导师姓名： 温玉刚 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属第一人民医院 三级学科/
专业领域： 普外
导师类型： 博士生导师 专业学位导师： 兼
联系方式： wenyg1502@hotmail.com, wenyg1502@sina.com
邮编： 200080 邮箱地址： wenyg1502@hotmail.com

研究方向 (点击浏览详细信息)
胃肠道肿瘤发生发展分子机制

社会任职
中华医学会上海分会会员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** miR-181a-5p-PI3K/Akt-c-Myc环路调控癌细胞叶酸代谢及自噬促进胃癌5-FU耐药机制研究 国家自然科学基金面上项目 2020-01~2023-12 55万元 课题负责人
17ZR** PAK6在结肠癌增殖转移中的功能及转录 调控机制研究 上海市自然科学基金 2017-05~2020-04 20万元 课题负责人
LiU Predictive and prognostic value of the screened biomarker panel in Swedish and Chinese colorectal cancer patients Forskningsanslag 2016 - Onkologiska klinikernas i Link?ping forskningsfond 2016-06~2018-06 7.5万元 课题负责人
** RASSF6-KRAS协同抑制胃癌发生与进展分子机制研究 国家自然科学基金面上项目 2013-01~2016-12 60万元 课题负责人
ESRRG基因对胃癌增殖的影响及作为新的治疗靶点的研究 上海市科委医学引导项目 2010-04~2013-03 15万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Weng J, Xiao J, Mi Y, Fang X, Sun Y, Li S, Qin ZW, Li X, Liu TT, Zhao SL, Zhou LS, Wen YG. （通讯作者） PCDHGA9 acts as a tumor suppressor to induce tumor cell apoptosis and autophagy and inhibit the EMT process in human gastric cancer. Cell Death Dis. 2018 9(2): 27
Mi YS, Zhang DY, Jiang WL, Weng JY, Zhou CZ, Huang KJ, Tang HM, Yu Y, Liu XS, Cui WY, Zhang M, Sun XF, Zhou ZG, Peng ZH, Zhao SL, Wen YG （通讯作者） miR-181a-5p promotes the progression of gastric cancer via RASSF6-mediated MAPK signaling activation. Cancer Lett 2017 389:11-22.
Mi Y, Zhao S, Zhang W, Zhang D, Weng J, Huang K, Sun H, Tang H, Zhang X, Sun X, Peng Z, Wen Y. （通讯作者） Down-regulation of Barx2 predicts poor survival in colorectal cancer. Biochem Biophys Res Commun 2016 478(1):67-73.
Mi Y, Zhao S, Zhou C, Weng J, Li J, Wang Z, Sun H, Tang H, Zhang X, Sun X, Peng Z, Wen Y. （通讯作者） Downregulation of homeobox gene Barx2 increases gastric cancer proliferation and metastasis and predicts poor patient outcomes. Oncotarget 2016 7(37):60593-60608
Dantong Cheng, Senlin Zhao, Huamei Tang, Dongyuan Zhang,Hongcheng Sun, Fudong Yu, Weiliang Jiang, Ben Yue, Jingtao Wang, Meng Zhang, Yang Yu, Xisheng Liu, Xiaofeng Sun, Zongguang Zhou, Xuebin Qin, Xin Zhang, Dongwang Yan, Yugang Wen （通讯作者）, Zhihai Peng MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4 Oncotarget 2016 7(29):45199-45213
Han Y, Lu S, Wen YG, Yu FD, Zhu XW, Qiu GQ, Tang HM, Peng ZH, Zhou CZ. Overexpression of HOXA10 promotes gastric cancer cells proliferation and HOXA10(+)/CD44(+) is potential prognostic biomarker for gastric cancer. Eur J Cell Biol. 2015 94(12):642-52
Han Y, Tu WW, Wen YG, Yan DW, Qiu GQ, Peng ZH, Zhou CZ. Increased expression of TBX2 is a novel independent prognostic biomarker of a worse outcome in colorectal cancer patients after curative surgery and a potential therapeutic target.. Med Oncol 2013 30(4):688.
Han Y, Tu WW, Wen YG, Li DP, Qiu GQ, Tang HM, Peng ZH, Zhou CZ. Identification and validation that up-expression of HOXA13 is a novel independent prognostic marker of a worse outcome in gastric cancer based on immunohistochemistry. Med Oncol 2013 30(2):564
Wang Q, Wen YG （共同第一作者）, Li DP, Xia J, Zhou CZ, Yan DW, Tang HM, Peng ZH. Upregulated INHBA expression is associated with poor survival in gastric cancer. Med Oncol 2012 29(1):77-83
Yang C, Wen YG （共同第一作者）, Li H, Zhang D, Zhang NM, Shi XR, Jiang B, Ma XQ, Yang P, Tang HM, Peng ZH, Yang YX. Overexpression of minichromosome maitenance 2 predicts poor prognosis on patients with gastric cancer. Oncol Rep. 2012 27(1):135-142
Wen YG, Wang Q, Zhou CZ, Yan DW, Qiu GQ, Yang C, Tang HM, Peng ZH. Decreased expression of RASSF6 is a novel independent prognostic marker of a worse outcome in gastric cancer patients after curative surgery Ann Surg Oncol 2011 18(13):3858-3867
Wen YG, Wang Q, Zhou CZ, Yan DW, Qiu GQ, Yang C, Tang HM, Peng ZH. Identification and validation of kallileren-related peptidase 11 as a novel prognostic marker of gastric cancer based on immunohistochemistry. J Surg Oncol 2011 104:516-524
Wang Q, Wen YG （共同第一作者）, Li DP, Huang F, Zhou CZ, Qiu GQ, Tang HM, Peng ZH. Refined mapping of loss of heterozygosity in Chinese sporadic gastric carcinoma. Afr J Biotechnol. 2010 9(35):5754-5761.
Wen YG, Wang Q, Zhou CZ, Qiu GQ, Peng ZH, Tang HM. Mutation analysis of tumor suppressor gene PTEN in Shanghai patients with gastric carcinomas and its impact on PI3K/AKT pathway. Oncol Rep 2010 24(1):89-95