导师姓名： 罗学廷 专业代码： 100212
性别： 男 专业名称： 眼科学
培养单位： 附属第一人民医院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式： 海宁路100号
邮编： 200080 邮箱地址： xuetingluo@126.com

研究方向 (点击浏览详细信息)
视网膜神经节细胞凋亡/存活机制
眼遗传病致病机制及基因治疗
老年黄斑变性的病理机制

社会任职
上海医学会视觉研究学组委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
ZH2018ZDA16 PROM1基因缺陷导致遗传性视网膜病变的基因治疗研究 上海交通大学“转化医学交叉研究基金”项目 2019-01~2021-12 100万元 课题负责人
18SJKJGG25 PROM1基因缺陷导致遗传性视网膜病变的基因治疗研究 上海市松江区科学技术攻关项目 2019-01~2020-12 5万元 课题负责人
** SIRT6启动视网膜神经节细胞变性机制及干预研究 国家自然科学基金 2018-01~2020-12 20万元 课题负责人
17QA** Sirtuin6参与视网膜神经节细胞死亡机制及干预策略研究 上海市科委 2017-04~2020-03 40万元 课题负责人
** 年龄相关性黄斑变性-地图状萎缩实验动物模型的建立与研究 上海市科委 2016-10~2018-09 30万元 课题负责人
QD** 上海市高校青年**** 上海市教委 2016-09~2019-08 60万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Guo Y, Gao M, Wan X, Li X, Wang Y, Sun M, Li T, Jiang M, Luo X （通讯作者）, Sun X An improved method for establishment of murine retinal detachment model and its 3D vascular evaluation Exp Eye Res 2020 29:107949
Xiao M, Liu Y, Wang L, Liang J, Wang T, Zhai Y, Wang Y, Liu S, Liu W, Luo X （通讯作者）, Wang F, Sun X. Intraocular VEGF deprivation induces degeneration and fibrogenic response in retina FASEB J 2019 33(12):13920-13934
Li T; Yang S, She X, Yan Q, Zhang P, Zhu H, Wang F, Luo X*, Sun X* （通讯作者） Pharmacological Interference of Adrenergic Receptor Signaling Preserve Photoreceptors after Retinal Detachment British Journal of Pharmacology 2019 176(6):801-813
Liang J, She X, Chen J, Zhai Y, Liu Y, Zheng K,?Gong Y, Zhu H, Luo X* （通讯作者）, Sun X Identification of novel PROM1 mutations responsible for autosomal recessive maculopathy with rod-cone dystrophy Graefe's Archive for Clinical and Experimental Ophthalmology 2019 257(3):619-628
Pan D, Chang X, Xu M, Zhang M, Zhang S, Wang Y, Luo X* （通讯作者）, Xu J*, Yang X*, Sun X UMSC-derived exosomes promote retinal ganglion cells survival in a rat model of optic nerve crush J Chem Neuroanat 2019 96:134-139
Luo X （通讯作者）, Yang S, Liang J, Zhai Y, Shen M, Sun J, Feng Y, Lu X, Zhu H, Wang F, Sun X Choroidal pericytes promote subretinal fibrosis after experimental photocoagulation Dis Model Mech 2018 Apr 23;11(4).
罗学廷等 眼遗传病基因诊断方法专家共识 中华实验眼科杂志 2018 36（7）：481-488
She X, Lu X, Li T, Sun J, Liang J, Zhai Y, Yang S, Gu Q, Wei F, Zhu H, Wang F, Luo X （通讯作者）, Sun X Inhibition of mitochondrial fission preserves photoreceptors after retinal detachment Am. J Pathol 2018 Apr 22
Huang P, Sun J, Wang F, Luo X, Zhu H, Gu Q, Sun X, Liu T, Sun X DNMT1 and Sp1 competitively regulate the expression of BACE1 in A2E-mediated photo-oxidative damage in RPE cells .Neurochem Int 2018 121:59-68
Sun J, Huang P, Liang J, Li J, Shen M, She X, Feng Y, Luo X, Liu T, Sun X Cooperation of Rel family members in regulating Aβ1-40-mediated pro-inflammatory cytokine secretion by retinal pigment epithelial cells Cell Death Dis 2018 2017 Oct 12;8(10)
Wang J, Feng Y, Han P, Wang F, Luo X, Liang J, Sun X, Ye J, Lu Y, Sun X Photosensitization of A2E triggers telomere dysfunction and accelerates retinal pigment epithelium senescence Cell Death Dis 2018 7;9(2):178
Feng Y, Liang J, Zhai Y, Sun J, Wang J, She X, Gu Q, Liu Y, Zhu H, Luo X （通讯作者）, Sun X Autophagy activated by SIRT6 regulates Aβ induced inflammatory response in RPEs Biochem Biophys Res Commun 2018 19;496(4):1148-1154
Lu B, Zhang P, Zhou M, Wang W, Gu Q, Feng J, Luo X, Sun X, Wang F, Sun X Involvement of XBP1s in Blue Light-Induced A2E-Containing Retinal Pigment Epithelium Cell Death Ophthalmic Res 2017 57(4):252-262
Zhang P, Wang H, Luo X, Liu H, Lu B, Li T, Yang S, Gu Q, Li B, Wang F, Sun X MicroRNA-155 Inhibits Polarization of Macrophages to M2-Type and Suppresses Choroidal Neovascularization Inflammation 2017 41(1):143-153
Huang P, Sun J, Wang F, Luo X, Feng J, Gu Q, Liu T, Sun X MicroRNA Expression Patterns Involved in Amyloid Beta-Induced Retinal Degeneration Invest Ophthalmol Vis Sci 2017 58(3):1726-1735
Sun J, Huang P, Liang J, Li J, Shen M, She X, Feng Y, Luo X, Liu T, Sun X Cooperation of Rel family members in regulating Aβ1-40-mediated pro-inflammatory cytokine secretion by retinal pigment epithelial cells Cell Death Dis 2017 12;8(10):e3115
Guo J, Luo X, Liang J, Xiao M, Sun X Antiangiogenic Effects of Doxazosin on Experimental Choroidal Neovascularization in Mice J Ocul Pharmacol Ther 2017 33(1):50-56
Park KK*, Luo X, Mooney SJ, Yungher BJ, Belin S, Wang C, Holmes MM, He Z* Retinal ganglion cell survival and axon regeneration after optic nerve injury in naked mole-rats Journal of Comparative Neurology 2016 525(2):380-388
Guo J, Luo X, Liang J, Xiao M, Sun X Antiangiogenic Effects of Doxazosin on Experimental Choroidal Neovascularization in Mice Journal of Ocular Pharmacology and Therapeutics 2016 2016 Dec 19
Luo X, Ribeiro M, Bray ER, Lee DH, Yungher B, Mehta ST, Thakor KA, Diaz F, Lee JK, Moraes CT, Bixby JL, Lemmon VP, Park KK* Enhanced transcriptional activity and mitochondrial localization of STAT3 co-induce axon regrowth in the adult central nervous system Cell Reports 2016 15(2): 398-410
Mehta S, Luo X, Park KK, Bixby JL, Lemmon VP* Hyperactivated Stat3 boosts axon regeneration in the CNS Experimental Neurology 2016 280:115-20
Dvoriantchikova G, Pappas S, Luo X, Ribeiro M, Danek D, Pelaez D, Park KK, Ivanov D* Virally delivered, constitutively active NFκB improves survival of injured retinal ganglion cells European Journal of Neuroscience 2016 11:2935-2943
Yungher BJ, Luo X, Salgueiro Y, Blackmore MG, Park KK* Viral vector-based improvement of optic nerve regeneration:characterization of individual axons' growth patterns and synaptogenesis in a visual target Gene Therapy 2015 22(10):811-21
Lee DH, Luo X, Yungher BJ, Bray E, Lee JK, Park KK* Mammalian target of rapamycin's distinct roles and effectiveness in promoting compensatory axonal sprouting in the injured CNS Journal of Neuroscience 2014 34(46):15347-55
Luo X, Yungher B, Park KK* Application of tissue clearing and light sheet fluorescence microscopy to assess optic nerve regeneration in unsectioned tissues Methods in Molecular Biology 2014 1162:209-17
Soderblom C, Luo X, Blumenthal E, Bray E, Lyapichev K, Ramos J, Krishnan V, Lai-Hsu C, Park KK, Tsoulfas P, Lee JK* Perivascular fibroblasts form the fibrotic scar after contusive spinal cord injury Journal of Neuroscience 2013 33(34):13882-7
Luo X, Salgueiro Y, Beckerman SR, Lemmon VP, Tsoulfas P, Park KK* Three-dimensional evaluation of retinal ganglion cell axon regeneration and pathfinding in whole mouse tissue after injury Experimental Neurology 2013 247:653-62
Chou TH, Park KK, Luo X, Porciatti V* Retrograde signaling in the optic nerve is necessary for electrical responsiveness of retinal ganglion cells Investigative Ophthalmology & Visual Science 2013 54(2):1236-43
Kuboyama T, Luo X, Park K, Blackmore MG, Tojima T, Tohda C, Bixby JL, Lemmon VP, Kamiguchi H* Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration Experimental Neurology 2013 248:157-69
Luo X, Park KK* Neuron-intrinsic inhibitors of axon regeneration: PTEN and SOCS3 International Review of Neurobiology 2012 105:141-73
Luo X, Nerlick S, An W, King ML* Xenopus germline nanos1 is translationally repressed by a novel structure-based mechanism Development 2011 138(3):589-98
Lai F, Zhou Y, Luo X, Fox J, King ML* Nanos1 functions as a translational repressor in the Xenopus germline Mechanisms of Development 2011 128(1-2):153-63
Venkatarama T, Lai F, Luo X, Zhou Y, Newman K, King ML* Repression of zygotic gene expression in the Xenopus germline Development 2010 137(4):651-60
Liu HQ, Zhang WY, Luo XT, Ye Y, Zhu XZ* Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson's disease by activation of adenosine A1 receptor British Journal of Pharmacology 2006 148(3):314-25
Xiao L, Wang YZ, Liu J, Luo XT, Ye Y, Zhu XZ* Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats Life Science 2005 78(4):413-20