导师姓名： 郑志 专业代码： 100212
性别： 男 专业名称： 眼科学
培养单位： 附属第一人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： zhengzhi139@163.com
邮编： 200080 邮箱地址： zzheng8@yahoo.com.cn

研究方向 (点击浏览详细信息)
玻璃体视网膜疾病

社会任职
中国视力残疾康复专业委员会委员
《中华眼底病杂志》编委
中华医学会眼科分会眼外伤学组委员
上海市社会医疗机构协会眼科专业委员会副主任委员
上海医学会眼科分会玻璃体视网膜学组副组长
中国研究型医院学会眼科学与视觉科学专业委员会常务委员
上海医学会眼科分会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 基于EZH2调节的NLRP3炎症小体通路研究尿酸在糖尿病视网 膜病变发病中的作用 国家自然基金面上项目 2018-01~2021-12 54万元 课题负责人
2017ZX** 示范性眼底病新药临床评价技术平台建设 科技部重大专项 2017-01~2019-12 1284万元 课题负责人
** ANGPTL3通路在糖尿病视网膜病变发病中的作用 国家自然基金面上项目 2015-01~2018-12 73万元 课题负责人
** SIRT1 调节的组蛋白H3 表观遗传修饰在糖尿病视网膜病变代谢记忆中的作用 国家自然基金面上项目 2013-01~2016-12 85万元 课题负责人
** 泛素-蛋白酶体通路在糖尿病视网膜病变发病中的作用机制及意义 上海市领军人才计划 2012-01~2015-12 25万元 课题负责人
201158 LKB1/AMPK通路在糖尿病视网膜病变发病中的作用 上海市卫生局优秀学科带头人计划 2011-01~2013-12 100万元 课题负责人
** 基于线粒体ROS通路的糖尿病视网膜病变早期发病干预研究 上海市人才发展基金 2011-01~2013-12 10万元 课题负责人
** PGC-1α调控的线粒体ROS通路在2型糖尿病视网膜病变早期发病中的作用 国家自然科学基金面上项目 2011-01~2013-12 35万元 课题负责人
2010B097 PGC-1α在糖尿病视网膜病变新生血管发病中的作用及其临床意义 上海市白玉兰科技人才基金项目 2011-01~2012-12 2.5万元 课题负责人
2010CB535006 AMPKα对线粒体ROS通路的调控在2型糖尿病视网膜病变早期发病中的作用 973计划前期研究专项课题 2010-07~1013-08 65万元 课题负责人
** SOCS-3在糖尿病性视网膜病变发病中作用机制及意义 国家自然科学基金面上项目 2009-01~2011-12 30万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zou C, Han C, Zhao M, Yu J, Bai L, Yao Y, Gao S, Cao H, Zheng Z （通讯作者） Change of ranibizumab-induced human vitreous protein profile in patients with proliferativediabetic retinopathy based on proteomics analysis Clin Proteomics 2018 15:12. doi: 10.1186/s12014-018-9187-z
Zou C, Zhao M, Yu J, Zhu D, Wang Y, She X, Hu Y, Zheng Z （通讯作者） Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection J Ophthalmol 2018 2018:**. doi: 10.1155/2018/**
Zhu DD, Wang YZ, Zou C, She XP, Zheng Z （通讯作者） The role of uric acid in the pathogenesis of diabetic retinopathy based on Notch pathway Biochem Biophys Res Commun 2018 pii: S0006-291X(18)31409-8
Lu Q, Lu P, Chen W, Lu L, Zheng Z （通讯作者） ANGPTL-4 induces diabetic retinal inflammation by activating Profilin-1 Exp Eye Res 2018 166:140-150
Wang N, Zou C, Zhao S, Wang Y, Han C, Zheng Z （通讯作者） Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway Invest Ophthalmol Vis Sci 2018 59(10): 4210-4217
Chen W, Zhao M, Zhao S, Lu Q, Ni L, Zou C, Lu L, Xu X, Guan H, Zheng Z （通讯作者）, Qiu Q Activation of the TXNIP/NLRP3 inflammasome pathway contributes to inflammation in diabetic retinopathy: a novel inhibitory effect of minocycline Inflamm Res 2017 66(2):157-166
Lu Q, Zou W, Chen B, Zou C, Zhao M, Zheng Z （通讯作者） ANGPTL-4 correlates with vascular endothelial growth factor in patients with proliferative diabetic retinopathy Graefes Arch Clin Exp Ophthalmol 2016 254(7):1281-1288
Zhao S,Li T, Li J, Lu Q, Han C, Wang N, Qiu Q, Cao H, Xu X, Chen H, Zheng Z （通讯作者） miR-23b-3p induces cellular metabolic memory of high glucose in diabetic retinopathy through a SIRT1-dependent signaling pathway Diabetologia 2016 59(3):644-654
Lu Q, Zou C, Cao H, Zhao M, Yu S, Qiu Q, Xu X, Zheng Z （通讯作者） Preoperative intravitreal injection of ranibizumab for patients with severe proliferative diabetic retinopathy contributes to a decreased risk of postoperative neovascular glaucoma Acta Ophthalmol 2016 94(4):414-415
Zhou C, Qiu Q, Zheng Z. AIR VERSUS GAS TAMPONADE IN RHEGMATOGENOUS RETINAL DETACHMENT WITH INFERIOR BREAKS AFTER 23-GAUGE PARS PLANA VITRECTOMY: A Prospective, Randomized Comparative Interventional Study Retina 2015 35(5):886-891
Zhao S, Li J, Wang N, Zheng B, Li T, Gu Q, Xu X, Zheng Z （通讯作者） Fenofibrate suppresses cellular metabolic memory of high glucose in diabetic retinopathy via a sirtuin 1-dependent signalling pathway Mol Med Rep 2015 12(4):6112-118
Lu Q, Lu L, Chen W, Chen H, Xu X, Zheng Z （通讯作者） RhoA/mDia-1/profilin-1 signaling targets microvascular endothelial dysfunction in diabetic retinopathy Graefes Arch Clin Exp Ophthalmol 2015 253(5):669-680
Lu QY, Chen W, Lu L, Zheng Z （通讯作者）, Xu X Involvement of RhoA/ROCK1 signaling pathway in hyperglycemia-induced microvascular endothelial dysfunction in diabetic retinopathy Int J Clin Exp Pathol 2014 7(10):7268-7277
Chen W, Cao H, Lu QY, Wang N, Zhao SZ, Xu X, Zheng Z （通讯作者） Urinary 6-sulfatoxymelatonin level in diabetic retinopathy patients with type 2 diabetes Int J Clin Exp Pathol 2014 7(7):4317-4322
Chen H,Zheng Z （共同第一作者）,Huang Y,Guo K,Lu J,Zhang L,Yu H,Bao Y,Jia W A microalbuminuria threshold to predict the risk for the development of diabetic retinopathy in type 2 diabetes mellitus patients PLoS One 2012 7(5): e36718
Zheng Z （通讯作者）, Chen H, Li J, Li T, Zheng B, Zheng Y, Jin H, He Y, Gu Q, Xu X Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin Diabetes 2012 61(1):217-228
Zhao S, Li T, Zheng B, Zheng Z （通讯作者） Nitric oxide synthase 3 (NOS3) 4b/a, T-786C and G894T polymorphisms in association with diabetic retinopathy susceptibility: A meta-analysis Ophthalmic Genet 2012 33(4):200-7
Zheng B, Li T, Chen H, Xu X, Zheng Z （通讯作者） Correlation between Ficolin-3 and Vascular Endothelial Growth Factor-to-Pigment Epithelium-Derived Factor Ratio in the Vitreous of Eyes with Proliferative Diabetic Retinopathy Am J Ophthalmol 2011 152(6):1039-1043
Jin J, Zhou KK, Park K, Hu Y, Xu X, Zheng Z （通讯作者）, Tyagi P, Kompella UB, Ma JX Anti-inflammatory and Antiangiogenic Effects of Nanoparticle-Mediated Delivery of a Natural Angiogenic Inhibitor Invest Ophthalmol Vis Sci 2011 52(9):6230-6237
Zheng Z （通讯作者）, Chen HB, Wang H, Ke BL, Zheng BQ, Li Q, Li PY, Su L, Gu Q, Xu X Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial ROS pathway mediated by PGC-1α Diabetes 2010 59(9): 2315-2325.
Wu H, Xia X, Jiang C, Wu J, Zhang S, Zheng Z, Liu W, Zhang Y, Ren H, Wei C, Xu X High glucose attenuates insulin-induced VEGF expression in bovine retinal microvascular endothelial cells Eye 2010 24(1):145-151
Chen HB, Zheng Z （共同第一作者）, Li RX, Lu JX, Bao YQ, Ying XF, Zeng R, Jia WP Urinary pigment epithelium-derived factor as a marker of diabetic nephropathy Am J Nephrol 2010 32(1):47-56
Zhu D, Xu X, Zheng Z, Gu Q Regulation of vascular endothelial growth factor and pigment epithelium-derived factor in rat retinal explants under retinal acidification Eye 2009 23(11):2105-2111
Chen YH, Xu X, Sheng MJ, Zhang XY, Gu Q, Zheng Z （通讯作者） PRMT-1 and DDAHs-induced ADMA upregulation is involved in ROS- and RAS-mediated diabetic retinopathy Exp Eye Res 2009 89(6):1028-1034
Zhao H, Jin H, Li Q, Gu Q, Zheng Z, Wu H, Ye S, Sun X, Xu X, Ho PC KV11, a small peptide derived from human apolipoprotein(a), inhibits VEGF-induced retinal neovascularization: the safety, penetration, and efficacy Invest Ophthalmol Vis Sci 2009 50(11):5384-5395
Zheng Z, Chen HB, Ke GJ, Fan Y, Zou HD, Sun XD, Gu Q, Xu X,Ho PC The protective effect of perindopril on diabetic retinopathy is associated with decreased VEGF/PEDF ratio: involvement of a mitochondria-ROS pathway Diabetes 2009 58(4):954-964
Chen HB, Jia W, Xu X, Fan Y, Zhu D, Wu H, Xie Z, Zheng Z （通讯作者） Upregulation of PEDF expression by PARP inhibition contributes to the decrease in hyperglycemia-induced apoptosis in HUVECs Biochem Biophys Res Commun 2008 369(2):718-724
Chen YD, Xu X, Xia X, Wu H, Liu K, Zheng Z, Zhu D MMP9 is involved in glycation end-products induced increase of retinal vascular permeability in rats and the therapeutic effect of minocycline Curr Eye Res 2008 33(11):977-983
Zheng Z, Chen HB, Xu X, Li CX Effects of angiotensin-converting enzyme inhibitors and β-adrenergic blockers on retinal vascular endothelial growth factor expression in rat diabetic retinopathy Exp Eye Res 2007 84(4):745-752