导师姓名： 许迅 专业代码： 100212
性别： 男 专业名称： 眼科学
培养单位： 附属第一人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 200080 邮箱地址： drxuxun@tom.com

研究方向 (点击浏览详细信息)
眼底病、临床与基础研究
糖尿病视网膜病变的发病机理及防治研究

社会任职
《激光眼科学》副主编
中国医师协会眼科分会 副会长
国家卫生和计生委住院医师规范化培训规划教材 评审委员会委员
《中华眼底病杂志》副主编
全国眼底病学组 组长
《中华眼视光学与视觉科学杂志》副主编
《ACTA OPHTHALMOLOGICA》 编委
《Ophthalmologica》编委
中国医师协会眼科分会副会长兼眼底病专委会主委
中华医学会眼科学分会 副主任委员
《中华眼科杂志》编委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
?** ?基于组合机器学习算法的病理性近视眼底多模态影像资料自动化定量分析研 究 国家自然基金委，面上项目 2020-01~2023-12 55万元 课题负责人
2016YFC** 抑制VEGF治疗黄斑下新生血管疾病药物基因组学研究 国家重点研发计划精准医学研究 2017-01~2020-12 2500万元 课题负责人
** 抑制新生血管多肽ZY9优化及作用机制研究 国家自然基金委,面上项目 2016-01~2019-12 68.4万元 课题负责人
** 抑制新生血管多肽ZY9优化及作用机制研究 国家自然基金委,面上项目 2016-01~2019-12 68.4万元 课题负责人
** 新型多肽抑制眼部炎症的作用机制及通透性和安全性研究 国家自然基金委,面上项目 2013-01~2016-12 67万元 课题负责人
** 新型多肽抑制视网膜新生血管机制及眼内缓释系统研究 国家自然基金委,面上项目 2012-01~2015-12 62万元 课题负责人
2011ZX09302-007-02 新药临床研究技术平台建设—治疗眼底病创新药物临床评价研究平台的构筑 “十二五“国家科技重大专项 2011-01~2013-12 1420.29万元 课题负责人
** UCP-2调节的线粒体增殖及功能在2型糖尿病视网膜病变发病和防治中的作用及其临床意义 国家自然基金委, 重点项目 2010-01~2013-12 170万元 课题负责人
C170602 UCP-2调节的线粒体增殖及功能在2型糖尿病视网膜病变发病和防治中的作用及其临床意义 国家自然基金，重点项目 2010-01~2013-12 170万元
** 抑制眼部新生血管新肽的作用机制研究 国家自然基金委,面上项目 2009-01~2011-12 36万元 课题负责人
** STAT3信号系统在糖尿病视网膜病变中的作用机制及意义 国家自然基金委,面上项目 2008-01~2010-12 29万元 课题负责人
2007BAI18B07 糖尿病视网膜病变视功能保护关键技术的研究 “十一五”国家科技支撑计划 2007-01~2009-12 250万元 课题负责人
聚腺苷二磷酸核糖聚合酶对糖尿病视网膜病变发病的作用机制及干预研究 国家教育部,博士点基金 2007-01~2009-12 6万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Liu K, Song Y, Xu G, Ye J, Wu Z, Liu X, Dong X, Zhang M, Xing Y, Zhu S, Chen X, Shen Y, Huang H, Yu L, Ke Z, Rosenfeld PJ, Kaiser PK, Ying G, Sun X, Xu X; PHOENIX Study Group. （通讯作者） Conbercept for Treatment of Neovascular Age-related Macular Degeneration: Results of the Randomized Phase 3 PHOENIX Study. Am J Ophthalmol. 2019 197:156-167
Yang Fu, Min Tang, Xiaoqiong Xiang , Kun Liu , Xun Xu （通讯作者） Glucose affects cell viability, migration, angiogenesis and cellular adhesion of human retinal capillary endothelial cells via SPARC Exp Ther Med. 2019 17(1):273-283
Liu X, Bi L, Xu Y, Feng D, Kim J, Xu X. （通讯作者） Robust deep learning method for choroidal vessel segmentation on swept source optical coherence tomography images Biomed Opt Express. 2019 10(4):1601-1612.
Lu Cheng; Mingjin Wang; Junjie Deng; Minzhi Lv; Wenhan Jiang; Shuyu Xiong; Sifei Sun; Jianfeng Zhu; Haidong Zou; Xiangui He; Xun Xu. Macular Ganglion Cell-Inner Plexiform Layer, Ganglion Cell Complex, and Outer Retinal Layer Thicknesses in a Large Cohort of Chinese Children. Invest Ophthalmol Vis Sci 2019 60(14):4792-480
Ma M, Xu Y, Xiong S, Zhang J, Gu Q, Ke B, Xu X. （通讯作者） Involvement of ciliary neurotrophic factor in early diabetic retinal neuropathy in streptozotocin-induced diabetic rats Eye 2018 (2018) 32:1463–1471?
Lu Y, Tai PWL, Ai J, Gessler DJ, Su Q, Yao X, Zheng Q, Zamore PD, Xu X （通讯作者）, Gao G. Transcriptome profiling of neovascularized corneas reveals miR-204 as a multi-target biotherapy deliverable by rAAVs Molecular Therapy-Nucleic Acids 2018 2;10:349-360
Zhang J, Suo Y, Liu M, Xu X. （通讯作者） Identification of genes related to proliferative diabetic retinopathy through RWR algorithm based on protein-protein interaction network. Biochim Biophys Acta-Molecular Basis of Disease 2018 1864:2369-2375
He X, Zhao R, Sankaridurg P, Zhu J, Naduvilath T, Ma Y, Lu L, Lv M, Smith EL 3rd, Resnikoff S, Naidoo K, Zou H*, Xu X* （通讯作者） Design and methodology of the Shanghai child and adolescent large-scale eye study (SCALE) Clin Exp Ophthalmol 2017 oi: 10.1111/ceo.13065
Xiong S, He X*, Deng J, Lv M, Jin J, Sun S, Yao C, Zhu J, Zou H, Xu X*. （通讯作者） Choroidal Thickness in 3001 Chinese Children Aged 6 to 19 Years Using Swept-Source OCT. Sci Rep 2017 22;7:45059
Qian TW, Zhao MY, Li XX, Xu X （通讯作者） Efficiency and safety of laser photocoagulation with or without intravitreal ranibizumab for treatment of diabetic macular edema: a systematic review and Meta-analysis Int J Ophthalmol 2017 18;10(7):1134-1143
Xu Y, Yan K, Kim J, Wang X, Li C, Su L, Yu S, Xu X, Feng DD （通讯作者） Dual-stage?deep?learning framework for pigment epithelium detachment segmentation in polypoidal choroidal vasculopathy Biomed Opt Express 2017 10;8(9):4061-4076
Lu Y, Zheng Y, Ai J, Xu X*. （通讯作者） Therapeutic Effects of a Novel PIGF-1 Derived Peptide, ZY-1, on Corneal Neovascularization In Vitro and In Vivo Discovery Medicine 2016 21(117):349-61
Liu K, Liu H, Zhang Z, Ye W, Xu X* （通讯作者） The role of N-glycosylation in high glucose-induced upregulation of intercellular adhesion molecule-1 on bovine retinal endothelial cells. Acta Ophthalmol. 2016 94(4):353-7
Lu Y, Ai J, Gessler D, Su Q, Tran K, Zheng Q, Xu X* （通讯作者）,Gao G* Efficient Transduction of Corneal Stroma by Adeno-Associated Viral Serotype Vectors for Implications in Gene Therapy of Corneal Diseases Human Gene Therapy 2016 27(8) 598-608
Gao J, Chen X, Gu Q, Liu X, Xu X* （通讯作者） SENP1-Mediated Desumoylation of DBC1 Inhibits Apoptosis Induced by High Glucose in Bovine Retinal Pericytes. J Ophthalmol 2016 2016:**
Tang M, Fu Y, Wang Y, Zheng Z, Fan Y, Sun X, Xu X* （通讯作者） Efficacy?of?intravitreal?ranibizumab?combined?with?Ahmed?glaucoma?valve?implantation?for the treatment of neovascular?glaucoma. BMC Ophthalmol 2016 9;16:7
Chen C, Liu K, Xu Y, Zhang P, Suo Y, Lu Y, Zhang W, Su L, Gu Q, Wang H, Gu J, Li Z*, Xu X* （通讯作者） Anti-angiogenesis?through?noninvasive?to?minimally?invasive?intraocular?delivery?of the?peptide?CC12 identified by in?vivo-directed evolution.Anti-angiogenesis?through?noninvasive?to?minimally?invasive?intraocular?delivery?of the?peptide?CC12 identified by in?vivo-directed evolution. Biomaterials 2016 112:218-233
Liu K, Huang J, Luo D, Xu K, Wu Z, Xu X* （通讯作者） Analysis and quality control of carbohydrates in therapeutic proteins with fluorescence HPLC Biochem Biophys Res Commun 2016 16;478(2):864-7
Sun Q, Xu X A Promising Future for Peptides in Ophthalmology: Work Effectively and Smartly Current Medicinal Chemistry 2015 22, 8 ,1030 - 1040
Luo DW, Zheng Z, Wang H, Fan Y, Chen F, Sun Y, Wang WJ, Sun T, Xu X （通讯作者） UPP mediated Diabetic Retinopathy via ROS/PARP and NF-κB inflammatory factor pathways Curr Mol Med 2015 15(8):790-9
Zhongxiao Wang, Kyungwon Lee, Tyagi Puneet, Rui Cheng, Lexi Ding, Xun Xu* （通讯作者）, Uday B. Kompella, and Jian-xing Ma* Nanoparticle-Mediated Expression of a Wnt Pathway Inhibitor Ameliorates Ocular Neovascularization Arterioscler Thromb Vasc Biol 2015 无
Zuo L, Zou H, Zhang J, Fei X, Xu X （通讯作者） Vision Health-Related Quality of Life in Chinese Glaucoma Patients J Ophthalmol 2015 2015:271425
Chen C, Zhu M, Sun Y, Qu X, Xu X （通讯作者） Bimanual microincision versus standard coaxial small-incision cataract surgery: meta-analysis of randomized controlled trials Eur J Ophthalmol 2015 4.25(2):119-27
Wang L, Xu Y, Yu Q, Sun Q, Xu Y, Gu Q, Xu X* （通讯作者） H-RN, a novel antiangiogenic peptide derived from hepatocyte growth factor inhibits inflammation in vitro and in vivo through PI3K/AKT/IKK/NF-κB signal pathway Biochem Pharmacol 2014 89(2):255-65
Zhang J, Xing Z, Ma M, Wang N, Cai YD, Chen L*, Xu X* （通讯作者） Gene ontology and KEGG enrichment analyses of genes related to age-related macular degeneration Biomed Res Int 2014 2014:450386
He Y, Wang N, Shen Y, Zheng Z, Xu X* （通讯作者） Inhibition of high glucose-induced apoptosis by uncoupling protein 2 in human umbilical vein endothelial cells Int J Mol Med 2014 33(5):1275-81
Yu Q, Liu K, Su L, Xia X, Xu X* （通讯作者） Perfluorocarbon liquid: its application in vitreoretinal surgery and related ocular inflammation Biomed Res Int 2014 2014:250323
Ma M, Zhang Z, Du E, Zheng W, Gu Q, Xu X* （通讯作者）,Ke B* Wnt signaling in form deprivation myopia of the mice retina PLoS One 2014 22;9(4):e91086
Mario R. Romano*, Xun Xu, Kenneth K. W. Li. Vitreous substitutes: from tamponade effect to intraocular inflammation Biomed Res Int 2014 2014:159832
Zhou S, Gao J, Xu X* （通讯作者） Antivascular endothelial growth factors in the treatment of macular oedema secondary to central retinal vein occlusion: a meta-analysis. Clin Experiment Ophthalmol 2014 42(7):637-49.
Luo D, Liu K, Zhu B, Xu X* （通讯作者） Expression Profiling in Glaucomatous Human Lamina Cribrosa Cells Based on Graph-clustering Approach Curr Eye Res 2013 38(7):767-73
Lu Y, Su L, Xu X* （通讯作者） Bevacizumab for macular edema secondary to retinal vein occlusion: a systematic review J Ocul Pharmacol Ther 2013 29(8):702-708
Ye Sun, Li Su, Zhongxiao Wang, Yi Xu and Xun Xu* H-RN, a peptide derived from hepatocyte growth factor, inhibits corneal neovascularization by inducing endothelial apoptosis and arresting the cell cycle BMC Cell Biol 2013 24;14:8,
Jian Zhang,Min Jiang, Fei Yuan, Kai-Yan Feng,Yu-Dong Cai,Xun Xu* （通讯作者）, and Lei Chen Identification of Age-Related Macular Degeneration Related Genes by Applying Shortest Path Algorithm in Protein-Protein Interaction Network.. BioMed Research International 2013 无
Li J, Zhao SZ, Wang PP, Yu SP, Zheng Z, Xu X （通讯作者） Calcium mediates high glucose-induced HIF-1α and VEGF expression in cultured rat retinal Müller cells through CaMKII-CREB pathway Acta Pharmacologica Sinica 2012 33(8):1030-1036
Dongqing Zhu, Jibo Zhou, Xun Xu （通讯作者） Influence of Lactic Acid on Differential Expression ofVascular Endothelial Growth Factor and PigmentEpithelium-derived Factor in Explants of Rat Retina Current Eye Research 2012 37(11), 1025–1029
Dawei Luo, Ying Fan, Xun Xu （通讯作者） The effects of aminoguanidine on retinopathy in STZ-induced diabetic rats Bioorganic & Medicinal Chemistry Letters 2012 22(13):4386-4390
Ying Zheng, Qing Gu, Xun Xu （通讯作者） Inhibition of ocularneovascularization by a novelpeptide derived from humanplacenta growth factor-1 Acta Ophthalmologica 2012 90:512-523
WANG Hai-yan, GU Qing, XU Xun （通讯作者） Methanesulfonic acid sodium salt protects retina from acute lightdamage in mice Chin Med J 2012 125(13):2310-2315
Jun Li,Peipei Wang,Songping Yu,Zhi Zheng,Xun Xu （通讯作者） Calcium entry mediates hyperglycemia-induced apoptosisthrough Ca2+/calmodulin-dependent kinase ll in retinal capillaryendothelial cells Molecular Vision 2012 18:2371-2379
Wang HY, Cui XF, Gu Q, Chen Y, Zhou J, Kuang Y, Wang ZG, Xu X （通讯作者） Retinol dehydrogenase 13 protects the mouse retina from acute light damage Mol Vis 2012 18:1021-1030
Sun Q, Sun T, Xu Y, Yang XL, Xu X （通讯作者）, Wang BS, Tetsuya Nishimura, Heinrich Heimann Primary Vitrectomy Versus Scleral Buckling for the Treatment of Rhegmatogenous Retinal Detachment: A Meta-Analysis of Randomized Controlled Clinical Trials Current Eye Research 2012 37(6):492-499
Xu Yan, Zhou Huan-Ming, Li Jun, Ke Bi-Lin, Xu Xun （通讯作者） Efficacy of treatment for pterygium by autologous conjunctival transplantation and mitomycin C Chinese Medical Journal 2012 125(20):3730-3734
Yang X, Jin H, Liu K, Gu Q, Xu X （通讯作者） A novel peptide derived from human pancreatitis-associated protein inhibits inflammation in vivo and in vitro and blocks NF-kappa B signaling pathway PLoS One 2011 6(12):29155
Chen YH, Xu X （通讯作者）, Sheng MJ, Zheng Z, Gu Q Effects of asymmetric dimethylarginine on bovine retinal capillary endothelial cell proliferation, reactive oxygen species production, permeability, intercellular adhesion molecule-1, and occludin expression Mol Vis 2011 17:332-40
Zhang. ZH, Jin HY, Suo Y, Patel SV, Montes-Mico R, Manche EE, Xu X （通讯作者） Femtosecond laser versus mechanical microkeratome laser in situ keratomileusis for myopia: Metaanalysis of randomized controlled trials Journal of Cataract and Refractive Surgery 2011 37:2151-9
Jin H, Yang X, Liu K, Gu Q, Xu X （通讯作者） Effects of a novel peptide derived from human thrombomodulin on endotoxin-induced uveitis in vitro and in vivo FEBS Lett 2011 585(21):3457-64
Sun T, Cao H, Xu L, Zhu B, Gu Q, Xu X （通讯作者） lnsulin-Like Growth Factor Binding Protein-Related Protein l Mediates VEGF-lnduced Proliferation,Migration and Tube Formation of Retinal Endothelial Cells Curr Eye Res 2011 36(4):341-349
Xu L, Liu YM, Yao ZJ, Xun GL, Yu WJ, Liu K, Sun XD, Qiu YP, Wu HX, Xu X （通讯作者） Generation of trans-arachidonic acid under nitrative stress is associated with upreulation of thromposdin-1 in diabetic rats Chin Med J 2011 124(12):1885-1889
Xu Y, Zhao H, Zheng Y, Gu Q, Ma J, Xu X （通讯作者） A novel antiangiogenic peptide derived from hepatocyte growth factor inhibits neovascularization in vitro and in vivo Mol Vis 2010 16(7):1982-1995
Zheng Z, Chen H, Wang H, Ke B, Zheng B, Li Q, Li P, Su L, Gu Q, Xu X （通讯作者） Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated receptor gamma coactivator 1alpha Diabetes 2010 59(9):2315-25
Wang H, Zheng Z, Gong Y, Zhu B, Xu X （通讯作者） Effects of asymmetric dimethylarginine on bovine retinal capillary endothelial cell proliferation, reactive oxygen species production, U83836E Inhibits Retinal Neurodegeneration in Early-Stage Streptozotocin-Induced Diabetic Rats Ophthalmic Res 2010 46(1):19-24
Zheng Z, Chen HB, Zhao H, Liu K, Luo DW, Chen YD, Chen YH, Yang XL, Gu Q, Xu X （通讯作者） Inhibition of JAK2/STAT3-mediated VEGF upregulation under high glucose conditions by PEDF through a mitochondrial ROS pathway in vitro Invest Ophthalmol Vis Sci 2010 51(1):64-71