导师姓名： 夏术阶 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属第一人民医院 三级学科/
专业领域： 泌尿外
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 邮箱地址： xsjurologist@163.com

研究方向 (点击浏览详细信息)
泌尿系肿瘤；前列腺疾病；微创泌尿外科新技术

社会任职
《Asian Journal of Andrology》助理主编，《中华医学杂志》副总编辑，《中华诊断学杂志》副总编辑，《中国内镜杂志》副主编辑，中国医师协会男科与性医学分会会长，亚洲男科协会主席，世界华人男科医师协会会长，中国男性健康联盟主席，中华医学会泌尿外科学会常委兼男科学组组长，上海医学会男科分会主任委员，上海激光学会副理事长。

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 前列腺上皮干细胞转分化在BPH术后创面修复中的作用和分子机制研究 国家自然科学基金重点项目 2020-01~2024-12 297万元 课题负责人
0506N17006 前列腺增生手术膀胱功能评分建立和评估的多中心研究 申康发展中心“三年行动计划” 2017-04~2020-03 60万元 课题负责人
** 前列腺术后创面修复过程中雄激素受体信号通路调控前列腺上皮基底细胞及其微环境的作用及机制研究 国自然面上项目 2016-01~2018-12 57万元 课题负责人
2013ZYJB0102 以铥激光为基础前列腺增生治疗策略的优化及并发症治疗 市卫生系统重要疾病联合攻关项目重大项目 2014-01~2016-12 150万元 课题负责人
HDC** 铥钬双波长激光器剥橘式前列腺切除新技术的应用推广及切面修复新认识的研究 申康市级医院新兴前沿技术联合攻关项目 2013-07~2016-06 180万元 课题负责人
国家重点专科项目 国家重点专科 卫生部 2012-01~2016-12 10000万元 课题负责人
包皮环切方法的优化及其对前列腺疾病影响的评价研究 上海市卫生局 2011-01~2013-12 20万元 课题负责人
输尿管镜下灌注致肾脏微通道开放机制及对肾脏影响的实验研究 上海市卫生局 2011-01~2013-12 6万元 课题负责人
不同年龄阶段的前列腺移行带和外周带基质细胞生物活性差异的研究 上海市卫生局 2011-01~2011-12 4万元 课题负责人
雄激素及其受体在膀胱癌细胞侵袭转移中的作用 上海市自然科学基金 2010-01~2012-12 10万元 课题参与人
前列腺外周带基质细胞强势基因表达活性与前列腺癌发生的关系 国家自然科学基金 2010-01~2012-12 30万元 课题负责人
前列腺外周带基质细胞的"老龄化"生长特征及其对上皮细胞的影响 国家自然科学基金 2010-01~2012-12 28万元 课题负责人
不同年龄阶段前列腺基质细胞对前列腺上皮细胞生长特性的影响 上海市科委 2009-01~2011-12 15万元 课题负责人
男性更年期性腺轴功能减退对前列腺影响的研究 上海市科委 2009-01~2011-12 25万元 课题负责人
07XD14027 前列腺移行带和外周带生物学行为差异的研究 上海市科委 2007-09~2009-11 35万元 课题负责人
前列腺移行带和外周带生物学行为差异的研究 上海市科委 2007-01~2010-12 35万元 课题负责人
前列腺癌早期诊断新指标的综合筛选 上海市科委 2007-01~2010-12 60万元 课题负责人
前列腺癌早期诊断新指标的综合筛选 上海市科委 2007-01~2010-12 60万元 课题负责人
男性更良性前列腺增生症的规范化微创治疗推广与疾病经济学研究 上海市申康项目 2007-01~2010-12 30万元 课题负责人
** 前列腺移行带和外周带生物学行为差异的分子机制研究 国家自然基金委,面上项目 2007-01~2009-12 33万元 课题负责人
微创多功能手术床加载三维导航系统的开发研究 上海市经委 2007-01~2009-12 50万元 课题负责人
荧光原位杂交技术膀胱癌早期诊断和复发监测的临床应用研究 卫生部 2007-01~2008-12 30万元 课题负责人
前列腺移行带和外带阶段性生长的分子调控 国家自然基金 2004-01~2007-12 8万元 课题负责人
前列腺移行带和外带阶段性生长的分子调控 国家自然基金 2004-01~2007-12 8万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhao R1, Sun F1, Bei X1, Wang X1, Zhu Y1, Jiang C1, Zhao F1, Han B1, Xia S1. （通讯作者） Upregulation of the long non-coding RNA FALEC promotes proliferation and migration of prostate cancer cell lines and predicts prognosis of PCa patients. prostate 2017 77(10):1107-1117
Tan M, Xu Y, Xu D, Jiang J, Zhao W, Cui D, Ruan Y, Xia S. （通讯作者） Laparoscopic Partial Nephrectomy with Sequential Precise Tumor-Specific Segmental Renal Artery Clamping for Multiple Ipsilateral Renal Tumors: a New Treatment Approach and Initial Experience. urology 2017 epub
Sun F, Han B, Cui D, Zhao F, Sun X, Zhuo J, Jing Y, Liu H, Xia S （通讯作者）, Yang Y, Luo G, Guo F Long-term results of thulium laser resection of the prostate: a prospective study at multiple centers World J Urol 2015 33(4):503-8
Yan Z, Jiang J, Li F, Yang W, Xie G, Zhou C, Xia S （通讯作者）, Cheng Y. Adenovirus-mediated LRIG1 expression enhances the chemosensitivity of bladder cancer cells to cisplatin. Oncol Rep. 2015 33(4):1791-8
Cui D, Dai J, Keller JM, Mizokami A, Xia S （通讯作者）, Keller ET Notch pathway inhibition using PF-**, a γ-secretase inhibitor (GSI), enhances the anti-tumor effect of docetaxel in prostate cancer Clin Cancer Res 2015 21 (15)：
Zhao Y, Zhao W, Lang G, Chen Y, Liu J, Wang G, Ma X, Gong M, Xu D, Xia S （通讯作者） Circumcision plus antibiotic, anti-inflammatory, and α-blocker therapy for the treatment for chronic prostatitis/chronic pelvic pain syndrome: a prospective, randomized, multicenter trial World J Urol 2015 33(5):617-22
Kyriazis I, ?winiarski PP, Jutzi S, Wolters M, Netsch C, Burchardt M, Liatsikos E, Xia S, Bach T, Gross AJ, Herrmann TR Transurethral anatomical enucleation of the prostate with Tm:YAG support (ThuLEP): review of the literature on a novel surgical approach in the management of benign prostatic enlargement World J Urol 2015 33（4）：525-530
Cao Y, Luo GH, Luo L, Yang XS, Hu JX, Shi H, Huang P, Sun ZL, Xia SJ. （通讯作者） Re-epithelialization resulted from prostate basal cells in Asian J Androl 2015 17(5):831-8
Liang S, Zou Q, Han B, Jing Y, Cui D, An X, Gao Y, Hu J, Xia S （通讯作者） Intra-arterial chemotherapy for muscle-invasive bladder cancer following transurethral resection Urol Int 2015 94（4）:406-411
Du Y, Wang Y, Zhang F, Wu W, Wang W, Li H, Xia S, Liu H Regulation of metastasis of bladder cancer cells through the WNT signaling pathway Tumour Biol 2015 2015 Jun 12
Shao Y, Li WH, Hasimu S, Shan DL, Lu J, Xia SJ. （通讯作者） Urgent percutaneous nephrolithotomy for acute kidney injury World J Urol 2015 33(9):1345-9
Yan Z, Jiang J, Li F, Yang w, Xie G, Zhou C, Xia S, Cheng Y Adenovirus-mediated LRIG1 expression enhances the chemosensitivity of bladder cancer cells to cisplatin Oncol Rep 2015 33（4）：1791-1798(8)
Jiang JT, Xu HL, Zhu YP, Wood K, Li EH, Sun WL,Yuan Q, Xu DL, Liu ZH, Zhao W, Xia SJ. （通讯作者） Reduced Fgf10/Fgfr2 and androgen receptor (AR) in anorectal malformations male rats induced by di-n-butyl Toxicology 2015 338:77-85
Cui D1, Dai J2, Keller JM3, Mizokami A4, Xia S5 （通讯作者）, Keller ET6. Notch Pathway Inhibition Using PF-**, a γ-Secretase Inhibitor (GSI), Enhances the Antitumor Effect of Docetaxel in Prostate Cancer. clinical cancer research 2015 21(20):4619-29.
Jing Y, Cui D, Guo W, Jiang J, Jiang B, Lu Y, Zhao W, Wang X, Jiang Q, Han B, Xia S （通讯作者） Activated androgen receptor promotes bladder cancer metastasis via Slug mediated epithelial-mesenchymal transition Cancer Lett 2014 348(1-2):135-45
Du Y, Bi W, Zhang F, Wu W, Xia S （通讯作者）, Liu H G-protein-coupled receptor 137 accelerates proliferation of urinary bladder cancer cells in vitro Biotechnol Appl Biochem 2014 2014 Dec 11
Jiang Q, Xia S （通讯作者） Two-micron (Thulium) Laser Prostatectomy: An Effective Method for BPH Treatment Curr Bladder Dysfunct Rep 2014 2014;9:142-144
Xu S, Shi H, Zhu J, Wang Y, Cao Y, Li K, Wang Y, Sun Z, Xia S （通讯作者） A prospective comparative study of haemodynamic, electrolyte, and metabolic changes during percutaneous nephrolithotomy and minimally invasive percutaneous nephrolithotomy World J Urol 2014 32(5):1275-80
Yu J, Lu Y, Cui D, Li E, Zhu Y, Zhao Y, Zhao F, Xia S （通讯作者） miR-200b suppresses cell proliferation, migration and enhances chemosensitivity in prostate cancer by regulating Bmi-1 Oncol Rep 2014 31(2):910-8
Han B, Liang S, Jing Y, Cui D, An X, Zou Q, Wei H, Xia S （通讯作者） Organ preservation for muscle-invasive bladder cancer by preoperative intra-arterial chemotherapy and transurethral resection Med Oncol 2014 31(4):912
Zhu Y, Zhuo J, Xu D, Xia S （通讯作者）, Herrmann TR Thulium laser versus standard transurethral resection of the prostate for benign prostatic obstruction: a systematic review and meta-analysis World J Urol 2014 33(4):509-15
Cui D, Sun F, Zhuo J, Sun X, Han B, Zhao F, Jing Y, Lu J, Xia S （通讯作者） A randomized trial comparing thulium laser resection to standard transurethral resection of the prostate for symptomatic benign prostatic hyperplasia: four-year follow-up results World J Urol 2014 32(3):683-9
Wei H, Shao Y, Sun F, Sun X, Zhuo J, Zhao F, Han B, Jiang J, Chen H, Xia S （通讯作者） Thulium laser resection versus plasmakinetic resection of prostates larger than 80 ml World J Urol 2014 32(4):1077-85
Yu S, Xia S （共同第一作者）, Yang D, Wang K, Yeh S, Gao Z, Chang C Androgen receptor in human prostate cancer-associated fibroblasts promotes prostate cancer epithelial cell growth and invasion Med Oncol 2013 30(3):674
Wang X, Lee SO, Xia S, Jiang Q, Luo J, Li L, Yeh S, Chang C Endothelial cells enhance prostate cancer metastasis via IL6→androgen receptor→TGFβ→MMP9 signals Mol Cancer Ther 2013 12(6):1026-37
Du T, Zou X, Cheng J, Wu S, Zhong L, Ju G, Zhu J, Liu G, Zhu Y, Xia S （通讯作者） Human Wharton's jelly-derived mesenchymal stromal cells reduce renal fibrosis through induction of native and foreign hepatocyte growth factor synthesis in injured tubular epithelial cells Stem Cell Res Ther 2013 4(3):59
Wang X, Lin WJ, Izumi K, Jiang Q, Lai KP, Xu D, Fang LY, Lu T, Li L, Xia S （通讯作者）, Chang C Increased infiltrated macrophages in benign prostatic hyperplasia (BPH): role of stromal androgen receptor in macrophage-induced prostate stromal cell proliferation J Biol Chem 2012 287(22):18376-85
Yong-Chuan Wang,Sheng-Qiang Yu,Xiao-Hai Wang,Bang-Min Han,Fu-Jun zhao,Guang-Hui Zhu,Yan Hong,Shu-Jie Xia （通讯作者） Differences in phenotype and gene expression of prostate stromal cells from patients of varying ages and their influence on tumour formation by prostate epithelial cells Asian J Androl 2011 13:732-741
Zhao FJ, Zhang S, Yu ZM, Xia SJ （通讯作者）, Li H. Chimeric molecules facilitate the Specific targeting of prostate cancer cells in vitro by the suicide gene/prodrug system, uracil phosphoribosyltransferase/5-fluorouracil, under the control of prostate-specific membrane antigen promoter/enhancer. Prostate Cancer Prostatic Dis. 2009 12(2):166-71
Niu YN, Xia SJ. （通讯作者） Stroma-epithelium crosstalk in prostate cancer Asian J Androl 2009 11(1):28-35.
Runsheng Li, Yan Guo, Shujie Xia. Proteomics cataloging analysis of human expressed prostatic secretions reveals rich source of biomarker candidates Proteomics Clin. Appl 2008 2: 543- 555.
Lu J, Zhang Q, Liang CM, Xia SJ （通讯作者）, Zhong CP, Wang DW. Antitumor immunity by a dendritic cell vaccine encoding secondary lymphoid chemokine and tumor lysate on murine prostate cancer Asian J Androl 2008 10(6):883-889.
Xia SJ. Androgen, Oestrogen, progesterone and epidermal growth factor receptor levels and their distribution between transition zone and perpheral zone of prostate. China Medical abstracts 1997 6(2):115.
Xia SJ. Androgen receptor isoforms in benign prostatic hyperplasia and prostatic cancer. China Medical abstracts 1996 5(4):248.
Xia SJ. Prostate Volume in men with Obstructive Symptoms and Age-matched Asymptomatic controls Contemporary Surgery 1996 3(5)
Han B, Cui D, Jing Y, Hong Y, Xia S. （通讯作者） Estrogen receptor β (ERβ) is a novel prognostic marker of recurrence survival in non-muscle-invasive bladder cancer potentially by inhibiting cadherin switch. World J Urol. 30(6):861-7
Wu JT, Han BM, Yu SQ, Wang HP, Xia SJ. （通讯作者） In vitro comparison of the vaporesection of human benign Androgen receptor is a potential therapeutic target for bladder cancer. Urology. 75(4):820-7.
Xia SJ （通讯作者）, Zhuo J, Sun XW, Han BM, Shao Y, Zhang YN. Thulium laser versus standard transurethral resection of the prostate: a randomized prospective trial. Eur Urol. 53(2):382-89.
Jiang Q, Xia SJ. （通讯作者） Zonal differences in prostate diseases. Chin Med J (Engl). 125(9):1523-8.
Xia SJ, Tang XD, Ma QZ. Androgen receptor isoforms in human prostatic cancer tissue and LNCaP cell line. Asian J Androl. 3(3):223-5.
Liu H, Xue S, Ruan Y, Sun X, Han B, Xia S. （通讯作者） 2-micrometer continuous wave laser treatment for multiple non-muscle-invasive bladder cancer with intravesical instillation of epirubicin. Lasers Surg Med. 43(1):15-20.
Wang XH, Zhao FJ, Han BM, Jiang Q, Wang YC, Wu JH, Tang YQ, Zhang YP, Xia SJ. （通讯作者） Primary stromal cells isolated from human various histological/pathological prostate have different phenotypes and tumor promotion role. Chin Med J (Engl). 124(11):1700-7.
Shao Y, Shen ZJ, Zhu YY, Sun XW, Lu J, Xia SJ. （通讯作者） Fluid-electrolyte and renal pelvic pressure changes during ureteroscopic lithotripsy. Minim Invasive Ther Allied Technol. 21(4):302-6.
Kirby R, Xia SJ. （通讯作者） Editorial and introduction to Asian Journal of Andrology Prostate Cancer special issue. Asian J Androl. 11(1):6-8.
Shao ZQ, Guo FF, Yang WY, Wang GJ, Tan SF, Li HL, He XF, Wang JM, Liu HJ, Xia SJ. （通讯作者） Percutaneous intrarenal marsupialization of symptomatic peripelvic renal cysts: A single-centre experience in China. Scand J Urol.
Xia SJ （通讯作者）, Jing YF. Biochemical recurrence of prostate cancer: the controversial recognition and management. Chin Med J (Engl). 124(9):1283-5.
Xia SJ, Xu XX, Teng JB, Xu CX, Tang XD. Characteristic pattern of human prostatic growth with age. Asian J Androl. 4(4):269-71.
Niu YN, Xia SJ. （通讯作者） Tumor formation of prostate cancer Stroma-epithelium crosstalk in prostate cancer. Asian J Androl. 11(1):28-35.
Luo GH, Xia SJ （通讯作者）, Sun ZL. In vitro comparison of the vaporesection of human benign prostatic hyperplasia using 70- and 120-W 2-μm lasers. Asian J Androl. 13(4):636-9.
Jiang JT, Sun WL, Jing YF, Liu SB, Ma Z, Hong Y, Ma L, Qin C, Liu Q, Stratton HJ, Xia SJ. （通讯作者） Prenatal exposure to di-n-butyl phthalate induces anorectal malformations in male rat offspring. Toxicology. 290(2-3):322-6.
Yu SQ, Han BM, Shao Y, Wu JT, Zhao FJ, Liu HT, Sun XW, Tang YQ, Xia SJ. （通讯作者） Androgen receptor functioned as a suppressor in the prostate cancer cell line PC3 in vitro and in vivo. Chin Med J (Engl). 122(22):2779-83.
Wu JH, Xia SJ. （通讯作者） Stem cell-based therapy for erectile dysfunction. Chin Med J (Engl). 124(22):3810-5.
Zhong C, Guo S, Tang Y, Xia S. （通讯作者） 2-micrometer continuous wave laser treatment for multiple non-muscle-invasive bladder cancer with intravesical instillation of epirubicin. World J Urol. 28(2):157-61
Zhao FJ, Han BM, Yu SQ, Xia SJ. （通讯作者） Tumor formation of prostate cancer cells influenced by stromal cells from the transitional or peripheral zones of the normal prostate. Asian J Androl. 11(2):176-82.
Xia SJ （通讯作者）, Cui D, Jiang Q. An overview of prostate diseases and their characteristics specific to Asian men. Asian J Androl. 14(3):458-64.
Wang X, Lin WJ, Izumi K, Jiang Q, Lai KP, Xu D, Fang LY, Lu T, Li L, Xia S （通讯作者）, Chang C. Increased infiltrated macrophages in benign prostatic hyperplasia (BPH): role of stromal androgen receptor in macrophage-induced prostate stromal cell proliferation. J Biol Chem. 287(22):18376-85.
Jiang JT, Sun WL, Jing YF, Liu SB, Ma Jiang Q, Han BM, Zhao FJ, Hong Y, Xia SJ. （通讯作者） The differential effects of prostate stromal cells derived from different zones on prostate cancer epithelial cells under the action of sex hormones. Asian J Androl. 13(6):798-805.
Xia SJ （共同第一作者）, Hao GY, Tang XD. Androgen receptor isoforms in human and rat prostate. Asian J Androl. 2(4):307-10.
Wu JT, Gao ZL, Shi L, Han BM, Men CP, Zhang P, Xia SJ. （通讯作者） Small incision combined with laparoscopy for ureteropelvic junction obstruction: comparison with retroperitoneal laparoscopic pyeloplasty. Chin Med J (Engl). 122(22):2728-32.
Li R, Guo Y, Han BM, Yan X, Utleg AG, Li W, Tu LC, Wang J, Hood L, Xia S （通讯作者）, Lin B. Proteomics cataloging analysis of human expressed prostatic secretions reveals rich source of biomarker candidates Proteomics Clin Appl. 2(4):543-555.
Jiang Q, Yeh S, Wang X, Xu D, Zhang Q, Wen X, Xia S （通讯作者）, Chang C. Targeting androgen receptor leads to suppression of prostate cancer via induction of autophagy. J Urol. 188(4):1361-8.
Sun X, Xia S, Lu J, Liu H, Han B, Li W. Treatment of large impacted proximal ureteral stones: randomized comparison of percutaneous antegrade ureterolithotripsy versus retrograde ureterolithotripsy. J Endourol. 22(5):913-7.
Yifeng J, Shujie X （通讯作者）, Hongbin S, Yaoting X, Jie F, Xiaoda T. Use of free peritoneal and bladder mucosal grafts as ureteral mucosa substitutes for management of avulsion of the ureteral mucosa in a dog model. J Endourol. 22(4):729-34.
Xia SJ, Xu CX, Tang XD, Wang WZ, Du DL. Apoptosis and hormonal milieu in ductal system of normal prostate and benign prostatic hyperplasia. Asian J Androl. 3(2):131-4.
Tang YQ, Han BM, Yao XQ, Hong Y, Wang Y, Zhao FJ, Yu SQ, Sun XW, Xia SJ. （通讯作者） Chimeric molecules facilitate the degradation of androgen receptors and repress the growth of LNCaP cells. Asian J Androl. 11(1):119-26.
Xia SJ. （通讯作者） Two-micron (thulium) laser resection of the prostate-tangerine technique: a new method for BPH treatment. Asian J Androl. 11(3):277-81.
Zhao W, Wang XS, Niu HT, Wang LL, Han BM, Xia SJ. （通讯作者） Clinical relevance of heparanase mRNA expression in bladder cancer and its usefulness as a detection marker in voided urine. Mol Med Report 2(2):327-31.
Wu ZL, Yuan Y, Geng H, Xia SJ. （通讯作者） Influence of immune inflammation on androgen receptor expression in benign prostatic hyperplasia tissue. Asian J Androl. 14(2):316-9.
Jiang B, Li EH, Lu YY, Jiang Q, Cui D, Jing YF, Xia SJ. （通讯作者） Inhibition of fatty-acid synthase suppresses P-AKT and induces apoptosis in bladder cancer. Urology. 80(2):484