导师姓名： 刘耀华 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属第一人民医院 三级学科/
专业领域： 神外
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 邮箱地址： liu_yaohua@163.com

研究方向 (点击浏览详细信息)
脑肿瘤的基础与临床

社会任职
中国医师协会胶质瘤专业委员会委员
中国抗癌协会神经肿瘤专业委员会常委
中华医学会神经外科分会青年委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 细胞自主性未折叠蛋白反应调控癌基因/重编程因子驱动下胶质瘤细胞可塑性研究 国家自然科学基金 2014-01~2017-12 70万元 课题负责人
** XBP1调控胶质瘤细胞能量代谢促进其适应体内应激微环境的 国家自然科学基金 2012-01~2015-12 60万元 课题负责人
** 以XBP1为靶向调控胶质瘤细胞氧化应激的实验研究 国家自然科学基金 2010-01~2013-12 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Peng F, Wang X, Shu M, Yang M, Wang L, Ouyang Z, Shen C, Hou X, Zhao B, Wang X, Zhang LW, Liu Y （通讯作者）, Zhao S. Raddeanin a Suppresses Glioblastoma Growth by Inducing ROS Generation and Subsequent JNK Activation to Promote Cell Apoptosis. Cell Physiol Biochem. 2018 2018 May 25;47(3):1108-1121.
Zhao W, Peng F, Shu M, Liu H, Hou X, Wang X, Ye J, Zhao B, Wang K, Zhong C, Xue L, Gao M, Liu Y （通讯作者）, Zhao S. Isogambogenic acid inhibits the growth of glioma through activation of AMPK-mTOR pathway. Cellular Physiology and Biochemistry. 2017 2017;44(4):1381-1395.
Sun T, Jiang X, Wang Q, Chen Q, Lu Y, Liu L, Zhang Y, He X, Ruan C, Zhang Y, Guo Q, Liu Y （通讯作者）, Jiang C. Substance P Mediated DGLs Complexing with DACHPt for Targeting Therapy of Glioma. ACS Appl Mater Interfaces. 2017 2017 Oct 11;9(40):34603-34617.
Wu J, Liu Y （共同第一作者）, Cho K, Dong X, Teng L, Han D, Liu H, Chen X, Chen X, Hou X, Peng F, Bi Y, Shen C, Zhao S. Downregulation of TRAP1 sensitizes glioblastoma cells to temozolomide chemotherapy through regulating metabolic reprogramming. Neuroreport. 2016 2016 Feb 10;27(3):136-44.
Liu Y, Hou X, Liu M, Yang Z, Bi Y, Zou H, Wu J, Che H, Li C, Wang X, Wang K, Zhong C, Zhang J, Yu T, Bian Q, Chai S, Liu H, Ai J, Zhao S. XBP1 silencing decreases glioma cell viability and glycolysis possibly by inhibiting HK2 expression. J Neurooncol. 2016 2016 Feb;126(3):455-62.
13.Li C, Liu Y （共同第一作者）, Liu H, Zhang W, Shen C, Cho K, Chen X, Peng F, Bi Y, Hou X, Yang Z, Zheng Z, Wang K, Wang X, Zhang J, Zhong C, Zou H, Zhang X, Zhao S. Impact of autophagy inhibition at different stages on cytotoxic effect of autophagy inducer in glioblastoma cells. Cell Physiol Biochem. 2015 2015;35(4):1303-16.
Hou X, Liu Y, Liu H, Chen X, Liu M, Che H, Guo F, Wang C, Zhang D, Wu J, Chen X, Shen C, Li C, Peng F, Bi Y, Yang Z, Yang G, Ai J, Gao X, Zhao S. PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation. Sci Rep. 2015 2015 Mar 12;5:9065.
Zhao SG, Liu HL, Liu YH （共同第一作者）, Wu JN, Wang CL, Hou X, Chen XF, Yang G, Zhao ZL, Che H, Bi YK, Wang HY, Peng F, Ai J. miR-143 inhibits glycolysis and depletes stemness of glioblastoma stem-like cells. Cancer Letters. 2013 2013 Jun 10;333(2):253–260.
Liu HL, Han DY, Liu YH （共同第一作者）, Hou X, Wu JN, Li HD, Yang J, Shen C, Yang G, Fu CY, Li XF, Che H, Ai J, Zhao SG. Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma. Journal of neuro-oncology. 2013 2013 Mar;112(1):39-48.
Liu YH, Zheng TH, Zhao SG, Liu HL, Han DY, Zhen YB, Xu DX, Wang Y, Yang HY, Zhang G, Wang CL, Wu JN, Ye YZ. Inhibition of Heat Shock Protein Response Enhances PS341-mediated cell death in glioma cells. Annals of Surgical Oncology. 2012 2012 Jul;19 Suppl 3:S421-9.
Liu Y, Sakamoto H, Adachi M, Zhao SG, Ukai W, Hashimoto E, Hareyama M, Ishida T, Imai K, Shinomura Y. Heat stress activates ER stress signals which suppress the heat shock response, an effect occurring preferentially in the cortex in rats. Molecular biology reports. 2012 2012 Apr;39(4):3987-93.
Lv M, Liu Y （共同第一作者）, Zhang J, Sun L, Liu Z, Zhang S, Wang B, Su D, Su Z. Roles of inflammation response in microglia cell through Toll-like receptors 2/interleukin-23/interleukin-17 pathway in cerebral ischemia/reperfusion injury. Neuroscience. 2011 2011 Mar 10;176:162-72.
Liu YH, Zhang XJ, Liang Y, Yu HW, Chen XF, Yang G, Zheng BJ, Shi CB, Zhao SG. Targeting XBP1 Enhances Sensitivity of Glioma Cells to Oxidative Stress. Neuropathology and applied neurobiology. 2011 2011 Jun;37(4):395-405.
Liu YH, Liang Y, Zheng TH, Yang G, Zhang X, Sun Z, Shi CB, Zhao SG. Inhibition of Heme Oxygenase-1 Enhances Anti-Cancer Effects of Arsenic Trioxide on Glioma Cells. Journal of neuro-oncology. 2011 2011 Sep;104(2):449-58.
Liu YH, Adachi M, Zhao S, Hareyama M, Koong AC, Luo D, Rando TA, Imai K, Shinomura Y. Preventing oxidative stress: A new role for XBP1. Cell death and differentiation. 2009 2009, Jun;16(6):847-57.