专委会常委
中华医学会外科学分会外科手术学组委员
上海市医学会外科学分会微创外科学组组长
中国临床肿瘤学会胰腺癌专家委员会委员
上海市医学会普外科专委会委员
中国抗癌协会胰腺癌专业委员会委员
中国研究型医院学会胰腺疾病专业委员会委员
上海市医学会外科学分会胰腺外科学组委员
中国成人教育协会医学继续教育专委会消化外科委员会常委
中国医师协会普外科分会结直肠外科专业委员会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 低氧下胰腺癌细胞外泌体来源的LncRNA-LUCAT1调控巨噬细胞M2型极化促进肿瘤转移的机制研究 国家自然基金面上项目 2020-01~2023-12 55万元 课题负责人
2019YFC** 全景复合式数字腹腔镜系统的临床验证与应用研究 中华人民共和国科技部，国家重点研发计划 2019-12~2021-12 25万元 子课题负责人
17YF** HIF-1α介导缺氧微环境下正反馈调控miR-301a-3p引起胰腺癌对吉西他滨耐药性的机制研究 上海市青年科技英才扬帆计划 2017-05~2020-04 20万元 课题参与人
** FoxM1亚型在胃癌诊断和预后中的临床应用研究 上海市科委 2014-10~2017-09 20万元 课题参与人
** miR-301a在缺氧诱导胰腺癌EMT中的功能机制研究 国家自然基金 2014-01~2017-12 70万元 课题负责人
w2012FZ092 分子诊断技术在结直肠癌个体化治疗中的应用研究 卫生部 2012-03~2016-05 30万元 课题负责人
** Caveolin-1 在胰腺癌转移和EMT 中的作用及其机制研究 国家自然基金 2012-01~2014-12 20万元 课题参与人
09QA** 调控STAT3信号通路对胰腺癌侵袭转移作用及其机制的研究 上海市科委人才计划项目 2009-07~2011-06 15万元 课题参与人
06BZ067 RNAi沉默STAT3对胰腺癌侵袭转移影响及其机制的研究 上海市教委,发展基金 2007-01~2009-12 6万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhang KD, Hu B, Cen G, Yang YH, Chen WW, Guo ZY, Wang XF, Zhao Q, Qiu ZJ. （通讯作者） MiR-301a transcriptionally activated by HIF-2α promotes hypoxia-induced epithelial-mesenchymal transition by targeting TP63 in pancreatic cancer. World J Gastroenterol. 2020 26(19):2349-2373.
Zhanshan Wang,Guangtao Luo,Zhengjun Qiu （通讯作者） Akt Inhibitor MK-2206 Reduces Pancreatic Cancer Oncol Lett 2020 19 (3), 1999-2004
Luo G, Xia X, Wang X, Zhang K, Cao J, Jiang T, Zhao Q, Qiu Z. （通讯作者） miR-301a plays a pivotal role in hypoxia-induced gemcitabine resistance in pancreatic cancer. Exp Cell Res 2018 369(1):120-128
Wang X, Luo G, Zhang K, Cao J, Huang C, Jiang T, Liu B, Su L, Qiu Z. （通讯作者） Hypoxic Tumor-Derived Exosomal miR-301a Mediates M2 Macrophage Polarization via PTEN/PI3Kγ to Promote Pancreatic Cancer Metastasis Cancer Res 2018 78(16):4586-4598
Xia X, Zhang K, Luo G, Cen G, Cao J, Huang K, Qiu Z. （通讯作者） Downregulation of miR-301a-3p sensitizes pancreatic cancer cells to gemcitabine treatment via PTEN Am J Transl Res. 2017 9(4):1886-1895
Cen G, Zhang K, Cao J, Qiu Z. （通讯作者） Downregulation of the N-myc downstream regulated gene 1 is related to enhanced proliferation, invasion and migration of pancreatic cancer. Oncol Rep 2017 37(2):1189-1195
Zhang J, Zhang K, Zhou L, Wu W, Jiang T, Cao J, Huang K, Qiu Z （通讯作者）, Huang C. Expression and potential correlation among Forkhead box protein M1, Caveolin-1 and E-cadherin in colorectal cancer. Oncol Lett 2016 12(4):2381-2388
Kundong Zhang, Guang Yang, Weidong Wu, Jing Zhang, Xiang Xia, Tao Jiang, Jun Cao, Kejan Huang, Zhengjun Qiu （通讯作者）, Chen Huang Decreased Expression of Caveolin-1 and E-Cadherin Correlates with the Clinicopathologic Features of Gastric Cancer and the EMT Process Recent Pat Anticancer Drug Discov 2016 11(2):236-44.
Xia X, Zhang K, Cen G, Jiang T, Cao J, Huang K, Huang C, Zhao Q, Qiu Z . （通讯作者） MicroRNA-301a-3p promotes pancreatic cancer progression via negative regulation of SMAD4 Oncotarget 2015 6(25):21046-63
Huang C, Shen JC, Zhang J, Jiang T, Wu WD, Cao J, Huang KJ, Qiu ZJ （通讯作者） Clinical comparison of laparoscopy vs open surgery in a radical operation for rectal cancer: A retrospective case-control study World J Gastroenterol 2015 21(48): 13532-13541
Xia X, Huang C, Cen G, Qiu ZJ （通讯作者） Preoperative diabetes as a protective factor for pancreatic fistula after pancreaticoduodenectomy: a meta-analysis Hepatobiliary Pancreat Dis Int. 2015 14(2):132-8.
Huang KJ, Cen G, Qiu ZJ （通讯作者）, Jiang T, Cao J, Fu CY. Application of international videoconferences for continuing medical education programs related to laparoscopic surgery Telemed J E Health 2014 20(2):157-60
Xia X, Wu W, Zhang K, Cen G, Jiang T, Cao J, Huang K, Huang C, Qiu Z. （通讯作者） Prognostic significance of complications after laparoscopic colectomy for colon cancer. PLoS One 2014 9(10):e108348
Xia X, Cen G, Jiang T, Cao J, Huang K, Huang C, Qiu Z. （通讯作者） Risk factor evaluation for postoperative complications in laparoscopic colorectal surgery by a classic severity grading system Tumour Biol 2014 35(8):8115-23
Xia X, Huang C, Jiang T, Cen G, Cao J, Huang K, Qiu Z （通讯作者） Is laparoscopic colorectal cancer surgery associated with an increased risk in obese patients? A retrospective study from China World J Surg Oncol 2014 12:184
Pu Y, Cen G, Sun J, Gong J, Zhang Y, Zhang M, Wu X, Zhang J, Qiu Z （通讯作者）, Fang F Warming with an underbody warming system reduces intraoperative hypothermia in patients undergoing laparoscopic gastrointestinal surgery: a randomized controlled study. Int J Nurs Stud 2014 51(2):181-9
Zhu G,Huang C, Feng Z,Lv X,Qiu Z. （通讯作者） Hypoxia-Induced Snail Expression Through Transcriptional Regulation by HIF-1a in Pancreatic Cancer Cells Dig Dis Sci 2013 58(12):3503–3515
HUANG C, LI H, WU W, JIANG T, QIU Z. （通讯作者） Regulation of miR-155 affects pancreatic cancer cell invasiveness and migration by modulating the STAT3 signaling pathway through SOCS1. Oncol Rep 2013 30（3）: 1223-1230
Chen Huang, Zhengjun Qiu （通讯作者）, Liwei Wang, Zhihai Peng, Zhiliang Jia, Craig D. Logsdon,Xiangdong Le, Daoyan Wei, Suyun Huang, and Keping Xie A Novel FoxM1-Caveolin Signaling Pathway PromotesPancreatic Cancer Invasion and Metastasis Cancer Res 2012 72(3); 1–11.
Huang C, Jiang T, Zhu L, Liu J, Cao J, Huang KJ, Qiu ZJ （通讯作者） STAT3-targeting RNA interference inhibits pancreatic cancer angiogenesis in vitro and in vivo Int J Oncol 2011 38(6):1637-44
Hai dong Li, Chen Huang, Ke jian Huang, Wei dong Wu ,Tao Jiang, Jun Cao, Zhen zhong Feng, Zheng jun Qiu （通讯作者） STAT3 Knockdown Reduces Pancreatic Cancer Cell Invasiveness and Matrix Metalloproteinase-7 Expression in Nude Mice. PLoS ONE 2011 6(10):e25941
Zhu GH, Huang C, Qiu ZJ （通讯作者）, Liu J, Zhang ZH, Zhao N, Feng ZZ, Lv XH Expression and prognostic significance of CD151, c-Met, and integrin alpha3/alpha6 in pancreatic ductal adenocarcinoma Dig Dis Sci 2011 56(4):1090-8
Sun J, Jiang T, Qiu Z （通讯作者）, Cen G, Cao J, Huang K, Pu Y, Liang H, Huang R, Chen S Short-term and medium-term clinical outcomes of laparoscopic-assisted and open surgery for colorectal cancer: a single center retrospective case-control study BMC Gastroenterol. 2011
Huang C, Yang G, Jiang T, Cao J, Huang KJ, Qiu ZJ （通讯作者） Down-regulation of STAT3 expression by vector-based small interfering RNA inhibits pancreatic cancer growth World J Gastroenterol 2011 17(25):2992-3001
Qiu Z （通讯作者）, Sun J, Pu Y, Jiang T, Cao J, Wu W Learning curve of transumbilical single incision laparoscopic cholecystectomy (SILS): a preliminary study of 80 selected patients with benign gallbladder diseases World J Surg 2011 35(9): 2092-101
Huang C, Yang G, Jiang T, Huang K, Cao J, Qiu Z （通讯作者） Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro J Exp Clin Cancer Res 2010
Liu X, Li J, Tian Y, Xu P, Chen X, Xie K, Qiu Z, Wang Y, Zhang D, Wolf F, Li C, Huang Q. Enhanced pancreatic cancer gene therapy by combination of adenoviral vector expressing c-erb-B2 (Her-2/neu)-targeted immunotoxin with a replication- competent adenovirus or etoposide Hum Gene Ther 2010 21(2):157-70
Huang C, Huang R, Jiang T, Huang K, Cao J, Qiu Z. （通讯作者） Laparoscopic and open resection for colorectal cancer: an evaluation of cellular immunity BMC Gastroenterol 2010
Liu J, Sun HC, Sun J, Huang C, Hu HH, Jin YB, Qiu ZJ （通讯作者） Phosph-Akt1 expression is associated with a favourable prognosis in pancreatic cancer Ann Acad Med Singapore 2010 39(7):548-7
Yang G, Huang C, Cao J, Huang KJ, Jiang T, Qiu ZJ. （通讯作者） Lentivirus-mediated shRNA interference targeting STAT3 inhibits human pancreatic cancer cell invasion World J Gastroenterol 2009 15(30):3757-66
Sun HC, Qiu ZJ （通讯作者）, Liu J, Sun J, Jiang T, Huang KJ, Yao M, Huang C. Expression of hypoxia-inducible factor-1 alpha and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis Int J Oncol 2007 30(6):1359-67
Qiu Z （通讯作者）, Huang C, Sun J, Qiu W, Zhang J, Li H, Jiang T, Huang K, Cao J. RNA interference-mediated signal transducers and activators of transcription 3 gene silencing inhibits invasion and metastasis of human pancreatic cancer cells Cancer Sci 2007 98(7):1099-106
Huang C, Cao J, Huang KJ, Zhang F, Jiang T, Zhu L, Qiu ZJ. （通讯作者） Inhibition of STAT3 activity with AG490 decreases the invasion of human pancreatic cancer cells in vitro. Cancer Sci 2006 97(12):1417-23